{"id":"https://openalex.org/W73775937","doi":"https://doi.org/10.18553/jmcp.2014.20.1.22","title":"Systematic Review of Migraine Prophylaxis Adherence and Persistence","display_name":"Systematic Review of Migraine Prophylaxis Adherence and Persistence","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W73775937","doi":"https://doi.org/10.18553/jmcp.2014.20.1.22","mag":"73775937","pmid":"https://pubmed.ncbi.nlm.nih.gov/24372457","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10437641"},"language":"en","primary_location":{"id":"doi:10.18553/jmcp.2014.20.1.22","doi":"https://doi.org/10.18553/jmcp.2014.20.1.22","is_oa":false,"landing_page_url":"https://doi.org/10.18553/jmcp.2014.20.1.22","pdf_url":null,"source":{"id":"https://openalex.org/S40961437","display_name":"Journal of Managed Care Pharmacy","issn_l":"1083-4087","issn":["1083-4087","1944-706X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4363609268","host_organization_name":"Academy of Managed Care Pharmacy","host_organization_lineage":["https://openalex.org/P4363609268"],"host_organization_lineage_names":["Academy of Managed Care Pharmacy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Managed Care Pharmacy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10437641/pdf/jmcp.2014.20.1.22.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051118604","display_name":"Zsolt Hepp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139498","display_name":"Allergan (United States)","ror":"https://ror.org/03pfqk412","country_code":"US","type":"company","lineage":["https://openalex.org/I2948728702","https://openalex.org/I4210139498"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zsolt Hepp","raw_affiliation_strings":["Global Health Outcomes Strategy and Research, Allergan, 2525 Dupont Dr., MI3-110A, Irvine, CA 92612, USA. Hepp_Zsolt@Allergan.com","Global Health Outcomes Strategy and Research, Allergan, 2525 Dupont Dr., MI3-110A, Irvine, CA 92612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Health Outcomes Strategy and Research, Allergan, 2525 Dupont Dr., MI3-110A, Irvine, CA 92612, USA. Hepp_Zsolt@Allergan.com","institution_ids":["https://openalex.org/I4210139498"]},{"raw_affiliation_string":"Global Health Outcomes Strategy and Research, Allergan, 2525 Dupont Dr., MI3-110A, Irvine, CA 92612, USA","institution_ids":["https://openalex.org/I4210139498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109959200","display_name":"Lisa M. Bloudek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa M. Bloudek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110063235","display_name":"Sepideh F. Varon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sepideh F. Varon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.605,"has_fulltext":true,"cited_by_count":337,"citation_normalized_percentile":{"value":0.98771816,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"20","issue":"1","first_page":"22","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11620","display_name":"Medication Adherence and Compliance","score":0.5814999938011169,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11620","display_name":"Medication Adherence and Compliance","score":0.5814999938011169,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.4047999978065491,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/migraine-prevention","display_name":"migraine prophylaxis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.9940000176429749},{"id":"https://openalex.org/keywords/medication-persistence","display_name":"treatment persistence","score":0.8270000219345093},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.953000009059906},{"id":"https://openalex.org/keywords/amitriptyline","display_name":"amitriptyline","score":1.0},{"id":"https://openalex.org/keywords/topiramate","display_name":"topiramate","score":1.0},{"id":"https://openalex.org/keywords/medication-discontinuation","display_name":"drug discontinuation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.800000011920929},{"id":"https://openalex.org/keywords/dental-prophylaxis","display_name":"dental prophylaxis","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9357737302780151},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.8674172759056091},{"id":"https://openalex.org/C2777683783","wikidata":"https://www.wikidata.org/wiki/Q221174","display_name":"Topiramate","level":3,"score":0.8208262920379639},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.7984906435012817},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.7112172842025757},{"id":"https://openalex.org/C2780216858","wikidata":"https://www.wikidata.org/wiki/Q58397","display_name":"Amitriptyline","level":2,"score":0.6649577021598816},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5738085508346558},{"id":"https://openalex.org/C2781009140","wikidata":"https://www.wikidata.org/wiki/Q7170389","display_name":"Persistence (discontinuity)","level":2,"score":0.5595406293869019},{"id":"https://openalex.org/C2910587157","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Chronic Migraine","level":3,"score":0.5541995167732239},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4914189577102661},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4661976397037506},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4176720380783081},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.12839359045028687},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.07125627994537354},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C187320778","wikidata":"https://www.wikidata.org/wiki/Q1349130","display_name":"Geotechnical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D055118","descriptor_name":"Medication Adherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.18553/jmcp.2014.20.1.22","doi":"https://doi.org/10.18553/jmcp.2014.20.1.22","is_oa":false,"landing_page_url":"https://doi.org/10.18553/jmcp.2014.20.1.22","pdf_url":null,"source":{"id":"https://openalex.org/S40961437","display_name":"Journal of Managed Care Pharmacy","issn_l":"1083-4087","issn":["1083-4087","1944-706X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4363609268","host_organization_name":"Academy of Managed Care Pharmacy","host_organization_lineage":["https://openalex.org/P4363609268"],"host_organization_lineage_names":["Academy of Managed Care Pharmacy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Managed Care Pharmacy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10437641","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10437641","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10437641/pdf/jmcp.2014.20.1.22.