{"id":"https://openalex.org/W7225835188","doi":"https://doi.org/10.3390/molecules31224050","title":"A Modular Antibody-Based Platform for PD-L1 Pretargeted SPECT Imaging and In Vitro 177Lu Cytotoxicity in a Murine Melanoma Model","display_name":"A Modular Antibody-Based Platform for PD-L1 Pretargeted SPECT Imaging and In Vitro 177Lu Cytotoxicity in a Murine Melanoma Model","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225835188","doi":"https://doi.org/10.3390/molecules31224050"},"language":"en","primary_location":{"id":"doi:10.3390/molecules31224050","doi":"https://doi.org/10.3390/molecules31224050","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules31224050","pdf_url":null,"source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/molecules31224050","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103328166","display_name":"Gonzalo Rodr\u00edguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Gonzalo Rodr\u00edguez","raw_affiliation_strings":["Grupo de Qu\u00edmica Org\u00e1nica Medicinal, Instituto de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo 11400, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Qu\u00edmica Org\u00e1nica Medicinal, Instituto de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo 11400, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022994057","display_name":"Ximena Camacho","orcid":"https://orcid.org/0000-0002-2371-1441","observed_orcids":["https://orcid.org/0000-0002-2371-1441"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Ximena Camacho","raw_affiliation_strings":["Instituto de Investigaci\u00f3n Una Salud, Universidad de la Rep\u00fablica, Montevideo 11600, Uruguay","\u00c1rea de Radiofarmacia, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo 11400, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Una Salud, Universidad de la Rep\u00fablica, Montevideo 11600, Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"\u00c1rea de Radiofarmacia, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo 11400, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091034059","display_name":"Laura Reyes","orcid":"https://orcid.org/0009-0005-5965-6906","observed_orcids":["https://orcid.org/0009-0005-5965-6906"]},"institutions":[{"id":"https://openalex.org/I4210162569","display_name":"Centro Uruguayo de Imagenolog\u00eda Molecular","ror":"https://ror.org/05ef3nj70","country_code":"UY","type":"facility","lineage":["https://openalex.org/I4210162569"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Ana Laura Reyes","raw_affiliation_strings":["Centro Uruguayo de Imagenolog\u00eda Molecular, Montevideo 11600, Uruguay"],"raw_orcid":"https://orcid.org/0009-0005-5965-6906","affiliations":[{"raw_affiliation_string":"Centro Uruguayo de Imagenolog\u00eda Molecular, Montevideo 11600, Uruguay","institution_ids":["https://openalex.org/I4210162569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024048166","display_name":"Carolina Perroni","orcid":"https://orcid.org/0000-0002-6790-4851","observed_orcids":["https://orcid.org/0000-0002-6790-4851"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Carolina Perroni","raw_affiliation_strings":["\u00c1rea de Radiofarmacia, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo 11400, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00c1rea de Radiofarmacia, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo 11400, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004723951","display_name":"Eduardo Savio","orcid":"https://orcid.org/0000-0002-2358-194X","observed_orcids":["https://orcid.org/0000-0002-2358-194X"]},"institutions":[{"id":"https://openalex.org/I4210162569","display_name":"Centro Uruguayo de Imagenolog\u00eda Molecular","ror":"https://ror.org/05ef3nj70","country_code":"UY","type":"facility","lineage":["https://openalex.org/I4210162569"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Eduardo Savio","raw_affiliation_strings":["Centro Uruguayo de Imagenolog\u00eda Molecular, Montevideo 11600, Uruguay"],"raw_orcid":"https://orcid.org/0000-0002-2358-194X","affiliations":[{"raw_affiliation_string":"Centro Uruguayo de Imagenolog\u00eda Molecular, Montevideo 11600, Uruguay","institution_ids":["https://openalex.org/I4210162569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161449372","display_name":"Marcelo Fern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Marcelo Fern\u00e1ndez","raw_affiliation_strings":["Laboratorio de Experimentaci\u00f3n Animal, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo 11400, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Experimentaci\u00f3n Animal, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo 11400, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022187304","display_name":"Mar\u00eda