{"id":"https://openalex.org/W7225835119","doi":"https://doi.org/10.1002/jsfa.71210","title":"Whey protein hydrolysate alleviates ovalbumin\u2010induced allergic responses in Brown Norway rats: associations with immunoglobulin E\u2010related responses and the gut microbiota\u2013short\u2010chain fatty acid axis","display_name":"Whey protein hydrolysate alleviates ovalbumin\u2010induced allergic responses in Brown Norway rats: associations with immunoglobulin E\u2010related responses and the gut microbiota\u2013short\u2010chain fatty acid axis","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225835119","doi":"https://doi.org/10.1002/jsfa.71210","pmid":"https://pubmed.ncbi.nlm.nih.gov/43010143"},"language":"en","primary_location":{"id":"doi:10.1002/jsfa.71210","doi":"https://doi.org/10.1002/jsfa.71210","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jsfa.71210","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jsfa.71210","source":{"id":"https://openalex.org/S206298197","display_name":"Journal of the Science of Food and Agriculture","issn_l":"0022-5142","issn":["0022-5142","1097-0010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Science of Food and Agriculture","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jsfa.71210","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100619769","display_name":"Yi Wang","orcid":"https://orcid.org/0000-0002-9149-9024","observed_orcids":["https://orcid.org/0000-0002-9149-9024"]},"institutions":[{"id":"https://openalex.org/I4210163645","display_name":"China National Research Institute of Food and Fermentation","ror":"https://ror.org/059nf5421","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210163645"]},{"id":"https://openalex.org/I49496784","display_name":"Beijing City University","ror":"https://ror.org/01jfjwr55","country_code":"CN","type":"education","lineage":["https://openalex.org/I49496784"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Wang","raw_affiliation_strings":["Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China","School of Biomedicine Beijing City University  Beijing China","State Key Laboratory of Dairy Biotechnology, Shanghai Engineering Research Center of Dairy Biotechnology, Dairy Research Institute, Bright Dairy & Food Co., Ltd Shanghai China"],"raw_orcid":"https://orcid.org/0009-0005-8595-0420","affiliations":[{"raw_affiliation_string":"Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China","institution_ids":["https://openalex.org/I4210163645"]},{"raw_affiliation_string":"School of Biomedicine Beijing City University  Beijing China","institution_ids":["https://openalex.org/I49496784"]},{"raw_affiliation_string":"State Key Laboratory of Dairy Biotechnology, Shanghai Engineering Research Center of Dairy Biotechnology, Dairy Research Institute, Bright Dairy & Food Co., Ltd Shanghai China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161485414","display_name":"Xinze Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163645","display_name":"China National Research Institute of Food and Fermentation","ror":"https://ror.org/059nf5421","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210163645"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinze Wang","raw_affiliation_strings":["Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China","institution_ids":["https://openalex.org/I4210163645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125612312","display_name":"Liang Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163645","display_name":"China National Research Institute of Food and Fermentation","ror":"https://ror.org/059nf5421","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210163645"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Chen","raw_affiliation_strings":["Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China","institution_ids":["https://openalex.org/I4210163645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161452402","display_name":"Xinxue Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163645","display_name":"China National Research Institute of Food and Fermentation","ror":"https://ror.org/059nf5421","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210163645"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinxue Zhang","raw_affiliation_strings":["Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China","institution_ids":["https://openalex.org/I4210163645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161450152","display_name":"Runqi Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163645","display_name":"China National Research Institute of Food and Fermentation","ror":"https://ror.org/059nf5421","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210163645"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Runqi Xu","raw_affiliation_strings":["Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China","institution_ids":["https://openalex.org/I4210163645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161451564","display_name":"Yurong Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163645","display_name":"China National Research Institute of Food and Fermentation","ror":"https://ror.org/059nf5421","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210163645"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yurong Ma","raw_affiliation_strings":["Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China","institution_ids":["https://openalex.org/I4210163645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161490306","display_name":"Yan Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163645","display_name":"China National Research Institute of Food and Fermentation","ror":"https://ror.org/059nf5421","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210163645"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Jiang","raw_affiliation_strings":["Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China","institution_ids":["https://openalex.org/I4210163645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161494748","display_name":"Guoming Li","orcid":"https://orcid.org/0009-0003-4389-6863","observed_orcids":["https://orcid.org/0009-0003-4389-6863"]},"institutions":[{"id":"https://openalex.org/I4210163645","display_name":"China