{"id":"https://openalex.org/W75099420","doi":"https://doi.org/10.1007/978-3-642-78666-2_11","title":"The \u03b2 Sliding Clamp of E. coli DNA Polymerase III Holoenzyme Balances Opposing Functions","display_name":"The \u03b2 Sliding Clamp of E. coli DNA Polymerase III Holoenzyme Balances Opposing Functions","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W75099420","doi":"https://doi.org/10.1007/978-3-642-78666-2_11","mag":"75099420"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-642-78666-2_11","doi":"https://doi.org/10.1007/978-3-642-78666-2_11","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-78666-2_11","pdf_url":null,"source":{"id":"https://openalex.org/S4210194239","display_name":"Nucleic acids and molecular biology","issn_l":"0933-1891","issn":["0933-1891","1869-2486"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids and Molecular Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W1586999333","display_name":"Nucleic Acids and Molecular Biology"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051770888","display_name":"Mike E. O\u2019Donnell","orcid":"https://orcid.org/0000-0001-9002-4214","observed_orcids":["https://orcid.org/0000-0001-9002-4214","https://orcid.org/0000-0002-8928-8068"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. O\u2019donnell","raw_affiliation_strings":["Microbiology Department, Hearst Research Center, Howard Hughes Medical Institute, Cornell Medical College, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology Department, Hearst Research Center, Howard Hughes Medical Institute, Cornell Medical College, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038330393","display_name":"John Kuriyan","orcid":"https://orcid.org/0000-0002-4414-5477","observed_orcids":["https://orcid.org/0000-0002-4414-5477"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Kuriyan","raw_affiliation_strings":["Laboratories of Molecular Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratories of Molecular Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067196402","display_name":"Xiang\u2010Peng Kong","orcid":"https://orcid.org/0000-0001-5773-2681","observed_orcids":["https://orcid.org/0000-0001-5773-2681"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X.-P. Kong","raw_affiliation_strings":["Laboratories of Molecular Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratories of Molecular Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072633316","display_name":"P. Todd Stukenberg","orcid":"https://orcid.org/0000-0002-6788-2111","observed_orcids":["https://orcid.org/0000-0002-6788-2111"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. T. Stukenberg","raw_affiliation_strings":["Microbiology Department, Hearst Research Center, Howard Hughes Medical Institute, Cornell Medical College, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology Department, Hearst Research Center, Howard Hughes Medical Institute, Cornell Medical College, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014900887","display_name":"Ren\u00e9 Onrust","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Onrust","raw_affiliation_strings":["Microbiology Department, Hearst Research Center, Howard Hughes Medical Institute, Cornell Medical College, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology Department, Hearst Research Center, Howard Hughes Medical Institute, Cornell Medical College, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003107288","display_name":"Nina Y. Yao","orcid":"https://orcid.org/0000-0002-4728-6531","observed_orcids":["https://orcid.org/0000-0002-4728-6531"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Yao","raw_affiliation_strings":["Microbiology Department, Hearst Research Center, Howard Hughes Medical Institute, Cornell Medical College, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology Department, Hearst Research Center, Howard Hughes Medical Institute, Cornell Medical College, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0448654,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"197","last_page":"216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.663100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.663100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.28299999237060547,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-sliding-clamp","display_name":"beta sliding clamp","score":0.8500000238418579},{"id":"https://openalex.org/keywords/dna-polymerase-iii-holoenzyme","display_name":"DNA polymerase III holoenzyme","score":0.9860000014305115},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9629999995231628},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.8500000238418579},{"id":"https://openalex.org/keywords/processivity","display_name":"processivity","score":0.628000020980835},{"id":"https://openalex.org/keywords/dna-polymerase-processivity","display_name":"DNA polymerase