{"id":"https://openalex.org/W73940970","doi":null,"title":"Association of programmed cell death-1 (PDCD-1) gene polymorphisms with rheumatoid arthritis in Iranian patients.","display_name":"Association of programmed cell death-1 (PDCD-1) gene polymorphisms with rheumatoid arthritis in Iranian patients.","publication_year":2011,"publication_date":"2011-09-01","ids":{"openalex":"https://openalex.org/W73940970","mag":"73940970","pmid":"https://pubmed.ncbi.nlm.nih.gov/21961966"},"language":"en","primary_location":{"id":"pmid:21961966","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21961966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002500457","display_name":"Mohammad Taher Tahoori","orcid":"https://orcid.org/0000-0003-2304-536X","observed_orcids":["https://orcid.org/0000-0003-2304-536X"]},"institutions":[{"id":"https://openalex.org/I1516879","display_name":"Tarbiat Modares University","ror":"https://ror.org/03mwgfy56","country_code":"IR","type":"education","lineage":["https://openalex.org/I1516879"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Taher Tahoori","raw_affiliation_strings":["Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. m.tahoori@modares.ac.ir","Department of Immunology,\u00a0Faculty of Medical Sciences Tarbiat Modares University  Tehran Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. m.tahoori@modares.ac.ir","institution_ids":["https://openalex.org/I1516879"]},{"raw_affiliation_string":"Department of Immunology,\u00a0Faculty of Medical Sciences Tarbiat Modares University  Tehran Iran","institution_ids":["https://openalex.org/I1516879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037527203","display_name":"Ali Akbar Pourfathollah","orcid":"https://orcid.org/0000-0002-1814-0875","observed_orcids":["https://orcid.org/0000-0002-1814-0875","https://orcid.org/0000-0001-7160-5873"]},"institutions":[{"id":"https://openalex.org/I1516879","display_name":"Tarbiat Modares University","ror":"https://ror.org/03mwgfy56","country_code":"IR","type":"education","lineage":["https://openalex.org/I1516879"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Ali Akbar Pourfathollah","raw_affiliation_strings":["[Tarbiat Modares University]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[Tarbiat Modares University]","institution_ids":["https://openalex.org/I1516879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042290372","display_name":"Masoomeh Akhlaghi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masoomeh Akhlaghi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071663185","display_name":"Saeed Daneshmandi","orcid":"https://orcid.org/0000-0001-7817-3006","observed_orcids":["https://orcid.org/0000-0001-7817-3006"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saeed Daneshmandi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000045592","display_name":"Mohammad Hossein Nicknam","orcid":"https://orcid.org/0000-0001-9132-1675","observed_orcids":["https://orcid.org/0000-0001-9132-1675"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammad Hosein Nicknam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5041463302","display_name":"Narjes Soleimanifar","orcid":"https://orcid.org/0000-0002-8886-2902","observed_orcids":["https://orcid.org/0000-0002-8886-2902"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Narjes Soleimanifar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2035,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.77169409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"29","issue":"5","first_page":"763","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pdcd1","display_name":"PDCD1","score":0.777999997138977},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.8410000205039978},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8270000219345093},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9629999995231628},{"id":"https://openalex.org/keywords/promoter-polymorphism","display_name":"promoter polymorphism","score":0.8679999709129333},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.847000002861023},{"id":"https://openalex.org/keywords/haplotypes","display_name":"haplotypes","score":0.8330000042915344},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.7099999785423279},{"id":"https://openalex.org/keywords/iranian-patients","display_name":"Iranian