{"id":"https://openalex.org/W746805377","doi":null,"title":"Aberrant V(D)J Recombination: Misrepair of DNA Breaks and Implications For Lymphomagenesis.","display_name":"Aberrant V(D)J Recombination: Misrepair of DNA Breaks and Implications For Lymphomagenesis.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W746805377","mag":"746805377"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/99898","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/99898","pdf_url":"https://hdl.handle.net/2027.42/99898","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/99898","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010980483","display_name":"Tehmina Masud","orcid":"https://orcid.org/0009-0003-4126-3130","observed_orcids":["https://orcid.org/0009-0003-4126-3130"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tehmina Masud","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-4126-3130","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5010980483"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/v-d-j-recombination","display_name":"V(D)J recombination","score":0.9649999737739563},{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.9440000057220459},{"id":"https://openalex.org/keywords/rag1","display_name":"RAG1","score":0.8209999799728394},{"id":"https://openalex.org/keywords/artemis","display_name":"Artemis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/alternative-end-joining","display_name":"alternative end-joining","score":0.7039999961853027},{"id":"https://openalex.org/keywords/chromosomal-translocation","display_name":"chromosomal translocation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.6710000038146973},{"id":"https://openalex.org/keywords/lymphomagenesis","display_name":"lymphomagenesis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.8349999785423279},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.7210000157356262},{"id":"https://openalex.org/keywords/p53-loss","display_name":"p53 deficiency","score":0.8299999833106995},{"id":"https://openalex.org/keywords/b-cell-lymphoma","display_name":"B-cell lymphoma","score":0.7329999804496765},{"id":"https://openalex.org/keywords/immunodeficiency","display_name":"immunodeficiency","score":0.6039999723434448},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5104026198387146},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.48172619938850403},{"id":"https://openalex.org/C2780254951","wikidata":"https://www.wikidata.org/wiki/Q1093098","display_name":"V(D)J recombination","level":4,"score":0.4462255835533142},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4348365068435669},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3989329934120178},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09584781527519226}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/99898","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/99898","pdf_url":"https://hdl.handle.net/2027.42/99898","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.846.833","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.846.833","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://deepblue.lib.umich.edu/bitstream/handle/2027.42/99898/tmasud_1.pdf%3Bjsessionid%3D0021A0F9B9C3FFB5BEEA15FFA1771994?sequence%3D1","raw_type":"text"},{"id":"mag:746805377","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/99898","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Deep Blue (University of Michigan)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/99898","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/99898","pdf_url":"https://hdl.handle.net/2027.42/99898","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W746805377.pdf","grobid_xml":"https://content.openalex.org/works/W746805377.grobid-xml"},"referenced_works_count":283,"referenced_works":["https://openalex.org/W18214391","https://openalex.org/W99705021","https://openalex.org/W107204128","https://openalex.org/W118163353","https://openalex.org/W127441596","https://openalex.org/W129919879","https://openalex.org/W130667881","https://openalex.org/W142058514","https://openalex.org/W180731264","https://openalex.org/W205345901","https://openalex.org/W1226506766","https://openalex.org/W1484480328","https://openalex.org/W1490921491","https://openalex.org/W1491106772","https://openalex.org/W1513093379","https://openalex.org/W1513105954","https://openalex.org/W1527833446","https://openalex.org/W1538419182","https://openalex.org/W1540628855","https://