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Manag Care Pharm","raw_type":"Text"},{"id":"pmid:24372457","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24372457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of managed care pharmacy : JMCP","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10437641","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10437641","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10437641/pdf/jmcp.2014.20.1.22.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Manag Care Pharm","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W73775937.pdf","grobid_xml":"https://content.openalex.org/works/W73775937.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1497148636","https://openalex.org/W1504340062","https://openalex.org/W1594567624","https://openalex.org/W1967343661","https://openalex.org/W1968884564","https://openalex.org/W1968958675","https://openalex.org/W1970386351","https://openalex.org/W1977574732","https://openalex.org/W1987760785","https://openalex.org/W1988012785","https://openalex.org/W1991277549","https://openalex.org/W1993422535","https://openalex.org/W2000441292","https://openalex.org/W2016030981","https://openalex.org/W2017444456","https://openalex.org/W2018354064","https://openalex.org/W2031917973","https://openalex.org/W2047455969","https://openalex.org/W2057538972","https://openalex.org/W2062631632","https://openalex.org/W2062818994","https://openalex.org/W2063780338","https://openalex.org/W2067211528","https://openalex.org/W2078203204","https://openalex.org/W2084808219","https://openalex.org/W2084970097","https://openalex.org/W2095305121","https://openalex.org/W2103575883","https://openalex.org/W2109238714","https://openalex.org/W2112122325","https://openalex.org/W2113187067","https://openalex.org/W2115616533","https://openalex.org/W2123467413","https://openalex.org/W2128306223","https://openalex.org/W2131599492","https://openalex.org/W2135195377","https://openalex.org/W2136950115","https://openalex.org/W2137354881","https://openalex.org/W2139062201","https://openalex.org/W2141664066","https://openalex.org/W2142890626","https://openalex.org/W2145355470","https://openalex.org/W2155441883","https://openalex.org/W2156350405","https://openalex.org/W2167304006","https://openalex.org/W2184962418","https://openalex.org/W2334366154","https://openalex.org/W2335316218","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2407718941","https://openalex.org/W2549116677","https://openalex.org/W2004916007","https://openalex.org/W2062631632","https://openalex.org/W1897338340","https://openalex.org/W4389437025","https://openalex.org/W1847061406","https://openalex.org/W2343101676","https://openalex.org/W2114955880","https://openalex.org/W2067825166"],"abstract_inverted_index":{"BACKGROUND:":[0],"Migraine":[1],"is":[2,33],"a":[3],"common":[4,224],"neurological":[5],"disease":[6],"affecting":[7,28],"12%":[8],"of":[9,62,88,106,126,137,153,176,210],"Americans":[10],"and":[11,53,68,79,83,91,100,104,111,166,173,189,203,213,232,239,247],"millions":[12],"worldwide.":[13],"Medication":[14],"adherence":[15,26,36,52,151,246],"has":[16],"been":[17],"studied":[18],"extensively":[19],"in":[20,116,141],"many":[21],"chronic":[22],"conditions,":[23],"with":[24],"poor":[25,245],"adversely":[27],"treatment":[29],"outcomes.":[30],"However,":[31],"little":[32],"known":[34],"about":[35],"to":[37,66,71,76,155,161,168,178,184,191,249],"oral":[38,49,250],"prophylaxis":[39,50],"for":[40,113,120,226,230,234],"migraine.":[41],"OBJECTIVE:":[42],"To":[43],"examine":[44],"the":[45,63,133,142,222],"literature":[46],"on":[47,200],"assessing":[48],"medication":[51],"persistence":[54,109,174,197,248],"among":[55],"migraine":[56,251],"patients.":[57],"METHODS:":[58],"A":[59,124],"systematic":[60],"search":[61,134],"PubMed":[64],"(1966":[65],"present)":[67,72],"EMBASE":[69],"(1974":[70],"databases":[73],"was":[74],"conducted":[75],"locate":[77],"prospective":[78],"retrospective":[80],"observational":[81],"studies":[82,146,238],"randomized":[84],"controlled":[85],"trials":[86],"(RCTs)":[87],"propranolol,":[89,201],"amitriptyline,":[90,202],"topiramate.":[92],"RCTs":[93,117,199,243],"were":[94,118,130,139,221],"pooled,":[95],"weighted":[96],"by":[97,102],"sample":[98],"size,":[99],"stratified":[101],"drug":[103],"length":[105],"study.":[107],"Average":[108],"rates":[110,209],"reasons":[112],"discontinuation":[114,227],"cited":[115,228],"examined":[119],"each":[121],"medication.":[122],"RESULTS:":[123],"total":[125],"788":[127],"unique":[128],"articles":[129],"identified":[131],"using":[132],"criteria,":[135],"33":[136],"which":[138],"included":[140],"final":[143],"review.":[144],"Observational":[145,237],"(n":[147,205],"=":[148,206],"14)":[149],"showed":[150,208],"ranges":[152,175],"41%":[154,177],"95%":[156],"at":[157,163,170,180,186,193,216],"2":[158,181],"months,":[159,165,182,188],"21%":[160],"80%":[162],"6":[164,187],"35%":[167],"56%":[169],"12":[171,194],"months":[172],"88%":[179],"19%":[183],"79%":[185],"7%":[190],"55%":[192],"months.":[195],"Pooled":[196],"from":[198,242],"topiramate":[204,231],"19)":[207],"77%,":[211],"55%,":[212],"57%,":[214],"respectively,":[215],"16-26":[217],"weeks.":[218],"Adverse":[219],"events":[220],"most":[223],"reason":[225],"(24%":[229],"17%":[233],"amitriptyline).":[235],"CONCLUSION:":[236],"pooled":[240],"data":[241],"demonstrate":[244],"prophylaxis.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":33},{"year":2023,"cited_by_count":34},{"year":2022,"cited_by_count":55},{"year":2021,"cited_by_count":45},{"year":2020,"cited_by_count":41},{"year":2019,"cited_by_count":38},{"year":2018,"cited_by_count":23},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}