{"id":"https://openalex.org/W744364702","doi":null,"title":"Identification and Biochemical Characterization of PGC-1beta-Interacting Proteins","display_name":"Identification and Biochemical Characterization of PGC-1beta-Interacting Proteins","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W744364702","mag":"744364702"},"language":"en","primary_location":{"id":"pmh:oai:kuscholarworks.ku.edu:1808/4341","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1808/4341","pdf_url":"http://hdl.handle.net/1808/4341","source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1808/4341","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100657590","display_name":"Hongsheng Zhang","orcid":"https://orcid.org/0000-0002-2022-1826","observed_orcids":["https://orcid.org/0000-0002-2022-1826"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hongsheng Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2022-1826","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100657590"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.635699987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.635699987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.30660000443458557,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pgc-1beta","display_name":"PGC-1\u03b2","score":0.953000009059906},{"id":"https://openalex.org/keywords/pgc-1alpha","display_name":"PGC-1\u03b1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.828000009059906},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7910000085830688},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.4690000116825104},{"id":"https://openalex.org/keywords/hepatic-lipogenesis","display_name":"hepatic lipogenesis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/gluconeogenesis","display_name":"gluconeogenesis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.6840000152587891},{"id":"https://openalex.org/keywords/adaptive-thermogenesis","display_name":"adaptive thermogenesis","score":0.6650000214576721},{"id":"https://openalex.org/keywords/fatty-acid-beta-oxidation","display_name":"fatty acid beta-oxidation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.7170000076293945},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.8366566896438599},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7096613049507141},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6595488786697388},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.5937337279319763},{"id":"https://openalex.org/C146777309","wikidata":"https://www.wikidata.org/wiki/Q1132599","display_name":"Corepressor","level":5,"score":0.5870593190193176},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5199055075645447},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.47970670461654663},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.47325780987739563},{"id":"https://openalex.org/C124170894","wikidata":"https://www.wikidata.org/wiki/Q14914591","display_name":"Nuclear receptor coactivator 2","level":5,"score":0.43420568108558655},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4151787757873535},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32013535499572754},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:kuscholarworks.ku.edu:1808/4341","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1808/4341","pdf_url":"http://hdl.handle.net/1808/4341","source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:744364702","doi":null,"is_oa":false,"landing_page_url":"https://kuscholarworks.ku.edu/handle/1808/4341","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:kuscholarworks.ku.edu:1808/4341","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1808/4341","pdf_url":"http://hdl.handle.net/1808/4341","source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W744364702.pdf","grobid_xml":"https://content.openalex.org/works/W744364702.