{"id":"https://openalex.org/W7225880331","doi":"https://doi.org/10.64898/2026.11.10.26367628","title":"How Does Psilocybin Affect Daily Life Experience and Behavior? Protocol For a Multimethod Ambulatory Assessment Study Within a Clinical Trial of Psilocybin for Depression","display_name":"How Does Psilocybin Affect Daily Life Experience and Behavior? Protocol For a Multimethod Ambulatory Assessment Study Within a Clinical Trial of Psilocybin for Depression","publication_year":2026,"publication_date":"2026-11-12","ids":{"openalex":"https://openalex.org/W7225880331","doi":"https://doi.org/10.64898/2026.11.10.26367628"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.10.26367628","doi":"https://doi.org/10.64898/2026.11.10.26367628","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.10.26367628","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"parent_works":[],"lineage":["https://openalex.org/W7225880331"],"child_works_count":0,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.11.10.26367628","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050188588","display_name":"Andreea Sutu","orcid":"https://orcid.org/0000-0003-3958-3154","observed_orcids":["https://orcid.org/0000-0003-3958-3154"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andreea Sutu","raw_affiliation_strings":["Emory University;"],"raw_orcid":"https://orcid.org/0000-0003-3958-3154","affiliations":[{"raw_affiliation_string":"Emory University;","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088822196","display_name":"Deanna M. Kaplan","orcid":"https://orcid.org/0000-0002-9300-3029","observed_orcids":["https://orcid.org/0000-0002-9300-3029"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deanna Kaplan","raw_affiliation_strings":["Emory University School of Medicine;"],"raw_orcid":"https://orcid.org/0000-0002-9300-3029","affiliations":[{"raw_affiliation_string":"Emory University School of Medicine;","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024726266","display_name":"Charles L. Raison","orcid":"https://orcid.org/0000-0001-6687-0066","observed_orcids":["https://orcid.org/0000-0001-6687-0066","https://orcid.org/0000-0002-4653-0483"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles L Raison","raw_affiliation_strings":["University of Wisconsin-Madison;"],"raw_orcid":"https://orcid.org/0000-0001-6687-0066","affiliations":[{"raw_affiliation_string":"University of Wisconsin-Madison;","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052770687","display_name":"Christina J. Sauder","orcid":"https://orcid.org/0000-0003-2208-0171","observed_orcids":["https://orcid.org/0000-0003-2208-0171","https://orcid.org/0009-0007-4283-2832"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina J Sauder","raw_affiliation_strings":["University of Wisconsin-Madison;"],"raw_orcid":"https://orcid.org/0009-0007-4283-2832","affiliations":[{"raw_affiliation_string":"University of Wisconsin-Madison;","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045564767","display_name":"Santiago Jose Arconada Alvarez","orcid":"https://orcid.org/0000-0003-0737-6679","observed_orcids":["https://orcid.org/0000-0003-0737-6679"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Santiago Jose Arconada Alvarez","raw_affiliation_strings":["Emory University;"],"raw_orcid":"https://orcid.org/0000-0003-0737-6679","affiliations":[{"raw_affiliation_string":"Emory University;","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094068512","display_name":"Nicole S. Pozzo","orcid":"https://orcid.org/0009-0003-7325-6373","observed_orcids":["https://orcid.org/0009-0003-7325-6373"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole S Pozzo","raw_affiliation_strings":["Emory University School of Medicine;"],"raw_orcid":"https://orcid.org/0009-0003-7325-6373","affiliations":[{"raw_affiliation_string":"Emory University School of Medicine;","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160088677","display_name":"Zainab Salako","orcid":"https://orcid.org/0009-0002-1188-2558","observed_orcids":["https://orcid.org/0009-0002-1188-2558"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zainab Salako","raw_affiliation_strings":["Emory University School of Medicine;"],"raw_orcid":"https://orcid.org/0009-0002-1188-2558","affiliations":[{"raw_affiliation_string":"Emory University School of Medicine;","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075823524","display_name":"Zhuo Job Chen","orcid":"https://orcid.org/0000-0003-0839-1627","observed_orcids":["https://orcid.org/0000-0003-0839-1627"]},"institutions":[{"id":"https://openalex.org/I102149020","display_name":"University of North Carolina at