{"id":"https://openalex.org/W73343870","doi":"https://doi.org/10.1016/s0022-5347(17)47303-4","title":"Experimental Observations on Dissolution of Uric Acid Calculi","display_name":"Experimental Observations on Dissolution of Uric Acid Calculi","publication_year":1985,"publication_date":"1985-09-01","ids":{"openalex":"https://openalex.org/W73343870","doi":"https://doi.org/10.1016/s0022-5347(17)47303-4","mag":"73343870","pmid":"https://pubmed.ncbi.nlm.nih.gov/2993675"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-5347(17)47303-4","doi":"https://doi.org/10.1016/s0022-5347(17)47303-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)47303-4","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021087019","display_name":"Marcus Vinicius Sadi","orcid":"https://orcid.org/0000-0001-8332-9343","observed_orcids":["https://orcid.org/0000-0001-8332-9343"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus V. Sadi","raw_affiliation_strings":["From the Division of Urology, Brigham & Womens Hospital and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Urology, Brigham & Womens Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016776923","display_name":"Ned Saltzman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ned Saltzman","raw_affiliation_strings":["From the Division of Urology, Brigham & Womens Hospital and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Urology, Brigham & Womens Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021537694","display_name":"Guillermo Feria","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guillermo Feria","raw_affiliation_strings":["From the Division of Urology, Brigham & Womens Hospital and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Urology, Brigham & Womens Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108439731","display_name":"Ruben F. Gittes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruben F. Gittes","raw_affiliation_strings":["From the Division of Urology, Brigham & Womens Hospital and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Urology, Brigham & Womens Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":4.7068,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.94005848,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"134","issue":"3","first_page":"575","last_page":"579"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10606","display_name":"Kidney Stones and Urolithiasis Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10606","display_name":"Kidney Stones and Urolithiasis Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12634","display_name":"Ureteral procedures and complications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uric-acid-stones","display_name":"uric acid stones","score":0.9919999837875366},{"id":"https://openalex.org/keywords/rock-dissolution","display_name":"stone dissolution","score":0.5960000157356262},{"id":"https://openalex.org/keywords/tris-hydroxymethyl-aminomethane","display_name":"tris(hydroxymethyl)aminomethane","score":0.8820000290870667},{"id":"https://openalex.org/keywords/sodium-bicarbonate","display_name":"sodium bicarbonate","score":0.9810000061988831},{"id":"https://openalex.org/keywords/irrigation-solutions","display_name":"irrigating solutions","score":0.8679999709129333},{"id":"https://openalex.org/keywords/dissolution-rate","display_name":"dissolution rate","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.8527144193649292},{"id":"https://openalex.org/C2781014771","wikidata":"https://www.wikidata.org/wiki/Q413961","display_name":"Tris","level":2,"score":0.8164739608764648},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.7832623720169067},{"id":"https://openalex.org/C2776420369","wikidata":"https://www.wikidata.org/wiki/Q179731","display_name":"Sodium bicarbonate","level":2,"score":0.781214714050293},{"id":"https://openalex.org/C2780591741","wikidata":"https://www.wikidata.org/wiki/Q899405","display_name":"Hydroxymethyl","level":2,"score":0.7608320713043213},{"id":"https://openalex.org/C2781112554","wikidata":"https://www.wikidata.org/wiki/Q409202","display_name":"Bicarbonate","level":2,"score":0.5077758431434631},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.4423626661300659},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42389559745788574},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3858945667743683},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.34705936908721924},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.32234662771224976},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24955832958221436},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24274447560310364},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2278885841369629},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.15077754855155945}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001639","descriptor_name":"Bicarbonates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007507","descriptor_name":"Therapeutic