{"id":"https://openalex.org/W75050466","doi":null,"title":"THE ZEBRAFISH AS A MODEL TO ELUCIDATE HUMAN DISEASES AND DEVELOPMENT","display_name":"THE ZEBRAFISH AS A MODEL TO ELUCIDATE HUMAN DISEASES AND DEVELOPMENT","publication_year":2011,"publication_date":"2011-08-15","ids":{"openalex":"https://openalex.org/W75050466","mag":"75050466"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26922034","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/The_zebrafish_as_a_model_to_elucidate_human_diseases_and_development/26922034","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/40662","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086918254","display_name":"Samantha Lin Chiou Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Samantha Lin Chiou Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5086918254"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.8610000014305115},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/intravasation","display_name":"intravasation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9409999847412109},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8510000109672546},{"id":"https://openalex.org/keywords/sunitinib","display_name":"sunitinib","score":0.9850000143051147},{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.6650000214576721},{"id":"https://openalex.org/keywords/motility-mutants","display_name":"motility mutants","score":0.8159999847412109},{"id":"https://openalex.org/keywords/atg10","display_name":"ATG10","score":0.9649999737739563},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dystrophy","display_name":"dystrophy","score":0.902999997138977},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C2778050619","wikidata":"https://www.wikidata.org/wiki/Q6058567","display_name":"Intravasation","level":4,"score":0.9484238624572754},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.9199590682983398},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.7728224396705627},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6884841322898865},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6531682014465332},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5585184097290039},{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.46186381578445435},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.429558128118515},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4282415807247162},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3601101040840149},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3361503779888153},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2658184766769409},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11139628291130066},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26922034","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/The_zebrafish_as_a_model_to_elucidate_human_diseases_and_development/26922034","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/40662","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/40662","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:75050466","doi":null,"is_oa":false,"landing_page_url":"http://publications.ki.se/xmlui/bitstream/handle/10616/40662/Thesis_Samantha_LEE.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/40662","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/40662","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":125,"referenced_works":["https://openalex.org/W194075173","https://openalex.org/W645508545","https://openalex.org/W1488520865","https://openalex.org/W1581429301","https://openalex.org/W1626086977","https://openalex.org/W1767712531","https://openalex.org/W1780295430","https://openalex.org/W1784425676","https://openalex.org/W1875913653","https://openalex.org/W1947859348","https://openalex.org/W1967474254","https://openalex.org/W1967740895","https://openalex.org/W1968896842","https://openalex.org/W1969457299","https://openalex.org/W1970927745","https://openalex.org/W1970944947","https://openalex.org/W1975663116","https://openalex.org/W1977394233","https://openalex.org/W1978751572","https://openalex.org/W1978791549","https://openalex.org/W1979606683","https://openalex.org/W1982111644","https://openalex.org/W1983216934","https://openalex.org/W1985727076","https://openalex.org/W1985827566","https://openalex.org/W1985920188","https://openalex.org/W1991105254","https://openalex.org/W1991484745","https://openalex.org/W1992938999","https://openalex.org/W2000345746","https://openalex.org/W2000586937","https://openalex.org/W2002450099","https://openalex.org/W2003161345","https://openalex.org/W2011580247","https://openalex.org/W2011647003","https://openalex.org/W2011745504","https://openalex.org/W2012451546","https://openalex.org/W2017051563","https://openalex.org/W2017