{"id":"https://openalex.org/W73679991","doi":null,"title":"Mechanisms underlying exercise -induced muscle damage","display_name":"Mechanisms underlying exercise -induced muscle damage","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W73679991","mag":"73679991"},"language":"en","primary_location":{"id":"pmh:oai:scholarworks.umass.edu:dissertations-4306","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.umass.edu/dissertations/AAI3215766","pdf_url":null,"source":{"id":"https://openalex.org/S4306402240","display_name":"ScholarWorks@UMassAmherst (University of Massachusetts Amherst)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24603500","host_organization_name":"University of Massachusetts Amherst","host_organization_lineage":["https://openalex.org/I24603500"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations Available from Proquest","raw_type":"text"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021612557","display_name":"Monica J. Hubal","orcid":"https://orcid.org/0000-0001-6579-6036","observed_orcids":["https://orcid.org/0000-0001-6579-6036"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Monica J. Hubal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6579-6036","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5021612557"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exercise-induced-muscle-damage","display_name":"exercise-induced muscle damage","score":0.9990000128746033},{"id":"https://openalex.org/keywords/eccentric-exercise","display_name":"eccentric exercise","score":0.8970000147819519},{"id":"https://openalex.org/keywords/muscle-strength-loss","display_name":"muscle strength decline","score":0.7670000195503235},{"id":"https://openalex.org/keywords/muscle-soreness","display_name":"muscle soreness","score":0.8320000171661377},{"id":"https://openalex.org/keywords/creatine-kinase","display_name":"creatine kinase","score":0.8270000219345093},{"id":"https://openalex.org/keywords/muscle-gene-expression","display_name":"muscle gene expression","score":0.777999997138977},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/repeated-bout-effect","display_name":"repeated bout effect","score":0.972000002861023},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9430000185966492},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8500000238418579},{"id":"https://openalex.org/keywords/satellite-cells","display_name":"satellite cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/muscle-regeneration","display_name":"muscle regeneration","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cebpd","display_name":"CEBPD","score":0.703000009059906},{"id":"https://openalex.org/keywords/zfp36","display_name":"ZFP36","score":0.9509999752044678},{"id":"https://openalex.org/keywords/elbow-flexors","display_name":"elbow flexors","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C2993817360","wikidata":"https://www.wikidata.org/wiki/Q692536","display_name":"Muscle damage","level":2,"score":0.65748131275177},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.4368568956851959},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.41926687955856323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3692924380302429},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20172539353370667}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholarworks.umass.edu:dissertations-4306","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.umass.edu/dissertations/AAI3215766","pdf_url":null,"source":{"id":"https://openalex.org/S4306402240","display_name":"ScholarWorks@UMassAmherst (University of Massachusetts Amherst)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24603500","host_organization_name":"University of Massachusetts Amherst","host_organization_lineage":["https://openalex.org/I24603500"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations Available from