{"id":"https://openalex.org/W746743940","doi":"https://doi.org/10.1038/cddis.2015.143","title":"APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells","display_name":"APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells","publication_year":2015,"publication_date":"2015-06-18","ids":{"openalex":"https://openalex.org/W746743940","doi":"https://doi.org/10.1038/cddis.2015.143","mag":"746743940","pmid":"https://pubmed.ncbi.nlm.nih.gov/26086967","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4669826"},"language":"en","primary_location":{"id":"doi:10.1038/cddis.2015.143","doi":"https://doi.org/10.1038/cddis.2015.143","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2015.143","pdf_url":"https://www.nature.com/articles/cddis2015143.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/cddis2015143.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004434386","display_name":"Nina Mohell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"N Mohell","raw_affiliation_strings":["Aprea AB, Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aprea AB, Solna, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042746726","display_name":"Jessica Alfredsson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Alfredsson","raw_affiliation_strings":["Aprea AB, Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aprea AB, Solna, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039876048","display_name":"\u00c5sa Fransson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u00c5 Fransson","raw_affiliation_strings":["Aprea AB, Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aprea AB, Solna, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046022131","display_name":"Maria Uustalu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Uustalu","raw_affiliation_strings":["Aprea AB, Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aprea AB, Solna, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108496962","display_name":"Styrbj\u00f6rn E. Bystr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Bystr\u00f6m","raw_affiliation_strings":["Aprea AB, Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aprea AB, Solna, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074895961","display_name":"Joachim Gullbo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"J Gullbo","raw_affiliation_strings":["1] Clinical Pharmacology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden [2] Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden","Department of Medical Sciences, Clinical Pharmacology, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] Clinical Pharmacology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden [2] Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Department of Medical Sciences, Clinical Pharmacology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108389244","display_name":"Anders Hallberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"A Hallberg","raw_affiliation_strings":["Department of Medicinal Chemistry, BMC, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, BMC, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078991694","display_name":"Vladimir J.N. Bykov","orcid":"https://orcid.org/0000-0002-7199-8942","observed_orcids":["https://orcid.org/0000-0002-7199-8942"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"V J N Bykov","raw_affiliation_strings":["Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"U Bj\u00f6rklund","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Bj\u00f6rklund","raw_affiliation_strings":["Aprea AB, Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aprea AB, Solna, Sweden","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087783342","display_name":"Klas G. Wiman","orcid":"https://orcid.org/0000-0002-7113-524X","observed_orcids":["https://orcid.org/0000-0002-7113-524X"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"K G Wiman","raw_affiliation_strings":["Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004434386"],"corresponding_institution_ids":[],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":7.9356,"has_fulltext":true,"cited_by_count":188,"citation_normalized_percentile":{"value":0.98672153,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"6","issue":"6","first_page":"e1794","last_page":"e1794"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.739300012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.739300012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.20469999313354492,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apr-246","display_name":"APR-246","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.6620000004768372},{"id":"https://openalex.org/keywords/platinum-resistance","display_name":"platinum resistance","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.8970000147819519},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cysteine-binding","display_name":"cysteine binding","score":0.7900000214576721},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.7649999856948853},{"id":"https://openalex.org/keywords/high-grade-serous-ovarian-carcinoma","display_name":"high-grade serous ovarian cancer","score":0.8690000176429749},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.5339999794960022},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6370000243186951},{"id":"https://openalex.org/keywords/thioredoxin-reductase","display_name":"thioredoxin reductase","score":0.8460000157356262},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.871999979019165},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.9860000014305115}],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.7207062244415283},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.6815245747566223},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.6191162467002869},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5827505588531494},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5602073073387146},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.5461236238479614},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5144293904304504},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4798416793346405},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.47219929099082947},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.41654863953590393},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4119487702846527},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4085198640823364},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38396045565605164},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3466145396232605},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.28491532802581787},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2787088453769684},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13828474283218384},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11891064047813416},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06678855419158936}],"mesh":[{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011812","descriptor_name":"Quinuclidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/cddis.2015.143","doi":"https://doi.org/10.1038/cddis.2015.143","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2015.143","pdf_url":"https://www.nature.com/articles/cddis2015143.