openalex.org/W1542005181","https://openalex.org/W1550791622","https://openalex.org/W1552177814","https://openalex.org/W1555218304","https://openalex.org/W1579358829","https://openalex.org/W1620761868","https://openalex.org/W1660787335","https://openalex.org/W1752089945","https://openalex.org/W1765804919","https://openalex.org/W1767627963","https://openalex.org/W1820180700","https://openalex.org/W1827569717","https://openalex.org/W1833217925","https://openalex.org/W1844994454","https://openalex.org/W1890527410","https://openalex.org/W1966254031","https://openalex.org/W1966427800","https://openalex.org/W1967151453","https://openalex.org/W1967167923","https://openalex.org/W1967867591","https://openalex.org/W1968044233","https://openalex.org/W1969262167","https://openalex.org/W1969985598","https://openalex.org/W1970111581","https://openalex.org/W1970948155","https://openalex.org/W1972070781","https://openalex.org/W1972313386","https://openalex.org/W1973475745","https://openalex.org/W1974446138","https://openalex.org/W1974596630","https://openalex.org/W1974763280","https://openalex.org/W1975445093","https://openalex.org/W1975833912","https://openalex.org/W1976231348","https://openalex.org/W1978177909","https://openalex.org/W1979385111","https://openalex.org/W1979568780","https://openalex.org/W1979699797","https://openalex.org/W1980494998","https://openalex.org/W1980636468","https://openalex.org/W1981235416","https://openalex.org/W1983403009","https://openalex.org/W1983450672","https://openalex.org/W1984251526","https://openalex.org/W1986262530","https://openalex.org/W1986990473","https://openalex.org/W1987552589","https://openalex.org/W1987590932","https://openalex.org/W1987615467","https://openalex.org/W1987705460","https://openalex.org/W1987764631","https://openalex.org/W1988845313","https://openalex.org/W1989924028","https://openalex.org/W1989925441","https://openalex.org/W1990319128","https://openalex.org/W1990576900","https://openalex.org/W1990909659","https://openalex.org/W1991872459","https://openalex.org/W1991963226","https://openalex.org/W1992272549","https://openalex.org/W1992985050","https://openalex.org/W1995252171","https://openalex.org/W1996073092","https://openalex.org/W1996314558","https://openalex.org/W1997911676","https://openalex.org/W1998129814","https://openalex.org/W1999287382","https://openalex.org/W1999388807","https://openalex.org/W2000988406","https://openalex.org/W2001748204","https://openalex.org/W2001784394","https://openalex.org/W2003411878","https://openalex.org/W2003774526","https://openalex.org/W2004707654","https://openalex.org/W2004735306","https://openalex.org/W2004932721","https://openalex.org/W2005689613","https://openalex.org/W2007369689","https://openalex.org/W2007984480","https://openalex.org/W2008283905","https://openalex.org/W2009639920","https://openalex.org/W2011522975","https://openalex.org/W2011984142","https://openalex.org/W2012631231","https://openalex.org/W2012759709","https://openalex.org/W2014238550","https://openalex.org/W2016999017","https://openalex.org/W2017314109","https://openalex.org/W2017351036","https://openalex.org/W2018237947","https://openalex.org/W2018468994","https://openalex.org/W2018486465","https://openalex.org/W2019654778","https://openalex.org/W2020284598","https://openalex.org/W2022811243","https://openalex.org/W2022873453","https://openalex.org/W2025592993","https://openalex.org/W2026959390","https://openalex.org/W2027121633","https://openalex.org/W2027379868","https://openalex.org/W2029545121","https://openalex.org/W2032067907","https://openalex.org/W2032166136","https://openalex.org/W2032598589","https://openalex.org/W2033200608","https://openalex.org/W2034718433","https://openalex.org/W2034925688","https://openalex.org/W2036331912","https://openalex.org/W2039704215","https://openalex.org/W2040838669","https://openalex.org/W2041358036","https://openalex.org/W2043430069","https://openalex.org/W2045016058","https://openalex.org/W2045526190","https://openalex.org/W2045818966","https://openalex.org/W2046589688","https://openalex.org/W2046961998","https://openalex.org/W2048504577","https://openalex.org/W2050812646","https://openalex.org/W2050997453","https://openalex.org/W2051426742","https://openalex.org/W2051808137","https://openalex.org/W2053016947","https://openalex.org/W2053926251","https://openalex.org/W2059239585","https://openalex.org/W2059347700","https://openalex.org/W2059424039","https://openalex.org/W2061907379","https