Moreno","orcid":"https://orcid.org/0000-0002-7294-6693","observed_orcids":["https://orcid.org/0000-0002-7294-6693"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Moreno","raw_affiliation_strings":["Instituto de Higiene, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo 11600, Uruguay","Instituto de Investigaci\u00f3n Una Salud, Universidad de la Rep\u00fablica, Montevideo 11600, Uruguay"],"raw_orcid":"https://orcid.org/0000-0002-7294-6693","affiliations":[{"raw_affiliation_string":"Instituto de Higiene, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo 11600, Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Una Salud, Universidad de la Rep\u00fablica, Montevideo 11600, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083692113","display_name":"Roger J. Chammas","orcid":"https://orcid.org/0000-0003-0342-8726","observed_orcids":["https://orcid.org/0000-0003-0342-8726"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210088998","display_name":"Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo","ror":"https://ror.org/005vqqr19","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210088998"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Roger Chammas","raw_affiliation_strings":["Center for Translational Research in Oncology, ICESP, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 01246-000, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-0342-8726","affiliations":[{"raw_affiliation_string":"Center for Translational Research in Oncology, ICESP, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 01246-000, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210088998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024816595","display_name":"Pablo Cabral","orcid":"https://orcid.org/0000-0001-7344-2027","observed_orcids":["https://orcid.org/0000-0001-7344-2027"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Pablo Cabral","raw_affiliation_strings":["Instituto de Investigaci\u00f3n Una Salud, Universidad de la Rep\u00fablica, Montevideo 11600, Uruguay","\u00c1rea de Radiofarmacia, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo 11400, Uruguay"],"raw_orcid":"https://orcid.org/0000-0001-7344-2027","affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Una Salud, Universidad de la Rep\u00fablica, Montevideo 11600, Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"\u00c1rea de Radiofarmacia, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo 11400, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103189067","display_name":"Juan Pablo Gambini","orcid":"https://orcid.org/0000-0001-5368-3464","observed_orcids":["https://orcid.org/0000-0001-5368-3464"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]},{"id":"https://openalex.org/I4210162569","display_name":"Centro Uruguayo de Imagenolog\u00eda Molecular","ror":"https://ror.org/05ef3nj70","country_code":"UY","type":"facility","lineage":["https://openalex.org/I4210162569"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Juan Pablo Gambini","raw_affiliation_strings":["Centro Uruguayo de Imagenolog\u00eda Molecular, Montevideo 11600, Uruguay","Instituto de Investigaci\u00f3n Una Salud, Universidad de la Rep\u00fablica, Montevideo 11600, Uruguay"],"raw_orcid":"https://orcid.org/0000-0001-5368-3464","affiliations":[{"raw_affiliation_string":"Centro Uruguayo de Imagenolog\u00eda Molecular, Montevideo 11600, Uruguay","institution_ids":["https://openalex.org/I4210162569"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Una Salud, Universidad de la Rep\u00fablica, Montevideo 11600, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015747605","display_name":"Marcos Couto","orcid":"https://orcid.org/0000-0003-2925-7347","observed_orcids":["https://orcid.org/0000-0003-2925-7347"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Marcos Couto","raw_affiliation_strings":["Grupo de Qu\u00edmica Org\u00e1nica Medicinal, Instituto de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo 11400, Uruguay","Instituto de Investigaci\u00f3n Una Salud, Universidad de la Rep\u00fablica, Montevideo 11600, Uruguay"],"raw_orcid":"https://orcid.org/0000-0003-2925-7347","affiliations":[{"raw_affiliation_string":"Grupo de Qu\u00edmica Org\u00e1nica Medicinal, Instituto de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo 11400, Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Una Salud, Universidad de la Rep\u00fablica, Montevideo 11600, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080927889","display_name":"Hugo Cerecetto","orcid":"https://orcid.org/0000-0003-1256-3786","observed_orcids":["https://orcid.org/0000-0003-1256-3786"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Hugo Cerecetto","raw_affiliation_strings":["Grupo