{"id":"https://openalex.org/W73225732","doi":null,"title":"Alterations in the sensitivity to endogenous proteolysis due to storage of fructose-1,6-bisphosphatase extracts of liver and muscle of young and old rats.","display_name":"Alterations in the sensitivity to endogenous proteolysis due to storage of fructose-1,6-bisphosphatase extracts of liver and muscle of young and old rats.","publication_year":1987,"publication_date":"1987-06-01","ids":{"openalex":"https://openalex.org/W73225732","mag":"73225732","pmid":"https://pubmed.ncbi.nlm.nih.gov/2839296"},"language":"en","primary_location":{"id":"pmid:2839296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2839296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comprehensive gerontology. Section A, Clinical and laboratory sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071367897","display_name":"Surendra Kumar Trigun","orcid":"https://orcid.org/0000-0002-5655-9618","observed_orcids":["https://orcid.org/0000-0002-5655-9618"]},"institutions":[{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S K Trigun","raw_affiliation_strings":["Biochemistry Laboratory, Banaras Hindu University, Varanasi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Laboratory, Banaras Hindu University, Varanasi, India","institution_ids":["https://openalex.org/I91357014"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108101102","display_name":"SASHA SINGH","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S N Singh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1162,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.32176101,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"2","first_page":"87","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.5692999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.5692999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12604","display_name":"Glycogen Storage Diseases and Myoclonus","score":0.2094999998807907,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.08079999685287476,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fructose-1-6-bisphosphatase","display_name":"fructose-1,6-bisphosphatase","score":1.0},{"id":"https://openalex.org/keywords/endogenous-proteolysis","display_name":"endogenous proteolysis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/enzyme-storage-stability","display_name":"enzyme storage stability","score":0.8450000286102295},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8349999785423279},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.6830000281333923},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9789999723434448},{"id":"https://openalex.org/keywords/amp-inhibition","display_name":"AMP inhibition","score":0.8539999723434448},{"id":"https://openalex.org/keywords/enzyme-activity-ratio","display_name":"enzyme activity ratio","score":0.7829999923706055},{"id":"https://openalex.org/keywords/age-related-enzyme-changes","display_name":"age-related enzyme changes","score":0.5590000152587891},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.8675211668014526},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.8407148122787476},{"id":"https://openalex.org/C189909181","wikidata":"https://www.wikidata.org/wiki/Q899507","display_name":"Fructose 1,6-bisphosphatase","level":3,"score":0.7268429398536682},{"id":"https://openalex.org/C2776970464","wikidata":"https://www.wikidata.org/wiki/Q122043","display_name":"Fructose","level":2,"score":0.6581194996833801},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5935365557670593},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.5918130874633789},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5491688847541809},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5371559262275696},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5230308771133423},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5070552825927734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33350640535354614},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09962013363838196}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005943","descriptor_name":"Gluconeogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006597","descriptor_name":"Fructose-Bisphosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2839296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2839296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comprehensive gerontology. Section A, Clinical and laboratory sciences","raw_type":"Journal Article"},{"id":"mag:73225732","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2839296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2313286806","https://openalex.org/W2023797874","https://openalex.org/W2397968828","https://openalex.org/W2032911283","https://openalex.org/W2087821771","https://openalex.org/W2051920476","https://openalex.org/W1560115230","https://openalex.org/W2009654839","https://openalex.org/W2211170941","https://openalex.org/W2084842711"],"abstract_inverted_index":{"The":[0],"sensitivity":[1,57,89],"of":[2,17,45,69,88,98,124,137],"fructose-1,6-bisphosphatase":[3],"(FBPase:":[4],"EC":[5],"3.1.3.11)":[6],"to":[7,58,90,139],"endogenous":[8,140],"proteolysis":[9,141],"was":[10,65,117],"studied":[11],"in":[12,38,50,78,83,119,134,145],"liver":[13,71],"and":[14,21,56,86],"muscle":[15,99],"extracts":[16],"young":[18,107],"(28":[19],"weeks)":[20,24],"old":[22,103,125,143],"(97":[23],"rats":[25,104],"(stored":[26],"at":[27],"4":[28],"degrees":[29,32],"+/-":[30],"2":[31],"C)":[33],"by":[34],"monitoring":[35],"the":[36,43,70,96,135,146],"alterations":[37,133],"its":[39],"properties.":[40],"Apart":[41],"from":[42,102,106],"level":[44],"total":[46],"enzyme":[47,100],"activity,":[48,79],"decrease":[49,82],"activity":[51,84],"ratio":[52],"(at":[53],"pH":[54],"7.0/9.2)":[55],"AMP":[59,91],"inhibition":[60,92],"no":[61],"age-dependent":[62],"significant":[63,76],"change":[64],"found":[66],"during":[67,95,142],"storage":[68,97],"extract.":[72],"However,":[73],"a":[74],"more":[75],"increase":[77],"comparatively":[80],"less":[81],"ratio,":[85],"retention":[87],"were":[93],"observed":[94,118],"extract":[101],"than":[105],"rats.":[108],"Using":[109],"gel":[110],"electrophoresis,":[111],"an":[112],"extra":[113],"degradative":[114],"active":[115],"product":[116],"all":[120],"samples":[121],"except":[122],"those":[123],"rat":[126],"muscle.":[127],"These":[128],"results":[129],"may":[130],"indicate":[131],"tissue-specific":[132],"susceptibility":[136],"FBPase":[138],"age":[144],"rat.":[147]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}