Irrigation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014325","descriptor_name":"Tromethamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014545","descriptor_name":"Urinary Calculi","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014545","descriptor_name":"Urinary Calculi","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D017693","descriptor_name":"Sodium Bicarbonate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0022-5347(17)47303-4","doi":"https://doi.org/10.1016/s0022-5347(17)47303-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)47303-4","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:2993675","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2993675","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1973640726","https://openalex.org/W1973922615","https://openalex.org/W1983899169","https://openalex.org/W2015683713","https://openalex.org/W2019710989","https://openalex.org/W2030408336","https://openalex.org/W2088016240","https://openalex.org/W2090451213","https://openalex.org/W2093207855","https://openalex.org/W2181147224","https://openalex.org/W2394664258","https://openalex.org/W2401761324","https://openalex.org/W2403330661","https://openalex.org/W2410105375","https://openalex.org/W2412705286","https://openalex.org/W2415721622","https://openalex.org/W2426642197","https://openalex.org/W2469954760","https://openalex.org/W4302605547"],"related_works":["https://openalex.org/W2410105375","https://openalex.org/W4409881051","https://openalex.org/W2792920567","https://openalex.org/W4282935999","https://openalex.org/W2411628806","https://openalex.org/W1973922615","https://openalex.org/W2077841669","https://openalex.org/W1971004078","https://openalex.org/W4248501127","https://openalex.org/W2013469692"],"abstract_inverted_index":{"An":[0],"in":[1,35,56,76,80,96,138,143,145,149,158,175,185],"vitro":[2,139],"model":[3],"was":[4,44,54,88],"devised":[5],"to":[6,27,112,134,165,177],"evaluate":[7],"the":[8,11,47,65,123,167,171,192],"efficacy":[9],"of":[10,19,51,128,170,181,188,194,199,206],"different":[12],"irrigating":[13],"solutions":[14,97,172],"utilized":[15],"for":[16],"local":[17],"dissolution":[18,42,110,180],"uric":[20,37,153,182],"acid":[21,38,154,183],"stones.":[22],"Tris":[23,52],"(hydroxymethyl)":[24],"aminomethane":[25],"proved":[26],"be":[28,94,113],"several":[29],"times":[30],"faster":[31],"than":[32,82,101],"sodium":[33,129],"bicarbonate":[34,91],"dissolving":[36],"calculi.":[39],"The":[40,137],"maximal":[41],"rate":[43],"obtained":[45],"when":[46,85],"highest":[48],"pH":[49,105],"(10.5)":[50],"buffer":[53,201],"used":[55,95],"concentrations":[57,99],"at":[58,203],"or":[59],"above":[60,118],"0.2":[61,102],"M.":[62],"This":[63],"makes":[64],"commercially":[66],"available":[67,174],"THAM-E":[68],"an":[69],"optimal":[70],"choice.":[71],"Stones":[72],"averaging":[73],"1":[74],"cm.":[75],"diameter":[77],"were":[78,141],"dissolved":[79],"less":[81],"48":[83],"hours":[84],"this":[86,200],"compound":[87],"used.":[89],"Sodium":[90],"should":[92],"only":[93],"with":[98,125,151],"lower":[100],"M":[103],"and":[104,116],"below":[106],"9,":[107],"if":[108],"some":[109],"is":[111],"attempted.":[114],"Concentrations":[115],"pH's":[117],"these":[119],"levels":[120],"will":[121],"coat":[122],"stones":[124,184],"hard":[126],"shells":[127],"urate,":[130],"making":[131],"it":[132],"impossible":[133],"dissolve":[135],"them.":[136],"findings":[140],"confirmed":[142],"vivo":[144],"a":[146,195],"limited":[147],"study":[148],"pigs":[150],"human":[152],"calculi":[155],"surgically":[156],"placed":[157],"their":[159],"kidneys.":[160],"Our":[161],"results":[162],"indicate":[163],"how":[164],"make":[166],"best":[168],"use":[169,193],"clinically":[173],"order":[176],"obtain":[178],"total":[179],"short":[186],"periods":[187],"time.":[189],"We":[190],"recommend":[191],"0.3":[196],"molar":[197],"concentration":[198],"(THAM-E)":[202],"flow":[204],"rates":[205],"about":[207],"50":[208],"cc":[209],"per":[210],"hour.":[211]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}