National Research Institute of Food and Fermentation","ror":"https://ror.org/059nf5421","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210163645"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoming Li","raw_affiliation_strings":["Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China"],"raw_orcid":"https://orcid.org/0009-0003-4389-6863","affiliations":[{"raw_affiliation_string":"Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China","institution_ids":["https://openalex.org/I4210163645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161486774","display_name":"Rongrong Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49496784","display_name":"Beijing City University","ror":"https://ror.org/01jfjwr55","country_code":"CN","type":"education","lineage":["https://openalex.org/I49496784"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongrong Tian","raw_affiliation_strings":["School of Biomedicine Beijing City University  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedicine Beijing City University  Beijing China","institution_ids":["https://openalex.org/I49496784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102418447","display_name":"Ruizeng Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163645","display_name":"China National Research Institute of Food and Fermentation","ror":"https://ror.org/059nf5421","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210163645"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruizeng Gu","raw_affiliation_strings":["Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China","institution_ids":["https://openalex.org/I4210163645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101693826","display_name":"Wenying Liu","orcid":"https://orcid.org/0000-0001-8369-0809","observed_orcids":["https://orcid.org/0000-0001-8369-0809"]},"institutions":[{"id":"https://openalex.org/I4210163645","display_name":"China National Research Institute of Food and Fermentation","ror":"https://ror.org/059nf5421","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210163645"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenying Liu","raw_affiliation_strings":["Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China","State Key Laboratory of Dairy Biotechnology, Shanghai Engineering Research Center of Dairy Biotechnology, Dairy Research Institute, Bright Dairy & Food Co., Ltd Shanghai China"],"raw_orcid":"https://orcid.org/0000-0001-8369-0809","affiliations":[{"raw_affiliation_string":"Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China","institution_ids":["https://openalex.org/I4210163645"]},{"raw_affiliation_string":"State Key Laboratory of Dairy Biotechnology, Shanghai Engineering Research Center of Dairy Biotechnology, Dairy Research Institute, Bright Dairy & Food Co., Ltd Shanghai China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101326281","display_name":"Ganlu Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163645","display_name":"China National Research Institute of Food and Fermentation","ror":"https://ror.org/059nf5421","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210163645"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ganlu Meng","raw_affiliation_strings":["Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China","State Key Laboratory of Dairy Biotechnology, Shanghai Engineering Research Center of Dairy Biotechnology, Dairy Research Institute, Bright Dairy & Food Co., Ltd Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Engineering Research Center of Protein & Functional Peptides China National Research Institute of Food and Fermentation Industries Beijing China","institution_ids":["https://openalex.org/I4210163645"]},{"raw_affiliation_string":"State Key Laboratory of Dairy Biotechnology, Shanghai Engineering Research Center of Dairy Biotechnology, Dairy Research Institute, Bright Dairy & Food Co., Ltd Shanghai China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101326281","https://openalex.org/A5101693826"],"corresponding_institution_ids":["https://openalex.org/I4210163645"],"apc_list":{"value":4620,"currency":"USD","value_usd":4620},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.8740000128746033,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.8740000128746033,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.11940000206232071,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C28800991","wikidata":"https://www.wikidata.org/wiki/Q15634405","display_name":"Hydrolysate","level":3,"score":0.906499981880188},{"id":"https://openalex.org/C2777897731","wikidata":"https://www.wikidata.org/wiki/Q424430","display_name":"Whey protein","level":2,"score":0.7452999949455261},{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.673799991607666},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6340000033378601},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.5523999929428101},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.5468999743461609},{"id":"https://openalex.org/C2776027960","wikidata":"https://www.wikidata.org/wiki/Q769815","display_name":"Food allergy","level":3,"score":0.39489999413490295},{"id":"https://openalex.org/C2776953665","wikidata":"https://www.wikidata.org/wiki/Q4732121","display_name":"Allergic response","level":4,"score":0.39410001039505005},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.3935999870300293},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.3702000081539154},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35679998993873596},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.34150001406669617},{"id":"https://openalex.org/C2775900134","wikidata":"https://www.wikidata.org/wiki/Q424430","display_name":"Whey protein isolate","level":3,"score":0.33739998936653137},{"id":"https://openalex.org/C49802076","wikidata":"https://www.wikidata.org/wiki/Q5251810","display_name":"Degranulation","level":3,"score":0.33230000734329224},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3199999928474426},{"id":"https://openalex.org/C2779675166","wikidata":"https://www.wikidata.org/wiki/Q4732119","display_name":"Allergic