{"id":"https://openalex.org/W7225848948","doi":"https://doi.org/10.3390/pharmaceutics18111466","title":"Development of Terpene-Containing Polymeric Micelles and Evaluation of Their Potential Skin Penetration Pathways for Improving Dermal Delivery of Resveratrol","display_name":"Development of Terpene-Containing Polymeric Micelles and Evaluation of Their Potential Skin Penetration Pathways for Improving Dermal Delivery of Resveratrol","publication_year":2026,"publication_date":"2026-11-12","ids":{"openalex":"https://openalex.org/W7225848948","doi":"https://doi.org/10.3390/pharmaceutics18111466"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics18111466","doi":"https://doi.org/10.3390/pharmaceutics18111466","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics18111466","pdf_url":null,"source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7225848948"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/pharmaceutics18111466","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108076584","display_name":"Thirapit Subongkot","orcid":"https://orcid.org/0000-0001-5980-2196","observed_orcids":["https://orcid.org/0000-0001-5980-2196"]},"institutions":[{"id":"https://openalex.org/I129488602","display_name":"Burapha University","ror":"https://ror.org/01ff74m36","country_code":"TH","type":"education","lineage":["https://openalex.org/I129488602"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Thirapit Subongkot","raw_affiliation_strings":["Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Burapha University, Chonburi 20131, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Burapha University, Chonburi 20131, Thailand","institution_ids":["https://openalex.org/I129488602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108076584"],"corresponding_institution_ids":["https://openalex.org/I129488602"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"11","first_page":"1466","last_page":"1466"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10721","display_name":"Surfactants and Colloidal Systems","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polymeric-micelles","display_name":"polymeric micelles","score":0.9599999785423279},{"id":"https://openalex.org/keywords/terpenes","display_name":"terpenes","score":0.8949999809265137},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":0.9430000185966492},{"id":"https://openalex.org/keywords/dermal-drug-delivery","display_name":"dermal drug delivery","score":0.8799999952316284},{"id":"https://openalex.org/keywords/d-limonene","display_name":"D-limonene","score":0.9850000143051147},{"id":"https://openalex.org/keywords/citral","display_name":"citral","score":0.7730000019073486},{"id":"https://openalex.org/keywords/1-8-cineole","display_name":"1,8-cineole","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.6809999942779541},{"id":"https://openalex.org/keywords/transcellular-pathway","display_name":"transcellular pathway","score":0.9909999966621399},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C11268172","wikidata":"https://www.wikidata.org/wiki/Q421110","display_name":"Micelle","level":3,"score":0.9003999829292297},{"id":"https://openalex.org/C80107235","wikidata":"https://www.wikidata.org/wiki/Q7162625","display_name":"Penetration (warfare)","level":2,"score":0.8046000003814697},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.7519000172615051},{"id":"https://openalex.org/C101335993","wikidata":"https://www.wikidata.org/wiki/Q408943","display_name":"Poloxamer","level":4,"score":0.6927000284194946},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6822999715805054},{"id":"https://openalex.org/C176285220","wikidata":"https://www.wikidata.org/wiki/Q7833830","display_name":"Transcellular","level":2,"score":0.4796000123023987},{"id":"https://openalex.org/C2780306666","wikidata":"https://www.wikidata.org/wiki/Q7225971","display_name":"Poloxamer 407","level":5,"score":0.4706999957561493},{"id":"https://openalex.org/C2778370115","wikidata":"https://www.wikidata.org/wiki/Q2038676","display_name":"Stratum corneum","level":2,"score":0.4564000070095062},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4142000079154968},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.37389999628067017},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.3677999973297119},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3587999939918518},{"id":"https://openalex.org/C2778123984","wikidata":"https://www.wikidata.org/wiki/Q187634","display_name":"Emulsion","level":2,"score":0.3431999981403351},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.33480000495910645},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3124000132083893},{"id":"https://openalex.org/C64237528","wikidata":"https://www.wikidata.org/wiki/Q607000","display_name":"Critical micelle