{"id":"https://openalex.org/W7425791","doi":null,"title":"Effects of propylthiouracil on growth hormone and prolactin messenger ribonucleic acids in the rat pituitary.","display_name":"Effects of propylthiouracil on growth hormone and prolactin messenger ribonucleic acids in the rat pituitary.","publication_year":1990,"publication_date":"1990-03-01","ids":{"openalex":"https://openalex.org/W7425791","mag":"7425791","pmid":"https://pubmed.ncbi.nlm.nih.gov/2314053"},"language":"en","primary_location":{"id":"pmid:2314053","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2314053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110331817","display_name":"Ricardo V. Lloyd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R V Lloyd","raw_affiliation_strings":["Department of Pathology, University of Michigan, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Michigan, Ann Arbor","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037586182","display_name":"Long Guo Jin","orcid":"https://orcid.org/0000-0002-6055-4692","observed_orcids":["https://orcid.org/0000-0002-6055-4692"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Jin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050117238","display_name":"J Y Song","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Y Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110029425","display_name":"L. Cass Terry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L C Terry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045003878","display_name":"\u00c9va Horv\u00e1th","orcid":"https://orcid.org/0009-0002-2526-7070","observed_orcids":["https://orcid.org/0009-0002-2526-7070"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Horvath","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110132096","display_name":"K\u00e1lm\u00e1n Kov\u00e1cs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Kovacs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5688,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.63168371,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"62","issue":"3","first_page":"347","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propylthiouracil","display_name":"propylthiouracil","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.9909999966621399},{"id":"https://openalex.org/keywords/growth-hormone-mrna","display_name":"growth hormone mRNA","score":0.8740000128746033},{"id":"https://openalex.org/keywords/prolactin-mrna","display_name":"prolactin mRNA","score":1.0},{"id":"https://openalex.org/keywords/pituitary-adenohypophysis","display_name":"pituitary adenohypophysis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.8379999995231628},{"id":"https://openalex.org/keywords/growth-hormone-cells","display_name":"growth hormone cells","score":0.5770000219345093},{"id":"https://openalex.org/keywords/pituitary-cell-types","display_name":"pituitary cell types","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.8402881622314453},{"id":"https://openalex.org/C2775960720","wikidata":"https://www.wikidata.org/wiki/Q377342","display_name":"Propylthiouracil","level":3,"score":0.8001617193222046},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7795888781547546},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7539379596710205},{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.7254642248153687},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.6247913241386414},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.584019124507904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5192204117774963},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5140167474746704},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.4795122444629669},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.442121297121048},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3720015585422516},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1014937162399292},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07689642906188965},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.051317960023880005}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011441","descriptor_name":"Propylthiouracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2314053","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2314053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:7425791","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2314053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2070033793","https://openalex.org/W4234589556","https://openalex.org/W2008130983","https://openalex.org/W1968649374","https://openalex.org/W1965470204","https://openalex.org/W2084444108","https://openalex.org/W2057075461","https://openalex.org/W2047834021","https://openalex.org/W2045992248","https://openalex.org/W1984186016"],"abstract_inverted_index":{"The":[0],"effects":[1],"of":[2,39,71],"hypothyroidism":[3,150],"induced":[4],"by":[5,28,58,77,112,144],"propylthiouracil":[6],"(PTU)":[7],"treatment":[8,41,99],"on":[9,79],"growth":[10],"hormone":[11,107,128,139],"(GH)":[12],"and":[13,33,50,64,89,105,123,137,157,162,173],"prolactin":[14],"(PRL)":[15],"messenger":[16],"ribonucleic":[17],"acid":[18],"(mRNA)":[19],"levels":[20,49],"were":[21,109,141],"analyzed":[22],"in":[23,29,46,54,60,72,92,120,126,130,154,169],"adult":[24],"female":[25],"rat":[26],"adenohypophyses":[27],"situ":[30,61,73],"hybridization":[31,35,62,66,74],"histochemistry":[32,63,75],"Northern":[34,65],"analyses.":[36,67],"Twenty-eight":[37],"days":[38],"PTU":[40],"produced":[42],"a":[43,51,118],"significant":[44,152],"decrease":[45,53,119],"GH":[47,87,103,121,136,155],"mRNA":[48,56,88,104,156,161],"smaller":[52],"PRL":[55,90,160],"determined":[57],"both":[59,135],"A":[68],"combined":[69],"procedure":[70],"followed":[76],"immunochemistry":[78],"the":[80,93],"same":[81,94],"sections":[82],"revealed":[83,117],"mammosomatotropic":[84,164],"cells":[85,96,122,129,165],"expressing":[86,102,134],"protein":[91,108,140],"pituitary":[95],"from":[97,171],"all":[98],"groups.":[100],"Cells":[101,133],"thyroid-stimulating":[106,127,138],"not":[110,142],"detected":[111,143,168],"this":[113],"method.":[114],"Immunochemical":[115],"staining":[116],"an":[124],"increase":[125],"hypothyroid":[131,174],"rats.":[132,175],"immunostaining.":[145],"These":[146],"results":[147],"indicate":[148],"that":[149,163],"produces":[151],"decreases":[153,159],"also":[158],"can":[166],"be":[167],"pituitaries":[170],"normal":[172]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
