{"id":"https://openalex.org/W744788307","doi":null,"title":"Genetic influence on brain volumes in psychosis","display_name":"Genetic influence on brain volumes in psychosis","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W744788307","mag":"744788307"},"language":"en","primary_location":{"id":"pmh:oai:uilis.unsyiah.ac.id:20514","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/20514","pdf_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/20514","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"book"},"volume":null,"type":"book","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/20514","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035723534","display_name":"Ana Miorelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ana Miorelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5035723534"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psychosis","display_name":"psychosis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/brain-volume","display_name":"brain volume","score":0.8040000200271606},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7570000290870667},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.5419999957084656},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":1.0},{"id":"https://openalex.org/keywords/grey-matter-volume","display_name":"gray matter volume","score":0.9319999814033508},{"id":"https://openalex.org/keywords/white-matter-volume","display_name":"white matter volume","score":1.0},{"id":"https://openalex.org/keywords/total-brain-volume","display_name":"total brain volume","score":0.824999988079071},{"id":"https://openalex.org/keywords/family-based-association","display_name":"family-based association","score":0.4410000145435333},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8500000238418579},{"id":"https://openalex.org/keywords/olig2","display_name":"Olig2","score":0.902999997138977},{"id":"https://openalex.org/keywords/dtnbp1","display_name":"DTNBP1","score":0.953000009059906},{"id":"https://openalex.org/keywords/brain-morphometry","display_name":"brain morphometry","score":0.6809999942779541},{"id":"https://openalex.org/keywords/heritability","display_name":"heritability","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.6821759939193726},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5119785070419312},{"id":"https://openalex.org/C65835030","wikidata":"https://www.wikidata.org/wiki/Q1030681","display_name":"Brain size","level":3,"score":0.43728888034820557},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3740180432796478},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36704736948013306},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28661519289016724},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.05560702085494995},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uilis.unsyiah.ac.id:20514","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/20514","pdf_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/20514","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"book"},{"id":"mag:744788307","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.628442","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uilis.unsyiah.ac.id:20514","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/20514","pdf_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/20514","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"book"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W744788307.pdf","grobid_xml":"https://content.openalex.org/works/W744788307.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1555679702","https://openalex.org/W1596415735","https://openalex.org/W1651307453","https://openalex.org/W1663973292","https://openalex.org/W1974702488","https://openalex.org/W1976027227","https://openalex.org/W1980719669","https://openalex.org/W1981253098","https://openalex.org/W1983668233","https://openalex.org/W1988486070","https://openalex.org/W1993058292","https://openalex.org/W1994118653","https://openalex.org/W1995780438","https://openalex.org/W2009485462","https://openalex.org/W2010993988","https://openalex.org/W2011843626","https://openalex.org/W2022428482","https://openalex.org/W2025292926","https://openalex.org/W2027313865","https://openalex.org/W2028693746","https://openalex.org/W2039130870","https://openalex.org/W2040710034","https://openalex.org/W2049409353","https://openalex.org/W2053758053","https://openalex.org/W2065540313","https://openalex.org/W2074556753","https://openalex.org/W2077455126","https://openalex.org/W2084741079","https://openalex.org/W2088842558","https://openalex.org/W2089752613","https://openalex.org/W2099