de Qu\u00edmica Org\u00e1nica Medicinal, Instituto de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo 11400, Uruguay","Instituto de Investigaci\u00f3n Una Salud, Universidad de la Rep\u00fablica, Montevideo 11600, Uruguay","\u00c1rea de Radiofarmacia, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo 11400, Uruguay"],"raw_orcid":"https://orcid.org/0000-0003-1256-3786","affiliations":[{"raw_affiliation_string":"Grupo de Qu\u00edmica Org\u00e1nica Medicinal, Instituto de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo 11400, Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Una Salud, Universidad de la Rep\u00fablica, Montevideo 11600, Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"\u00c1rea de Radiofarmacia, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo 11400, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070618450","display_name":"Mar\u00eda Fernanda Garc\u00eda","orcid":"https://orcid.org/0000-0002-2918-5761","observed_orcids":["https://orcid.org/0000-0002-2918-5761"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":true,"raw_author_name":"Mar\u00eda Fernanda Garc\u00eda","raw_affiliation_strings":["Instituto de Investigaci\u00f3n Una Salud, Universidad de la Rep\u00fablica, Montevideo 11600, Uruguay","\u00c1rea de Radiofarmacia, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo 11400, Uruguay"],"raw_orcid":"https://orcid.org/0000-0002-2918-5761","affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Una Salud, Universidad de la Rep\u00fablica, Montevideo 11600, Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"\u00c1rea de Radiofarmacia, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo 11400, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5070618450"],"corresponding_institution_ids":["https://openalex.org/I180910786"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"22","first_page":"4050","last_page":"4050"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2775949291","wikidata":"https://www.wikidata.org/wiki/Q20707748","display_name":"Atezolizumab","level":5,"score":0.7930999994277954},{"id":"https://openalex.org/C2777836882","wikidata":"https://www.wikidata.org/wiki/Q22907915","display_name":"Pretargeting","level":5,"score":0.7703999876976013},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6294000148773193},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5820000171661377},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5622000098228455},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.551800012588501},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5023999810218811},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.43140000104904175},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.41100001335144043},{"id":"https://openalex.org/C2780333294","wikidata":"https://www.wikidata.org/wiki/Q7914515","display_name":"Vandetanib","level":4,"score":0.3732999861240387},{"id":"https://openalex.org/C3020495827","wikidata":"https://www.wikidata.org/wiki/Q426141","display_name":"Bispecific antibody","level":4,"score":0.3619999885559082},{"id":"https://openalex.org/C2779931791","wikidata":"https://www.wikidata.org/wiki/Q161515","display_name":"DOTA","level":3,"score":0.3587000072002411},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.3452000021934509},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.34360000491142273},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.33970001339912415},{"id":"https://openalex.org/C2984398910","wikidata":"https://www.wikidata.org/wiki/Q849737","display_name":"Spect imaging","level":2,"score":0.3327000141143799},{"id":"https://openalex.org/C2778172261","wikidata":"https://www.wikidata.org/wiki/Q3796563","display_name":"Imaging agent","level":3,"score":0.2922999858856201},{"id":"https://openalex.org/C2777325958","wikidata":"https://www.wikidata.org/wiki/Q1069596","display_name":"Antibody-drug conjugate","level":4,"score":0.2856000065803528},{"id":"https://openalex.org/C33618052","wikidata":"https://www.wikidata.org/wiki/Q6013136","display_name":"In vitro toxicology","level":3,"score":0.2822999954223633},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.27570000290870667},{"id":"https://openalex.org/C2780616701","wikidata":"https://www.wikidata.org/wiki/Q1738547","display_name":"Sodium-iodide symporter","level":5,"score":0.2703999876976013},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.26840001344680786},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.2583000063896179},{"id":"https://openalex.org/C136339569","wikidata":"https://www.wikidata.org/wiki/Q1142297","display_name":"Molecular