{"id":"https://openalex.org/W75076737","doi":null,"title":"The genetic basis for adaptation of Escherichia coli to growth in minimal media","display_name":"The genetic basis for adaptation of Escherichia coli to growth in minimal media","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W75076737","mag":"75076737"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt2m58s9b0","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/2m58s9b0","pdf_url":"https://escholarship.org/uc/item/2m58s9b0","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/2m58s9b0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065978869","display_name":"Thomas Conrad","orcid":"https://orcid.org/0000-0001-5618-6295","observed_orcids":["https://orcid.org/0000-0001-5618-6295"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Thomas Conrad","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5618-6295","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5065978869"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.984000027179718},{"id":"https://openalex.org/keywords/genome-scale-metabolic-reconstruction","display_name":"genome-scale metabolic reconstruction","score":0.8059999942779541},{"id":"https://openalex.org/keywords/adaptive-evolution","display_name":"adaptive evolution","score":0.7129999995231628},{"id":"https://openalex.org/keywords/whole-genome-resequencing","display_name":"whole-genome resequencing","score":0.9319999814033508},{"id":"https://openalex.org/keywords/isoenzymes","display_name":"isozymes","score":0.8190000057220459},{"id":"https://openalex.org/keywords/novel-metabolic-pathways","display_name":"novel metabolic pathways","score":0.8270000219345093},{"id":"https://openalex.org/keywords/metabolic-network-structure","display_name":"metabolic network structure","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.5909382700920105},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.5817004442214966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5693387389183044},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5412378907203674},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.5114871263504028},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.45014575123786926},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.449638307094574},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4395591616630554},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.434257447719574},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4013117551803589},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31199076771736145},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt2m58s9b0","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/2m58s9b0","pdf_url":"https://escholarship.org/uc/item/2m58s9b0","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"mag:75076737","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt2m58s9b0/qt2m58s9b0.pdf?t=ml36u0","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt2m58s9b0","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/2m58s9b0","pdf_url":"https://escholarship.org/uc/item/2m58s9b0","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W75076737.pdf","grobid_xml":"https://content.openalex.org/works/W75076737.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1980207389","https://openalex.org/W21121628","https://openalex.org/W2025663053","https://openalex.org/W2003489966","https://openalex.org/W3027140915","https://openalex.org/W2127289933","https://openalex.org/W2160541874","https://openalex.org/W2161827792","https://openalex.org/W2760308229","https://openalex.org/W1986082851"],"abstract_inverted_index":{"Bottom-up,":[0],"genome-scale":[1],"metabolic":[2,64],"reconstructions":[3],"have":[4],"been":[5],"used":[6],"to":[7,27,36,50,76,79,103,118],"model":[8,21,39],"the":[9,52,60,85,96,135],"growth":[10,107,119],"phenotypes":[11],"of":[12,32,59,87,114,129],"E.":[13,33,62,93],"coli":[14,34,63],"in":[15,38,92,120],"various":[16],"conditions.":[17],"Experimental":[18],"discrepancies":[19],"with":[20],"predictions":[22,58],"indicate":[23],"1)":[24],"modeling":[25,57],"failed":[26],"predict":[28],"an":[29],"achievable":[30],"state":[31,108],"due":[35],"errors":[37],"parameters":[40],"or":[41],"network":[42,80],"structure;":[43],"OR":[44],"2)":[45],"adaptive":[46],"evolution":[47],"is":[48],"required":[49],"achieve":[51],"computationally":[53,105],"predicted":[54,106],"state.":[55],"The":[56],"iAF1260":[61],"reconstruction":[65],"were":[66],"tested":[67],"experimentally":[68],"for":[69,84,101],"over":[70],"4,000":[71],"scenarios,":[72],"uncovering":[73],"both":[74],"improvements":[75],"be":[77],"made":[78],"structure":[81],"and":[82,90,98,125,138],"hypotheses":[83],"discovery":[86],"novel":[88],"isozymes":[89],"pathways":[91],"coli.":[94],"Furthermore,":[95],"genetic":[97],"molecular":[99],"basis":[100],"adaptation":[102],"a":[104],"was":[109],"determined":[110],"through":[111,126],"whole-genome":[112],"resequencing":[113],"eleven":[115],"strains":[116],"adapted":[117],"lactate":[121],"M9":[122],"minimal":[123],"medium":[124],"detailed":[127],"studies":[128],"highly-adaptive":[130],"RNA":[131],"polymerase":[132],"mutants":[133],"at":[134],"kinetic,":[136],"physiological,":[137],"systems":[139],"biology":[140],"levels":[141]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}