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W134153864","https://openalex.org/W140425272","https://openalex.org/W1501286679","https://openalex.org/W1523158326","https://openalex.org/W1564289967","https://openalex.org/W1570612145","https://openalex.org/W1613446635","https://openalex.org/W1633325203","https://openalex.org/W1963739832","https://openalex.org/W1964876127","https://openalex.org/W1969369593","https://openalex.org/W1974220331","https://openalex.org/W1975600010","https://openalex.org/W1976998737","https://openalex.org/W1977000651","https://openalex.org/W1979026271","https://openalex.org/W1984668213","https://openalex.org/W1984793963","https://openalex.org/W1986946962","https://openalex.org/W1990755760","https://openalex.org/W1997312454","https://openalex.org/W2004988279","https://openalex.org/W2007980073","https://openalex.org/W2008632158","https://openalex.org/W2017011351","https://openalex.org/W2026833147","https://openalex.org/W2026901592","https://openalex.org/W2028053287","https://openalex.org/W2028980494","https://openalex.org/W2031877157","https://openalex.org/W2035747081","https://openalex.org/W2036639816","https://openalex.org/W2044495919","https://openalex.org/W2045497589","https://openalex.org/W2046079276","https://openalex.org/W2046566365","https://openalex.org/W2049652810","https://openalex.org/W2057145009","https://openalex.org/W2068972095","https://openalex.org/W2069853996","https://openalex.org/W2072062691","https://openalex.org/W2074442179","https://openalex.org/W2077528576","https://openalex.org/W2088086126","https://openalex.org/W2101797210","https://openalex.org/W2104360623","https://openalex.org/W2104389054","https://openalex.org/W2124155893","https://openalex.org/W2124612536","https://openalex.org/W2125407920","https://openalex.org/W2131144673","https://openalex.org/W2131354928","https://openalex.org/W2135716791","https://openalex.org/W2141789735","https://openalex.org/W2141956604","https://openalex.org/W2155045727","https://openalex.org/W2157199218","https://openalex.org/W2158088166","https://openalex.org/W2160769801","https://openalex.org/W2167569899","https://openalex.org/W2168681882","https://openalex.org/W2886534997","https://openalex.org/W6931824552"],"related_works":["https://openalex.org/W1969598812","https://openalex.org/W2123115740","https://openalex.org/W2157199218","https://openalex.org/W2072972072","https://openalex.org/W2147609336","https://openalex.org/W2017011351","https://openalex.org/W1968743437","https://openalex.org/W7099969759","https://openalex.org/W2160769801","https://openalex.org/W7096187772"],"abstract_inverted_index":{"Nuclear":[0],"receptors":[1],"(NRs)":[2],"are":[3],"ligand-activated":[4],"transcription":[5,28,190],"factors.":[6],"They":[7],"regulate":[8,26],"key":[9,73,157,244,261],"biological":[10,262],"processes":[11,71,159],"including":[12,164],"homeostasis":[13,163],"of":[14,23,44,68,78,86,172,198,281,287,319,345,420,424,433,454,464,477,480,494,501],"lipophilic":[15],"molecules,":[16],"organogenesis,":[17],"development,":[18],"and":[19,63,99,118,148,170,187,200,218,263,289,316,327,353,367,435,456,466],"reproduction.":[20],"The":[21,386,394,408,462],"ability":[22,33,91,181,453],"NRs":[24,49,87,186],"to":[25,34,37,52,58,92,182,273,347,359,375,458,473,489],"gene":[27,79],"is":[29,104,127,132,194,271,332,388,400,417],"dependent":[30],"upon":[31,89,254],"their":[32,45,90,274,308],"directly":[35,50],"binding":[36,350],"specific":[38],"enhancer":[39],"elements":[40],"within":[41],"the":[42,56,76,82,195,260,282,301,325,339,348,370,421,431,440,452,478,491],"promoters":[43],"target":[46,216],"genes.":[47],"While":[48],"bind":[51],"DNA,":[53,62],"they":[54],"lack":[55],"capacity":[57,142],"modify":[59],"chromatin,":[60],"unwind":[61],"recruit":[64],"transcriptional":[65],"machinery.":[66],"All":[67],"these":[69,222,267,495],"aforementioned":[70],"represent":[72],"steps":[74],"in":[75,135,155,161,207,247,307,437,497],"regulation":[77],"transcription.":[80,502],"Therefore,":[81],"full":[83],"functional":