{"id":"https://openalex.org/W72979498","doi":null,"title":"Nebulized nitroglycerin in children with pulmonary hypertension secondary to congenital heart disease.","display_name":"Nebulized nitroglycerin in children with pulmonary hypertension secondary to congenital heart disease.","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W72979498","mag":"72979498","pmid":"https://pubmed.ncbi.nlm.nih.gov/10214095"},"language":"en","primary_location":{"id":"pmid:10214095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10214095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The West Virginia medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1151&context=pediatrics_facpub","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104360842","display_name":"Hatim \u0391. Omar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H A Omar","raw_affiliation_strings":["University of Kentucky, Lexington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kentucky, Lexington, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110406627","display_name":"Fangqi Gong","orcid":"https://orcid.org/0000-0001-8925-5904","observed_orcids":["https://orcid.org/0000-0001-8925-5904","https://orcid.org/0000-0003-2081-096X","https://orcid.org/0009-0004-1386-477X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Gong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044498094","display_name":"Ming\u2010Li Sun","orcid":"https://orcid.org/0000-0002-0535-2545","observed_orcids":["https://orcid.org/0000-0002-0535-2545"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Y Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088609876","display_name":"Stanley Einzig","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Einzig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2622,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.59211759,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"95","issue":"2","first_page":"74","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11579","display_name":"Cardiovascular and Diving-Related Complications","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.9850000143051147},{"id":"https://openalex.org/keywords/congenital-heart-disease","display_name":"congenital heart disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/perimembranous-ventricular-septal-defect","display_name":"perimembranous ventricular septal defect","score":0.9110000133514404},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cardiac-catheterization","display_name":"cardiac catheterization","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9215525388717651},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.7880572080612183},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.6942400932312012},{"id":"https://openalex.org/C2776858399","wikidata":"https://www.wikidata.org/wiki/Q1385195","display_name":"Extracorporeal membrane oxygenation","level":2,"score":0.5702460408210754},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.5648930072784424},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5645073652267456},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5586526989936829},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5014674663543701},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4937165677547455},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4658214747905731},{"id":"https://openalex.org/C2777385415","wikidata":"https://www.wikidata.org/wiki/Q1615191","display_name":"Cardiac catheterization","level":2,"score":0.4285953640937805}],"mesh":[{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005996","descriptor_name":"Nitroglycerin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005996","descriptor_name":"Nitroglycerin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmid:10214095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10214095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The West Virginia medical journal","raw_type":"Journal Article"},{"id":"pmh:oai:uknowledge.uky.edu:pediatrics_facpub-1151","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/pediatrics_facpub/152","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1151&context=pediatrics_facpub","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pediatrics Faculty Publications","raw_type":"text"},{"id":"pmh:oai:works.bepress.com:hatim_omar-10122","doi":null,"is_oa":true,"landing_page_url":"https://works.bepress.com/hatim_omar/265","pdf_url":"https://works.bepress.com/hatim_omar/265","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hatim A. Omar","raw_type":"text"},{"id":"mag:72979498","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10214095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:uknowledge.uky.edu:pediatrics_facpub-1151","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/pediatrics_facpub/152","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1151&context=pediatrics_facpub","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pediatrics Faculty Publications","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W72979498.pdf","grobid_xml":"https://content.openalex.org/works/W72979498.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W1907994445","https://openalex.org/W2017402165","https://openalex.org/W2068600461","https://openalex.org/W2092145002","https://openalex.org/W2128139551","https://openalex.org/W2169182236","https://openalex.org/W2415662714"],"related_works":["https://openalex.org/W7098083460","https://openalex.org/W2383480308","https://openalex.org/W2139847397","https://openalex.org/W4388079380","https://openalex.org/W3028810519","https://openalex.org/W3083748874","https://openalex.org/W3164723376","https://openalex.org/W2383944465","https://openalex.org/W2075359024","https://openalex.org/W1900412604"],"abstract_inverted_index":{"Pulmonary":[0],"hypertension":[1,36,51,201],"continues":[2],"to":[3,22,33,53,120,138,149,161,173,190],"be":[4,23,186],"a":[5],"major":[6],"cause":[7],"of":[8,70,198],"morbidity":[9],"and":[10,193],"mortality,":[11],"despite":[12],"new":[13],"treatments.":[14],"Since":[15],"inhaled":[16,220],"nitric":[17,221],"oxide":[18,222],"has":[19],"been":[20],"reported":[21],"effective":[24],"in":[25,37,86,103,202,209],"some":[26],"cases,":[27],"we":[28],"investigated":[29],"using":[30],"nebulized":[31,71,82,183],"nitroglycerine":[32,83,100,184],"treat":[34],"pulmonary":[35,50,113,132,200],"children":[38,44,203],"with":[39,48,58,204],"congenital":[40,54,205],"heart":[41,55,144,206],"disease.":[42],"Four":[43],"(ages":[45],"6-72":[46],"months)":[47],"severe":[49,199],"secondary":[52],"disease":[56],"(all":[57],"membranous":[59],"ventricular":[60],"septal":[61],"defect,":[62],"undergoing":[63],"cardiac":[64],"catheterization)":[65],"were":[66],"given":[67],"3":[68,87,164],"cc":[69,88],"normal":[72,89],"saline":[73,92],"over":[74],"10":[75,125],"min":[76,126],"as":[77,215],"placebo":[78],"control,":[79],"followed":[80],"by":[81],"(20":[84],"micrograms/Kg":[85],"saline).":[90],"Normal":[91],"administration":[93,101],"did":[94],"not":[95],"elicit":[96],"any":[97],"change,":[98],"but":[99],"resulted":[102],"the":[104],"following":[105],"changes":[106],"(mean":[107],"+/-":[108,118,122,136,140,147,151,159,163,171,175],"SE,":[109],"paired":[110],"statistics):":[111],"systolic":[112,155],"artery":[114,133],"pressure":[115,134,157,169],"from":[116],"68":[117],"8":[119,148,160],"53":[121],"6":[123,172],"at":[124],"into":[127],"treatment":[128,197],"(P":[129,142,153,165,177],"0.006),":[130],"mean":[131,167],"47":[135],"4":[137,141,176],"38":[139],"0.005),":[143],"rate":[145],"131":[146],"127":[150],"7":[152],"0.13),":[154],"blood":[156,168],"85":[158],"88":[162],"0.7),":[166],"59":[170],"63":[174],"0.5).":[178],"These":[179],"results":[180],"indicate":[181],"that":[182],"may":[185],"an":[187],"effective,":[188],"easy":[189],"administer,":[191],"inexpensive,":[192],"safe":[194],"alternative":[195],"for":[196],"disease,":[207],"especially":[208],"areas":[210],"where":[211],"other":[212],"treatments":[213],"such":[214],"extracorporeal":[216],"membrane":[217],"oxygenation":[218],"or":[219],"are":[223],"inaccessible.":[224]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}