{"id":"https://openalex.org/W72861453","doi":null,"title":"Inhibiting insulin resistance mechanisms by DTS phytocompound: an experimental study on metabolic syndrome-prone adipocytes.","display_name":"Inhibiting insulin resistance mechanisms by DTS phytocompound: an experimental study on metabolic syndrome-prone adipocytes.","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W72861453","mag":"72861453","pmid":"https://pubmed.ncbi.nlm.nih.gov/23393916"},"language":"en","primary_location":{"id":"pmh:oai:mattioli1885journals.com:article/2368","doi":null,"is_oa":true,"landing_page_url":"https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/2368","pdf_url":"https://www.mattioli1885journals.com/index.php/actabiomedica/article/download/2368/1800","source":{"id":"https://openalex.org/S4393915150","display_name":"Acta bio-medica dell'Ateneo parmense/Acta biomedica","issn_l":"0392-4203","issn":["0392-4203","2531-6745"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1","poland-20","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0392-4203","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.mattioli1885journals.com/index.php/actabiomedica/article/download/2368/1800","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063152020","display_name":"Roberto Catanzaro","orcid":"https://orcid.org/0000-0003-4852-9125","observed_orcids":["https://orcid.org/0000-0003-4852-9125"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Catanzaro","raw_affiliation_strings":["Dept. of Internal Medicine, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Internal Medicine, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058114937","display_name":"Aldo Lorenzetti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aldo Lorenzetti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090551729","display_name":"Flavio Allegri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Flavio Allegri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015254485","display_name":"Hariom Yadav","orcid":"https://orcid.org/0000-0003-4504-1597","observed_orcids":["https://orcid.org/0000-0003-4504-1597"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hariom Yadav","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091479738","display_name":"Umberto Solimene","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Umberto Solimene","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105121919","display_name":"Ajit K Kumaraju","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ajit K Kumaraju","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077879513","display_name":"Emilio Minelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emilio Minelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075725159","display_name":"Claudio Tomella","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudio Tomella","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030246563","display_name":"Ascanio Polimeni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ascanio Polimeni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066889527","display_name":"Francesco Marotta","orcid":"https://orcid.org/0000-0002-6016-1864","observed_orcids":["https://orcid.org/0000-0002-6016-1864"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesco Marotta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"83","issue":"2","first_page":"95","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.031199999153614044,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9390000104904175},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9819999933242798},{"id":"https://openalex.org/keywords/adipocytes","display_name":"adipocytes","score":0.9810000061988831},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8259999752044678},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9810000061988831},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9359999895095825},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9470000267028809},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.38199999928474426},{"id":"https://openalex.org/keywords/3t3-l1-adipocytes","display_name":"3T3-L1 adipocytes","score":0.8930000066757202}],"concepts":[{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7839940786361694},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6777744293212891},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.6561437845230103},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6467801332473755},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6343700885772705},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6279492378234863},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5960782170295715},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5515834093093872},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5180649757385254},{"id":"https://openalex.org/C98270193","wikidata":"https://www.wikidata.org/wiki/Q3359522","display_name":"P50","level":4,"score":0.4483257830142975},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.4313427805900574},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4184371829032898},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.2970256805419922},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22675755620002747},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21616584062576294},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.14743033051490784},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14702850580215454},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013830","descriptor_name":"Thiadiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:mattioli1885journals.com:article/2368","doi":null,"is_oa":true,"landing_page_url":"https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/2368","pdf_url":"https://www.mattioli1885journals.com/index.php/actabiomedica/article/download/2368/1800","source":{"id":"https://openalex.org/S4393915150","display_name":"Acta