{"id":"https://openalex.org/W746571053","doi":null,"title":"From Sequence to Sorting : Prediction of Signal Peptides","display_name":"From Sequence to Sorting : Prediction of Signal Peptides","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W746571053","mag":"746571053"},"language":"en","primary_location":{"id":"mag:746571053","doi":null,"is_oa":false,"landing_page_url":"https://orbit.dtu.dk/en/publications/from-sequence-to-sorting-prediction-of-signal-peptides(05f684a3-c1f0-4146-a47b-c2a56c2d5fe2).html","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002675555","display_name":"Henrik Nielsen","orcid":"https://orcid.org/0000-0002-9412-9643","observed_orcids":["https://orcid.org/0000-0002-9412-9643"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Henrik Nielsen","raw_affiliation_strings":["Center for Biological Sequence Analysis"],"raw_orcid":"https://orcid.org/0000-0002-9412-9643","affiliations":[{"raw_affiliation_string":"Center for Biological Sequence Analysis","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5002675555"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0958,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.31395557,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/signal-peptide-prediction","display_name":"signal peptide prediction","score":0.949999988079071},{"id":"https://openalex.org/keywords/protein-sorting","display_name":"protein sorting","score":0.8080000281333923},{"id":"https://openalex.org/keywords/secreted-proteins","display_name":"secreted proteins","score":0.7799999713897705},{"id":"https://openalex.org/keywords/signalp","display_name":"SignalP","score":0.753000020980835},{"id":"https://openalex.org/keywords/chlorops","display_name":"Chlorops","score":0.9240000247955322},{"id":"https://openalex.org/keywords/chloroplast-transit-peptide","display_name":"chloroplast transit peptide","score":0.9570000171661377},{"id":"https://openalex.org/keywords/translation-initiation","display_name":"translation initiation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/protein-secretion","display_name":"protein secretion","score":0.6790000200271606},{"id":"https://openalex.org/keywords/neural-network","display_name":"artificial neural networks","score":0.8669999837875366},{"id":"https://openalex.org/keywords/hidden-markov-models","display_name":"hidden Markov models","score":0.9900000095367432}],"concepts":[{"id":"https://openalex.org/C10858879","wikidata":"https://www.wikidata.org/wiki/Q899790","display_name":"Signal peptide","level":4,"score":0.7737393379211426},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6023366451263428},{"id":"https://openalex.org/C2908929163","wikidata":"https://www.wikidata.org/wiki/Q658882","display_name":"Protein Sorting Signals","level":5,"score":0.5506531596183777},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.5206496119499207},{"id":"https://openalex.org/C66746571","wikidata":"https://www.wikidata.org/wiki/Q1134833","display_name":"ENCODE","level":3,"score":0.4868389964103699},{"id":"https://openalex.org/C111696304","wikidata":"https://www.wikidata.org/wiki/Q2303697","display_name":"Sorting","level":2,"score":0.4708161950111389},{"id":"https://openalex.org/C105565629","wikidata":"https://www.wikidata.org/wiki/Q1248292","display_name":"Gene prediction","level":4,"score":0.46947845816612244},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4674473702907562},{"id":"https://openalex.org/C559089031","wikidata":"https://www.wikidata.org/wiki/Q658882","display_name":"Protein targeting","level":4,"score":0.46273502707481384},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44133275747299194},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44065284729003906},{"id":"https://openalex.org/C23224414","wikidata":"https://www.wikidata.org/wiki/Q176769","display_name":"Hidden Markov