processivity","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C131140672","wikidata":"https://www.wikidata.org/wiki/Q2031164","display_name":"Processivity","level":4,"score":0.814325213432312},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.7908704280853271},{"id":"https://openalex.org/C31254050","wikidata":"https://www.wikidata.org/wiki/Q22328799","display_name":"DNA clamp","level":5,"score":0.7792196273803711},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5312072038650513},{"id":"https://openalex.org/C88354546","wikidata":"https://www.wikidata.org/wiki/Q3502973","display_name":"DNA polymerase II","level":5,"score":0.5285847187042236},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.4862560033798218},{"id":"https://openalex.org/C164965036","wikidata":"https://www.wikidata.org/wiki/Q2529148","display_name":"DNA polymerase I","level":5,"score":0.46739065647125244},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4642513394355774},{"id":"https://openalex.org/C76535049","wikidata":"https://www.wikidata.org/wiki/Q3487941","display_name":"DNA polymerase delta","level":5,"score":0.4565145969390869},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.4339104890823364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4117875397205353},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3990750014781952},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3852095603942871},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3447824716567993},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29573357105255127},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15161997079849243},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.09449830651283264},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.0878739058971405}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-642-78666-2_11","doi":"https://doi.org/10.1007/978-3-642-78666-2_11","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-78666-2_11","pdf_url":null,"source":{"id":"https://openalex.org/S4210194239","display_name":"Nucleic acids and molecular biology","issn_l":"0933-1891","issn":["0933-1891","1869-2486"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids and Molecular Biology","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W170319054","https://openalex.org/W202706838","https://openalex.org/W1483085618","https://openalex.org/W1483862752","https://openalex.org/W1484791891","https://openalex.org/W1486742670","https://openalex.org/W1492751534","https://openalex.org/W1493097357","https://openalex.org/W1495523186","https://openalex.org/W1507551858","https://openalex.org/W1512268896","https://openalex.org/W1515304043","https://openalex.org/W1515794053","https://openalex.org/W1516580953","https://openalex.org/W1517952165","https://openalex.org/W1518359286","https://openalex.org/W1531749456","https://openalex.org/W1534957409","https://openalex.org/W1535209874","https://openalex.org/W1535843470","https://openalex.org/W1536976216","https://openalex.org/W1537032296","https://openalex.org/W1540214411","https://openalex.org/W1541300405","https://openalex.org/W1542141332","https://openalex.org/W1543542376","https://openalex.org/W1545377574","https://openalex.org/W1548939450","https://openalex.org/W1551043626","https://openalex.org/W1551254087","https://openalex.org/W1562566862","https://openalex.org/W1575133253","https://openalex.org/W1577257516","https://openalex.org/W1577577942","https://openalex.org/W1579564253","https://openalex.org/W1590183989","https://openalex.org/W1599908987","https://openalex.org/W1603869179","https://openalex.org/W1638621963","https://openalex.org/W1653821563","https://openalex.org/W1883762470","https://openalex.org/W1941809860","https://openalex.org/W1965743560","https://openalex.org/W1979170904","https://openalex.org/W1985188411","https://openalex.org/W2006986935","https://openalex.org/W2008769081","https://openalex.org/W2009412786","https://openalex.org/W2016119662","https://openalex.org/W2019054377","https://openalex.org/W2021345772","https://openalex.org/W2031504305","https://openalex.org/W2031645882","https://openalex.org/W2047577950","https://openalex.org/W2055707621","https://openalex.org/W2060769308","https://openalex.org/W2065014822","https://openalex.org/W2070936740","https://openalex.org/W2076849893","https://openalex.org/W2091790979","https://openalex.org/W2092713502","https://openalex.org/W2100639153","https://openalex.org/W2106315897","https://openalex.org/W2171367003","https://openalex.org/W2746255352","https://openalex.org/W3148418966","https://openalex.org/W4231654880"],"related_works":["https://openalex.org/W1551254087","https://openalex.org/W2065014822","https://openalex.org/W2041249795","https://openalex.org/W2009509451","https://openalex.org/W1917556319","https://openalex.org/W7097209799","https://openalex.org/W2103880400","https://openalex.org/W3176838149","https://openalex.org/W42506871","https://openalex.org/W2088036936"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