Charlotte","ror":"https://ror.org/04dawnj30","country_code":"US","type":"education","lineage":["https://openalex.org/I102149020"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhuo Job Chen","raw_affiliation_strings":["University of North Carolina at Charlotte"],"raw_orcid":"https://orcid.org/0000-0003-0839-1627","affiliations":[{"raw_affiliation_string":"University of North Carolina at Charlotte","institution_ids":["https://openalex.org/I102149020"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079412671","display_name":"Roman Palitsky","orcid":"https://orcid.org/0000-0002-0415-6411","observed_orcids":["https://orcid.org/0000-0002-0415-6411"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roman Palitsky","raw_affiliation_strings":["Emory University School of Medicine;"],"raw_orcid":"https://orcid.org/0000-0002-0415-6411","affiliations":[{"raw_affiliation_string":"Emory University School of Medicine;","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10475","display_name":"Psychological Well-being and Life Satisfaction","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psilocybin","display_name":"psilocybin","score":1.0},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9290000200271606},{"id":"https://openalex.org/keywords/ambulatory-assessment","display_name":"ambulatory assessment","score":0.656000018119812},{"id":"https://openalex.org/keywords/ecological-momentary-assessment","display_name":"ecological momentary assessment","score":0.9679999947547913},{"id":"https://openalex.org/keywords/differential-treatment-response","display_name":"differential treatment response","score":0.6850000023841858},{"id":"https://openalex.org/keywords/social-support","display_name":"social support","score":0.9589999914169312},{"id":"https://openalex.org/keywords/interpersonal-conflict","display_name":"interpersonal conflict","score":0.9990000128746033},{"id":"https://openalex.org/keywords/psychological-well-being","display_name":"psychological well-being","score":0.7889999747276306},{"id":"https://openalex.org/keywords/everyday-experience","display_name":"everyday experience","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2776502132","wikidata":"https://www.wikidata.org/wiki/Q208118","display_name":"Psilocybin","level":3,"score":0.9031000137329102},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.5503000020980835},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5364000201225281},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.5353999733924866},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5231000185012817},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4950999915599823},{"id":"https://openalex.org/C164850336","wikidata":"https://www.wikidata.org/wiki/Q3685487","display_name":"Interpersonal communication","level":2,"score":0.4611999988555908},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.4596000015735626},{"id":"https://openalex.org/C65499552","wikidata":"https://www.wikidata.org/wiki/Q5421061","display_name":"Experience sampling method","level":2,"score":0.44179999828338623},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4271000027656555},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.4000999927520752},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37770000100135803},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.36959999799728394},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.3659999966621399},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.3578999936580658},{"id":"https://openalex.org/C68122502","wikidata":"https://www.wikidata.org/wiki/Q764527","display_name":"Informed consent","level":3,"score":0.3361999988555908},{"id":"https://openalex.org/C35785553","wikidata":"https://www.wikidata.org/wiki/Q756720","display_name":"Ambulatory","level":2,"score":0.3337000012397766},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.31299999356269836},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.30869999527931213},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.30730000138282776},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.3019999861717224},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3018999993801117},{"id":"https://openalex.org/C26760741","wikidata":"https://www.wikidata.org/wiki/Q160402","display_name":"Perception","level":2,"score":0.28299999237060547},{"id":"https://openalex.org/C2780553607","wikidata":"https://www.wikidata.org/wiki/Q684868","display_name":"Attrition","level":2,"score":0.28130000829696655},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.2712000012397766},{"id":"https://openalex.org/C79544238","wikidata":"https://www.wikidata.org/wiki/Q423243","display_name":"Activities of daily living","level":2,"score":0.26820001006126404},{"id":"https://openalex.org/C2779018934","wikidata":"https://www.wikidata.org/wiki/Q1129653","display_name":"Everyday