{"id":"https://openalex.org/W744938011","doi":null,"title":"Analysis of Antioxidant Responsive Gene Expression Changes by Thioredoxin System Inhibitors and Hypoxia","display_name":"Analysis of Antioxidant Responsive Gene Expression Changes by Thioredoxin System Inhibitors and Hypoxia","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W744938011","mag":"744938011"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/195542","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/195542","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011412582","display_name":"Amy Coon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Amy Coon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5011412582"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.5884000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.5884000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.4041000008583069,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/px-12","display_name":"PX-12","score":0.9940000176429749},{"id":"https://openalex.org/keywords/antioxidant-response-element","display_name":"antioxidant response element","score":0.7369999885559082},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.925000011920929},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9079999923706055},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9350000023841858},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8029999732971191},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.8450000286102295},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9660000205039978},{"id":"https://openalex.org/keywords/perk","display_name":"PERK","score":0.9079999923706055},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.7799999713897705},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C3623737","wikidata":"https://www.wikidata.org/wiki/Q421219","display_name":"Thioredoxin","level":3,"score":0.7614157199859619},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6595278382301331},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5995078086853027},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5794708132743835},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5272858738899231},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5256513357162476},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.4994957447052002},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48963385820388794},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46408459544181824},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4098132252693176},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34299930930137634},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1681927740573883},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12841781973838806}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/195542","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/195542","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},{"id":"mag:744938011","doi":null,"is_oa":false,"landing_page_url":"http://arizona.openrepository.com/arizona/handle/10150/195542","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":153,"referenced_works":["https://openalex.org/W38783263","https://openalex.org/W55609255","https://openalex.org/W113661270","https://openalex.org/W136128967","https://openalex.org/W181261420","https://openalex.org/W187263029","https://openalex.org/W1493042866","https://openalex.org/W1497318066","https://openalex.org/W1501442799","https://openalex.org/W1503667331","https://openalex.org/W1508786321","https://openalex.org/W1516245997","https://openalex.org/W1516817503","https://openalex.org/W1517639918","https://openalex.org/W1523021466","https://openalex.org/W1534972478","https://openalex.org/W1537780786","https://openalex.org/W1547863599","https://openalex.org/W1551392207","https://openalex.org/W1555938743","https://openalex.org/W1561096292","https://openalex.org/W1565745037","https://openalex.org/W1567647424","https://openalex.org/W1594054294","https://openalex.org/W1595716614","https://openalex.org/W1595838029","https://openalex.org/W1767331507","https://