{"id":"https://openalex.org/W73252299","doi":null,"title":"Plasma homocysteine in patients of migraine without aura.","display_name":"Plasma homocysteine in patients of migraine without aura.","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W73252299","mag":"73252299","pmid":"https://pubmed.ncbi.nlm.nih.gov/21702266"},"language":"en","primary_location":{"id":"pmid:21702266","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21702266","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ayub Medical College, Abbottabad : JAMC","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054302741","display_name":"Faraz Ahmed Bokhari","orcid":"https://orcid.org/0009-0002-2394-8905","observed_orcids":["https://orcid.org/0009-0002-2394-8905"]},"institutions":[{"id":"https://openalex.org/I2803096283","display_name":"University of Health Sciences Lahore","ror":"https://ror.org/00gt6pp04","country_code":"PK","type":"education","lineage":["https://openalex.org/I2803096283"]},{"id":"https://openalex.org/I4210163284","display_name":"Shaikh Zayed Postgraduate Medical Institute","ror":"https://ror.org/058prbp42","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4210163284"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Faraz Ahmed Bokhari","raw_affiliation_strings":["Department of Physiology, University of Health Sciences/Federal Postgraduate Medical Institute, Shaikh Zayed Medical Complex, Lahore, Pakistan. drfarazbokhari@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Health Sciences/Federal Postgraduate Medical Institute, Shaikh Zayed Medical Complex, Lahore, Pakistan. drfarazbokhari@yahoo.com","institution_ids":["https://openalex.org/I2803096283","https://openalex.org/I4210163284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041253157","display_name":"Tania Ahmed Shakoori","orcid":"https://orcid.org/0000-0002-3975-8738","observed_orcids":["https://orcid.org/0000-0002-3975-8738"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tania A Shakoori","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046402939","display_name":"Syed Ahmad Ali Hassan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Syed Ahmad A Hassan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108599715","display_name":"H Qureshi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hamid J Qureshi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103590751","display_name":"Ghulam Ali Qureshi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ghulam A Qureshi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.00713824,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"22","issue":"2","first_page":"52","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-homocysteine","display_name":"plasma homocysteine","score":0.8920000195503235},{"id":"https://openalex.org/keywords/migraine-without-aura","display_name":"migraine without aura","score":0.996999979019165},{"id":"https://openalex.org/keywords/migraine-with-aura","display_name":"migraine with aura","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mthfr-c677t-polymorphism","display_name":"MTHFR C677T polymorphism","score":0.984000027179718},{"id":"https://openalex.org/keywords/hyperhomocysteinemia","display_name":"hyperhomocysteinemia","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C43563269","wikidata":"https://www.wikidata.org/wiki/Q424709","display_name":"Methylenetetrahydrofolate reductase","level":4,"score":0.9298929572105408},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.8771342039108276},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.8556995391845703},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8277532458305359},{"id":"https://openalex.org/C2777350023","wikidata":"https://www.wikidata.org/wiki/Q1154226","display_name":"Aura","level":3,"score":0.7753904461860657},{"id":"https://openalex.org/C2776497919","wikidata":"https://www.wikidata.org/wiki/Q739481","display_name":"Migraine with aura","level":4,"score":0.6136234998703003},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5833669900894165},{"id":"https://openalex.org/C3017560507","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Plasma