{"id":"https://openalex.org/W72852593","doi":null,"title":"Transcription levels of sirtuin family in neural stem cells and brain tissues of adult mice.","display_name":"Transcription levels of sirtuin family in neural stem cells and brain tissues of adult mice.","publication_year":2012,"publication_date":"2012-09-10","ids":{"openalex":"https://openalex.org/W72852593","mag":"72852593","pmid":"https://pubmed.ncbi.nlm.nih.gov/22992439"},"language":"en","primary_location":{"id":"pmid:22992439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22992439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular biology (Noisy-le-Grand, France)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059665548","display_name":"H.F. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"H F Wang","raw_affiliation_strings":["Laboratory of Molecular Neurobiology, School of Life Sciences, and Institute of Systems Biology, Shanghai University, Shanghai 200444, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Neurobiology, School of Life Sciences, and Institute of Systems Biology, Shanghai University, Shanghai 200444, China","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016671432","display_name":"Q Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Q Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101641441","display_name":"Ruili Feng","orcid":"https://orcid.org/0000-0001-9463-8045","observed_orcids":["https://orcid.org/0000-0001-9463-8045"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R L Feng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100660633","display_name":"Tieqiao Wen","orcid":"https://orcid.org/0000-0001-7986-8475","observed_orcids":["https://orcid.org/0000-0001-7986-8475"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Q Wen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3434,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.87690476,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"Suppl.58","issue":null,"first_page":"OL1737","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirtuins","display_name":"sirtuins","score":0.9549999833106995},{"id":"https://openalex.org/keywords/neural-stem-cells","display_name":"neural stem cells","score":0.9580000042915344},{"id":"https://openalex.org/keywords/c17-2-cells","display_name":"C17.2 cells","score":0.7360000014305115},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.656000018119812},{"id":"https://openalex.org/keywords/sirt2","display_name":"SIRT2","score":0.875},{"id":"https://openalex.org/keywords/sirt3","display_name":"SIRT3","score":0.9919999837875366},{"id":"https://openalex.org/keywords/sirt4","display_name":"SIRT4","score":0.9869999885559082},{"id":"https://openalex.org/keywords/sirt5","display_name":"SIRT5","score":0.996999979019165},{"id":"https://openalex.org/keywords/sirt6","display_name":"SIRT6","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sirt7","display_name":"SIRT7","score":1.0},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.8820000290870667},{"id":"https://openalex.org/keywords/nicotinamide","display_name":"nicotinamide","score":0.9399999976158142},{"id":"https://openalex.org/keywords/trichostatin-a","display_name":"trichostatin A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.5429999828338623},{"id":"https://openalex.org/keywords/brain-tissue","display_name":"brain tissue","score":0.503000020980835},{"id":"https://openalex.org/keywords/embryonic-neural-stem-cells","display_name":"embryonic neural stem cells","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C199848840","wikidata":"https://www.wikidata.org/wiki/Q18036605","display_name":"SIRT2","level":5,"score":0.9062644839286804},{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.8770178556442261},{"id":"https://openalex.org/C2777865847","wikidata":"https://www.wikidata.org/wiki/Q425894","display_name":"Trichostatin A","level":5,"score":0.7108151912689209},{"id":"https://openalex.org/C138488276","wikidata":"https://www.wikidata.org/wiki/Q18037158","display_name":"SIRT3","level":5,"score":0.6713159084320068},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.669867753982544},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6024291515350342},{"id":"https://openalex.org/C2776536020","wikidata":"https://www.wikidata.org/wiki/Q21113719","display_name":"Sirtuin 1","level":4,"score":0.570035457611084},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.5428183078765869},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.49892210960388184},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4656568169593811},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.4615841507911682},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4558897614479065},{"id":"https://openalex.org/C2777595374","wikidata":"https://www.wikidata.org/wiki/Q18040385","display_name":"SIRT6","level":5,"score":0.4507293403148651},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.4316338002681732},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.32585716247558594},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.2845354676246643},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.15136560797691345},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11755213141441345},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08881938457489014}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D037761","descriptor_name":"Sirtuins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037761","descriptor_name":"Sirtuins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056565","descriptor_name":"Sirtuin 