{"id":"https://openalex.org/W751022221","doi":null,"title":"Flt3 receptor tyrosine kinase in AML and its modulation of the p53/Hdm2/Bcl-2 pathway","display_name":"Flt3 receptor tyrosine kinase in AML and its modulation of the p53/Hdm2/Bcl-2 pathway","publication_year":2007,"publication_date":"2007-09-06","ids":{"openalex":"https://openalex.org/W751022221","mag":"751022221"},"language":"en","primary_location":{"id":"pmh:oai:bora.uib.no:1956/2453","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1956/2453","pdf_url":"http://hdl.handle.net/1956/2453","source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1956/2453","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015161549","display_name":"Line Wergeland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Line Wergeland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5015161549"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.02539999969303608,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flt3-itd-mutation","display_name":"FLT3-ITD","score":0.7649999856948853},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9010000228881836},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.7590000033378601},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.8970000147819519},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9620000123977661},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.9350000023841858},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.7599999904632568},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5170000195503235},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.777999997138977},{"id":"https://openalex.org/keywords/receptor-turnover","display_name":"receptor turnover","score":0.5450000166893005},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C23440912","wikidata":"https://www.wikidata.org/wiki/Q18030230","display_name":"ROR1","level":5,"score":0.5977140665054321},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.5739785432815552},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5391424298286438},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5038434863090515},{"id":"https://openalex.org/C79186569","wikidata":"https://www.wikidata.org/wiki/Q14897880","display_name":"Tropomyosin receptor kinase C","level":5,"score":0.5010941028594971},{"id":"https://openalex.org/C41650920","wikidata":"https://www.wikidata.org/wiki/Q14912399","display_name":"CD135","level":4,"score":0.4376183748245239},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32048457860946655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2926817834377289},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2694500684738159},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.24308261275291443},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17169079184532166},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:bora.uib.no:1956/2453","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1956/2453","pdf_url":"http://hdl.handle.net/1956/2453","source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:751022221","doi":null,"is_oa":false,"landing_page_url":"https://bora.uib.no/bora-xmlui/handle/1956/2453","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:bora.uib.no:1956/2453","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1956/2453","pdf_url":"http://hdl.handle.net/1956/2453","source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310758","display_name":"Kreftforeningen","ror":"https://ror.org/01925vb10"},{"id":"https://openalex.org/F4320322496","display_name":"Helse Vest","ror":"https://ror.org/001212e83"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W751022221.pdf","grobid_xml":"https://content.openalex.org/works/W751022221.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W15453418","https://openalex.org/W27758711","https://openalex.org/W109236707","https://openalex.org/W134922517","https://openalex.org/W143783909","https://openalex.org/W1211118294","https://openalex.org/W1534965621","https://openalex.org/W1567124794","https://openalex.org/W1570595295","https://openalex.org/W1589900156","https://openalex.org/W1592701464","https://openalex.org/W1964095007","https://openalex.org/W1968306285","https://openalex.org/W1970353405","https://openalex.org/W1971028883","https://openalex.org/W1972164385","https://openalex.org/W1975489275","https://openalex.org/W1977873175","https://openalex.org/W1980608195","https://openalex.org/W1983636872","https://openalex.org/W1984552603","https://openalex.org/W1988108713","https://openalex.org/W1989512056","https://openalex.org/W1990259051","https://openalex.org/W1995926647","https://openalex.org/W2006805941","https://openalex.org/W2011768640","https://openalex.org/W2016612145","https://openalex.org/W2016677649","https://openalex.org/W2017247060","https://openalex.org/W2021371527","https://openalex.org/W2021493109","https://openalex.org/W2022794649","https://openalex.org/W2027151723","https://openalex.org/W2027395744","https://openalex.org/W2032359283","https://openalex.org/W2039778682","https://openalex.org/W2040950977","https://openalex.org/W2044745267","https://openalex.org/W2046135777","https://openalex.org/W2052071780","https://openalex.org/W2059549751","https://openalex.org/W2073576377","https://openalex.org/W2073