{"id":"https://openalex.org/W72790950","doi":null,"title":"Human immunoglobulin production in SCID mice following primary sensitisation of human lymphocytes in situ.","display_name":"Human immunoglobulin production in SCID mice following primary sensitisation of human lymphocytes in situ.","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W72790950","mag":"72790950","pmid":"https://pubmed.ncbi.nlm.nih.gov/8572894"},"language":"en","primary_location":{"id":"pmid:8572894","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8572894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archivum immunologiae et therapiae experimentalis","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031104979","display_name":"Maciej Krzysztof Kurpisz","orcid":"https://orcid.org/0000-0003-3275-3245","observed_orcids":["https://orcid.org/0000-0003-3275-3245"]},"institutions":[{"id":"https://openalex.org/I4210119107","display_name":"Institute of Human Genetics","ror":"https://ror.org/02jzt6t86","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210119107","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"M Kurpisz","raw_affiliation_strings":["Institute of Human Genetics, Polish Academy of Sciences, Pozna\u0144"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Genetics, Polish Academy of Sciences, Pozna\u0144","institution_ids":["https://openalex.org/I4210119107","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103214010","display_name":"William Walker","orcid":"https://orcid.org/0000-0002-1940-5329","observed_orcids":["https://orcid.org/0000-0002-1940-5329"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Walker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037272197","display_name":"Max Field","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Field","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108202677","display_name":"Grant E. Gallagher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Gallagher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.00441631,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"5-6","first_page":"369","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.13989999890327454,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scid-mice","display_name":"SCID mice","score":0.9599999785423279},{"id":"https://openalex.org/keywords/human-peripheral-blood-mononuclear-cells","display_name":"human peripheral blood mononuclear cells","score":0.8029999732971191},{"id":"https://openalex.org/keywords/xenotransplantation","display_name":"xenotransplantation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/primary-antibody-response","display_name":"primary antibody response","score":0.6389999985694885},{"id":"https://openalex.org/keywords/igm","display_name":"IgM","score":0.5529999732971191},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":1.0},{"id":"https://openalex.org/keywords/antigen-specificity","display_name":"antigen specificity","score":0.7829999923706055},{"id":"https://openalex.org/keywords/soluble-antigen","display_name":"soluble antigen","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.8223010897636414},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7386482357978821},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.6378581523895264},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6168075799942017},{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.6106876730918884},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.510532021522522},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.49096444249153137},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45336583256721497},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35739076137542725},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3392345905303955},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07668006420135498},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000912","descriptor_name":"Antibodies, Neoplasm","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002689","descriptor_name":"Chlamydia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016913","descriptor_name":"Blood Component Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8572894","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8572894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archivum immunologiae et therapiae experimentalis","raw_type":"Journal Article"},{"id":"mag:72790950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8572894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1938066104","https://openalex.org/W2402507063","https://openalex.org/W2108673503","https://openalex.org/W30334389","https://openalex.org/W1488613407","https://openalex.org/W2048914162","https://openalex.org/W1568631834","https://openalex.org/W1577336125","https://openalex.org/W1991153825","https://openalex.org/W1522787838"],"abstract_inverted_index":{"We":[0],"have":[1],"grafted":[2],"human":[3,92],"peripheral":[4],"blood":[5],"mononuclear":[6],"cells":[7,41],"to":[8,17,29,96],"the":[9,21,55,76,98],"peritoneal":[10],"cavity":[11],"of":[12,23,35,39,68],"SCID":[13,56,111],"mice,":[14,112],"exposed":[15],"them":[16],"soluble":[18],"antigens":[19,95],"in":[20,36,54,59,84,107,110],"absence":[22],"adjuvant":[24],"and":[25,49,63,75],"examined":[26],"their":[27],"ability":[28,80],"make":[30],"specific":[31],"antibody.":[32],"The":[33,71,87],"effect":[34],"vitro":[37,85],"pre-priming":[38],"donor":[40,99],"on":[42],"antibody":[43],"production":[44],"was":[45,65],"determined.":[46],"Human":[47],"IgM":[48],"IgG":[50],"antibodies":[51,93],"were":[52,81],"found":[53],"serum":[57],"following":[58],"situ":[60,108],"antigenic":[61],"challenge":[62],"there":[64],"good":[66],"evidence":[67],"antigen":[69,78,118],"specificity.":[70],"total":[72],"Ig":[73],"levels":[74],"relative":[77],"binding":[79],"diminished":[82],"by":[83,106],"pre-priming.":[86],"results":[88],"demonstrate":[89],"that":[90,114],"primary":[91],"against":[94],"which":[97],"is":[100],"probably":[101],"naive":[102],"can":[103],"be":[104,120],"generated":[105],"sensitisation":[109],"but":[113],"optimisation":[115],"for":[116],"each":[117],"may":[119],"required.":[121]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}