://openalex.org/W2062428046","https://openalex.org/W2064194162","https://openalex.org/W2064631075","https://openalex.org/W2066664553","https://openalex.org/W2067022774","https://openalex.org/W2067228541","https://openalex.org/W2068012172","https://openalex.org/W2068668324","https://openalex.org/W2069651213","https://openalex.org/W2071674290","https://openalex.org/W2072149435","https://openalex.org/W2072623685","https://openalex.org/W2075784029","https://openalex.org/W2076258498","https://openalex.org/W2077154575","https://openalex.org/W2077342759","https://openalex.org/W2078288351","https://openalex.org/W2079466993","https://openalex.org/W2080404967","https://openalex.org/W2080686406","https://openalex.org/W2080959953","https://openalex.org/W2081788687","https://openalex.org/W2082912695","https://openalex.org/W2082981258","https://openalex.org/W2083170703","https://openalex.org/W2083326500","https://openalex.org/W2084253472","https://openalex.org/W2087470609","https://openalex.org/W2087604899","https://openalex.org/W2088698677","https://openalex.org/W2088740611","https://openalex.org/W2088909687","https://openalex.org/W2088987673","https://openalex.org/W2090482045","https://openalex.org/W2091456268","https://openalex.org/W2092700608","https://openalex.org/W2093535706","https://openalex.org/W2094111999","https://openalex.org/W2094950317","https://openalex.org/W2095687796","https://openalex.org/W2096033448","https://openalex.org/W2097346153","https://openalex.org/W2098238130","https://openalex.org/W2098977954","https://openalex.org/W2099719096","https://openalex.org/W2100213817","https://openalex.org/W2100285961","https://openalex.org/W2100462578","https://openalex.org/W2100557384","https://openalex.org/W2101668231","https://openalex.org/W2101988823","https://openalex.org/W2102618729","https://openalex.org/W2103425962","https://openalex.org/W2104631734","https://openalex.org/W2104676795","https://openalex.org/W2105277962","https://openalex.org/W2106087857","https://openalex.org/W2106607866","https://openalex.org/W2107864294","https://openalex.org/W2109393673","https://openalex.org/W2109456034","https://openalex.org/W2110508317","https://openalex.org/W2111763240","https://openalex.org/W2112161923","https://openalex.org/W2112310046","https://openalex.org/W2112846033","https://openalex.org/W2113422570","https://openalex.org/W2114527746","https://openalex.org/W2114616141","https://openalex.org/W2115914182","https://openalex.org/W2116718924","https://openalex.org/W2117707303","https://openalex.org/W2117973542","https://openalex.org/W2119274866","https://openalex.org/W2119947571","https://openalex.org/W2120290512","https://openalex.org/W2121070277","https://openalex.org/W2121142552","https://openalex.org/W2122161903","https://openalex.org/W2123395657","https://openalex.org/W2126679757","https://openalex.org/W2128205954","https://openalex.org/W2128771565","https://openalex.org/W2129953000","https://openalex.org/W2131269209","https://openalex.org/W2131554214","https://openalex.org/W2131694075","https://openalex.org/W2131922518","https://openalex.org/W2133291090","https://openalex.org/W2135812215","https://openalex.org/W2140150688","https://openalex.org/W2140336226","https://openalex.org/W2140647623","https://openalex.org/W2140862616","https://openalex.org/W2141620707","https://openalex.org/W2142405966","https://openalex.org/W2142463988","https://openalex.org/W2142572246","https://openalex.org/W2144476116","https://openalex.org/W2145568913","https://openalex.org/W2148267271","https://openalex.org/W2149063792","https://openalex.org/W2150990082","https://openalex.org/W2152054208","https://openalex.org/W2152218579","https://openalex.org/W2152343731","https://openalex.org/W2153172596","https://openalex.org/W2154897918","https://openalex.org/W2155246914","https://openalex.org/W2156529317","https://openalex.org/W2158279161","https://openalex.org/W2158975515","https://openalex.org/W2159825246","https://openalex.org/W2160089420","https://openalex.org/W2160186676","https://openalex.org/W2161451383","https://openalex.org/W2161831419","https://openalex.org/W2162185991","https://openalex.org/W2163811249","https://openalex.org/W2164518522","https://openalex.org/W2164711234","https://openalex.org/W2164850825","https://openalex.org/W2164995160","https://openalex.org/W2165789547","https://openalex.org/W2166567807","https://openalex.org/W2166575072","https://openalex.org/W2166958955","https://openalex.org/W2167064466