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056565","descriptor_name":"Sirtuin 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056566","descriptor_name":"Sirtuin 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056566","descriptor_name":"Sirtuin 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:22992439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22992439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular biology (Noisy-le-Grand, France)","raw_type":"Journal Article"},{"id":"mag:72852593","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22992439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W86716384","https://openalex.org/W1538419182","https://openalex.org/W1598427976","https://openalex.org/W1965296401","https://openalex.org/W1974869071","https://openalex.org/W1987107175","https://openalex.org/W1988354925","https://openalex.org/W1991848485","https://openalex.org/W1998974491","https://openalex.org/W1999569750","https://openalex.org/W2000216767","https://openalex.org/W2007065171","https://openalex.org/W2013841882","https://openalex.org/W2014655396","https://openalex.org/W2016496971","https://openalex.org/W2016549941","https://openalex.org/W2019986565","https://openalex.org/W2021432006","https://openalex.org/W2029671211","https://openalex.org/W2042710774","https://openalex.org/W2047231656","https://openalex.org/W2052130151","https://openalex.org/W2056673958","https://openalex.org/W2063084036","https://openalex.org/W2076186906","https://openalex.org/W2083434423","https://openalex.org/W2085846712","https://openalex.org/W2087019732","https://openalex.org/W2096977244","https://openalex.org/W2097948853","https://openalex.org/W2106715610","https://openalex.org/W2116556443","https://openalex.org/W2124595934","https://openalex.org/W2127144132","https://openalex.org/W2130876797","https://openalex.org/W2158092222","https://openalex.org/W2160700740","https://openalex.org/W2171723578"],"related_works":["https://openalex.org/W1973831249","https://openalex.org/W2955869933","https://openalex.org/W2007065171","https://openalex.org/W2093271417","https://openalex.org/W2891342570","https://openalex.org/W4388365503","https://openalex.org/W2322436909","https://openalex.org/W7168120662","https://openalex.org/W3134944506","https://openalex.org/W1965813410"],"abstract_inverted_index":{"Neural":[0],"stem":[1,17],"cells":[2,18],"(NSCs)":[3],"has":[4],"been":[5],"used":[6,142],"as":[7],"a":[8,112,170,178],"well-known":[9],"model":[10],"to":[11,127,143],"investigate":[12],"apoptosis,":[13],"differentiation,":[14,49],"maintenance":[15],"of":[16,22,34,63,86,116,151,158,192,215],"status,":[19],"and":[20,71,91,137,161,175,177,185,208],"therapy":[21],"neurological":[23],"disease.":[24],"The":[25],"C17.2":[26,67,101,128,204],"NSCs":[27,95,207],"line":[28],"was":[29,119,163],"produced":[30],"after":[31],"v-myc":[32],"transformation":[33],"neural":[35],"progenitor":[36],"from":[37],"mouse":[38,124],"cerebellar":[39],"cortex.":[40],"Sirtuin":[41],"family":[42,65,118,217],"plays":[43],"important":[44],"roles":[45],"involved":[46],"in":[47,66,75,93,100,121,173,181,189],"neuronal":[48],"genomic":[50],"stability,":[51],"lifespan,":[52],"cell":[53],"survival.":[54],"However,":[55],"little":[56],"is":[57],"known":[58],"about":[59],"gene":[60],"expression":[61,84,157,201],"variation":[62],"sirtuin":[64,117,199,216],"NSCs,":[68,70,102,205],"primary":[69],"different":[72,198,222],"brain":[73,125,209],"tissues":[74],"adult":[76,123],"mice.":[77],"Here,":[78],"we":[79],"confirmed":[80],"that":[81,104,155],"the":[82,122,148,156,190,212],"mRNA":[83,114,200],"levels":[85],"sirt2,":[87,182],"3,":[88],"4,":[89],"5,":[90],"7":[92],"E14.5":[94,206],"were":[96,141,187],"significantly":[97],"higher":[98,113],"than":[99],"whereas":[103],"sirt":[105],"6":[106],"displayed":[107],"an":[108],"opposing":[109],"mode.":[110],"Moreover,":[111],"level":[115,150],"observed":[120,188],"compared":[126],"NSCs.":[129],"In":[130],"addition,":[131],"histone":[132,223],"deacetylase":[133],"(HDAC)":[134],"inhibitors":[135],"nicotinamide":[136,167],"Trichostatin":[138],"A":[139],"(TSA)":[140],"explore":[144],"differential":[145],"changes":[146],"at":[147],"transcriptional":[149,213],"sirtuins.":[152],"Results":[153],"indicated":[154],"sirt1,":[159],"sirt5":[160],"sirt6":[162],"significant":[164,171,179],"downregulated":[165],"by":[166,221],"treatment.":[168],"Whereas,":[169],"downregulation":[172],"sirt1":[174],"sirt3":[176],"upregulation":[180],"sirt4,":[183],"sirt6,":[184],"sirt7":[186],"treatment":[191],"TSA.":[193],"Thus":[194],"our":[195],"studies":[196],"indicate":[197],"profiles":[202],"between":[203],"tissues,":[210],"suggesting":[211],"regulation":[214],"could":[218],"be":[219],"mediated":[220],"acetylation.":[224]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