241624","https://openalex.org/W2103691876","https://openalex.org/W2104961530","https://openalex.org/W2113121748","https://openalex.org/W2124524555","https://openalex.org/W2125244470","https://openalex.org/W2127442418","https://openalex.org/W2128610280","https://openalex.org/W2130581420","https://openalex.org/W2136662452","https://openalex.org/W2137579871","https://openalex.org/W2140327288","https://openalex.org/W2143060791","https://openalex.org/W2143629083","https://openalex.org/W2144034070","https://openalex.org/W2163214444","https://openalex.org/W2164717493","https://openalex.org/W2168331311","https://openalex.org/W2169657200","https://openalex.org/W2170405806","https://openalex.org/W2290014919","https://openalex.org/W2395962202"],"related_works":["https://openalex.org/W2057970036","https://openalex.org/W2166418902","https://openalex.org/W1988903920","https://openalex.org/W7074253338","https://openalex.org/W4297460925","https://openalex.org/W2151295206","https://openalex.org/W1991219891","https://openalex.org/W927446170","https://openalex.org/W2034980583","https://openalex.org/W2911150802"],"abstract_inverted_index":{"This":[0],"study":[1,53],"explored":[2,17,295],"the":[3,40,82,145,185,195,201,214,221,231,242,254,261,271,280,288,292,366,377],"genetic":[4,296],"influence":[5,297,304,355],"of":[6,187,203,220,230,241,260,270,279,291,298,350,363,388],"susceptibility":[7],"genes":[8,369],"on":[9,205,313,356],"brain":[10,26,91,117,152,171,182,247,285,305,334,372],"volumes":[11,27,92,153,183,207,315],"in":[12,28,35,151,181,224,234,245,264,273,283,307,310],"psychosis.":[13],"More":[14],"specifically,":[15],"I":[16,43,66,85,148,199,294,318,359],"whether":[18],"certain":[19],"allelic":[20],"variations":[21],"are":[22],"associated":[23],"with":[24,30,73,101,131,165,189,212,251],"global":[25],"subjects":[29],"psychosis,":[31,74],"their":[32,174],"relatives":[33,76,155,186],"and":[34,77,89,95,109,114,156,158,194,238,277,309,327,329,353,370],"healthy":[36,79,96,120,142,159,196,311],"controls.":[37,121,143],"To":[38],"increase":[39],"statistical":[41],"power,":[42],"combined":[44],"three":[45],"different":[46],"MRI":[47,62],"scan":[48],"datasets":[49],"since":[50],"a":[51],"calibration":[52],"showed":[54,105,124,168],"high":[55,351],"intra-class":[56],"correlations":[57],"(ICC":[58],"above":[59],"0.9)":[60],"between":[61,93,154,184,324,365],"protocols":[63],"(Chapter":[64,98,161,208,316],"3).":[65],"therefore":[67],"included":[68],"535":[69],"participants":[70],"(225":[71],"patients":[72,94,130,157,164,188],"130":[75],"180":[78],"volunteers).":[80],"In":[81,144,210,249,287,345],"first":[83],"analysis":[84],"compared":[86],"grey,":[87,330],"white":[88,111,138,235,274,331],"whole":[90,116,170,246,284,333],"controls":[97,160],"5).":[99],"Patients":[100],"schizophrenia":[102,193,213],"spectrum":[103],"psychoses":[104],"smaller":[106,115,125,137,169],"grey":[107,126,225,265],"matter":[108,112,127,139,226,236,266,275],"larger":[110],"volume,":[113,227,237,267,276],"volume":[118,128,140,172],"than":[119,129,141,173],"They":[122],"also":[123,135],"bipolar":[132,166,190,252],"disorder,":[133],"who":[134],"had":[136],"second":[146,289],"analysis,":[147],"estimated":[149],"differences":[150,180],"6).":[162,209],"Only":[163],"disorder":[167,191,253],"relatives.":[175],"There":[176],"were":[177],"no":[178],"significant":[179],"or":[192,332],"volunteers.":[197],"Finally,":[198],"evaluated":[200],"role":[202],"familiarity":[204],"these":[206,314,371],"families":[211,250],"family":[215,255],"clusters":[216,256],"accounted":[217,257],"for":[218,228,239,258,268,321],"48%":[219,259],"total":[222,232,243,262,281],"variance":[223,233,244,263,272,282],"27%":[229],"35%":[240],"volume.":[248,286],"43%":[269],"22%":[278],"part":[290],"thesis":[293],"20":[299],"SNPs":[300],"previously":[301],"reported":[302],"to":[303,379],"morphometry":[306],"psychosis":[308],"individuals,":[312],"7).":[317],"found":[319,360],"evidence":[320,349,362],"an":[322],"association":[323,338,364],"OLIG2_rs762178,":[325],"MCPH_rs930557":[326],"DTNBP1_rs1047631":[328],"volumes.":[335],"However,":[336],"this":[337,386],"did":[339],"not":[340,361],"survive":[341],"multiple":[342],"comparison":[343],"corrections.":[344],"conclusion,":[346],"despite":[347],"strong":[348],"heritability":[352],"familial":[354],"volumetric":[357],"measures,":[358],"selected":[367],"candidate":[368],"regions.":[373],"These":[374],"findings":[375],"highlight":[376],"need":[378],"use":[380],"large":[381],"sample":[382],"sizes":[383],"when":[384],"conducting":[385],"type":[387],"studies.":[389]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
