{"id":"https://openalex.org/W72903577","doi":"https://doi.org/10.1093/sleep/22.4.515","title":"Transdermal Scopolamine Alters Phasic REM Activity in Normal Young Adults","display_name":"Transdermal Scopolamine Alters Phasic REM Activity in Normal Young Adults","publication_year":1999,"publication_date":"1999-06-01","ids":{"openalex":"https://openalex.org/W72903577","doi":"https://doi.org/10.1093/sleep/22.4.515","mag":"72903577","pmid":"https://pubmed.ncbi.nlm.nih.gov/10389227"},"language":"en","primary_location":{"id":"doi:10.1093/sleep/22.4.515","doi":"https://doi.org/10.1093/sleep/22.4.515","is_oa":false,"landing_page_url":"https://doi.org/10.1093/sleep/22.4.515","pdf_url":null,"source":{"id":"https://openalex.org/S42921845","display_name":"SLEEP","issn_l":"0161-8105","issn":["0161-8105","1550-9109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103182459","display_name":"Eui-Joong Kim","orcid":"https://orcid.org/0000-0002-0156-1964","observed_orcids":["https://orcid.org/0000-0002-0156-1964"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eui-Joong Kim","raw_affiliation_strings":["Department of Neuropsychiatry, Seoul National University Hospital, Korea","Department of Neuropsychiatry and Division of Sleep Studies, Seoul National University Hospital, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry, Seoul National University Hospital, Korea","institution_ids":["https://openalex.org/I2802835388"]},{"raw_affiliation_string":"Department of Neuropsychiatry and Division of Sleep Studies, Seoul National University Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010204225","display_name":"Do\u2010Un Jeong","orcid":"https://orcid.org/0000-0002-2902-6832","observed_orcids":["https://orcid.org/0000-0002-2902-6832"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Do-Un Jeong","raw_affiliation_strings":["Department of Neuropsychiatry and Division of Sleep Studies, Seoul National University Hospital, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry and Division of Sleep Studies, Seoul National University Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010204225"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"],"apc_list":{"value":4388,"currency":"USD","value_usd":4388},"apc_paid":null,"fwci":0.1635,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.41495459,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"22","issue":"4","first_page":"515","last_page":"520"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transdermal-scopolamine","display_name":"transdermal scopolamine","score":0.9890000224113464},{"id":"https://openalex.org/keywords/rem-sleep","display_name":"REM sleep","score":0.8790000081062317},{"id":"https://openalex.org/keywords/rem-density","display_name":"REM density","score":0.765999972820282},{"id":"https://openalex.org/keywords/rem-latency","display_name":"REM latency","score":0.6340000033378601},{"id":"https://openalex.org/keywords/rem-sleep-duration","display_name":"REM sleep duration","score":0.8190000057220459},{"id":"https://openalex.org/keywords/cholinergic-system","display_name":"cholinergic system","score":0.7979999780654907},{"id":"https://openalex.org/keywords/anticholinergic-effects","display_name":"anticholinergic effects","score":0.9169999957084656},{"id":"https://openalex.org/keywords/sleep-architecture","display_name":"sleep architecture","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C2778576352","wikidata":"https://www.wikidata.org/wiki/Q337188","display_name":"Scopolamine","level":2,"score":0.7671710252761841},{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.6938241720199585},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5409084558486938},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4618787467479706},{"id":"https://openalex.org/C2909050532","wikidata":"https://www.wikidata.org/wiki/Q337188","display_name":"Scopolamine Hydrobromide","level":4,"score":0.4146891236305237},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4127839505672455},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20028653740882874},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1826552152633667},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.12371712923049927},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012601","descriptor_name":"Scopolamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012895","descriptor_name":"Sleep, REM","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017286","descriptor_name":"Polysomnography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018727","descriptor_name":"Muscarinic Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/sleep/22.4.515","doi":"https://doi.org/10.1093/sleep/22.4.515","is_oa":false,"landing_page_url":"https://doi.org/10.1093/sleep/22.4.515","pdf_url":null,"source":{"id":"https://openalex.org/S42921