{"id":"https://openalex.org/W74988696","doi":null,"title":"Amlodipine: a cardiovascular drug with powerful antimicrobial property.","display_name":"Amlodipine: a cardiovascular drug with powerful antimicrobial property.","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W74988696","mag":"74988696","pmid":"https://pubmed.ncbi.nlm.nih.gov/14743981"},"language":"en","primary_location":{"id":"pmid:14743981","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14743981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta microbiologica Polonica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112005947","display_name":"K. Asok Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170979836","display_name":"Jadavpur University","ror":"https://ror.org/02af4h012","country_code":"IN","type":"education","lineage":["https://openalex.org/I170979836"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"K Asok Kumar","raw_affiliation_strings":["Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700 032, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700 032, India","institution_ids":["https://openalex.org/I170979836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008394285","display_name":"Kumkum Ganguly","orcid":"https://orcid.org/0000-0002-2255-8940","observed_orcids":["https://orcid.org/0000-0002-2255-8940"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kumkum Ganguly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056585092","display_name":"Kaushiki Mazumdar","orcid":"https://orcid.org/0000-0002-1036-1980","observed_orcids":["https://orcid.org/0000-0002-1036-1980"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaushiki Mazumdar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011032997","display_name":"Noton Kumar Dutta","orcid":"https://orcid.org/0000-0002-5066-3342","observed_orcids":["https://orcid.org/0000-0002-5066-3342"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N K Dutta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110272012","display_name":"Sujata Ghosh Dastidar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sujata G Dastidar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"A N Chakrabarty","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A N Chakrabarty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4475,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.56015038,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"52","issue":"3","first_page":"285","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amlodipine","display_name":"amlodipine","score":1.0},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cardiovascular-drugs","display_name":"cardiovascular drugs","score":0.7910000085830688},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.8489999771118164},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.8970000147819519},{"id":"https://openalex.org/keywords/vibrio-cholerae","display_name":"Vibrio cholerae","score":0.9950000047683716},{"id":"https://openalex.org/keywords/vibrio-parahaemolyticus","display_name":"Vibrio parahaemolyticus","score":0.9129999876022339},{"id":"https://openalex.org/keywords/shigella-boydii","display_name":"Shigella boydii","score":0.8859999775886536},{"id":"https://openalex.org/keywords/salmonella-typhimurium","display_name":"Salmonella typhimurium","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bactericidal-activity","display_name":"bactericidal activity","score":0.7139999866485596},{"id":"https://openalex.org/keywords/gram-positive-bacteria","display_name":"Gram-positive bacteria","score":0.6629999876022339},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":1.0}],"concepts":[{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7767170667648315},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.6158223152160645},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5937098264694214},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.5681139826774597},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5392706394195557},{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.5121800899505615},{"id":"https://openalex.org/C2779116282","wikidata":"https://www.wikidata.org/wiki/Q131854","display_name":"Klebsiella","level":4,"score":0.4512747824192047},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.44257980585098267},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.40180885791778564},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006094","descriptor_name":"Gram-Positive Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017311","descriptor_name":"Amlodipine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017311","descriptor_name":"Amlodipine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:14743981","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14743981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta microbiologica Polonica","raw_type":"Journal Article"},{"id":"mag:74988696","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14743981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2136814021","https://openalex.org/W2143313257","https://openalex.org/W7120527884","https://openalex.org/W2939663903","https://openalex.org/W7026791477","https://openalex.org/W1968638561","https://openalex.org/W2359335437","https://openalex.org/W3184319841","https://openalex.org/W2058088353","https://openalex.org/W4394912048"],"abstract_inverted_index":{"Ten":[0],"cardiovascular":[1],"drugs":[2],"were":[3,31,51,82,95,141,233],"procured":[4],"in":[5,11,63,109,117,159,190,230],"pure":[6],"form":[7],"from":[8],"their":[9],"manufacturers":[10],"India":[12],"and":[13,26,73,92,138,175,206],"screened":[14],"for":[15],"antimicrobial":[16],"property":[17],"against":[18,65,168],"fifteen":[19],"known":[20],"bacteria":[21,30,50,67,105],"belonging":[22],"to":[23,53,56,143,146,156,196,225],"both":[24],"gram-positive":[25,72],"gram-negative":[27,77],"types.":[28],"These":[29],"inhibited":[32,83],"by":[33,84],"the":[34,49,85,110,118,147,151,213,229],"common":[35],"antibiotics":[36],"at":[37,87,98,202],"1-5":[38],"mg":[39],"ml(-1)":[40,90],"level":[41,91],"through":[42],"our":[43],"earlier":[44],"studies.":[45],"Since":[46],"most":[47],"of":[48,71,76,80,113,150,164,184,199,219],"moderate":[52],"highly":[54,234],"responsive":[55],"amlodipine,":[57],"this":[58],"compound":[59],"was":[60,154,166,194],"further":[61],"tested":[62],"vitro":[64],"504":[66],"comprising":[68],"4":[69],"genera":[70,75],"15":[74],"bacteria.":[78],"Most":[79],"these":[81],"drug":[86],"50-200":[88],"microg":[89,102],"few":[93],"strains":[94],"sensitive":[96],"even":[97],"lower":[99,148],"concentrations":[100,149],"(10":[101],"ml(-1)).":[103],"The":[104,181],"could":[106,186,210],"be":[107,144,157,188],"arranged":[108],"decreasing":[111],"order":[112],"sensitivity":[114],"towards":[115],"amlodipine":[116,185],"following":[119],"manner:":[120],"Staphylococcus":[121],"aureus,":[122],"Vibrio":[123,125],"cholerae,":[124],"parahemolyticus,":[126],"Shigella":[127],"spp.,":[128,130,132],"Salmonella":[129,220],"Bacillus":[131],"whereas":[133],"Escherichia":[134],"coli,":[135],"Klebsiella":[136],"spp.":[137],"Pseudomonas":[139],"aeruginosa":[140],"found":[142,155],"resistant":[145],"drug.":[152],"Amlodipine":[153],"bactericidal":[158],"nature":[160],"when":[161],"its":[162],"mode":[163],"action":[165],"studied":[167],"S.":[169],"aureus":[170],"6571,":[171],"V.":[172],"cholerae":[173],"14035":[174],"Sh":[176],"boydii":[177],"8":[178],"NCTC":[179,222],"254/66.":[180],"antibacterial":[182],"activity":[183],"also":[187],"confirmed":[189],"vivo.":[191],"When":[192],"it":[193,209],"given":[195],"Swiss":[197],"strain":[198],"white":[200],"mice":[201],"different":[203],"dosages":[204],"(30":[205],"60":[207],"microg/mouse),":[208],"significantly":[211],"protect":[212],"animals":[214],"challenged":[215],"with":[216],"50":[217],"MLD":[218],"typhimurium":[221],"74.":[223],"According":[224],"Chi":[226],"square":[227],"test":[228],"vivo":[231],"data":[232],"significant":[235],"(p<0.001).":[236]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}