{"id":"https://openalex.org/W72513393","doi":null,"title":"Unmeasured anion during severe sepsis with metabolic acidosis.","display_name":"Unmeasured anion during severe sepsis with metabolic acidosis.","publication_year":1990,"publication_date":"1990-02-01","ids":{"openalex":"https://openalex.org/W72513393","mag":"72513393","pmid":"https://pubmed.ncbi.nlm.nih.gov/2311201"},"language":"en","primary_location":{"id":"pmid:2311201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2311201","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulatory shock","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109186376","display_name":"Eric C. Rackow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E C Rackow","raw_affiliation_strings":["Department of Medicine, University of Health Sciences, Chicago Medical School, IL 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Health Sciences, Chicago Medical School, IL 60064","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006295252","display_name":"Carter Mecher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Mecher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039668592","display_name":"Mark E. Astiz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M E Astiz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111859912","display_name":"C Goldstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Goldstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057951330","display_name":"D. McKee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D McKee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109262750","display_name":"M H Weil","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M H Weil","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3307,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.77859636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"2","first_page":"107","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.54830002784729,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.54830002784729,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.4375,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-acidosis","display_name":"metabolic acidosis","score":0.7799999713897705},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cecal-perforation","display_name":"cecal perforation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/lactic-acidosis","display_name":"lactic acidosis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/anion-gap","display_name":"anion gap","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.7229999899864197},{"id":"https://openalex.org/keywords/arterial-lactate","display_name":"arterial lactate","score":0.734000027179718},{"id":"https://openalex.org/keywords/blood-gases","display_name":"blood gases","score":0.5299999713897705},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C2777299393","wikidata":"https://www.wikidata.org/wiki/Q548646","display_name":"Anion gap","level":3,"score":0.8030576705932617},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6915705800056458},{"id":"https://openalex.org/C2779246250","wikidata":"https://www.wikidata.org/wiki/Q1598200","display_name":"Metabolic acidosis","level":2,"score":0.670009970664978},{"id":"https://openalex.org/C2780317664","wikidata":"https://www.wikidata.org/wiki/Q1500373","display_name":"Lactic acidosis","level":2,"score":0.6670271158218384},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6340274214744568},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5740191340446472},{"id":"https://openalex.org/C2778553927","wikidata":"https://www.wikidata.org/wiki/Q185089","display_name":"Acidosis","level":2,"score":0.5525436997413635},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.541142463684082},{"id":"https://openalex.org/C2781112554","wikidata":"https://www.wikidata.org/wiki/Q409202","display_name":"Bicarbonate","level":2,"score":0.5399489402770996},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.5023093223571777},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.4893128573894501},{"id":"https://openalex.org/C2779537118","wikidata":"https://www.wikidata.org/wiki/Q618362","display_name":"Arterial blood","level":2,"score":0.45210713148117065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.404933899641037},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3488299250602722},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3100334405899048},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000136","descriptor_name":"Acid-Base Equilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000138","descriptor_name":"Acidosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000138","descriptor_name":"Acidosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2311201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2311201","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulatory shock","raw_type":"Journal Article"},{"id":"mag:72513393","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2311201","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1994434855","https://openalex.org/W2560741613","https://openalex.org/W4214642779","https://openalex.org/W2159394835","https://openalex.org/W4411568401","https://openalex.org/W4396930586","https://openalex.org/W1993066910","https://openalex.org/W2004755558","https://openalex.org/W2767037499","https://openalex.org/W2949069845"],"abstract_inverted_index":{"It":[0],"is":[1,11],"assumed":[2],"that":[3],"the":[4,18,21,34,82,86,112,204,215,227],"development":[5],"of":[6,20,229],"metabolic":[7],"acidosis":[8],"during":[9,24],"sepsis":[10,26],"secondary":[12],"to":[13,72,91,100,116,209],"lactic":[14],"acidosis.":[15],"We":[16,136],"assessed":[17],"composition":[19],"anion":[22,183,196],"gap":[23,184,197],"severe":[25],"induced":[27],"by":[28],"cecal":[29],"perforation":[30],"in":[31,52,57,81,96,105,121,129,142,146,174,203,214,226],"rats.":[32,84,180],"In":[33],"first":[35],"experiment,":[36],"cardiac":[37,65],"output,":[38],"arterial":[39,43,87,148],"blood":[40,149,156],"gases,":[41,157],"and":[42,56,158,171,177],"lactate":[44,88],"were":[45,223],"measured":[46],"over":[47],"a":[48,143],"6":[49,153],"hr":[50,154],"interval":[51],"five":[53,58,175,178],"septic":[54,83,97,122,176,205],"rats":[55,59,98,107,123,131],"serving":[60],"as":[61,187,207],"sham-operated":[62],"controls.":[63],"The":[64,181,195],"output":[66],"decreased":[67,115],"from":[68],"331":[69],"+/-":[70,74,93,102,118,126,200,211],"32":[71],"172":[73],"9":[75],"ml/kg/min":[76],"(P":[77,108,132,218],"less":[78,109,133,219],"than":[79,110,134,220],"0.01)":[80],"Although":[85],"was":[89,114,150,185,198],"increased":[90],"2.1":[92],"0.2":[94],"mEq/L":[95,104,120,128,202,213],"compared":[99,208],"0.8":[101],"0.1":[103],"sham":[106,130,179,216],"0.01),":[111],"HCO3-":[113],"16.5":[117],"0.6":[119],"versus":[124],"23.8":[125],"1.10":[127],"0.01).":[135,221],"further":[137],"investigated":[138],"this":[139],"bicarbonate":[140],"deficit":[141],"second":[144],"study":[145],"which":[147],"sampled":[151],"at":[152],"for":[155],"plasma":[159],"Na+,":[160],"K+,":[161],"Cl-,":[162],"HCO3-,":[163],"lactate,":[164],"pyruvate,":[165,230],"beta-hydroxybutyrate,":[166,231],"acetoacetate,":[167,232],"citrate,":[168,233],"creatinine,":[169,234],"albumin,":[170,235],"amino":[172,237],"acids":[173],"serum":[182],"calculated":[186],"[(Na(+)":[188],"+":[189,193],"K+)":[190],"-":[191],"(Cl(-)":[192],"HCO3-)].":[194],"21.6":[199],"1.6":[201],"animals":[206,217],"13.2":[210],"0.5":[212],"There":[222],"no":[224],"differences":[225],"concentration":[228],"or":[236],"acids.(ABSTRACT":[238],"TRUNCATED":[239],"AT":[240],"250":[241],"WORDS)":[242]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
