{"id":"https://openalex.org/W74967844","doi":null,"title":"Resveratrol, a natural chemopreventive agent against degenerative diseases.","display_name":"Resveratrol, a natural chemopreventive agent against degenerative diseases.","publication_year":2001,"publication_date":"2001-11-01","ids":{"openalex":"https://openalex.org/W74967844","mag":"74967844","pmid":"https://pubmed.ncbi.nlm.nih.gov/11985329"},"language":"en","primary_location":{"id":"pmid:11985329","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11985329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polish journal of pharmacology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074156261","display_name":"Ewa Ignatowicz","orcid":"https://orcid.org/0000-0002-8128-0408","observed_orcids":["https://orcid.org/0000-0002-8128-0408"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"E Ignatowicz","raw_affiliation_strings":["Department of Pharmaceutical Biochemistry, Karol Marcinkowski University of Medical Sciences, Pozna\u0144, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biochemistry, Karol Marcinkowski University of Medical Sciences, Pozna\u0144, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090294516","display_name":"Wanda Baer\u2010Dubowska","orcid":"https://orcid.org/0000-0002-6625-5343","observed_orcids":["https://orcid.org/0000-0002-6625-5343"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Baer-Dubowska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6067,"has_fulltext":false,"cited_by_count":99,"citation_normalized_percentile":{"value":0.8984081,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"53","issue":"6","first_page":"557","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":1.0},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.9819999933242798},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7900000214576721},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":0.8140000104904175},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8270000219345093},{"id":"https://openalex.org/keywords/lipid-turnover","display_name":"lipid turnover","score":0.5230000019073486},{"id":"https://openalex.org/keywords/eicosanoid-biosynthesis","display_name":"eicosanoid biosynthesis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/ldl-oxidation","display_name":"LDL oxidation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.5849999785423279},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.734000027179718},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.49000000953674316},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5120000243186951},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.8545334935188293},{"id":"https://openalex.org/C33594762","wikidata":"https://www.wikidata.org/wiki/Q155750","display_name":"Aryl hydrocarbon receptor","level":4,"score":0.672693133354187},{"id":"https://openalex.org/C2780122803","wikidata":"https://www.wikidata.org/wiki/Q7852681","display_name":"Tumor promotion","level":4,"score":0.6201223134994507},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6075388193130493},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5253826379776001},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.5006890296936035},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48859816789627075},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4870500862598419},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46791842579841614},{"id":"https://openalex.org/C2778751241","wikidata":"https://www.wikidata.org/wiki/Q422870","display_name":"Phytoalexin","level":3,"score":0.43603238463401794},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.39247623085975647},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.375120609998703},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.342881977558136},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22646906971931458},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077185","descriptor_name":"Resveratrol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:11985329","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11985329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polish journal of pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.414.3094","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.414.3094","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rabbit.if-pan.krakow.pl/pjp/pdf/2001/6_557.pdf","raw_type":"text"},{"id":"mag:74967844","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11985329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":124,"referenced_works":["https://openalex.org/W6570301","https://openalex.org/W22837245","https://openalex.org/W70136130","https://openalex.org/W94267445","https://openalex.org/W100744879","https://openalex.org/W107529729","https://openalex.org/W145786783","https://openalex.org/W154564172","https://openalex.org/W157402533","https://openalex.org/W168696379","https://openalex.org/W170657851","https://openalex.org/W183162841","https://openalex.org/W186355398","https://openalex.org/W193749533","https://openalex.org/W786455748","https://openalex.org/W1524139871","https://openalex.org/W1527647899","https://openalex.org/W1539601638","https://openalex.org/W1591881963","https://openalex.org/W1599671902","https://openalex.org/W1845409971","https://openalex.org/W1857052429","https://openalex.org/W1881147845","https://openalex.org/W1965179084","https://openalex.org/W1966060421","https://openalex.org/W1970139931","https://openalex.org/W1971123698","https://openalex.org/W1971135728","https://openalex.org/W1976929342","https://openalex.org/W1979092465","https://openalex.org/W1979501382","https://openalex.org/W1980855715","https://openalex.org/W1984863418","https://openalex.org/W1988497727","https://openalex.org/W1988711085","https://openalex.org/W1989969820","https://openalex.org/W1996721832","https://openalex.org/W1999373749","https://openalex.org/W2002708977","https://openalex.org/W2002851624","https://openalex.org/W2003148847","https://openalex.org/W2006200791","https://openalex.org/W2007603406","https://openalex.org/W2007796985","https://openalex.org/W2010974807","https://openalex.org/W2015200132","https://openalex.org/W2020637829","https://openalex.org/W2021837043","https://openalex.org/W2024009261","https://openalex.org/W2026602634","https://openalex.org/W2027062593","https://openalex.org/W2027280527","https://openalex.org/W2031298315","https://openalex.org/W2032869206","https://openalex.org/W2037154470","https://openalex.org/W2039249065","https://openalex.org/W2040923416","https://openalex.org/W2045947499","https://openalex.org/W2046542347","https://openalex.org/W2046885170","https://openalex.org/W2047964022","https://openalex.org/W2050144029","https://openalex.org/W2052124418","https://openalex.org/W2054253197","https://openalex.org/W2054639376","https://openalex.org/W2056577607","https://openalex.org/W2058557786","https://openalex.org/W2060760516","https://openalex.org/W2063105575","https://openalex.org/W2070768928","https://openalex.org/W2070834527","https://openalex.org/W2072727557","https://openalex.org/W2076018821","https://openalex.org/W2077106449","https://openalex.org/W2079012946","https://openalex.org/W2079383900","https://openalex.org/W2082157761","https://openalex.org/W2085139923","https://openalex.org/W2085984187","https://openalex.org/W2089076228","https://openalex.org/W2089362925","https://openalex.org/W2089750544","https://openalex.org/W2090950224","https://openalex.org/W2091799228","https://openalex.org/W2093282160","https://openalex.org/W2094366418","https://openalex.org/W2094908670","https://openalex.org/W2095840354","https://openalex.org/W2096699393","https://openalex.org/W2097620342","https://openalex.org/W2099947030","https://openalex.org/W2100983356","https://openalex.org/W2103816786","https://openalex.org/W2106032666","https://openalex.org/W2106877484","https://openalex.org/W2107867330","https://openalex.org/W2107889250","https://openalex.org/W2115553022","https://openalex.org/W2122390360","https://openalex.org/W2124098523","https://openalex.org/W2125947878","https://openalex.org/W2127678138","https://openalex.org/W2137256427","https://openalex.org/W2139967865","https://openalex.org/W2143841515","https://openalex.org/W2145337751","https://openalex.org/W2150795293","https://openalex.org/W2151089147","https://openalex.org/W2161746179","https://openalex.org/W2162248918","https://openalex.org/W2163624012","https://openalex.org/W2166185936","https://openalex.org/W2166781237","https://openalex.org/W2167702935","