patients","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.8352742195129395},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.7098112106323242},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.642495334148407},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6285505890846252},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6252249479293823},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6171030402183533},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.5099772214889526},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4379129409790039},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.4282871186733246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41555488109588623},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40066713094711304},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30182647705078125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22616249322891235}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007492","descriptor_name":"Iran","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012150","descriptor_name":"Polymorphism, Restriction Fragment Length","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:21961966","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21961966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},{"id":"mag:73940970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21961966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W111368972","https://openalex.org/W117033937","https://openalex.org/W1538902372","https://openalex.org/W1558813989","https://openalex.org/W1967581879","https://openalex.org/W1988331425","https://openalex.org/W1996486759","https://openalex.org/W2001287101","https://openalex.org/W2015085911","https://openalex.org/W2017051726","https://openalex.org/W2040164466","https://openalex.org/W2042797177","https://openalex.org/W2056535502","https://openalex.org/W2074676100","https://openalex.org/W2082012343","https://openalex.org/W2083340623","https://openalex.org/W2098853737","https://openalex.org/W2103532863","https://openalex.org/W2118471749","https://openalex.org/W2144953100","https://openalex.org/W2145871366","https://openalex.org/W2152348310"],"related_works":["https://openalex.org/W2119788225","https://openalex.org/W2079719408","https://openalex.org/W2337611787","https://openalex.org/W2069609977","https://openalex.org/W2753654588","https://openalex.org/W3193624145","https://openalex.org/W2061161607","https://openalex.org/W6960211197","https://openalex.org/W1272279277","https://openalex.org/W1965323971"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Programmed":[1],"cell":[2,15],"death":[3],"1":[4],"(PDCD-1,":[5],"also":[6],"named":[7],"PD-1,":[8],"CD279,":[9],"and":[10,32,65,94,110,128,203,211],"SLEB2),":[11],"a":[12,35],"negative":[13,22],"T":[14,25],"regulator":[16],"to":[17,24,184],"maintain":[18],"peripheral":[19],"tolerance,":[20],"induces":[21],"signals":[23],"cells":[26],"during":[27],"interaction":[28],"with":[29,57,176,238],"its":[30],"ligands":[31],"is":[33,174,235],"therefore":[34],"candidate":[36],"gene":[37,173,234],"in":[38,98,167,200,228,241],"the":[39,52,58,74,84,122,140,146,168,219,225,229],"development":[40],"of":[41,54,60,113,132,139,150,153,171,180,205,232],"autoimmune":[42],"diseases":[43],"such":[44],"as":[45,102,104],"rheumatoid":[46],"arthritis":[47],"(RA).":[48],"Herein,":[49],"we":[50,222],"investigate":[51],"association":[53,124],"PDCD-1":[55,89,172,206,233],"polymorphisms":[56,220],"risk":[59,179],"RA":[61,100,126,141,181,209,239],"among":[62,218],"Iranian":[63,242],"patients":[64,101,127,142],"healthy":[66,106],"controls.":[67,107,129,212],"METHODS:":[68],"Genomic":[69],"DNA":[70,79],"was":[71,143],"extracted":[72],"from":[73],"whole":[75],"blood":[76],"samples":[77],"using":[78],"Purification":[80],"kit":[81],"(DNG-plus).":[82],"Using":[83],"PCR-":[85],"RFLP":[86],"method,":[87],"3":[88],"SNPs,":[90],"including":[91],"PD1.1G/A,":[92],"PD1.3G/A,":[93],"PD1.9C/T":[95],"were":[96,116,135,196],"genotyped":[97],"120":[99],"well":[103],"188":[105],"The":[108],"genotype":[109],"allele":[111,163,227],"frequencies":[112],"these":[114,133],"SNPs":[115,134,207],"analysed":[117],"by":[118,145],"statistical":[119],"tests":[120],"for":[121],"significant":[123,198],"between":[125,208],"Haplotype":[130],"constructions":[131],"performed.":[136],"Clinical":[137],"diagnosis":[138],"confirmed":[144],"Rheumatology":[147],"Research":[148],"Centere":[149],"Tehran":[151],"University":[152],"Medical":[154],"Sciences.":[155],"RESULTS:":[156],"Our":[157,214],"study":[158],"revealed":[159],"that":[160,217],"PD1.1":[161],"A":[162],"at":[164],"position":[165],"-538":[166],"promoter":[169,230],"region":[170,231],"associated":[175,237],"an":[177],"increased":[178],"disease":[182],"compared":[183],"controls":[185],"(2.9%":[186],"vs.":[187],"0.7%,":[188],"OR=":[189],"3.735,":[190],"95%":[191],"CI=":[192],"0.956-14.588,":[193],"p=0.046).":[194],"There":[195],"no":[197],"differences":[199],"other":[201],"alleles":[202],"genotypes":[204],"cases":[210],"CONCLUSIONS:":[213],"results":[215],"indicate":[216],"which":[221],"evaluated":[223],"only":[224],"PD1.1A":[226],"significantly":[236],"susceptibility":[240],"patients.":[243]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