bio-medica dell'Ateneo parmense/Acta biomedica","issn_l":"0392-4203","issn":["0392-4203","2531-6745"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1","poland-20","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0392-4203","raw_type":"info:eu-repo/semantics/article"},{"id":"pmid:23393916","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23393916","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta bio-medica : Atenei Parmensis","raw_type":"Comparative Study"},{"id":"mag:72861453","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23393916","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:mattioli1885journals.com:article/2368","doi":null,"is_oa":true,"landing_page_url":"https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/2368","pdf_url":"https://www.mattioli1885journals.com/index.php/actabiomedica/article/download/2368/1800","source":{"id":"https://openalex.org/S4393915150","display_name":"Acta bio-medica dell'Ateneo parmense/Acta biomedica","issn_l":"0392-4203","issn":["0392-4203","2531-6745"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1","poland-20","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0392-4203","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W72861453.pdf","grobid_xml":"https://content.openalex.org/works/W72861453.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W109817387","https://openalex.org/W1801231504","https://openalex.org/W1923643609","https://openalex.org/W1963979793","https://openalex.org/W1969888505","https://openalex.org/W1974387131","https://openalex.org/W1977931864","https://openalex.org/W1992566993","https://openalex.org/W1993304290","https://openalex.org/W1994806443","https://openalex.org/W2015279175","https://openalex.org/W2015628428","https://openalex.org/W2030858473","https://openalex.org/W2033996868","https://openalex.org/W2034865357","https://openalex.org/W2035176469","https://openalex.org/W2036640037","https://openalex.org/W2057328368","https://openalex.org/W2064862450","https://openalex.org/W2071926369","https://openalex.org/W2071965027","https://openalex.org/W2092846652","https://openalex.org/W2093452330","https://openalex.org/W2100837269","https://openalex.org/W2108292604","https://openalex.org/W2110363788","https://openalex.org/W2118149136","https://openalex.org/W2120314099","https://openalex.org/W2129316761","https://openalex.org/W2139177629","https://openalex.org/W2141753226","https://openalex.org/W2144534316","https://openalex.org/W2158079900","https://openalex.org/W2326349441","https://openalex.org/W2372143054","https://openalex.org/W2374426969","https://openalex.org/W2409761919","https://openalex.org/W2414518120","https://openalex.org/W2596652271"],"related_works":["https://openalex.org/W4410815807","https://openalex.org/W52025855","https://openalex.org/W2074282219","https://openalex.org/W79014188","https://openalex.org/W157065868","https://openalex.org/W7099802083","https://openalex.org/W2016465975","https://openalex.org/W2086598341","https://openalex.org/W2042949287","https://openalex.org/W2048744799"],"abstract_inverted_index":{"The":[0,71,86],"present":[1],"study":[2],"was":[3,75,93,114,137,149],"designed":[4,185],"to":[5],"determine":[6],"whether":[7],"DTS":[8,61,92,126,161],"a":[9,68,97,152,179],"phytocompound":[10],"endowed":[11],"with":[12,44,60,96,122],"antioxidant":[13],"properties,":[14],"could":[15],"beneficially":[16],"modulate":[17],"nitric":[18,101],"oxide":[19,102],"(NO)":[20],"production":[21,52,72,90,133,167],"stimulated":[22],"by":[23,37,77,91,117,130,140,155],"lipopolysaccharide":[24],"(LPS)":[25],"and":[26,106,143,165,176],"tumor":[27],"necrosis":[28],"factor-alpha":[29],"(TNF-alpha)":[30],"in":[31,53,67,88,99,134,151,168],"adipocytes.":[32,55],"Combined":[33],"stimulation":[34],"(CS-treatment)":[35],"exerted":[36],"using":[38],"5":[39],"microg/ml":[40],"of":[41,47,57,73,82,84,125,147,174],"LPS":[42],"together":[43],"100":[45],"ng/ml":[46],"TNF-alpha":[48],"significantly":[49,115],"enhanced":[50,116,145],"NO":[51,74,89,166],"3T3-L1":[54,135],"Preincubation":[56],"the":[58,80,120,128,144,171],"adipocytes":[59,136,169],"(10-30":[62],"mM)":[63],"inhibited":[64],"such":[65],"phenomenon":[66],"dose-dependent":[69,153],"fashion.":[70],"decreased":[76],"52%":[78],"at":[79],"concentration":[81],"30mM":[83],"DTS.":[85,156],"decrease":[87,98],"associated":[94],"also":[95],"inducible":[100],"synthase":[103],"(iNOS)":[104],"protein":[105],"iNOS":[107,163],"mRNA":[108],"expression.":[109],"Nuclear":[110],"factor-kappa":[111],"B":[112],"(NF-kappaB)":[113],"CS-treatment,":[118],"while":[119],"pretreatment":[121],"30":[123],"mM":[124],"prevented":[127],"activity":[129],"27%.":[131],"IL-6":[132,148],"markedly":[138],"increased":[139],"CS":[141],"stimulus,":[142],"secretion":[146],"suppressed":[150],"manner":[154],"These":[157],"results":[158],"suggest":[159],"that":[160],"regulates":[162],"expression":[164],"through":[170],"modulating":[172],"activation":[173],"NF-kappaB":[175],"may":[177],"have":[178],"potential":[180],"clinical":[181],"application":[182],"within":[183],"protocols":[184],"for":[186],"treating":[187],"metabolic":[188],"syndrome.":[189],"(www.actabiomedica.it).":[190]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