model","level":2,"score":0.42497098445892334},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3806373178958893},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3734080195426941},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35310810804367065},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.34874022006988525},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.3395337164402008},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.20797935128211975},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.16850551962852478},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:746571053","doi":null,"is_oa":false,"landing_page_url":"https://orbit.dtu.dk/en/publications/from-sequence-to-sorting-prediction-of-signal-peptides(05f684a3-c1f0-4146-a47b-c2a56c2d5fe2).html","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":232,"referenced_works":["https://openalex.org/W17346934","https://openalex.org/W55769182","https://openalex.org/W124178974","https://openalex.org/W163282153","https://openalex.org/W171398818","https://openalex.org/W205578041","https://openalex.org/W1276010910","https://openalex.org/W1426702512","https://openalex.org/W1490167130","https://openalex.org/W1490959320","https://openalex.org/W1498183065","https://openalex.org/W1499450468","https://openalex.org/W1499598577","https://openalex.org/W1502621331","https://openalex.org/W1517698908","https://openalex.org/W1520794681","https://openalex.org/W1522596503","https://openalex.org/W1526754730","https://openalex.org/W1529950285","https://openalex.org/W1544690761","https://openalex.org/W1551915691","https://openalex.org/W1554807519","https://openalex.org/W1557193358","https://openalex.org/W1571379445","https://openalex.org/W1571712687","https://openalex.org/W1572001614","https://openalex.org/W1577280748","https://openalex.org/W1581406946","https://openalex.org/W1589516143","https://openalex.org/W1592870802","https://openalex.org/W1606770439","https://openalex.org/W1652691445","https://openalex.org/W1659313070","https://openalex.org/W1722305119","https://openalex.org/W1729771463","https://openalex.org/W1753153312","https://openalex.org/W1832071610","https://openalex.org/W1881940044","https://openalex.org/W1885047062","https://openalex.org/W1912879893","https://openalex.org/W1932645010","https://openalex.org/W1953718851","https://openalex.org/W1953745208","https://openalex.org/W1968451768","https://openalex.org/W1969051510","https://openalex.org/W1971120607","https://openalex.org/W1971403296","https://openalex.org/W1971447046","https://openalex.org/W1973578915","https://openalex.org/W1975304761","https://openalex.org/W1975775347","https://openalex.org/W1977262269","https://openalex.org/W1977523126","https://openalex.org/W1978279776","https://openalex.org/W1978701884","https://openalex.org/W1979228662","https://openalex.org/W1979839256","https://openalex.org/W1980653793","https://openalex.org/W1981378404","https://openalex.org/W1987179671","https://openalex.org/W1989033034","https://openalex.org/W1989704540","https://openalex.org/W1994226923","https://openalex.org/W1994529409","https://openalex.org/W1994595595","https://openalex.org/W1994704939","https://openalex.org/W1995930498","https://openalex.org/W1997391192","https://openalex.org/W1997479358","https://openalex.org/W1998519909","https://openalex.org/W1999808704","https://openalex.org/W2000023769","https://openalex.org/W2002180966","https://openalex.org/W2002538503","https://openalex.org/W2002712119","https://openalex.org/W2002785901","https://openalex.org/W2003046928","https://openalex.org/W2003217244","https://openalex.org/W2003546739","https://openalex.org/W2004676677","https://openalex.org/W2005211587","https://openalex.org/W2006211612","https://openalex.org/W2009105413","https://openalex.org/W2009463705","https://openalex.org/W2009570821","https://openalex.org/W2009572502","https://openalex.org/W2010262693","https://openalex.org/W2010816372","https://openalex.org/W2012040490","https://openalex.org/W2012507271","https://openalex.org/W2013212337","https://openalex.org/W2013490788","https://openalex.org/W2014181394","https://openalex.org/W2016043834","https://openalex.org/W2017449280","https://openalex.org/W2017651459","https://openalex.org/W2019009308","https://openalex.org/W2019978236","https://openalex.org/W2020194549","https://openalex.org/W2020295119","https://openalex.org/W2021578268","https://openalex.org/W2021706375","https://openalex.org/W2022572800","https://openalex.org/W2025131366","https://openalex.org/W2025655984","https://openalex.org/W2026538661","https://openalex.org/W2028703398","https://openalex.org/W2028858498","https://openalex.org/W2035564383","https://openalex.org/W2038605297","https://openalex.org/W2039398418","https://openalex.org/W2040762413","https://openalex.org/W2041652393","https://openalex.org/W2041877620","https://openalex.org/W2042096080","https://openalex.org/W2043076104","https://openalex.org/W2043251127","https://openalex.org/W2045067706","https://openalex.org/W2045722009","https://openalex.org/W2045985595","https://openalex.org/W2047766633","https://openalex.org/W2049701913","https://openalex.org/W2051164564","https://openalex.org/W2051293392","https://openalex.org/W2051378879","https://openalex.org/W2053300816","https://openalex.org/W2053766935","https://openalex.org/W2054284840","https://openalex.org/W2056145435","https://openalex.org/W2057029228","https://openalex.org/W2057097492","https://openalex.org/W2061833373","https://openalex.org/W2062492647","https://openalex.org/W2064644935","https://openalex.org/W2064653860","https://openalex.org/W2065232854","https://openalex.org/W2065316371","https://openalex.org/W2066804008","https://openalex.org/W2069748910","https://openalex.org/W2071292183","https://openalex.org/W2071748696","https://openalex.org/W2073269369","https://openalex.org/W2073832303","https://openalex.org/W2074231493","https://openalex.org/W2075046123","https://openalex.org/W2076232532","https://openalex.org/W2081132023","https://openalex.org/W2082142372","https://openalex.org/W2082270046","https://openalex.org/W2082528610","https://openalex.org/W2082605863","https://openalex.org/W2083671140","https://openalex.org/W2083877419","https://openalex.org/W2085022192","https://openalex.org/W2085527675","https://openalex.org/W2087064593","https://openalex.org/W2087344385","https://openalex.org/W2088762095","https://openalex.org/W2089606003","https://openalex.org/W2090574716","https://openalex.org/W2093810663","https://openalex.org/W2094261260","https://openalex.org/W2094403468","https://openalex.org/W2094519647","https://openalex.org/W2096325537","https://openalex.org/W2097634886","https://openalex.org/W2099254366","https://openalex.org/W2099383515","https://openalex.org/W2099616208","https://openalex.org/W2100882223","https://openalex.org/W2102122585","https://openalex.org/W2106269045","https://openalex.org/W2109553965","https://openalex.org/W2109623706","https://openalex.org/W2114010544","https://openalex.org/W2114083522","https://openalex.org/W2114840608","https://openalex.org/W2115474397","https://openalex.org/W2115840790","https://openalex.org/W2116171543","https://openalex.org/W2116503869","https://openalex.org/W2117919289","https://openalex.org/W2118278390","https://openalex.org/W2119452210","https://openalex.org/W2120609288","https://openalex.org/W2120684043","https://openalex.org/W2122349370","https://openalex.org/W2124306486","https://openalex.org/W2124380712","https://openalex.org/W2128073546","https://openalex.org/W2129942096","https://openalex.org/W2130032853","https://openalex.org/W2132893816","https://openalex.org/W2133025816","https://openalex.org/W2133671888","https://openalex.org/W2134322017","https://openalex.org/W2134759004","https://openalex.org/W2136767810","https://openalex.org/W2137045431","https://openalex.org/W2137424160","https://openalex.org/W2137995988","https://openalex.org/W2138879032","https://openalex.org/W2139170911","https://openalex.org/W2139833905","https://openalex.org/W2140014285","https://openalex.org/W2143599839","https://openalex.org/W2144878722","https://openalex.org/W2153193431","https://openalex.org/W2153449964","https://openalex.org/W2154786726","https://openalex.org/W2156628505","https://openalex.org/W2157570951","https://openalex.org/W2157729659","https://openalex.org/W2158120166","https://openalex.org/W2158906