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4669826","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4669826","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Dis","raw_type":"Text"},{"id":"pmid:26086967","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26086967","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death & disease","raw_type":"Journal Article"},{"id":"pmh:oai:DiVA.org:uu-259117","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-259117","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/cddis.2015.143","doi":"https://doi.org/10.1038/cddis.2015.143","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2015.143","pdf_url":"https://www.nature.com/articles/cddis2015143.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308970","display_name":"Teva Pharmaceutical Industries","ror":"https://ror.org/01wfv3m53"},{"id":"https://openalex.org/F4320322225","display_name":"Link\u00f6pings Universitet","ror":"https://ror.org/05ynxx418"},{"id":"https://openalex.org/F4320322315","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691"},{"id":"https://openalex.org/F4320324119","display_name":"Uppsala Universitet","ror":"https://ror.org/048a87296"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W746743940.pdf","grobid_xml":"https://content.openalex.org/works/W746743940.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W301924703","https://openalex.org/W1502767888","https://openalex.org/W1558366281","https://openalex.org/W1758361781","https://openalex.org/W1978728170","https://openalex.org/W1978782811","https://openalex.org/W1987437563","https://openalex.org/W1994201724","https://openalex.org/W1995068068","https://openalex.org/W1996027687","https://openalex.org/W2006422601","https://openalex.org/W2012952677","https://openalex.org/W2013911067","https://openalex.org/W2017936372","https://openalex.org/W2020203596","https://openalex.org/W2023842642","https://openalex.org/W2023886879","https://openalex.org/W2028387032","https://openalex.org/W2032167680","https://openalex.org/W2032974696","https://openalex.org/W2042619042","https://openalex.org/W2042994971","https://openalex.org/W2043888207","https://openalex.org/W2058624670","https://openalex.org/W2068577449","https://openalex.org/W2071756286","https://openalex.org/W2077902171","https://openalex.org/W2077945404","https://openalex.org/W2089477889","https://openalex.org/W2092560324","https://openalex.org/W2092902276","https://openalex.org/W2095287544","https://openalex.org/W2096258216","https://openalex.org/W2102399972","https://openalex.org/W2105616976","https://openalex.org/W2116011904","https://openalex.org/W2119994407","https://openalex.org/W2126371858","https://openalex.org/W2127286396","https://openalex.org/W2127961309","https://openalex.org/W2129141930","https://openalex.org/W2130177169","https://openalex.org/W2142765738","https://openalex.org/W2147186597","https://openalex.org/W2153906296","https://openalex.org/W2164277862","https://openalex.org/W2169249953","https://openalex.org/W2170204650","https://openalex.org/W2276982989","https://openalex.org/W4244817134","https://openalex.org/W4248347759","https://openalex.org/W4251310081","https://openalex.org/W7095779489"],"related_works":["https://openalex.org/W1483242826","https://openalex.org/W2180969930","https://openalex.org/W2334236738","https://openalex.org/W2355389606","https://openalex.org/W2563764112","https://openalex.org/W2210082861","https://openalex.org/W3127786418","https://openalex.org/W2276371085","https://openalex.org/W3110888894","https://openalex.org/W2587854885"],"abstract_inverted_index":{"Two":[0],"main":[1],"causes":[2],"of":[3,28,118,230,251,255],"platinum":[4,151,241],"resistance":[5],"are":[6],"mutation":[7],"in":[8,17,22,25,67,84,124,134,140,148,153,167,212,217],"the":[9,34,53,101,135,141,184,196,206],"tumor":[10],"suppressor":[11],"gene":[12],"TP53":[13,23,234],"and":[14,42,70,103,128,158,188,240],"drug-induced":[15],"increase":[16],"intracellular":[18,88],"glutathione":[19,90,129],"concentration.":[20,91],"Mutations":[21],"occur":[24],"about":[26],"50%":[27],"human":[29],"tumors.":[30,260],"APR-246":[31,45,98,147,211,239],"(PRIMA-1(MET))":[32],"is":[33,46,50],"first":[35],"clinical-stage":[36],"compound":[37,55],"that":[38,49,62,78,95,114],"reactivates":[39],"mutant":[40,68,126,259],"p53":[41,69,127,258],"induces":[43],"apoptosis.":[44],"a":[47,59,131,202,252],"prodrug":[48],"converted":[51],"to":[52,64,82,106,120,122,165],"active":[54],"methylene":[56],"quinuclidinone":[57],"(MQ),":[58],"Michael":[60],"acceptor":[61],"binds":[63,81],"cysteine":[65,83],"residues":[66],"restores":[71,100],"its":[72],"wild-type":[73],"conformation.":[74],"Here,":[75],"we":[76],"show":[77,94],"MQ":[79,163],"also":[80,93,181],"glutathione,":[85],"thus":[86],"decreasing":[87],"free":[89],"We":[92,112],"treatment":[96,237],"with":[97,146,150,183,195,210,214,219,238],"completely":[99],"cisplatin":[102],"doxorubicin":[104,187],"sensitivity":[105],"p53-mutant":[107,220],"drug-resistant":[108],"ovarian":[109,154,225],"cancer":[110,155,160],"cells.":[111,161],"propose":[113],"this":[115],"unique":[116],"ability":[117],"APR-246/MQ":[119],"bind":[121],"cysteines":[123,166],"both":[125],"has":[130],"key":[132],"role":[133],"resensitization":[136],"as":[137,139,176],"well":[138],"outstanding":[142],"synergistic":[143],"effects":[144,192],"observed":[145,182],"combination":[149,213],"compounds":[152],"cell":[156],"lines":[157],"primary":[159],"However,":[162],"binding":[164],"other":[168,243],"targets,":[169],"for":[170,205],"example,":[171],"thioredoxin":[172],"reductase,":[173],"may":[174],"contribute":[175],"well.":[177],"Strong":[178],"synergy":[179],"was":[180],"DNA-damaging":[185,244],"drugs":[186,245],"gemcitabine,":[189],"while":[190],"additive":[191],"were":[193],"found":[194],"taxane":[197],"docetaxel.":[198],"Our":[199],"results":[200],"provide":[201],"strong":[203],"rationale":[204],"ongoing":[207],"clinical":[208],"study":[209],"platinum-based":[215],"therapy":[216,250,256],"patients":[218,232],"recurrent":[221],"high-grade":[222],"serous":[223],"(HGS)":[224],"cancer.":[226],"More":[227],"than":[228],"96%":[229],"these":[231],"carry":[233],"mutations.":[235],"Combined":[236],"or":[242],"could":[246],"allow":[247],"dramatically":[248],"improved":[249],"wide":[253],"range":[254],"refractory":[257]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
