{"id":"https://openalex.org/W73520133","doi":"https://doi.org/10.1096/fasebj.21.5.a181-a","title":"Protein expression profiling in the spectrum of renal tumors","display_name":"Protein expression profiling in the spectrum of renal tumors","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W73520133","doi":"https://doi.org/10.1096/fasebj.21.5.a181-a","mag":"73520133"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.5.a181-a","doi":"https://doi.org/10.1096/fasebj.21.5.a181-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a181-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082981312","display_name":"Vladimir Valera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vladimir Alexander Valera","raw_affiliation_strings":["Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, 10 Center Drive Bethesda MD 20895"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, 10 Center Drive Bethesda MD 20895","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104358506","display_name":"Elsa Li\u2010Ning Tapia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elsa Li\u2010Ning Tapia","raw_affiliation_strings":["Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, 10 Center Drive Bethesda MD 20895"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, 10 Center Drive Bethesda MD 20895","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090486617","display_name":"Linda Teller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Teller","raw_affiliation_strings":["Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, 10 Center Drive Bethesda MD 20895"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, 10 Center Drive Bethesda MD 20895","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031078822","display_name":"David D. Roberts","orcid":"https://orcid.org/0000-0002-2481-2981","observed_orcids":["https://orcid.org/0000-0002-2481-2981"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David D. Roberts","raw_affiliation_strings":["Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, 10 Center Drive Bethesda MD 20895"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, 10 Center Drive Bethesda MD 20895","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107963543","display_name":"William Marston Linehan","orcid":"https://orcid.org/0000-0001-7983-3109","observed_orcids":["https://orcid.org/0000-0001-7983-3109"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Marston Linehan","raw_affiliation_strings":["Urologic Oncology Branch Center for Cancer Research, National Cancer Institute, 10 Center Drive Bethesda MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urologic Oncology Branch Center for Cancer Research, National Cancer Institute, 10 Center Drive Bethesda MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024598099","display_name":"Maria J. Merino","orcid":"https://orcid.org/0000-0003-2098-8426","observed_orcids":["https://orcid.org/0000-0003-2098-8426"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria J. Merino","raw_affiliation_strings":["Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, 10 Center Drive Bethesda MD 20895"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, 10 Center Drive Bethesda MD 20895","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01066084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/kidney-cancer","display_name":"kidney cancer","score":0.8460000157356262},{"id":"https://openalex.org/keywords/protein-expression-profiling","display_name":"protein expression profiling","score":0.9179999828338623},{"id":"https://openalex.org/keywords/differentially-expressed-proteins","display_name":"differentially expressed proteins","score":0.968999981880188},{"id":"https://openalex.org/keywords/tumor-classification","display_name":"tumor classification","score":0.7160000205039978},{"id":"https://openalex.org/keywords/benign-kidney-tumor","display_name":"benign kidney tumor","score":0.6380000114440918},{"id":"https://openalex.org/keywords/early-detection-biomarkers","display_name":"early diagnosis biomarkers","score":0.7789999842643738},{"id":"https://openalex.org/keywords/proteomic-profiling","display_name":"proteomic profiling","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.6676278114318848},{"id":"https://openalex.org/C11242284","wikidata":"https://www.wikidata.org/wiki/Q4293202","display_name":"Microdissection","level":3,"score":0.6596216559410095},{"id":"https://openalex.org/C125965507","wikidata":"https://www.wikidata.org/wiki/Q1516595","display_name":"Laser capture microdissection","level":4,"score":0.5830670595169067},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5505688786506653},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.48435768485069275},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4543078541755676},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4399886727333069},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4226756691932678},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36034947633743286},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17284834384918213},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17240333557128906},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1464948058128357},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11217853426933289}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.5.a181-a","doi":"https://doi.org/10.1096/fasebj.21.5.a181-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a181-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","score":0.6499999761581421,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2097179367","https://openalex.org/W2147165005","https://openalex.org/W2107527733","https://openalex.org/W3032627604","https://openalex.org/W1945155277","https://openalex.org/W2349917813","https://openalex.org/W2996905876","https://openalex.org/W2109782019","https://openalex.org/W2061733903","https://openalex.org/W2020224936"],"abstract_inverted_index":{"Background:":[0],"Several":[1,119],"genetic":[2],"and":[3,18,79,83,89,106,113,132,150,173],"epigenetic":[4],"alterations":[5],"have":[6,31],"been":[7,33],"described":[8,34],"in":[9,23,190],"renal":[10,45,194],"cell":[11,67],"carcinomas":[12],"(RCC)":[13],"related":[14],"to":[15,187],"tumor":[16],"initiation":[17],"progression.":[19],"However,":[20],"particular":[21],"changes":[22],"the":[24,39,155,181,191],"protein":[25,120,139,182],"expression":[26],"profiles":[27],"of":[28,38,41,77,86,167,193],"these":[29,53],"tumors":[30,88,153],"not":[32,48],"yet.":[35],"Accurate":[36],"knowledge":[37],"repertoire":[40],"proteins":[42,170],"associated":[43],"with":[44],"cancers":[46],"will":[47,56],"only":[49],"provide":[50,57],"insights":[51],"into":[52],"mechanisms":[54],"but":[55],"new":[58],"markers":[59],"for":[60],"early":[61],"detection.":[62],"Methods:":[63],"After":[64],"microdissection,":[65],"enriched":[66],"populations":[68],"from":[69,74],"frozen":[70],"tissue":[71],"sections":[72],"derived":[73],"a":[75,84,165],"spectrum":[76],"inherited":[78],"sporadic":[80],"RCC":[81,172],"patients,":[82],"set":[85],"benign":[87],"normal":[90,133,174],"kidney":[91],"were":[92,102,111,122,144],"analyzed":[93,114],"by":[94,115,154,161],"2\u2010dimensional":[95],"polyacrylamide":[96],"gel":[97],"electrophoresis":[98],"(2\u2010D":[99],"PAGE).":[100],"Gels":[101],"digitally":[103],"scanned,":[104],"compared,":[105],"significant,":[107],"differentially":[108,137,168],"expressed":[109,138,169],"spots":[110,121],"excised":[112],"MALDI\u2010TOF":[116],"MS.":[117],"Results:":[118],"found":[123],"statistically":[124],"(p<0.05)":[125],"up":[126],"or":[127],"down":[128],"regulated":[129],"between":[130,171],"cancer":[131],"tissues.":[134],"From":[135],"66":[136],"spots,":[140],"8":[141],"different":[142],"polypeptides":[143],"successfully":[145],"identified.":[146],"Classification":[147],"algorithms":[148],"efficiently":[149],"reproducibly":[151],"classified":[152],"spot":[156],"pattern.":[157],"Conclusions:":[158],"Proteomic":[159],"profiling":[160],"2\u2010D":[162],"PAGE":[163],"identified":[164],"series":[166],"tissue.":[175],"The":[176],"analysis":[177],"also":[178],"highlights":[179],"that":[180],"profile":[183],"may":[184],"eventually":[185],"prove":[186],"be":[188],"useful":[189],"classification":[192],"tumors.":[195]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}