concentration","level":4,"score":0.30140000581741333},{"id":"https://openalex.org/C2777239854","wikidata":"https://www.wikidata.org/wiki/Q902638","display_name":"Excipient","level":2,"score":0.2815999984741211},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.2741999924182892},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.267300009727478},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.2524999976158142},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.25099998712539673}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/pharmaceutics18111466","doi":"https://doi.org/10.3390/pharmaceutics18111466","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics18111466","pdf_url":null,"source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics18111466","doi":"https://doi.org/10.3390/pharmaceutics18111466","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics18111466","pdf_url":null,"source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1419755575","display_name":null,"funder_award_id":"FF2568","funder_id":"https://openalex.org/F4320322817","funder_display_name":"National Research Council of Thailand"}],"funders":[{"id":"https://openalex.org/F4320322817","display_name":"National Research Council of Thailand","ror":"https://ror.org/018wfhg78"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1980855715","https://openalex.org/W1991966167","https://openalex.org/W1993009149","https://openalex.org/W1995675654","https://openalex.org/W1997488570","https://openalex.org/W2001327595","https://openalex.org/W2001950053","https://openalex.org/W2011086526","https://openalex.org/W2035721941","https://openalex.org/W2092592955","https://openalex.org/W2102432127","https://openalex.org/W2113135060","https://openalex.org/W2150783039","https://openalex.org/W2277526673","https://openalex.org/W2566463473","https://openalex.org/W2734749483","https://openalex.org/W2744202900","https://openalex.org/W2749067209","https://openalex.org/W2804846127","https://openalex.org/W2889198580","https://openalex.org/W2946905380","https://openalex.org/W3011177534","https://openalex.org/W3089778541","https://openalex.org/W3095440351","https://openalex.org/W3134531697","https://openalex.org/W3217242895","https://openalex.org/W4296046266","https://openalex.org/W4297565169","https://openalex.org/W4310965235","https://openalex.org/W4393992097","https://openalex.org/W4403380819","https://openalex.org/W4410597329","https://openalex.org/W4412996161","https://openalex.org/W7117466201"],"related_works":[],"abstract_inverted_index":{"Background/Objectives:":[0],"This":[1],"study":[2,32,149],"aimed":[3],"to":[4,19,129],"develop":[5],"a":[6,74,135,192],"novel":[7],"polymeric":[8,50,71,81,122,152,174,207],"micelle":[9],"formulation":[10],"using":[11,102],"poloxamer":[12,58],"184":[13],"with":[14,154,166,209],"ethanol":[15,155],"and":[16,38,62,90,107,139,156,183,226],"various":[17],"terpenes":[18,28],"improve":[20],"the":[21,70,98,120,160,167,177,181,187,199,202,222],"skin":[22,94,147,161,178,200,223],"penetration":[23,95,148,162,220,231],"of":[24,54,76,97,119,163,215],"resveratrol.":[25],"Methods:":[26],"The":[27,48,79,93,115,144,195,206],"used":[29],"in":[30,145],"this":[31],"were":[33,42,52,83],"monoterpenes,":[34],"namely,":[35],"d-limonene,":[36],"citral,":[37],"cineole.":[39],"Polymeric":[40],"micelles":[41,51,72,82,99,123,153,175,208],"prepared":[43,49,121],"by":[44,217],"direct":[45],"dissolution":[46],"method.":[47],"composed":[53],"1%":[55],"terpenes,":[56],"25%":[57],"184,":[59],"5%":[60],"ethanol,":[61],"69%":[63],"water.":[64],"Resveratrol":[65],"was":[66,100],"successfully":[67],"loaded":[68],"into":[69],"at":[73],"concentration":[75],"0.24":[77],"mg/mL.":[78],"obtained":[80],"characterized":[84],"for":[85],"their":[86],"size,":[87],"surface":[88,137],"charge,":[89],"size":[91,118,142],"distribution.":[92,143],"pathway":[96,189,228],"investigated":[101],"dual":[103],"fluorescently":[104],"labeled":[105],"particles":[106,196],"observed":[108],"via":[109,180,224],"confocal":[110],"laser":[111],"scanning":[112],"microscopy.":[113],"Results:":[114],"average":[116],"particle":[117],"ranged":[124],"from":[125],"29.02":[126],"\u00b1":[127,131],"2.28":[128],"57.16":[130],"8.32":[132],"nm,":[133],"exhibiting":[134],"neutral":[136],"charge":[138],"an":[140],"acceptable":[141],"vitro":[146],"revealed":[150],"that":[151],"d-limonene":[157,210],"significantly":[158],"increased":[159],"resveratrol":[164,168,216],"compared":[165],"ethanolic":[169],"solution":[170],"as":[171,191,229],"control.":[172],"These":[173],"penetrated":[176,198],"primarily":[179],"intercellular":[182,225],"transcellular":[184,227],"pathways,":[185],"whereas":[186],"transfollicular":[188],"served":[190],"minor":[193],"route.":[194],"also":[197],"through":[201,221],"intercluster":[203],"pathway.":[204,232],"Conclusions:":[205],"effectively":[211],"enhanced":[212],"dermal":[213],"delivery":[214],"facilitating":[218],"its":[219],"major":[230]},"counts_by_year":[],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2026-11-13T00:00:00"}