","https://openalex.org/W2167216803","https://openalex.org/W2167863101","https://openalex.org/W2168265716","https://openalex.org/W2170270573","https://openalex.org/W2170601039","https://openalex.org/W2337190104","https://openalex.org/W2593504837","https://openalex.org/W4300506829"],"related_works":["https://openalex.org/W7035713982","https://openalex.org/W2626137907","https://openalex.org/W4411050826","https://openalex.org/W1968813490","https://openalex.org/W2094950317","https://openalex.org/W2109393673","https://openalex.org/W1999388807","https://openalex.org/W1999287382","https://openalex.org/W161837963","https://openalex.org/W18958871"],"abstract_inverted_index":{"Canonical":[0],"non-homologous":[1],"end":[2,63,74,257],"joining":[3,64,75,258],"(C-NHEJ),":[4],"a":[5,58,70,233],"major":[6],"DNA":[7,53,71,219,283],"double-strand":[8],"break":[9],"(DSB)":[10],"repair":[11,17],"pathway,":[12],"is":[13,76,143],"required":[14],"for":[15,78,311,341],"the":[16,38,113,124,147,163,184,210,293,329],"of":[18,112,149,206,218,235,241,282,295,328,331],"general":[19],"DSBs":[20,43],"as":[21,23],"well":[22],"programmed":[24],"breaks":[25,186],"generated":[26],"during":[27,157,319],"antigen":[28,125],"receptor":[29,126],"gene":[30],"rearrangements":[31],"by":[32,65,180],"V(D)J":[33,158,226,320],"recombination.":[34,159,227,321],"During":[35],"this":[36],"process,":[37],"lymphocyte-specific":[39],"RAG1/2":[40],"endonuclease":[41],"generates":[42],"at":[44,123,183,301],"numerous":[45],"V,":[46],"D":[47],"and":[48,83,92,98,151,171,195,240,250,313,336,346],"J":[49],"genomic":[50,132,155],"segments.":[51],"The":[52,128,268],"ends":[54,220],"are":[55,115,137,231,273],"maintained":[56],"in":[57,95,110,134,153,165,175,187,200,209,215,224,245,264,290,292,298,315],"postcleavage":[59,202],"complex":[60,203],"to":[61,84],"facilitate":[62],"C-NHEJ":[66,100,249],"proteins,":[67],"including":[68],"Artemis,":[69],"nuclease.":[72],"Proper":[73],"essential":[77],"lymphocyte":[79],"development,":[80],"immune":[81],"diversification":[82],"suppress":[85],"structural":[86],"chromosomal":[87,121,181,229,299,317,334],"aberrations.":[88],"Patients":[89],"with":[90,118,247],"null":[91],"hypomorphic":[93,169,211],"mutations":[94,107,173],"RAG,":[96],"Artemis":[97,106,152,172,196,296,314],"other":[99],"genes":[101],"develop":[102],"immunodeficiency":[103],"disorders.":[104],"Hypomorphic":[105],"that":[108,130,168,193,221,270,280],"result":[109,174],"loss":[111],"C-terminus":[114],"also":[116,232],"associated":[117],"lymphomas":[119,244],"harboring":[120],"translocations":[122,182,230,300,335],"loci.":[127],"mechanisms":[129,260,269],"promote":[131],"instability":[133,156],"these":[135,207,266],"patients":[136],"not":[138],"entirely":[139],"clear.":[140],"This":[141],"dissertation":[142],"focused":[144],"on":[145],"elucidating":[146],"roles":[148,199],"RAG1":[150,194],"preventing":[154],"These":[160,322],"studies":[161,277,323],"provide":[162],"first":[164],"vivo":[166],"evidence":[167],"Rag1":[170],"unique":[176],"molecular":[177],"defects":[178],"characterized":[179],"RAG-induced":[185,302],"non-malignant":[188],"cells.":[189],"My":[190,276],"findings":[191],"suggest":[192],"play":[197],"important":[198,338],"maintaining":[201,316],"stability.":[204],"Disruption":[205],"complexes":[208],"mutant":[212],"lymphocytes":[213,291],"results":[214],"premature":[216],"release":[217],"may":[222],"engage":[223],"aberrant":[225],"Recurrent":[228],"hallmark":[234],"sporadic":[236,347],"human":[237],"hematological":[238],"malignancies,":[239],"progenitor-B":[242],"cell":[243],"mice":[246],"combined":[248],"tumor":[251],"suppressor":[252],"p53":[253],"deficiencies.":[254],"Distinct":[255],"alternative":[256,287],"(A-EJ)":[259,289],"have":[261,278,307,324,337],"been":[262],"implicated":[263],"mediating":[265],"translocations.":[267],"activate":[271],"A-EJ":[272],"poorly":[274],"characterized.":[275],"demonstrated":[279],"induction":[281],"damage":[284],"response":[285],"triggers":[286],"end-joining":[288],"absence":[294],"resulting":[297],"breaks.":[303],"In":[304],"summary,":[305],"I":[306],"identified":[308],"novel":[309],"functions":[310],"RAG":[312],"integrity":[318],"improved":[325],"our":[326],"understanding":[327],"origin":[330],"potentially":[332],"oncogenic":[333],"clinical":[339],"implications":[340],"both":[342],"inherited":[343],"cancer":[344],"predisposition":[345],"tumors.":[348]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