life","level":2,"score":0.2662000060081482},{"id":"https://openalex.org/C160146798","wikidata":"https://www.wikidata.org/wiki/Q2471453","display_name":"Psychogenic disease","level":2,"score":0.2635999917984009},{"id":"https://openalex.org/C2779318504","wikidata":"https://www.wikidata.org/wiki/Q1438035","display_name":"Research design","level":2,"score":0.26089999079704285},{"id":"https://openalex.org/C104863432","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmacy","level":2,"score":0.260699987411499},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.25529998540878296},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.25270000100135803},{"id":"https://openalex.org/C2777106319","wikidata":"https://www.wikidata.org/wiki/Q362104","display_name":"Institutional review board","level":2,"score":0.25189998745918274},{"id":"https://openalex.org/C22467394","wikidata":"https://www.wikidata.org/wiki/Q849359","display_name":"Multidisciplinary approach","level":2,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.10.26367628","doi":"https://doi.org/10.64898/2026.11.10.26367628","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.10.26367628","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.10.26367628","doi":"https://doi.org/10.64898/2026.11.10.26367628","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.10.26367628","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Study Protocol","id":"https://openalex.org/study-designs/study-protocol"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Introduction:":[0],"Although":[1],"psilocybin":[2,89],"has":[3,23],"shown":[4],"promise":[5],"for":[6,109,126],"treating":[7],"depression,":[8],"responses":[9,55],"vary":[10],"considerably,":[11],"with":[12,53,61,95,203],"some":[13],"individuals":[14],"experiencing":[15],"limiting":[16],"improvement":[17,62],"and":[18,70,106,113,116,136,145,161,170,188,192,226],"even":[19],"adverse":[20,147],"effects.":[21],"Research":[22],"largely":[24],"relied":[25],"on":[26,207],"assessments":[27,100],"conducted":[28],"at":[29],"discrete":[30],"time":[31],"points,":[32],"providing":[33],"limited":[34],"insight":[35],"into":[36],"how":[37],"post-psilocybin":[38],"change":[39],"unfolds":[40],"in":[41],"everyday":[42,132],"life.":[43],"The":[44,194],"Dial-In":[45,72],"study":[46,79],"aims":[47],"to":[48,56,90,92,130],"characterize":[49,131],"daily-life":[50],"processes":[51],"associated":[52,60],"differential":[54,173],"psilocybin,":[57],"including":[58],"factors":[59,181],"or":[63],"worsening":[64],"following":[65],"challenging":[66,185],"dosing":[67,186],"experiences.":[68],"Methods":[69],"Analysis:":[71],"is":[73],"a":[74,82],"prospective,":[75],"observational,":[76],"multi-method":[77],"longitudinal":[78],"embedded":[80],"within":[81],"clinical":[83,189],"trial":[84],"administering":[85],"25":[86],"mg":[87],"of":[88],"up":[91],"141":[93],"adults":[94],"major":[96],"depressive":[97,141],"disorder.":[98],"Ambulatory":[99],"combine":[101],"ecological":[102],"momentary":[103],"assessment":[104],"(EMA)":[105],"voice":[107],"diaries":[108],"14":[110],"days":[111],"pre-":[112],"post-":[114],"dosing,":[115],"passive":[117],"audio":[118],"sampling":[119],"via":[120],"the":[121,210],"Electronically":[122],"Activated":[123],"Recorder":[124],"(EAR)":[125],"three":[127],"four-day":[128],"periods":[129],"affect,":[133],"behavior,":[134],"reflections,":[135],"social":[137,163],"interactions.":[138],"Outcomes":[139],"include":[140],"symptoms,":[142],"psychological":[143],"well-being,":[144],"psychedelic-related":[146],"effects":[148],"assessed":[149],"through":[150,223],"eight":[151],"weeks":[152],"post-dose.":[153],"Analyses":[154],"will":[155,177,220],"examine":[156],"whether":[157,179],"affective":[158],"sudden":[159],"gains":[160],"losses,":[162],"support,":[164],"interpersonal":[165],"conflict,":[166],"conversational":[167],"focus,":[168],"reflection":[169],"rigidity":[171],"predict":[172],"outcomes.":[174,190],"Additional":[175],"analyses":[176],"test":[178],"these":[180],"moderate":[182],"associations":[183],"between":[184],"experiences":[187],"Ethics":[191],"Dissemination:":[193],"project":[195],"was":[196],"approved":[197],"by":[198],"WCG":[199,208],"Institutional":[200],"Review":[201],"Board,":[202],"Emory":[204],"University":[205],"relying":[206],"as":[209],"reviewing":[211],"board.":[212],"All":[213],"participants":[214],"provide":[215],"written":[216],"informed":[217],"consent.":[218],"Findings":[219],"be":[221],"disseminated":[222],"peer-reviewed":[224],"publications":[225],"scientific":[227],"presentations.":[228]},"counts_by_year":[],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2026-11-13T00:00:00"}
