{"id":"https://openalex.org/W7372173","doi":null,"title":"Effect of age on C1q and C3 levels in human serum and their presence in colostrum.","display_name":"Effect of age on C1q and C3 levels in human serum and their presence in colostrum.","publication_year":1978,"publication_date":"1978-09-01","ids":{"openalex":"https://openalex.org/W7372173","mag":"7372173","pmid":"https://pubmed.ncbi.nlm.nih.gov/700781","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1457640"},"language":"en","primary_location":{"id":"pmid:700781","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/700781","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016197065","display_name":"Kunio Yonemasu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Yonemasu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"H Kitajima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Kitajima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"S Tanabe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Tanabe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110008723","display_name":"T. Ochi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Ochi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"H Shinkai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Shinkai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0258,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.72681502,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"35","issue":"3","first_page":"523","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c1q","display_name":"C1q","score":0.8790000081062317},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":1.0},{"id":"https://openalex.org/keywords/age-related-changes","display_name":"age-related changes","score":0.8629999756813049},{"id":"https://openalex.org/keywords/serum-complement-levels","display_name":"serum complement levels","score":0.7480000257492065},{"id":"https://openalex.org/keywords/colostrum","display_name":"colostrum","score":0.8799999952316284},{"id":"https://openalex.org/keywords/classical-complement-pathway","display_name":"classical complement pathway","score":0.8429999947547913},{"id":"https://openalex.org/keywords/alternative-complement-pathway","display_name":"alternative complement pathway","score":0.9980000257492065},{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.6380000114440918},{"id":"https://openalex.org/keywords/puberty","display_name":"puberty","score":0.625},{"id":"https://openalex.org/keywords/newborns","display_name":"neonates","score":0.4320000112056732},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.5260000228881836},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C2779073587","wikidata":"https://www.wikidata.org/wiki/Q192746","display_name":"Colostrum","level":3,"score":0.8121498823165894},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5010645389556885},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4973149597644806},{"id":"https://openalex.org/C51296783","wikidata":"https://www.wikidata.org/wiki/Q1645498","display_name":"Microgram","level":3,"score":0.49586614966392517},{"id":"https://openalex.org/C2780914630","wikidata":"https://www.wikidata.org/wiki/Q914952","display_name":"Cord blood","level":2,"score":0.4826381802558899},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47880488634109497},{"id":"https://openalex.org/C2986834420","wikidata":"https://www.wikidata.org/wiki/Q5932254","display_name":"Age groups","level":2,"score":0.43588557839393616},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42289072275161743},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33928462862968445},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.32846254110336304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2854682505130768},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27163398265838623},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.10836455225944519},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.09831503033638},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07892867922782898},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003126","descriptor_name":"Colostrum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003172","descriptor_name":"Complement C1","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:700781","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/700781","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"mag:7372173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/700781","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W168181547","https://openalex.org/W188265272","https://openalex.org/W1524025995","https://openalex.org/W1532813778","https://openalex.org/W1566689757","https://openalex.org/W1923821809","https://openalex.org/W1974054467","https://openalex.org/W1976870954","https://openalex.org/W2002983094","https://openalex.org/W2009701344","https://openalex.org/W2022838108","https://openalex.org/W2022867262","https://openalex.org/W2067513091","https://openalex.org/W2068386736","https://openalex.org/W2080500764","https://openalex.org/W2093321027","https://openalex.org/W2273521055","https://openalex.org/W4313316341"],"related_works":["https://openalex.org/W188265272","https://openalex.org/W1973253168","https://openalex.org/W2400399852","https://openalex.org/W2003959788","https://openalex.org/W2053951829","https://openalex.org/W2400611897","https://openalex.org/W2163287652","https://openalex.org/W2067513091","https://openalex.org/W2022912685","https://openalex.org/W2395106727"],"abstract_inverted_index":{"The":[0,29],"initiating":[1],"complement":[2],"component":[3,16],"(C1q)":[4],"in":[5,18,25,175,189],"the":[6,13,19,41,62,75,92,108,176],"classical":[7],"pathway":[8,21],"of":[9,22,33,49,69,86,104,115,160,205,208,216,220],"730":[10],"subjects":[11,24],"and":[12,40,56,117,128,154,162,169],"first":[14],"essential":[15],"(C3)":[17],"alternative":[20],"461":[23],"Japan":[26],"were":[27,58,165,181],"examined.":[28],"study":[30],"population":[31],"consisted":[32],"normal":[34,142],"healthy":[35,143],"newborns,":[36],"infants,":[37],"children,":[38],"adults":[39],"old":[42],"(from":[43],"birth":[44],"up":[45,82,99,136],"to":[46,61,74,83,100,131,137],"75":[47,102],"years":[48,85,103],"age).":[50],"In":[51,141],"cord":[52],"sera,":[53],"both":[54],"C1q":[55,71,93,153,161,172],"C3":[57,106,155,163,210],"about":[59,101,112,126,217],"60%":[60],"total":[63],"mean":[64,76,109],"level.":[65],"At":[66],"3":[67],"days":[68],"age,":[70,116],"markedly":[72],"increased":[73,95],"level":[77,94,110,123],"which":[78,179],"remained":[79],"relatively":[80],"invariable":[81],"40":[84,90],"age.":[87,105],"And":[88],"above":[89],"years,":[91],"steadily":[96,133],"with":[97,134,193],"age":[98,135],"reached":[107],"at":[111,125,203,214],"1":[113],"month":[114],"was":[118,150,173,201,211],"highest":[119],"during":[120],"infancy.":[121],"This":[122],"declined":[124],"puberty":[127],"then":[129],"continued":[130],"increase":[132],"around":[138],"55":[139],"years.":[140],"subjects,":[144],"a":[145,190,194],"moderate":[146],"positive":[147],"rank":[148],"correlation":[149],"found":[151],"between":[152,167],"amounts.":[156],"No":[157,171],"significant":[158],"differences":[159],"levels":[164],"evident":[166],"male":[168],"female.":[170],"demonstrable":[174],"colostrum":[177],"from":[178],"lipids":[180],"previously":[182],"removed,":[183],"but":[184],"after":[185],"concentration":[186],"by":[187],"precipitation":[188],"chelating":[191],"agent":[192],"low":[195],"ionic":[196],"strength,":[197],"C1q,":[198],"measured":[199],"immunochemically,":[200],"detectable":[202],"concentrations":[204,215],"300":[206],"ng/ml":[207],"colostrum.":[209,221],"also":[212],"detected":[213],"200":[218],"microgram/ml":[219]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