452459","https://openalex.org/W2018753432","https://openalex.org/W2019342767","https://openalex.org/W2019957886","https://openalex.org/W2020496676","https://openalex.org/W2020882844","https://openalex.org/W2021248248","https://openalex.org/W2022233074","https://openalex.org/W2025364264","https://openalex.org/W2026080348","https://openalex.org/W2026549488","https://openalex.org/W2028734899","https://openalex.org/W2034172998","https://openalex.org/W2035595755","https://openalex.org/W2036787961","https://openalex.org/W2036903182","https://openalex.org/W2040076280","https://openalex.org/W2041831658","https://openalex.org/W2043406624","https://openalex.org/W2049231184","https://openalex.org/W2050499474","https://openalex.org/W2051260870","https://openalex.org/W2054810866","https://openalex.org/W2057378555","https://openalex.org/W2057486637","https://openalex.org/W2058991502","https://openalex.org/W2061008107","https://openalex.org/W2062629975","https://openalex.org/W2063544030","https://openalex.org/W2066513668","https://openalex.org/W2067692987","https://openalex.org/W2073551059","https://openalex.org/W2075065864","https://openalex.org/W2077272494","https://openalex.org/W2077926756","https://openalex.org/W2078893058","https://openalex.org/W2081057817","https://openalex.org/W2084276666","https://openalex.org/W2086938764","https://openalex.org/W2088585878","https://openalex.org/W2090466892","https://openalex.org/W2091265794","https://openalex.org/W2091760375","https://openalex.org/W2094493695","https://openalex.org/W2095313258","https://openalex.org/W2096985044","https://openalex.org/W2099345094","https://openalex.org/W2101265172","https://openalex.org/W2105728643","https://openalex.org/W2106043356","https://openalex.org/W2106902692","https://openalex.org/W2108333200","https://openalex.org/W2109716633","https://openalex.org/W2111567059","https://openalex.org/W2112596275","https://openalex.org/W2115258708","https://openalex.org/W2115888489","https://openalex.org/W2120514632","https://openalex.org/W2120960764","https://openalex.org/W2123938765","https://openalex.org/W2125063742","https://openalex.org/W2125349610","https://openalex.org/W2128299875","https://openalex.org/W2131872473","https://openalex.org/W2133000461","https://openalex.org/W2133848888","https://openalex.org/W2136000647","https://openalex.org/W2136709809","https://openalex.org/W2139627902","https://openalex.org/W2140452645","https://openalex.org/W2140634904","https://openalex.org/W2141557806","https://openalex.org/W2141873651","https://openalex.org/W2142162357","https://openalex.org/W2143191505","https://openalex.org/W2150337400","https://openalex.org/W2150656456","https://openalex.org/W2154699417","https://openalex.org/W2154959571","https://openalex.org/W2155587446","https://openalex.org/W2161761622","https://openalex.org/W2162413397","https://openalex.org/W2168982460","https://openalex.org/W2171298396","https://openalex.org/W2171754171","https://openalex.org/W2428412196","https://openalex.org/W2783066217"],"related_works":["https://openalex.org/W4253002383","https://openalex.org/W2084613660","https://openalex.org/W2980964834","https://openalex.org/W1509933629","https://openalex.org/W45474750","https://openalex.org/W2158062858","https://openalex.org/W2597176650","https://openalex.org/W7099069930","https://openalex.org/W2080173566","https://openalex.org/W6990391675"],"abstract_inverted_index":{"This":[0,197,324],"thesis":[1],"explores":[2],"the":[3,17,27,36,45,49,82,100,105,110,166,169,184,191,222,226,232,243,284,294,312,316,319,329,344,354,357,375,382,402],"zebrafish":[4,67,112,148,303,358,376,457],"as":[5,119,219,251,359],"a":[6,31,127,177,277,339,360,393,456],"model":[7,34,198,361],"organism":[8,362],"to":[9,39,73,80,99,182,203,213,268,282,377,391,398],"illuminate":[10],"our":[11,414],"understanding":[12,415],"of":[13,19,30,44,61,84,107,115,168,187,208,225,234,237,259,299,301,331,356,374,387,416,422],"processes":[14,409],"that":[15,194,217,248,311,363,405],"orchestrate":[16],"progression":[18],"cancer":[20,32],"metastasis":[21,33,108,145,454],"and":[22,89,97,103,140,190,212,256,266,296,334,367,372,385,400,410,419,442,453,486,495,522,534],"myogenesis.":[23],"First,":[24],"I":[25,230,292,308],"describe":[26,293],"successful":[28],"establishment":[29],"in":[35,48,109,143,147,155,173,242,272,328,347,455,539],"zebrafish,":[37],"specifically":[38],"study":[40,81],"intravasation":[41,171],"-":[42],"one":[43,235],"earliest":[46,223],"steps":[47],"metastatic":[50,210,227],"cascade.":[51,228],"Fluorescently":[52],"labeled":[53],"tumour":[54,102,188,206],"cell":[55,450,493],"are":[56,71],"transplanted":[57,101],"into":[58],"pervitelline":[59],"space":[60],"2":[62],"days":[63],"post":[64],"fertilisation":[65],"(dpf)":[66],"embryos":[68,389],"before":[69],"they":[70],"exposed":[72],"normoxic":[74],"or":[75,133,158],"hypoxic":[76],"conditions,":[77],"allowing":[78,180],"us":[79,181],"effect":[83],"hypoxia":[85],"on":[86,413],"tumour-induced":[87,138],"angiogenesis":[88,139,447,490],"metastasis.":[90,141,196,496],"Hypoxia":[91],"elicited":[92],"an":[93],"enhanced":[94],"angiogenic":[95],"response":[96],"neovascularisation":[98],"escalated":[104],"extent":[106],"living":[111,178],"embryo.":[113],"Loss":[114],"function":[116],"experiments":[117],"such":[118],"vascular":[120],"endothelial":[121],"growth":[122],"factor":[123],"(VEGF)":[124],"blockade":[125],"using":[126],"clinically":[128],"available":[129],"drug":[130],"\u2013":[131],"Sunitinib":[132],"VEGF":[134],"morpholino":[135],"knockdown":[136],"attenuated":[137],"The":[142,162,370,525],"vivo":[144],"assay":[146],"delivers":[149],"numerous":[150],"unique":[151],"advantages":[152],"over":[153],"conventional":[154],"vitro":[156],"cell-based":[157],"biochemical":[159],"chemotaxis":[160],"assays.":[161],"transparent":[163],"embryo":[164],"facilitates":[165,491],"tracking":[167],"entire":[170],"process":[172],"real":[174],"time":[175],"within":[176],"organism,":[179],"explore":[183],"dynamic":[185],"interplay":[186],"cells":[189,207],"environmental":[192],"cues":[193],"drive":[195],"can":[199],"be":[200],"further":[201],"employed":[202],"discriminate":[204],"between":[205],"different":[209],"potential":[211],"identify":[214],"novel":[215],"factors":[216],"present":[218,309],"impetus":[220],"for":[221,253,343,532],"step":[224],"Next,":[229],"demonstrate":[231],"analysis":[233,325],"class":[236],"motility":[238,304],"mutants":[239,261],"originally":[240],"identified":[241],"1996":[244],"T\u00fcbingen":[245],"genetic":[246,378],"screen":[247],"potentially":[249],"serve":[250],"models":[252],"human":[254,417],"myopathies":[255],"dystrophies.":[257],"Two":[258],"these":[260,302],"have":[262],"previously":[263,340],"been":[264,280],"cloned":[265],"shown":[267],"encode":[269,283],"proteins":[270],"involved":[271],"muscle":[273,336,536],"fibre":[274,537],"attachment":[275],"whilst":[276],"third":[278],"has":[279],"found":[281],"molecular":[285,297],"chaperone":[286],"Heat":[287],"shock":[288],"protein":[289],"(HSP)":[290],"90.":[291],"phenotypic":[295],"characterization":[298],"another":[300],"mutants,":[305],"frozen":[306],"(fro).":[307],"evidence":[310],"frot027c":[313],"mutation":[314],"disrupts":[315],"locus":[317],"encoding":[318],"autophagy":[320,345],"pathway":[321,346],"component":[322],"Atg10.":[323],"implicates":[326],"Atg10":[327],"assembly":[330,538],"both":[332],"skeletal":[333,533],"cardiac":[335,535],"fibers":[337],"suggesting":[338],"uncharacterized":[341],"role":[342],"this":[348],"process.":[349],"Together,":[350],"my":[351],"findings":[352],"illustrate":[353],"utility":[355],"complements":[364],"established":[365],"mammalian":[366],"invertebrate":[368],"models.":[369],"fecundity":[371],"amenability":[373],"manipulation":[379],"together":[380],"with":[381,396],"rapid":[383],"development":[384,418],"translucency":[386],"its":[388],"combine":[390],"provide":[392],"powerful":[394],"system":[395],"which":[397],"unravel":[399],"inform":[401],"underlying":[403],"mechanisms":[404],"govern":[406],"fundamental":[407],"biological":[408],"shed":[411],"light":[412],"diseases.":[420],"List":[421],"scientific":[423],"papers":[424],"I.":[425],"Samantha":[426,476,508],"Lin":[427,477,509],"Chiou":[428,478,510],"Lee,":[429,511],"Pegah":[430,474],"Rouhi,":[431],"Lasse":[432,484],"Jensen,":[433],"Danfang":[434],"Zhang,":[435],"Hong":[436],"Ji,":[437],"Giselbert":[438],"Hauptmann,":[439],"Philip":[440,523],"Ingham":[441],"Yihai":[443,487],"Cao.":[444,488],"Hypoxia-induced":[445],"pathological":[446],"mediates":[448],"tumor":[449,458,492],"dissemination,":[451],"invasion,":[452],"model.":[459],"Proc":[460],"Natl":[461],"Acad":[462],"Sci":[463],"U":[464],"S":[465],"A.":[466],"Nov":[467],"17":[468],"2009;":[469],"106:46,":[470],"19485-90.":[471],"https://doi.org/10.1073/pnas.0909228106":[472],"II.":[473],"Rouhi*,":[475],"Lee*,":[479],"Ziquan":[480],"Cao,":[481],"Eva":[482],"Hedlund,":[483],"Jensen":[485],"Pathological":[489],"dissemination":[494],"Cell":[497],"Cycle.":[498],"Mar":[499],"1":[500],"2010;":[501],"9:5,":[502],"913-7.":[503],"*Co-first":[504],"author.":[505],"https://doi.org/10.4161/cc.9.5.10853":[506],"III.":[507],"Sarah":[512],"Baxendale,":[513],"Stephen":[514],"Moore,":[515],"Ng":[516],"Chee":[517],"Peng,":[518],"Tan":[519],"Swee":[520],"Chuan":[521],"Ingham.":[524],"Autophagy":[526],"Pathway":[527],"component,":[528],"Atg10,":[529],"is":[530],"required":[531],"zebrafish.":[540],"[Manuscript]":[541]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}