https://openalex.org/W2170507464","https://openalex.org/W2172010722","https://openalex.org/W2178947601","https://openalex.org/W2321203880","https://openalex.org/W2398917316","https://openalex.org/W2405144177","https://openalex.org/W2408773744","https://openalex.org/W2415065725","https://openalex.org/W2420170690","https://openalex.org/W2624706815"],"related_works":["https://openalex.org/W70136130","https://openalex.org/W2121016657","https://openalex.org/W2071102503","https://openalex.org/W2155554171","https://openalex.org/W2169999439","https://openalex.org/W2107889250","https://openalex.org/W2151089147","https://openalex.org/W1966011016","https://openalex.org/W2000740542","https://openalex.org/W2083821543"],"abstract_inverted_index":{"Resveratrol":[0,128],"(3,5,4'-trihydroxystilbene)":[1],"is":[2,194,210,244,250],"a":[3,82,274],"naturally":[4],"occurring":[5],"compound":[6],"shown":[7],"to":[8,97,197,271],"modulate":[9],"the":[10,27,50,123,144,162,171,187,222,229,251,256,264],"risk":[11],"of":[12,29,41,45,49,56,79,81,85,113,125,146,155,170,173,181,189,203,231,240,260,267],"cardiovascular":[13,156],"degenerative":[14],"diseases":[15,157,218],"(atherosclerosis)":[16],"and":[17,54,73,137,158,176,199,206,215,258,278,285],"inhibit":[18],"chemical":[19],"carcinogenesis":[20],"in":[21,36,60,134,288,292],"rodents.":[22],"Various":[23],"studies":[24],"have":[25,183],"demonstrated":[26],"effect":[28],"this":[30],"phytoalexin":[31],"on":[32,255,263,282,287],"biological":[33,265],"mechanisms":[34,223],"involved":[35,133],"cardioprotection.":[37],"These":[38],"include":[39],"modulation":[40,169],"lipid":[42],"turnover,":[43],"inhibition":[44,55,112,188,239],"eicosanoid":[46],"production,":[47],"prevention":[48],"low-density":[51],"lipoprotein":[52],"oxidation":[53],"platelet":[57],"aggregation.":[58],"Carcinogenesis":[59],"animal":[61],"models":[62],"can":[63],"be":[64,272],"divided":[65],"at":[66],"least":[67],"into":[68],"three":[69],"stages:":[70],"initiation,":[71],"promotion":[72,136],"progression.":[74,138],"Initiation":[75],"occurs":[76,120],"as":[77],"result":[78],"interaction":[80],"reactive":[83,98],"form":[84],"carcinogen":[86],"with":[87,152,186,228],"DNA.":[88],"Chemical":[89],"carcinogens":[90],"like":[91],"polycyclic":[92],"aromatic":[93],"hydrocarbons":[94],"are":[95,150,233,294],"metabolized":[96],"species":[99],"by":[100,116,224],"cytochrome":[101],"P450":[102],"dependent":[103],"enzymes":[104],"activated":[105],"through":[106,121],"aryl":[107],"hydrocarbon":[108],"(Ah)":[109],"receptor.":[110,127],"The":[111],"tumor":[114,135,140,213],"initiation":[115],"resveratrol":[117,182,226],"most":[118],"probably":[119],"preventing":[122],"activation":[124,230,249],"Ah":[126],"affects":[129],"also":[130],"several":[131],"factors":[132,175],"Since":[139],"promoting":[141],"agents":[142],"alter":[143],"expression":[145,172],"genes":[147],"whose":[148],"products":[149],"associated":[151,185],"inflammation,":[153],"chemoprevention":[154],"cancer":[159],"may":[160],"share":[161],"same":[163],"common":[164],"mechanisms.":[165],"This":[166,191],"includes":[167],"principally":[168],"growth":[174],"cytokines.":[177],"Recently,":[178],"chemopreventive":[179],"properties":[180],"been":[184],"NF-kappaB.":[190],"transcription":[192],"factor":[193],"strongly":[195],"linked":[196],"inflammatory":[198],"immune":[200],"responses,":[201],"regulation":[202],"cell":[204],"proliferation":[205],"apoptosis,":[207],"thus":[208],"it":[209,236,269],"important":[211],"for":[212,246],"development":[214],"many":[216],"other":[217],"including":[219],"atherosclerosis.":[220],"Although":[221],"which":[225,243],"interferes":[227],"NF-KB":[232],"not":[234],"clear,":[235],"seems":[237],"that":[238],"its":[241,247,283],"degradation":[242],"necessary":[245],"cellular":[248],"principal":[252],"target.":[253],"Based":[254],"quantity":[257],"diversity":[259],"data":[261],"available":[262],"activity":[266],"resveratrol,":[268],"has":[270],"considered":[273],"very":[275],"promising":[276],"chemoprotector":[277],"chemotherapeutic.":[279],"Urgent":[280],"investigations":[281],"bioavailability":[284],"effects":[286],"vivo":[289],"systems,":[290],"especially":[291],"humans,":[293],"necessary.":[295]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
