{"id":"https://openalex.org/W72302747","doi":null,"title":"p53 independent G0/G1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells.","display_name":"p53 independent G0/G1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells.","publication_year":1995,"publication_date":"1995-08-03","ids":{"openalex":"https://openalex.org/W72302747","mag":"72302747","pmid":"https://pubmed.ncbi.nlm.nih.gov/7630633"},"language":"en","primary_location":{"id":"pmid:7630633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7630633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110281563","display_name":"Zhimin Shao","orcid":"https://orcid.org/0000-0002-4503-148X","observed_orcids":["https://orcid.org/0000-0002-4503-148X"]},"institutions":[{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z M Shao","raw_affiliation_strings":["Department of Medicine, University of Maryland Cancer Center, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Maryland Cancer Center, Baltimore, USA","institution_ids":["https://openalex.org/I4390039317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110902581","display_name":"Marcia I. Dawson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M I Dawson","raw_affiliation_strings":["University of Maryland, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, Baltimore","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060934779","display_name":"X. S. Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X S Li","raw_affiliation_strings":["University of Maryland, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, Baltimore","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091506580","display_name":"Arun K. Rishi","orcid":"https://orcid.org/0000-0001-8611-9923","observed_orcids":["https://orcid.org/0000-0001-8611-9923"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A K Rishi","raw_affiliation_strings":["University of Maryland, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, Baltimore","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M S Sheikh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M S Sheikh","raw_affiliation_strings":["University of Maryland, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, Baltimore","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101927597","display_name":"Qi Han","orcid":"https://orcid.org/0000-0002-7944-9147","observed_orcids":["https://orcid.org/0000-0002-7944-9147"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Q X Han","raw_affiliation_strings":["University of Maryland, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, Baltimore","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111583596","display_name":"Jos\u00e9 V. Ord\u00f3\u00f1ez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J V Ordonez","raw_affiliation_strings":["University of Maryland, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, Baltimore","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075546538","display_name":"Braham Shroot","orcid":"https://orcid.org/0009-0005-8096-9616","observed_orcids":["https://orcid.org/0009-0005-8096-9616"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Shroot","raw_affiliation_strings":["University of Maryland, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, Baltimore","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039968524","display_name":"Joseph A. Fontana","orcid":"https://orcid.org/0000-0003-3829-3358","observed_orcids":["https://orcid.org/0000-0003-3829-3358"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Fontana","raw_affiliation_strings":["University of Maryland, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, Baltimore","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.1874,"has_fulltext":false,"cited_by_count":198,"citation_normalized_percentile":{"value":0.96737274,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"3","first_page":"493","last_page":"504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.09040000289678574,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-retinoids","display_name":"synthetic retinoids","score":0.8799999952316284},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8740000128746033},{"id":"https://openalex.org/keywords/g0-g1-cell-cycle-arrest","display_name":"G0/G1 cell cycle arrest","score":0.949999988079071},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/p53-independent-pathway","display_name":"p53-independent pathway","score":0.8849999904632568},{"id":"https://openalex.org/keywords/waf1-cip1","display_name":"WAF1/CIP1","score":0.890999972820282},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.8130000233650208},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.996999979019165},{"id":"https://openalex.org/keywords/retinoid-x-receptor","display_name":"retinoid X receptor","score":0.8040000200271606},{"id":"https://openalex.org/keywords/retinoid-x-receptor-alpha","display_name":"retinoid X receptor