845","display_name":"SLEEP","issn_l":"0161-8105","issn":["0161-8105","1550-9109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep","raw_type":"journal-article"},{"id":"pmid:10389227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10389227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W35710294","https://openalex.org/W47522008","https://openalex.org/W133669861","https://openalex.org/W255240257","https://openalex.org/W1516221483","https://openalex.org/W1964357132","https://openalex.org/W1974136760","https://openalex.org/W1975201295","https://openalex.org/W2005124036","https://openalex.org/W2008060633","https://openalex.org/W2016452337","https://openalex.org/W2023005921","https://openalex.org/W2029866425","https://openalex.org/W2034508861","https://openalex.org/W2037105155","https://openalex.org/W2037458411","https://openalex.org/W2039526407","https://openalex.org/W2049139864","https://openalex.org/W2052653072","https://openalex.org/W2055904512","https://openalex.org/W2057586336","https://openalex.org/W2060479471","https://openalex.org/W2067495470","https://openalex.org/W2080501319","https://openalex.org/W2081061326","https://openalex.org/W2083235604","https://openalex.org/W2084877059","https://openalex.org/W2087950544","https://openalex.org/W2088262299","https://openalex.org/W2092168779","https://openalex.org/W2095984639","https://openalex.org/W2114613490","https://openalex.org/W2151995555","https://openalex.org/W2340560969","https://openalex.org/W2411503642","https://openalex.org/W2411649104","https://openalex.org/W2414257572","https://openalex.org/W2423583984","https://openalex.org/W2439708665","https://openalex.org/W2975185535","https://openalex.org/W3022302886","https://openalex.org/W3034487035","https://openalex.org/W3166543270"],"related_works":["https://openalex.org/W2008723143","https://openalex.org/W133669861","https://openalex.org/W2081061326","https://openalex.org/W2414257572","https://openalex.org/W2020164120","https://openalex.org/W2439708665","https://openalex.org/W2080501319","https://openalex.org/W2095984639","https://openalex.org/W2059428049","https://openalex.org/W2412264613"],"abstract_inverted_index":{"Transdermal":[0],"scopolamine":[1,41,77,126,210],"has":[2],"been":[3],"widely":[4],"used":[5],"for":[6,103],"the":[7,20,34,38,51,73,92,171,177,183,197,209,229,236,250],"prevention":[8],"of":[9,22,40,65,75,128,176,196,245],"motion-sickness":[10],"by":[11,170],"travelers":[12],"due":[13],"to":[14,71,83],"its":[15,25],"potent":[16],"anticholinergic":[17],"effects":[18,26],"and":[19,62,116,124,144,160,182,240],"ease":[21],"administration.":[23],"Nevertheless,":[24],"on":[27,78,208],"sleep":[28,52,60,80,89,138,150,189,200],"physiology":[29],"are":[30],"not":[31],"known,":[32],"despite":[33],"wellknown":[35],"fact":[36],"that":[37,221],"administration":[39],"as":[42,90,141,153,191,193],"an":[43,46],"injection":[44],"or":[45],"oral":[47],"form":[48],"could":[49,241],"influence":[50,74],"architecture,":[53],"especially":[54],"prolonging":[55],"rapid":[56],"eye":[57],"movement":[58],"(REM)":[59],"latency":[61],"shortening":[63],"duration":[64,143],"REM":[66,79,88,118,137,142,145,149,155,162,174,188,194,199,223],"sleep.":[67],"This":[68],"study":[69],"aimed":[70],"measure":[72],"transdermal":[76,172],"in":[81,91,110,135,228,249],"order":[82],"examine":[84],"whether":[85],"it":[86],"affects":[87],"previous":[93],"studies.":[94],"We":[95,131],"studied":[96],"eight":[97],"young":[98],"healthy":[99],"male":[100],"adults":[101],"polysomnographically":[102],"three":[104],"nights":[105,212],"including":[106],"one":[107],"adaptation":[108],"night":[109],"a":[111],"double":[112],"blind":[113],"crossover":[114],"design":[115],"compared":[117,213],"sleep-related":[119],"variables":[120],"between":[121],"sleeps":[122],"with":[123,214],"without":[125],"patch":[127,211,216],"1.5":[129],"mg.":[130],"found":[132],"no":[133],"differences":[134],"tonic":[136],"measures":[139,151],"such":[140,152],"latency,":[146],"but":[147],"phasic":[148,222],"total":[154,161],"activity":[156,195],"(p":[157,164,179,185,202],"<":[158,165,180,186,203],"0.05)":[159,166,181,187,204],"density":[163],"were":[167,205],"significantly":[168,207],"suppressed":[169],"scopolamine;":[173],"densities":[175],"first":[178],"second":[184],"periods":[190],"well":[192],"fourth":[198],"period":[201],"decreased":[206],"placebo":[215],"nights.":[217],"These":[218],"results":[219],"suggest":[220],"components":[224],"reflect":[225],"cholinergic":[226,247],"mechanism":[227],"central":[230],"nervous":[231],"system":[232],"(CNS)":[233],"even":[234],"at":[235],"lowest":[237],"commercial":[238],"dose,":[239],"be":[242],"useful":[243],"markers":[244],"CNS":[246],"activities":[248],"future":[251],"research.":[252]},"counts_by_year":[{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