openalex.org/W1907965198","https://openalex.org/W1963557394","https://openalex.org/W1963712961","https://openalex.org/W1964037605","https://openalex.org/W1971465028","https://openalex.org/W1972352578","https://openalex.org/W1973328612","https://openalex.org/W1974525592","https://openalex.org/W1975077455","https://openalex.org/W1975512386","https://openalex.org/W1975621743","https://openalex.org/W1977780484","https://openalex.org/W1978029697","https://openalex.org/W1978368163","https://openalex.org/W1980000538","https://openalex.org/W1987761993","https://openalex.org/W1989778625","https://openalex.org/W1991265255","https://openalex.org/W1991387227","https://openalex.org/W1991631628","https://openalex.org/W1992533564","https://openalex.org/W1995414238","https://openalex.org/W1998199040","https://openalex.org/W2000462205","https://openalex.org/W2000508311","https://openalex.org/W2001013683","https://openalex.org/W2002123191","https://openalex.org/W2002593979","https://openalex.org/W2002598577","https://openalex.org/W2003607850","https://openalex.org/W2004737228","https://openalex.org/W2010888033","https://openalex.org/W2011810742","https://openalex.org/W2015837249","https://openalex.org/W2019358729","https://openalex.org/W2020795308","https://openalex.org/W2022842120","https://openalex.org/W2023971274","https://openalex.org/W2027355536","https://openalex.org/W2028854226","https://openalex.org/W2031643961","https://openalex.org/W2033243838","https://openalex.org/W2033274952","https://openalex.org/W2034260628","https://openalex.org/W2034269086","https://openalex.org/W2035022316","https://openalex.org/W2036907745","https://openalex.org/W2037039296","https://openalex.org/W2037206353","https://openalex.org/W2040071780","https://openalex.org/W2040114786","https://openalex.org/W2045899523","https://openalex.org/W2046987575","https://openalex.org/W2052548231","https://openalex.org/W2053291096","https://openalex.org/W2053350368","https://openalex.org/W2053671318","https://openalex.org/W2055106248","https://openalex.org/W2056881411","https://openalex.org/W2059129711","https://openalex.org/W2060792031","https://openalex.org/W2062803086","https://openalex.org/W2064193818","https://openalex.org/W2064280448","https://openalex.org/W2065190343","https://openalex.org/W2065404736","https://openalex.org/W2068001141","https://openalex.org/W2068642882","https://openalex.org/W2070693959","https://openalex.org/W2072227408","https://openalex.org/W2072963191","https://openalex.org/W2073880421","https://openalex.org/W2075584603","https://openalex.org/W2079062297","https://openalex.org/W2079892215","https://openalex.org/W2082265161","https://openalex.org/W2082355537","https://openalex.org/W2082730339","https://openalex.org/W2084111937","https://openalex.org/W2085201901","https://openalex.org/W2086277815","https://openalex.org/W2089032508","https://openalex.org/W2094026727","https://openalex.org/W2094613397","https://openalex.org/W2095585565","https://openalex.org/W2097634036","https://openalex.org/W2103650142","https://openalex.org/W2106450793","https://openalex.org/W2106653388","https://openalex.org/W2110806607","https://openalex.org/W2115338196","https://openalex.org/W2118484233","https://openalex.org/W2130004942","https://openalex.org/W2131330333","https://openalex.org/W2133308495","https://openalex.org/W2140575551","https://openalex.org/W2141874177","https://openalex.org/W2143343444","https://openalex.org/W2146883699","https://openalex.org/W2149659371","https://openalex.org/W2149982213","https://openalex.org/W2155148540","https://openalex.org/W2157607856","https://openalex.org/W2162748739","https://openalex.org/W2164001677","https://openalex.org/W2164484993","https://openalex.org/W2165623186","https://openalex.org/W2165643859","https://openalex.org/W2190156091","https://openalex.org/W2236241003","https://openalex.org/W2240454133","https://openalex.org/W2260835883","https://openalex.org/W2265836774","https://openalex.org/W2267935709","https://openalex.org/W2300075112","https://openalex.org/W2396628109","https://openalex.org/W2410861212","https://openalex.org/W2411514870","