[84,264],"activity":[85],"depends":[88],"interact":[93,183],"with":[94,184,205,300,460],"protein":[95,130,214,276,356,391,397,402,405,410,416],"cofactors,":[96],"termed":[97,406],"coactivator":[98,129,224,269],"corepressor":[100],"proteins.":[101,379,482],"Metabolic":[102],"syndrome":[103],"an":[105,152,314,474],"emerging":[106],"global":[107],"epidemic":[108],"characterized":[109],"by":[110],"a":[111,128,139,243,389,401,414,418],"complex":[112],"disorder":[113],"that":[114,131,137,259,292,323,331],"affects":[115],"both":[116,293],"glucose":[117],"lipid":[119],"metabolism.":[120],"Peroxisome":[121],"proliferator-activated":[122],"receptor-gamma":[123],"(PPARg)":[124],"co-activator-1alpha":[125],"(PGC-1a)":[126],"mainly":[133],"expressed":[134],"tissues":[136],"require":[138],"high":[140],"oxidative":[141],"such":[143],"as":[144,357,413,468],"fat,":[145],"muscle,":[146],"brain,":[147,366],"liver.":[149],"PGC-1a":[150,175,199,206,241,290],"plays":[151,242],"important":[153],"role":[154,246,493],"regulating":[156,498],"metabolic":[158],"involved":[160],"energy":[162],"gluconeogenesis,":[165,239],"mitochondrial":[166],"biogenesis,":[167],"adaptive":[168],"thermogenesis,":[169],"b-oxidation":[171],"fatty":[173],"acids.":[174],"accomplishes":[176],"this":[177,342,355],"feature":[178],"through":[179],"its":[180],"selected":[185],"certain":[188],"other":[189],"factor":[191],"types.":[192],"PGC-1b":[193,232,288,312,346],"closest":[196],"homolog":[197],"also":[201,226,486],"shares":[202],"some":[203],"similarities":[204],"amino":[208,284,320],"acid":[209,285,321],"sequence,":[210],"expression":[211,362],"pattern,":[212],"interacting":[213],"partners,":[215],"genes,":[217],"biochemical":[219],"function.":[220],"However,":[221,311],"two":[223,268,303,372],"proteins":[225,270,294,383,425,470,496],"display":[227],"distinct":[228,275],"proerties.":[229],"For":[230],"example,":[231],"mediates":[233],"hepatic":[234,248],"lipogenic":[235],"program":[236],"but":[237,250],"not":[238],"whereas":[240],"regulatory":[245,404],"gluconeogenesis":[249],"has":[251],"no":[252],"effects":[253],"lipogenesis.":[255],"We":[256,336,428],"therefore":[257,337],"hypothesized":[258],"differences":[265],"between":[266],"due":[272],"interaction":[277,432],"profile.":[278],"A":[279],"comparison":[280],"primary":[283],"sequence":[286,322],"revealed":[291],"contain":[295],"three":[296],"NR-interaction":[297,329],"motifs":[298],"(-LXXLL-)":[299],"first":[302,387],"being":[304],"highly":[305],"conserved":[306],"N-termini,":[309],"respectively.":[310],"contains":[313],"additional":[315],"unique":[317],"stretch":[318],"separates":[324],"second":[326,395],"third":[328,409],"motif":[330],"absent":[333],"from":[334,364],"PGC-1a.":[335],"fused":[338],"cDNA":[340,361],"encoding":[341],"N-terminal":[343],"region":[344],"GAL4-DNA":[349],"domain":[351],"(GAL4-NBT3)":[352],"used":[354],"`bait'":[358],"screen":[360],"libraries":[363],"liver,":[365],"embryo":[368],"using":[369,439,447],"yeast":[371],"hybrid":[373],"system":[374],"identify":[376],"novel":[377],"PGC-1b-interacting":[378,382,396,415,469,481],"Three":[380],"potential":[381,492],"were":[384],"identified.":[385],"NR":[390],"called":[392,426],"COUP-TF1.":[393],"we":[398,411],"identified":[399,412],"phosphatase":[403],"PP4R1.":[407],"member":[419],"SWI/SNF":[422],"family":[423],"BAF60a.":[427],"further":[429,450],"confirmed":[430],"PGC-1b/PP4R1":[434],"PGC-1b/BAF60a":[436],"vitro":[438],"GST":[441],"pull-down":[442],"assay.":[443],"In":[444],"vivo":[445],"analysis":[446],"immunohistochemical":[448],"methods":[449],"confirms":[451],"PP4R1":[455,465],"BAF60a":[457,467],"co-localize":[459],"PGC-1b.":[461],"identification":[463],"will":[471,485],"contribute":[472,488],"increased":[475],"understanding":[476,490],"repertoire":[479],"This":[483],"research":[484],"likely":[487],"PGC-1b-mediated":[499],"coactivation":[500]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