453","https://openalex.org/W2160075145","https://openalex.org/W2160188804","https://openalex.org/W2162045311","https://openalex.org/W2162515697","https://openalex.org/W2163409241","https://openalex.org/W2165570400","https://openalex.org/W2165570660","https://openalex.org/W2169769186","https://openalex.org/W2172135690","https://openalex.org/W2416530081","https://openalex.org/W2470854422","https://openalex.org/W2915190566","https://openalex.org/W2916116138","https://openalex.org/W2916193864","https://openalex.org/W3015634246","https://openalex.org/W3214380909","https://openalex.org/W4239620712"],"related_works":["https://openalex.org/W2119452210","https://openalex.org/W2946222253","https://openalex.org/W4388412015","https://openalex.org/W1485459927","https://openalex.org/W2029441437","https://openalex.org/W2161746138","https://openalex.org/W2020969907","https://openalex.org/W7070694587","https://openalex.org/W2063122849","https://openalex.org/W2129407328"],"abstract_inverted_index":{"In":[0,259],"the":[1,31,42,57,97,110,141,196,213,230,240,266],"present":[2],"age":[3],"of":[4,10,26,34,39,56,60,68,104,109,115,192,198,209,229,233,252,265,268],"genome":[5],"sequencing,":[6],"a":[7,61,92,151,226,236,249],"vast":[8],"number":[9],"predicted":[11],"genes":[12,40],"are":[13,165],"initially":[14],"known":[15],"only":[16],"by":[17,91],"their":[18,48],"putative":[19],"nucleotide":[20,49,214],"sequence.":[21],"The":[22,101],"newly":[23],"established":[24],"field":[25],"bioinformatics":[27],"is":[28,63,71,83,140,157,206,216],"concerned":[29],"with":[30,168],"computational":[32],"prediction":[33,67,114,143,163,191,208,276],"structural":[35],"and":[36,41,50,87,122,133,156,248,272],"functional":[37],"properties":[38,59],"proteins":[43],"they":[44],"encode,":[45],"based":[46],"on":[47],"amino":[51],"acid":[52],"sequences.":[53],"Since":[54],"one":[55,169],"crucial":[58],"protein":[62,69,81,220,234,256],"its":[64],"subcellular":[65],"location,":[66],"sorting":[70,82,95,180,221,257],"an":[72],"important":[73,218,242],"question":[74],"in":[75,80,119,187,246,278],"bioinformatics.":[76,279],"A":[77,137],"fundamental":[78],"distinction":[79],"that":[84],"between":[85],"secretory":[86,98,116],"non-secretory":[88],"proteins,":[89],"determined":[90],"cleavable":[93,178],"N-terminal":[94,179,194],"signal,":[96],"signal":[99,117],"peptide.":[100],"main":[102],"part":[103],"this":[105],"thesis,":[106],"including":[107],"four":[108],"six":[111],"papers,":[112],"concerns":[113],"peptides":[118],"both":[120],"eukaryotic":[121,188],"bacterial":[123],"data":[124,269],"using":[125],"two":[126],"machine":[127,243],"learning":[128,244],"techniques:":[129],"artificial":[130],"neural":[131],"networks":[132],"hidden":[134],"Markov":[135],"models.":[136],"central":[138],"result":[139],"SignalP":[142],"method,":[144],"which":[145,205],"has":[146],"been":[147],"made":[148],"available":[149],"as":[150],"World":[152],"Wide":[153],"Web":[154],"server":[155],"very":[158],"widely":[159],"used.":[160],"Two":[161],"additional":[162],"methods":[164,254,277],"also":[166,217],"included,":[167],"paper":[170],"each.":[171],"ChloroP":[172],"predicts":[173,184],"chloroplast":[174],"transit":[175],"peptides,":[176],"another":[177],"signal;":[181],"while":[182],"NetStart":[183],"start":[185,200],"codons":[186],"genes.":[189],"For":[190],"all":[193],"signals,":[195],"assignment":[197],"correct":[199],"codon":[201],"can":[202],"be":[203],"critical,":[204],"why":[207],"translation":[210],"initiation":[211],"from":[212],"sequence":[215],"for":[219,255,275],"prediction.":[222,258],"This":[223],"thesis":[224],"comprises":[225],"detailed":[227],"review":[228,251],"molecular":[231],"biology":[232],"secretion,":[235],"short":[237],"introduction":[238],"to":[239],"most":[241],"algorithms":[245],"bioinformatics,":[247],"critical":[250],"existing":[253],"addition,":[260],"it":[261],"contains":[262],"general":[263],"treatment":[264],"principles":[267],"set":[270],"construction":[271],"performance":[273],"evaluation":[274]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