https://openalex.org/W2413506053","https://openalex.org/W2414388747","https://openalex.org/W2415763315","https://openalex.org/W2418572439","https://openalex.org/W2469811704","https://openalex.org/W2497717981","https://openalex.org/W2965858921","https://openalex.org/W4366741679"],"related_works":["https://openalex.org/W817448018","https://openalex.org/W7136118463","https://openalex.org/W2966157203","https://openalex.org/W2157124363","https://openalex.org/W1990466105","https://openalex.org/W2164001677","https://openalex.org/W3048106124","https://openalex.org/W2622227247","https://openalex.org/W1910869416","https://openalex.org/W2059365920"],"abstract_inverted_index":{"Gene":[0,173],"expression":[1,102,174,286],"profiling":[2],"measured":[3],"by":[4,182,208,268,291],"cDNA":[5],"microarray":[6,178],"offers":[7],"a":[8,52,116],"powerful":[9],"tool":[10],"for":[11,22,54,133,170,218,298],"identifying":[12,23],"cancer":[13,25,81,85],"drug":[14,19,26,77],"mechanism":[15],"of":[16,31,111,136,144,147,188,221,226,270,279,281,287,302],"action,":[17],"defining":[18],"specificity":[20],"and":[21,48,66,82,155,186,203,213,232,238,256,300],"new":[24],"targets.":[27],"An":[28],"anti-tumor":[29],"inhibitor":[30],"the":[32,59,67,105,126,137,145,158,196,219,249,264,277],"thioredoxin-1":[33],"(Trx-1)":[34],"redox":[35],"system,":[36],"PX-12":[37],"(1-methylhydroxypropyl":[38],"2-imidazoloyl":[39],"disulfide),":[40],"is":[41],"currently":[42],"in":[43,64,73,90,100,107,120,130,153,156,161,164,241,251],"Phase":[44],"I":[45],"clinical":[46],"trials":[47],"was":[49,168,201,260,273],"used":[50],"as":[51,71,88],"model":[53],"targeted":[55],"therapy":[56],"to":[57,104,195,205,254,262,275],"evaluate":[58],"differences":[60],"between":[61],"cells":[62,69,86,106],"growing":[63,87],"culture":[65],"same":[68],"grown":[70],"xenografts":[72,89],"immunocompromised":[74],"mice.":[75],"Without":[76],"treatment,":[78],"MCF-7":[79],"breast":[80],"HT-29":[83],"colon":[84],"severe":[91],"combined":[92],"immune":[93],"deficient":[94],"(scid)":[95],"mice":[96],"showed":[97],"marked":[98],"changes":[99,128,175],"gene":[101,127],"compared":[103],"culture,":[108],"with":[109,124,210],"42%":[110],"genes":[112,139,162,290],"showing":[113],"more":[114],"than":[115],"two":[117],"fold":[118],"difference":[119],"expression.":[121],"Following":[122],"treatment":[123,209],"PX-12,":[125],"observed":[129,176],"common":[131,159],"accounted":[132],"approximately":[134],"1%":[135],"total":[138],"changed":[140],"vivo.":[141],"After":[142],"elimination":[143],"effects":[146],"Trx-1":[148,211,257],"inhibitors":[149,212],"on":[150],"known":[151],"targets":[152],"vivo":[154],"vitro,":[157],"increase":[160,220,240,250],"involved":[163],"antioxidant":[165,197,272],"response":[166],"pathway":[167],"chosen":[169],"further":[171],"investigation.":[172],"during":[177],"experimentation":[179],"were":[180],"validated":[181],"real-time":[183],"RT-PCR.":[184],"Binding":[185],"activation":[187,225,280],"Nrf2":[189],"(nuclear":[190],"factor":[191],"(erythroid-derived":[192],"2)-like":[193],"2)":[194],"responsive":[198],"element":[199],"(ARE)":[200],"evaluated":[202],"found":[204],"be":[206],"increased":[207,285],"hypoxia.":[214],"Potential":[215],"mechanisms":[216,293],"accounting":[217],"ARE-dependent":[222],"genes,":[223],"including":[224],"protein":[227],"kinase":[228],"C,":[229],"PI3K":[230],"(phosphoinositide-3-kinase)":[231],"p-PERK":[233],"(phospho-PRKR-like":[234],"endoplasmic":[235],"reticulum":[236],"kinase)":[237],"an":[239,271],"cellular":[242],"reactive":[243],"oxygen":[244],"species":[245],"(ROS),":[246],"determined":[247],"that":[248],"ROS":[252,267],"due":[253],"hypoxia":[255],"system":[258],"inhibition":[259],"sufficient":[261],"activate":[263],"pathway.":[265,283],"Decreasing":[266],"addition":[269],"able":[274],"reverse":[276],"effect":[278],"this":[282],"The":[284],"ARE/Nrf2":[288],"dependent":[289],"these":[292],"may":[294],"have":[295],"important":[296],"implications":[297],"chemotherapy":[299],"chemoprevention":[301],"human":[303],"tumors.":[304]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}