{"id":"https://openalex.org/W74611304","doi":null,"title":"Managing cetuximab hypersensitivity-infusion reactions: incidence, risk factors, prevention, and retreatment.","display_name":"Managing cetuximab hypersensitivity-infusion reactions: incidence, risk factors, prevention, and retreatment.","publication_year":2010,"publication_date":"2010-03-01","ids":{"openalex":"https://openalex.org/W74611304","mag":"74611304","pmid":"https://pubmed.ncbi.nlm.nih.gov/20464886"},"language":"en","primary_location":{"id":"pmid:20464886","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20464886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of supportive oncology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020154592","display_name":"Thomas J. George","orcid":"https://orcid.org/0000-0002-6249-9180","observed_orcids":["https://orcid.org/0000-0002-6249-9180"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J George","raw_affiliation_strings":["Department of Medicine, University of Florida Gainesville, Florida 32610-0278, USA. thom.george@medicine.ufl.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Florida Gainesville, Florida 32610-0278, USA. thom.george@medicine.ufl.edu","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043709967","display_name":"Kourtney D. LaPlant","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kourtney D Laplant","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035296195","display_name":"Edmund O. Walden","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edmund O Walden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029362912","display_name":"Arlene B. Davis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arlene B Davis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110315842","display_name":"Charles E. Riggs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles E Riggs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012498450","display_name":"Julia Close","orcid":"https://orcid.org/0000-0002-7649-0320","observed_orcids":["https://orcid.org/0000-0002-7649-0320"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julia L Close","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047849845","display_name":"Sarah N. George","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah N George","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5114125313","display_name":"James W. Lynch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James W Lynch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.4378,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.94227979,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"2","first_page":"72","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.035599999129772186,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":1.0},{"id":"https://openalex.org/keywords/anti-egfr-monoclonal-antibody","display_name":"anti-EGFR monoclonal antibody","score":0.9079999923706055},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.6480000019073486},{"id":"https://openalex.org/keywords/premedication","display_name":"premedication","score":0.9459999799728394},{"id":"https://openalex.org/keywords/test-dose","display_name":"test dose","score":0.8999999761581421},{"id":"https://openalex.org/keywords/panitumumab","display_name":"panitumumab","score":0.75},{"id":"https://openalex.org/keywords/retreatment","display_name":"retreatment","score":0.8019999861717224},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8820000290870667},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":1.0},{"id":"https://openalex.org/keywords/veterans","display_name":"veterans","score":0.6700000166893005},{"id":"https://openalex.org/keywords/bronchodilator-use","display_name":"bronchodilator use","score":0.7020000219345093},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.9682024717330933},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9578568935394287},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6262971758842468},{"id":"https://openalex.org/C2778332735","wikidata":"https://www.wikidata.org/wiki/Q417775","display_name":"Panitumumab","level":5,"score":0.567331075668335},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5668251514434814},{"id":"https://openalex.org/C2778300832","wikidata":"https://www.wikidata.org/wiki/Q1589604","display_name":"Premedication","level":2,"score":0.5551639199256897},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5310932397842407},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.43210506439208984},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.30382660031318665},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2688782513141632},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.13264688849449158},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068818","descriptor_name":"Cetuximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019233","descriptor_name":"Retreatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:20464886","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20464886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of