Proquest","raw_type":"text"},{"id":"mag:73679991","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.umass.edu/cgi/viewcontent.cgi?article=4306&context=dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2090027181","https://openalex.org/W2011732262","https://openalex.org/W3043710818","https://openalex.org/W1541862769","https://openalex.org/W2185183054","https://openalex.org/W4391383790","https://openalex.org/W4387052665","https://openalex.org/W4378650501","https://openalex.org/W2000661220","https://openalex.org/W7140427020"],"abstract_inverted_index":{"The":[0],"goal":[1],"of":[2,12,26,46,57,66,118,163,168,190,209,227,243,246,271,274,285],"this":[3,236],"dissertation":[4],"was":[5,305],"to":[6,20,31,113,232,307,315],"identify":[7,233],"and":[8,17,28,37,41,133,140,149,178,254,258,289,294,309,340],"characterize":[9],"underlying":[10,115],"mechanisms":[11,117,234],"exercise-induced":[13],"muscle":[14,18,108,192,216,316,346],"damage":[15,119,221],"(EIMD)":[16],"adaptation":[19],"damage.":[21],"Study":[22,94,229,279,281],"I":[23],"examined":[24],"contributions":[25],"central":[27,71],"peripheral":[29,67,99],"factors":[30,292],"EIMD.":[32,349],"Forty-six":[33],"subjects":[34,122,239],"performed":[35,123,137,240],"voluntary":[36],"stimulated":[38],"contractions":[39],"before":[40],"immediately":[42],"following":[43,110,296,348],"eccentric":[44,60,111,139,194,244],"exercise":[45,61,125,210,245],"the":[47,81,92,134,184,201,247,290,297,325,330],"elbow":[48],"flexors.":[49],"Subjects":[50],"demonstrating":[51],"greater":[52,64],"strength":[53,76,86,146,253],"loss":[54,77,87],"(a":[55],"hallmark":[56],"EIMD)":[58],"after":[59,193],"also":[62],"had":[63],"impairment":[65],"function,":[68],"but":[69],"similar":[70],"function":[72],"compared":[73],"with":[74],"lower":[75],"subjects,":[78],"suggesting":[79],"that":[80,217,321],"mechanism(s)":[82],"driving":[83,235],"variation":[84],"in":[85,104,126,171,219,278,324],"are":[88,313],"localized":[89],"mainly":[90],"within":[91,107],"periphery.":[93],"II":[95],"further":[96],"focused":[97],"on":[98,215],"factors,":[100],"specifically":[101],"molecular":[102,116],"changes":[103],"gene":[105,187],"expression":[106,188,270],"tissue":[109],"exercise,":[112],"determine":[114],"development.":[120],"Three":[121],"an":[124,206],"which":[127,312,343],"one":[128],"leg":[129,136,248],"underwent":[130],"concentric":[131,141],"contractions,":[132],"other":[135],"both":[138],"actions.":[142],"Dependent":[143],"variables":[144],"included":[145],"loss,":[147],"soreness":[148,255],"serum":[150],"creatine":[151],"kinase":[152],"activity.":[153],"Muscle":[154,252,265],"biopsy":[155],"samples":[156,165,266],"were":[157,256,260,267],"taken":[158],"4-8h":[159],"post-exercise.":[160,264],"Microarray":[161],"analysis":[162],"these":[164],"identified":[166,277],"upregulation":[167,284],"genes":[169,276],"involved":[170],"inflammation,":[172],"apoptosis":[173],"(programmed":[174],"cell":[175],"death),":[176],"structure":[177],"transcriptional":[179],"regulation.":[180],"These":[181,318],"results":[182,218],"provided":[183],"first":[185],"global":[186],"pattern":[189],"human":[191],"exercise.":[195,228],"EIMD":[196],"is":[197],"attenuated":[198],"naturally":[199],"via":[200],"repeated":[202,298,331],"bout":[203,208,226,332],"effect,":[204,333],"where":[205],"initial":[207],"confers":[211],"a":[212,224,272],"protective":[213],"effect":[214],"less":[220],"induced":[222],"by":[223,335],"second":[225],"III":[230,282],"aimed":[231],"adaptation.":[237],"Seven":[238],"two":[241],"bouts":[242],"spaced":[249],"4wk":[250],"apart.":[251],"evaluated":[257],"biopsies":[259],"collected":[261],"at":[262],"6h":[263],"tested":[268],"for":[269],"subset":[273],"inflammatory":[275],"II.":[280],"showed":[283],"monocyte":[286],"chemoattractant":[287,301],"protein-1":[288],"transcription":[291],"CEBPD":[293],"ZFP36":[295],"bout.":[299],"Monocyte":[300],"protein":[302],"1":[303],"(MCP-1)":[304],"co-localized":[306],"macrophages":[308,339],"satellite":[310,341],"cells,":[311,342],"vital":[314],"regeneration.":[317],"data":[319],"suggest":[320],"specific":[322],"alterations":[323],"inflammation":[326],"response":[327],"may":[328,344],"drive":[329],"possibly":[334],"enhancing":[336],"communication":[337],"between":[338],"strengthen":[345],"regeneration":[347]},"counts_by_year":[],"updated_date":"2026-08-27T14:10:00.468798","created_date":"2016-06-24T00:00:00"}