imaging","level":3,"score":0.2563000023365021},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.2540000081062317},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2513999938964844},{"id":"https://openalex.org/C2776074239","wikidata":"https://www.wikidata.org/wiki/Q2452042","display_name":"Sulforhodamine B","level":4,"score":0.25099998712539673}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/molecules31224050","doi":"https://doi.org/10.3390/molecules31224050","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules31224050","pdf_url":null,"source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/molecules31224050","doi":"https://doi.org/10.3390/molecules31224050","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules31224050","pdf_url":null,"source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1877385522","https://openalex.org/W1992160817","https://openalex.org/W2057893793","https://openalex.org/W2058426435","https://openalex.org/W2062524026","https://openalex.org/W2087683552","https://openalex.org/W2107484016","https://openalex.org/W2134413630","https://openalex.org/W2136859769","https://openalex.org/W2141349882","https://openalex.org/W2183147143","https://openalex.org/W2211363142","https://openalex.org/W2261927058","https://openalex.org/W2292383635","https://openalex.org/W2514976083","https://openalex.org/W2591239368","https://openalex.org/W2592055368","https://openalex.org/W2753432434","https://openalex.org/W2811406217","https://openalex.org/W2896600825","https://openalex.org/W2901272595","https://openalex.org/W2932851203","https://openalex.org/W2998501963","https://openalex.org/W3041475372","https://openalex.org/W3046619543","https://openalex.org/W3090720142","https://openalex.org/W3132448761","https://openalex.org/W4214759617","https://openalex.org/W4220849979","https://openalex.org/W4292181683","https://openalex.org/W4294958569","https://openalex.org/W4319333937","https://openalex.org/W4386407405","https://openalex.org/W4387044793","https://openalex.org/W4388301698","https://openalex.org/W4389617830","https://openalex.org/W4401250146","https://openalex.org/W4403966256","https://openalex.org/W7126121022"],"related_works":[],"abstract_inverted_index":{"Accurate":[0],"non-invasive":[1],"assessment":[2],"of":[3,17,115,133],"PD-L1":[4,31,116,125,204],"expression":[5],"and":[6,14,33,47,112,120,143,166,184],"function":[7],"remains":[8],"challenging":[9],"due":[10],"to":[11,44,192],"tumor":[12,76],"heterogeneity":[13],"the":[15,91,167,179],"limitations":[16],"conventional":[18],"biopsy-based":[19],"studies.":[20,65],"Here,":[21],"we":[22],"present":[23],"a":[24,59,67,85,98,127,131,138,160,175,188,200],"modular":[25,201],"platform":[26,202],"based":[27],"on":[28],"atezolizumab":[29,134],"for":[30,62,105,129,182,203],"imaging":[32,183],"radiopharmaceutical":[34,209],"evaluation":[35],"in":[36,57,63,106,145,172,195],"melanoma":[37],"models.":[38],"Atezolizumab":[39],"was":[40,103,141,169],"functionalized":[41],"with":[42,53,71,81,135,159,174],"trans-cyclooctene":[43],"allow":[45],"rapid":[46],"selective":[48],"conjugation,":[49],"via":[50,137],"inverse-demand":[51],"Diels\u2013Alder,":[52],"99mTc-HYNIC-tetrazine":[54],"probes,":[55],"generating":[56],"situ":[58],"SPECT":[60],"probe":[61],"vivo":[64],"In":[66],"syngeneic":[68],"C57BL/6J":[69],"model":[70],"Tm1":[72,152],"cells,":[73],"pretargeting":[74],"allowed":[75],"detection":[77],"at":[78,90,147],"4":[79],"h":[80],"heterogeneous":[82],"intratumoral":[83],"uptake;":[84],"directly":[86],"labeled":[87],"antibody":[88,181],"evaluated":[89,144],"same":[92,180],"time":[93],"point":[94],"is":[95],"reported":[96],"as":[97,126],"reference.":[99],"Cy5-tetrazine-enabled":[100],"fluorescence":[101],"labeling":[102],"used":[104],"vitro":[107],"studies,":[108],"i.e.,":[109],"flow":[110],"cytometry":[111],"quantitative":[113],"analysis":[114],"status":[117],"under":[118],"basal":[119],"interferon-\u03b3-stimulated":[121],"conditions.":[122],"To":[123],"analyze":[124],"target":[128],"radiotherapy,":[130],"conjugate":[132],"lutetium-177,":[136],"DOTA":[139],"chelator,":[140],"developed":[142],"vitro:":[146],"0.55":[148],"MBq,":[149],"it":[150],"reduced":[151],"cell":[153],"viability":[154],"more":[155],"than":[156],"free":[157],"177LuCl3,":[158],"greater":[161],"effect":[162,168],"after":[163],"interferon-\u03b3":[164],"stimulation,":[165],"further":[170,208],"increased":[171],"combination":[173],"PARP":[176],"inhibitor.":[177],"Using":[178],"radionuclide-based":[185],"cytotoxicity":[186],"suggests":[187],"potential":[189],"theranostic":[190],"application,":[191],"be":[193],"validated":[194],"vivo.":[196],"This":[197],"work":[198],"describes":[199],"interrogation":[205],"that":[206],"supports":[207],"development.":[210]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