supportive oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W2074773293","https://openalex.org/W2140035322","https://openalex.org/W2155384808"],"related_works":["https://openalex.org/W2589281517","https://openalex.org/W2125782607","https://openalex.org/W2484335427","https://openalex.org/W2566185003","https://openalex.org/W2141632745","https://openalex.org/W2588161112","https://openalex.org/W2590745037","https://openalex.org/W2334980981","https://openalex.org/W2883431885","https://openalex.org/W2013426116"],"abstract_inverted_index":{"Cetuximab":[0],"is":[1,250],"an":[2,208,213,230],"anti-epidermal":[3],"growth":[4],"factor":[5],"receptor":[6],"(EGFR)":[7],"monoclonal":[8],"antibody":[9],"approved":[10],"by":[11],"the":[12,19,140,180,196,257],"US":[13],"Food":[14],"and":[15,24,26,36,83,210,241,286,304],"Drug":[16],"Administration":[17],"for":[18,55,75],"treatment":[20],"of":[21,77,98,111,164,182,200,218,229,274,289],"colorectal":[22],"(CRC)":[23],"head":[25],"neck":[27],"(H&N)":[28],"cancers.":[29],"Hypersensitivity-infusion":[30],"reactions":[31],"(HIRs)":[32],"confer":[33],"moderate":[34],"morbidity":[35],"potential":[37],"mortality.":[38],"HIRs":[39,115,137,167],"have":[40],"a":[41,68,239,275,280,292],"wide":[42],"geographic":[43],"incidence":[44,197,247],"with":[45,65,79,156,224,252,298],"few":[46],"identifiable":[47,175],"risk":[48,176],"factors.":[49],"Limited":[50],"data":[51,86],"regarding":[52],"risk-reduction":[53],"interventions":[54],"HIR":[56,209,233,269,281,294],"or":[57,154,160,198,264],"post-HIR":[58],"retreatment":[59,223],"are":[60],"available.":[61],"All":[62,88,136],"patients":[63,101,119,165,220,297],"treated":[64],"cetuximab":[66,203,235,293],"at":[67,107],"single":[69],"Veterans":[70],"Affairs":[71],"facility":[72],"were":[73,144,173],"monitored":[74],"development":[76],"HIRs,":[78],"baseline":[80],"clinical,":[81,262],"demographic,":[82,263],"supportive":[84],"care":[85],"recorded.":[87],"received":[89,106],"standard":[90],"premedication":[91,185],"based":[92],"on":[93],"cohort":[94],"assignment.":[95],"A":[96,202],"total":[97],"51":[99],"consecutive":[100],"(30":[102],"CRC;":[103],"21":[104],"H&N)":[105],"least":[108],"one":[109],"dose":[110,205,277],"cetuximab.":[112],"Grades":[113],"II-IV":[114],"occurred":[116,138],"in":[117,212,256,270,295],"14":[118],"(27%;":[120],"6":[121,124],"grade":[122,125,128,133],"II,":[123],"Ill,":[126],"2":[127],"IV).":[129],"There":[130,143],"was":[131],"no":[132,145,174],"V":[134],"HIR.":[135,183,201,231],"during":[139,234],"first":[141],"infusion.":[142],"differences":[146],"between":[147],"age,":[148],"race,":[149],"diagnosis,":[150],"stage,":[151],"concurrent":[152],"chemotherapy,":[153],"radiotherapy":[155],"cetuximab,":[157],"allergy":[158],"history,":[159],"military":[161],"service":[162],"era":[163],"developing":[166],"versus":[168],"those":[169],"who":[170],"did":[171],"not.There":[172],"factors":[177],"that":[178,253],"predicted":[179,268],"severity":[181,199],"Neither":[184],"modifications":[186],"(P":[187],"=":[188],"0.34)":[189],"nor":[190],"bronchodilator":[191],"use":[192],"(P=":[193],"0.12)":[194],"impacted":[195],"test":[204,276],"successfully":[206],"elicited":[207],"resulted":[211],"87%":[214],"cost":[215],"savings.":[216],"None":[217],"five":[219],"receiving":[221],"subsequent":[222],"anti-EGFR":[225],"MoAb":[226],"had":[227],"recurrence":[228],"An":[232],"infusion":[236],"can":[237],"be":[238,284,302],"serious":[240],"underestimated":[242],"toxicity.":[243],"The":[244],"relatively":[245],"high":[246],"reported":[248],"here":[249],"consistent":[251],"previously":[254],"identified":[255],"Southeastern":[258],"United":[259],"States.":[260],"No":[261],"historic":[265],"variables":[266],"reliably":[267],"our":[271],"population.":[272],"Use":[273,288],"to":[278,283,301],"elicit":[279],"appears":[282,300],"feasible":[285,303],"cost-effective.":[287],"panitumumab":[290],"after":[291],"select":[296],"CRC":[299],"safe.":[305]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}