alpha","score":0.6579999923706055},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.7829999923706055},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/mutant-p53","display_name":"mutant p53","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7921018600463867},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7455581426620483},{"id":"https://openalex.org/C2775954498","wikidata":"https://www.wikidata.org/wiki/Q420418","display_name":"Retinoid","level":4,"score":0.7293050289154053},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5899731516838074},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.5157816410064697},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4917455017566681},{"id":"https://openalex.org/C25311885","wikidata":"https://www.wikidata.org/wiki/Q306383","display_name":"G1 phase","level":5,"score":0.45357146859169006},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.45229730010032654},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4478083550930023},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43871617317199707},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4205614924430847},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4135550856590271},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33847612142562866},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.20839139819145203},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15962788462638855},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006131","descriptor_name":"Growth Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009281","descriptor_name":"Naphthalenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012176","descriptor_name":"Retinoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7630633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7630633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"mag:72302747","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7630633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4500098090","display_name":"SELECTIVE RETINOIDS FOR BREAST CANCER THERAPY","funder_award_id":"P01CA051993","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4817431896","display_name":"RETINOID INHIBITION OF BREAST CANCER GROWTH","funder_award_id":"R01CA063335","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2152153239","https://openalex.org/W2133324535","https://openalex.org/W7100261198","https://openalex.org/W2003959071","https://openalex.org/W2330360672","https://openalex.org/W2328182378","https://openalex.org/W2040468663","https://openalex.org/W7095635343","https://openalex.org/W2137206833","https://openalex.org/W2328138132"],"abstract_inverted_index":{"The":[0],"biological":[1],"activity":[2],"of":[3,22,35,38,52,89,129,164,198,202],"a":[4,36,148,160,180,190,205],"novel":[5,181],"synthetic":[6],"retinoid":[7,182],"6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene":[8],"carboxylic":[9],"acid":[10],"(AHPN)":[11],"was":[12,124,156],"investigated":[13],"in":[14,72,86,204],"human":[15,54],"breast":[16,90],"carcinoma":[17,91],"(HBC)":[18],"cells.":[19],"Although":[20],"capable":[21],"selective":[23],"binding":[24],"to":[25,195],"the":[26,33,50,53],"RAR":[27],"gamma":[28],"nuclear":[29],"receptor,":[30],"AHPN":[31,47,76,102,178],"inhibited":[32,49,67],"growth":[34,51,92],"number":[37],"HBC":[39],"cell":[40,56,95],"lines":[41],"via":[42,189],"RAR-":[43],"or":[44,174],"RXR-independent":[45],"pathways.":[46],"also":[48,157],"leukemia":[55],"line":[57],"HL-60R":[58],"which":[59,146,193],"does":[60],"not":[61,171],"possess":[62,147],"functional":[63],"RARs.":[64],"RA":[65],"significantly":[66],"AP-1":[68],"mediated":[69],"gene":[70],"activation":[71,197],"MCF-7":[73,112],"cells":[74,113,145,169],"while":[75,137,167],"displayed":[77],"no":[78],"such":[79],"anti-AP-1":[80],"activity.":[81],"Retinoids":[82],"normally":[83],"are":[84],"cytostatic":[85],"their":[87,98],"inhibition":[88],"and":[93,122,154,187],"permit":[94],"proliferation":[96],"upon":[97],"removal,":[99],"wher":[100],"as":[101,131,133],"induced":[103],"G0/G1":[104,120,152,185],"arrest":[105,121,153,186],"within":[106],"6h":[107],"followed":[108],"by":[109,126],"apoptosis.":[110],"In":[111,143],"that":[114,183],"harbor":[115],"wild":[116],"type":[117],"p53,":[118,150],"AHPN-induced":[119],"apoptosis":[123,155,188],"accompanied":[125],"p53-independent":[127,206],"regulation":[128,163],"WAF1/CIP1":[130,165],"well":[132],"bax":[134,173],"mRNA":[135,139,166],"levels":[136,140],"bcl-2":[138,175],"were":[141],"decreased.":[142],"MDA-MB-231":[144],"mutant":[149],"AHPN-mediated":[151],"associated":[158],"with":[159],"concomitant":[161],"up":[162],"these":[168],"did":[170],"express":[172],"messages.":[176],"Thus":[177],"represents":[179],"induces":[184],"unique":[191],"pathway":[192],"appears":[194],"involve":[196],"known":[199],"downstream":[200],"effectors":[201],"p53":[203],"manner.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