homocysteine","level":3,"score":0.49273136258125305},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4908085763454437},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.46619194746017456},{"id":"https://openalex.org/C2776523773","wikidata":"https://www.wikidata.org/wiki/Q1093815","display_name":"Hyperhomocysteinemia","level":3,"score":0.41478031873703003},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1826038360595703},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10325339436531067},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06644302606582642}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020326","descriptor_name":"Migraine without Aura","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D020326","descriptor_name":"Migraine without Aura","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D042965","descriptor_name":"Methylenetetrahydrofolate Reductase (NADPH2)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:21702266","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21702266","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ayub Medical College, Abbottabad : JAMC","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W27690950","https://openalex.org/W634692462","https://openalex.org/W968487728","https://openalex.org/W1530643802","https://openalex.org/W1963663750","https://openalex.org/W1990130323","https://openalex.org/W1991400947","https://openalex.org/W1993569802","https://openalex.org/W1995839968","https://openalex.org/W1995931698","https://openalex.org/W2022491375","https://openalex.org/W2023657005","https://openalex.org/W2032666115","https://openalex.org/W2033390943","https://openalex.org/W2059001876","https://openalex.org/W2065455330","https://openalex.org/W2090897293","https://openalex.org/W2098514192","https://openalex.org/W2102102873","https://openalex.org/W2118159442","https://openalex.org/W2123700553","https://openalex.org/W2123709583","https://openalex.org/W2139514338","https://openalex.org/W2143296193","https://openalex.org/W2144770082","https://openalex.org/W2157569126","https://openalex.org/W2163946681","https://openalex.org/W2165397007","https://openalex.org/W2165715420","https://openalex.org/W2168003810"],"related_works":["https://openalex.org/W2187179435","https://openalex.org/W2390947054","https://openalex.org/W2033068889","https://openalex.org/W2060076775","https://openalex.org/W2168003810","https://openalex.org/W1567190417","https://openalex.org/W1530643802","https://openalex.org/W2123709583","https://openalex.org/W4237999929","https://openalex.org/W191869193"],"abstract_inverted_index":{"BACKGROUND:":[0],"Few":[1],"studies":[2],"have":[3,12],"studied":[4,52],"the":[5,34,37,43,126,187,199],"role":[6],"of":[7,26,36],"homocysteine":[8,45,86,103,147,157,167,184],"in":[9,28,71,85,102,171,174,206],"migraineurs":[10,56],"and":[11,47,64,113,129,146,186,204],"produced":[13],"conflicting":[14],"results.":[15],"The":[16],"MTHFR":[17,38,188,200],"C677T":[18,39],"genotype":[19],"has":[20],"been":[21],"associated":[22,162],"with":[23,41,57,163],"increased":[24],"risk":[25],"migraine":[27,60,127,205],"selected":[29],"clinical":[30],"samples.":[31],"We":[32,51,81,120,136],"assessed":[33],"association":[35,124,142],"variant":[40,131,145,189,201],"migraine,":[42],"corresponding":[44],"levels":[46,87,104,158,168,185],"their":[48],"correlation.":[49],"METHOD:":[50],"27":[53],"random":[54],"adult":[55],"aura":[58,62],"(MWA),":[59],"without":[61],"(MWOA),":[63],"32":[65],"non-migraineurs":[66],"(controls)":[67],"from":[68],"Lahore,":[69],"Pakistan":[70],"this":[72,151,207],"pilot":[73,152],"study":[74],"which":[75],"is":[76],"still":[77],"under":[78],"progress.":[79],"RESULTS:":[80],"found":[82,121,155],"significant":[83,100,123,141],"differences":[84,101],"between":[88,105,125,143,183,198],"various":[89],"diagnostic":[90],"groups":[91],"(K-W":[92],"test:":[93],"p=0.005).":[94],"One-way":[95],"ANOVA,":[96],"post-hoc":[97],"tests":[98],"revealed":[99],"Non-migraineurs,":[106],"MWA":[107,172],"(p=0.002,":[108,115],"CI:":[109,116],"1.93":[110],"-":[111,118],"9.19)":[112],"MWoA":[114],"-9.19":[117],"-1.9).":[119],"a":[122,140,181,196],"group":[128],"C677T-MTHFR":[130,144],"mutant":[132],"allele":[133],"(C/T)":[134],"(p=0.039).":[135],"did":[137,178],"not":[138,179],"find":[139,180],"levels.":[148],"CONCLUSION:":[149],"In":[150],"study,":[153],"we":[154,177],"plasma":[156,166],"to":[159],"be":[160,195],"significantly":[161],"MWOA.":[164,175],"Additionally,":[165],"were":[169],"lower":[170],"than":[173],"Furthermore,":[176],"relationship":[182,197],"(SNP":[190,202],"rs1801133).":[191],"Lastly,":[192],"there":[193],"may":[194],"rs1801133)":[203],"population.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}