936529","https://openalex.org/W2077964413","https://openalex.org/W2081545299","https://openalex.org/W2086402500","https://openalex.org/W2087505934","https://openalex.org/W2090549486","https://openalex.org/W2091818021","https://openalex.org/W2093229625","https://openalex.org/W2093686057","https://openalex.org/W2095013649","https://openalex.org/W2097382368","https://openalex.org/W2097583774","https://openalex.org/W2101157786","https://openalex.org/W2107369582","https://openalex.org/W2108247511","https://openalex.org/W2116036462","https://openalex.org/W2117217112","https://openalex.org/W2120447464","https://openalex.org/W2123211178","https://openalex.org/W2123986795","https://openalex.org/W2129615499","https://openalex.org/W2129834424","https://openalex.org/W2130864403","https://openalex.org/W2132912591","https://openalex.org/W2138546316","https://openalex.org/W2153345005","https://openalex.org/W2153762797","https://openalex.org/W2154248376","https://openalex.org/W2158682205","https://openalex.org/W2165392081","https://openalex.org/W2169761030","https://openalex.org/W2284010712","https://openalex.org/W2313401036","https://openalex.org/W2318118720","https://openalex.org/W2318674152","https://openalex.org/W2321946412","https://openalex.org/W2334818382","https://openalex.org/W2345038599","https://openalex.org/W2407963460","https://openalex.org/W2410122372","https://openalex.org/W2410693357","https://openalex.org/W2410905075","https://openalex.org/W2432985564","https://openalex.org/W2442914343","https://openalex.org/W2463627308","https://openalex.org/W2468281804","https://openalex.org/W2559548540","https://openalex.org/W2562482166","https://openalex.org/W3044574244","https://openalex.org/W3202912068","https://openalex.org/W7100962643"],"related_works":["https://openalex.org/W2981225134","https://openalex.org/W2109078622","https://openalex.org/W2750617616","https://openalex.org/W1971660876","https://openalex.org/W1907427689","https://openalex.org/W2998830459","https://openalex.org/W2165392081","https://openalex.org/W2899107007","https://openalex.org/W2045166052","https://openalex.org/W3209716189"],"abstract_inverted_index":{"Acute":[0],"myeloid":[1],"leukemia":[2],"(AML)":[3],"is":[4,62,193,204,214,221,246,262],"an":[5,119],"aggressive":[6],"disease":[7],"with":[8,19,114,141,264,282],"a":[9,82,131,154,199,229],"poor":[10],"overall":[11],"survival":[12],"rate.":[13],"The":[14,128,186,233],"most":[15],"frequent":[16],"mutations":[17,37],"associated":[18],"AML":[20,139,303],"are":[21],"internal":[22],"tandem":[23],"duplications":[24],"(ITD)":[25],"in":[26,118,126,138,164,178,196,217,222,241,280],"the":[27,31,39,72,91,102,107,110,115,147,161,207,265,283,299],"juxtamembrane":[28],"region":[29],"of":[30,58,66,84,90,104,109,134,157,174,188,191,202,231,235,274,288,301],"receptor":[32,40,166],"tyrosine":[33],"kinase":[34],"Flt3.":[35],"These":[36],"render":[38],"constitutively":[41],"active":[42],"and":[43,55,95,106,136,160,168,181,244,259,291],"alter":[44],"signaling":[45,80,112],"trough":[46],"FLT3-ITD":[47,85,105,144,150,175],"compared":[48],"to":[49,78,121,209,225],"wild":[50,257],"type":[51,258],"receptor.":[52],"Non-mutated":[53],"TP53":[54],"elevated":[56,179],"expression":[57],"its":[59],"regulator":[60,230],"Hdm2":[61,137,148,170,180,220,236,245,290],"another":[63],"interesting":[64,296],"feature":[65],"AML.":[67,127],"Studies":[68],"have":[69,153],"shown":[70,224],"that":[71],"p53":[73,97],"pathway":[74,113,117,268],"can":[75],"be":[76,226,278,295],"linked":[77],"Flt3":[79,111,135,158,261,275],"as":[81,228],"subset":[83],"patients":[86],"expresses":[87],"increased":[88,182,242],"levels":[89],"anti-apoptotic":[92],"protein":[93,159],"Bcl-2":[94,189,249,292],"hyperphosphorylated":[96],"protein.":[98],"This":[99],"thesis":[100],"investigates":[101],"properties":[103],"interconnection":[108],"p53/Hdm2/Bcl-2":[116,267,284],"attempt":[120],"elucidate":[122],"novel":[123,302],"therapeutic":[124],"targets":[125],"experiments":[129],"demonstrate":[130],"reciprocal":[132],"regulation":[133],"cells":[140,145,152,208],"Flt3-wt":[142,218],"while":[143],"suspend":[146],"modulation.":[149],"patient":[151],"higher":[155],"level":[156],"ITD":[162],"results":[163,240],"dysregulated":[165],"turnover":[167],"attenuated":[169],"down-regulation.":[171],"Thus":[172],"targeting":[173,273,287],"may":[176,293],"result":[177],"tolerance":[183],"for":[184,206,248],"p53.":[185],"involvement":[187],"family":[190],"proteins":[192],"also":[194],"seen":[195,216],"this":[197,213],"setting;":[198],"persistent":[200],"attenuation":[201],"Mcl-1":[203],"required":[205,247],"undergo":[210],"apoptosis,":[211],"however":[212],"only":[215],"cells.":[219],"addition":[223],"important":[227,266],"Bcl-2.":[232],"blockage":[234],"E3":[237],"ligase":[238],"activity":[239],"Bcl2":[243],"protection":[250],"from":[251],"p53-induced":[252],"cell":[253],"death.":[254],"To":[255],"conclude,":[256],"mutated":[260],"interconnected":[263],"at":[269],"several":[270],"levels.":[271],"Therapeutic":[272],"should":[276],"therefore":[277,294],"evaluated":[279],"co-operation":[281],"pathway.":[285],"Combined":[286],"FLT3-ITD,":[289],"when":[297],"approaching":[298],"development":[300],"therapy.":[304]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}