{"id":"https://openalex.org/W7225835365","doi":"https://doi.org/10.1021/acs.jmedchem.6c01788","title":"Narrow-Spectrum Oxadiazole Antibacterials that Target Cell\u2212Wall Septation in Clostridioides difficile and Spare the Gut Microbiota","display_name":"Narrow-Spectrum Oxadiazole Antibacterials that Target Cell\u2212Wall Septation in Clostridioides difficile and Spare the Gut Microbiota","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225835365","doi":"https://doi.org/10.1021/acs.jmedchem.6c01788"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jmedchem.6c01788","doi":"https://doi.org/10.1021/acs.jmedchem.6c01788","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.6c01788","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100695459","display_name":"Jingdong Yang","orcid":"https://orcid.org/0009-0008-1303-9007","observed_orcids":["https://orcid.org/0009-0008-1303-9007"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingdong Yang","raw_affiliation_strings":["University of Notre Dame , , , ,"],"raw_orcid":"https://orcid.org/0009-0008-1303-9007","affiliations":[{"raw_affiliation_string":"University of Notre Dame , , , ,","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026734513","display_name":"Xiaotan Yu","orcid":"https://orcid.org/0000-0002-4029-810X","observed_orcids":["https://orcid.org/0000-0002-4029-810X"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaotan Yu","raw_affiliation_strings":["University of Notre Dame , , , ,"],"raw_orcid":"https://orcid.org/0000-0002-4029-810X","affiliations":[{"raw_affiliation_string":"University of Notre Dame , , , ,","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161488111","display_name":"Yuanyuan Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanyuan Qian","raw_affiliation_strings":["University of Notre Dame , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Notre Dame , , , ,","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161482384","display_name":"Mehdi Alikhani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehdi Alikhani","raw_affiliation_strings":["University of Notre Dame , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Notre Dame , , , ,","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042319709","display_name":"Biruk Tesfaye Birhanu","orcid":"https://orcid.org/0000-0002-5261-8406","observed_orcids":["https://orcid.org/0000-0002-5261-8406"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Biruk T. Birhanu","raw_affiliation_strings":["University of Notre Dame , , , ,"],"raw_orcid":"https://orcid.org/0000-0002-5261-8406","affiliations":[{"raw_affiliation_string":"University of Notre Dame , , , ,","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060323017","display_name":"Amr M. El\u2010Araby","orcid":"https://orcid.org/0000-0002-3143-8801","observed_orcids":["https://orcid.org/0000-0002-3143-8801"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amr M. El-Araby","raw_affiliation_strings":["University of Notre Dame , , , ,"],"raw_orcid":"https://orcid.org/0000-0002-3143-8801","affiliations":[{"raw_affiliation_string":"University of Notre Dame , , , ,","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017516965","display_name":"Bharat Mishra","orcid":"https://orcid.org/0000-0002-7505-5722","observed_orcids":["https://orcid.org/0000-0002-7505-5722"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bharat Mishra","raw_affiliation_strings":["University of Notre Dame , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Notre Dame , , , ,","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049306478","display_name":"Choon Keun Kim","orcid":"https://orcid.org/0000-0003-0306-8935","observed_orcids":["https://orcid.org/0000-0003-0306-8935"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Choon Kim","raw_affiliation_strings":["University of Notre Dame , , , ,"],"raw_orcid":"https://orcid.org/0000-0003-0306-8935","affiliations":[{"raw_affiliation_string":"University of Notre Dame , , , ,","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052268873","display_name":"Valerie A. Schroeder","orcid":"https://orcid.org/0000-0001-6885-0288","observed_orcids":["https://orcid.org/0000-0001-6885-0288"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valerie A. Schroeder","raw_affiliation_strings":["University of Notre Dame , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Notre Dame , , , ,","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013812375","display_name":"Shahriar Mobashery","orcid":"https://orcid.org/0000-0002-7695-7883","observed_orcids":["https://orcid.org/0000-0002-7695-7883"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shahriar Mobashery","raw_affiliation_strings":["University of Notre Dame , , , ,"],"raw_orcid":"https://orcid.org/0000-0002-7695-7883","affiliations":[{"raw_affiliation_string":"University of Notre Dame , , , ,","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069483094","display_name":"Mayland Chang","orcid":"https://orcid.org/0000-0002-4333-3775","observed_orcids":["https://orcid.org/0000-0002-4333-3775"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mayland Chang","raw_affiliation_strings":["University of Notre Dame , , , ,"],"raw_orcid":"https://orcid.org/0000-0002-4333-3775","affiliations":[{"raw_affiliation_string":"University of Notre Dame , , , ,","institution_ids":["https://openalex.org/I107639228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I107639228"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.7893999814987183},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.7135000228881836},{"id":"https://openalex.org/C2779448499","wikidata":"https://www.wikidata.org/wiki/Q1227206","display_name":"Oxadiazole","level":2,"score":0.6032999753952026},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5985999703407288},{"id":"https://openalex.org/C2910067853","wikidata":"https://www.wikidata.org/wiki/Q27438828","display_name":"Clostridioides","level":2,"score":0.5572999715805054},{"id":"https://openalex.org/C2776634448","wikidata":"https://www.wikidata.org/wiki/Q206920","display_name":"Peptidoglycan","level":3,"score":0.5483999848365784},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.48829999566078186},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3788999915122986},{"id":"https://openalex.org/C2994496256","wikidata":"https://www.wikidata.org/wiki/Q27031090","display_name":"Clostridium difficile","level":3,"score":0.37209999561309814},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35190001130104065},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.3149999976158142},{"id":"https://openalex.org/C174802600","wikidata":"https://www.wikidata.org/wiki/Q12190","display_name":"Penicillin","level":3,"score":0.3061999976634979},{"id":"https://openalex.org/C2776653525","wikidata":"https://www.wikidata.org/wiki/Q7162855","display_name":"Penicillin binding proteins","level":4,"score":0.303600013256073},{"id":"https://openalex.org/C19655278","wikidata":"https://www.wikidata.org/wiki/Q3293735","display_name":"Bacterial cell structure","level":3,"score":0.2808000147342682},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2799000144004822},{"id":"https://openalex.org/C2776927270","wikidata":"https://www.wikidata.org/wiki/Q815962","display_name":"Colonization","level":2,"score":0.27300000190734863},{"id":"https://openalex.org/C177857423","wikidata":"https://www.wikidata.org/wiki/Q17077315","display_name":"Gut\u2013brain axis","level":3,"score":0.26080000400543213},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.2506999969482422}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.jmedchem.6c01788","doi":"https://doi.org/10.1021/acs.jmedchem.6c01788","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.6c01788","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W619830376","https://openalex.org/W1975691556","https://openalex.org/W2031168104","https://openalex.org/W2040182739","https://openalex.org/W2056279562","https://openalex.org/W2069153240","https://openalex.org/W2069894149","https://openalex.org/W2102219089","https://openalex.org/W2107772251","https://openalex.org/W2113556993","https://openalex.org/W2113679889","https://openalex.org/W2121291798","https://openalex.org/W2122459017","https://openalex.org/W2151539341","https://openalex.org/W2153228625","https://openalex.org/W2168453790","https://openalex.org/W2207819727","https://openalex.org/W2316573420","https://openalex.org/W2938868597","https://openalex.org/W2950785362","https://openalex.org/W2951160681","https://openalex.org/W2951912016","https://openalex.org/W2981413553","https://openalex.org/W2986925300","https://openalex.org/W2990618091","https://openalex.org/W3023413297","https://openalex.org/W3048152086","https://openalex.org/W3123646706","https://openalex.org/W3140075632","https://openalex.org/W3157320470","https://openalex.org/W3183487539","https://openalex.org/W4288080907","https://openalex.org/W4307029800","https://openalex.org/W4375954869","https://openalex.org/W4386910723","https://openalex.org/W4389266245","https://openalex.org/W4391169028","https://openalex.org/W4396721167","https://openalex.org/W4399163134","https://openalex.org/W4409839085","https://openalex.org/W4414161959","https://openalex.org/W4415397651","https://openalex.org/W4416719111","https://openalex.org/W7162506872"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Recurrence":[1],"of":[2,9,17,46,63,88,115,141,145],"infection":[3,12],"is":[4,137],"a":[5,60,142],"challenge":[6],"in":[7,15,99],"treatment":[8,114],"Clostridioides":[10],"difficile":[11,37,48,80],"(CDI),":[13],"observed":[14],"25%":[16],"patients.":[18],"The":[19],"first-line":[20],"antibiotics":[21,40],"disturb":[22],"the":[23,27,71,123],"gut":[24,31,52,124],"microbiota,":[25],"exacerbating":[26],"already":[28],"disrupted":[29],"commensal":[30,82],"homeostasis":[32],"and":[33,84,96,126],"allow":[34],"for":[35,43,74,139],"C.":[36,47,79,133],"colonization.":[38],"Narrow-spectrum":[39],"are":[41],"critical":[42],"selective":[44],"targeting":[45],"while":[49],"preserving":[50],"beneficial":[51],"flora,":[53],"thereby":[54],"mitigating":[55],"recurrence.":[56],"Our":[57],"study":[58],"investigates":[59],"novel":[61],"class":[62],"highly":[64],"selective,":[65],"nitroimidazole-based":[66],"oxadiazole":[67,118],"antibacterials.":[68],"We":[69,107],"detail":[70],"chemical":[72],"basis":[73],"their":[75,86],"exceptional":[76],"selectivity":[77],"against":[78],"over":[81],"bacteria":[83],"elucidate":[85],"mechanism":[87],"action.":[89],"Oxadiazole":[90],"2":[91,119],"inhibits":[92],"penicillin-binding":[93],"proteins":[94],"1":[95],"3":[97],"involved":[98],"septal":[100],"peptidoglycan":[101],"biosynthesis":[102],"during":[103],"vegetative":[104],"cell":[105],"division.":[106],"further":[108],"demonstrate":[109],"by":[110,132],"whole-genome":[111],"sequencing":[112],"that":[113],"mice":[116],"with":[117],"does":[120],"not":[121],"disrupt":[122],"microflora":[125],"confers":[127],"an":[128],"impediment":[129],"to":[130,148],"colonization":[131],"difficile.":[134],"This":[135],"work":[136],"foundational":[138],"development":[140],"new":[143],"generation":[144],"narrow-spectrum":[146],"therapeutics":[147],"combat":[149],"CDI.":[150]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