inflammation","level":3,"score":0.30889999866485596},{"id":"https://openalex.org/C53270655","wikidata":"https://www.wikidata.org/wiki/Q5381536","display_name":"Enzymatic hydrolysis","level":3,"score":0.3050000071525574},{"id":"https://openalex.org/C2780375986","wikidata":"https://www.wikidata.org/wiki/Q904015","display_name":"Hyaluronidase","level":3,"score":0.29260000586509705},{"id":"https://openalex.org/C2780124430","wikidata":"https://www.wikidata.org/wiki/Q3827578","display_name":"Beta-lactoglobulin","level":3,"score":0.27649998664855957},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.27399998903274536},{"id":"https://openalex.org/C2779102806","wikidata":"https://www.wikidata.org/wiki/Q79453","display_name":"Immunoglobulin A","level":4,"score":0.2621000111103058}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/jsfa.71210","doi":"https://doi.org/10.1002/jsfa.71210","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jsfa.71210","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jsfa.71210","source":{"id":"https://openalex.org/S206298197","display_name":"Journal of the Science of Food and Agriculture","issn_l":"0022-5142","issn":["0022-5142","1097-0010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Science of Food and Agriculture","raw_type":"journal-article"},{"id":"pmid:43010143","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43010143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the science of food and agriculture","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/jsfa.71210","doi":"https://doi.org/10.1002/jsfa.71210","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jsfa.71210","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jsfa.71210","source":{"id":"https://openalex.org/S206298197","display_name":"Journal of the Science of Food and Agriculture","issn_l":"0022-5142","issn":["0022-5142","1097-0010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Science of Food and Agriculture","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225835119.pdf","grobid_xml":"https://content.openalex.org/works/W7225835119.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1612783620","https://openalex.org/W1994832965","https://openalex.org/W2006846976","https://openalex.org/W2046298241","https://openalex.org/W2046632681","https://openalex.org/W2075667750","https://openalex.org/W2079133013","https://openalex.org/W2086202493","https://openalex.org/W2106650548","https://openalex.org/W2124314316","https://openalex.org/W2134562205","https://openalex.org/W2165654065","https://openalex.org/W2495700953","https://openalex.org/W2565119984","https://openalex.org/W2768181949","https://openalex.org/W2772177779","https://openalex.org/W2772340482","https://openalex.org/W2783754831","https://openalex.org/W2898990880","https://openalex.org/W2996851759","https://openalex.org/W2998284591","https://openalex.org/W3096518302","https://openalex.org/W3133693224","https://openalex.org/W3160116455","https://openalex.org/W3174536316","https://openalex.org/W3177765859","https://openalex.org/W4220920857","https://openalex.org/W4225274134","https://openalex.org/W4249254779","https://openalex.org/W4252284692","https://openalex.org/W4306292682","https://openalex.org/W4386304101","https://openalex.org/W4392100952","https://openalex.org/W4392429960","https://openalex.org/W4393398521","https://openalex.org/W4401057114","https://openalex.org/W4401662634","https://openalex.org/W4405260882","https://openalex.org/W4414619451","https://openalex.org/W7084063679"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Whey":[2,86,147,190,235],"protein":[3,87,98,148,191,236],"hydrolysate":[4,88,149,192,237],"(WPH)":[5],"has":[6],"considerable":[7],"potential":[8,30,77,263],"as":[9,264],"a":[10,143,265],"functional":[11,266],"food":[12,267],"ingredient;":[13],"however,":[14],"its":[15,50,262],"role":[16,31],"in":[17,55,66,79,125,168],"alleviating":[18],"allergic":[19,53,58,239,244,250],"responses":[20,54,240],"and":[21,35,61,69,113,136,180,195,205,213,227,249,253,259],"the":[22,29,41,63,80,101,114,224],"underlying":[23],"mechanisms":[24],"remain":[25],"insufficiently":[26],"understood,":[27],"particularly":[28],"of":[32,44,83,272],"gut":[33,67,256],"microbiota":[34,68],"their":[36,76],"metabolites.":[37],"This":[38],"study":[39],"characterized":[40],"structural":[42],"changes":[43,65],"WPH":[45,173,221],"following":[46],"enzymatic":[47,93],"hydrolysis,":[48],"evaluated":[49],"effects":[51,82],"on":[52],"an":[56,163],"ovalbumin\u2010induced":[57],"rat":[59],"model,":[60],"investigated":[62],"associated":[64],"short\u2010chain":[70],"fatty":[71],"acids":[72],"(SCFAs)":[73],"to":[74,108,121,129,134,140],"explore":[75],"involvement":[78],"antiallergic":[81],"WPH.":[84],"Results":[85],"was":[89,174],"prepared":[90],"by":[91,241],"two\u2010step":[92],"hydrolysis.":[94],"Compared":[95],"with":[96,123],"whey":[97],"isolate":[99],"(WPI),":[100],"amide":[102],"I":[103],"band":[104],"shifted":[105],"from":[106,119],"1651.85":[107],"1654.62":[109],"cm":[110],"\u22121":[111,160,184,186],",":[112],"\u03b1":[115],"\u2010helix":[116],"content":[117],"decreased":[118],"34.67%":[120],"23.23%,":[122],"increases":[124],"\u03b2":[126,131,206],"\u2010sheet":[127],"(10.69%":[128],"15.66%),":[130],"\u2010turn":[132],"(11.03%":[133],"12.63%),":[135],"random":[137],"coil":[138],"(43.61%":[139],"48.40%),":[141],"indicating":[142],"more":[144],"flexible":[145],"conformation.":[146],"inhibited":[150],"hyaluronidase":[151],"concentration\u2010dependently,":[152],"reaching":[153],"70%":[154],"inhibition":[155],"at":[156,177],"60":[157],"g":[158],"L":[159],".":[161],"In":[162],"ovalbumin":[164],"(OVA)\u2010induced":[165],"allergy":[166],"model":[167],"Brown":[169],"Norway":[170],"(BN)":[171],"rats,":[172],"administered":[175],"orally":[176],"200,":[178],"500,":[179],"1000":[181],"mg":[182],"kg":[183],"day":[185],"for":[187],"42":[188],"days.":[189],"attenuated":[193],"hypothermia":[194],"reduced":[196],"serum":[197],"immunoglobulin":[198],"E":[199],"(IgE),":[200],"OVA\u2010specific":[201],"IgE":[202],"(sIgE),":[203],"histamine,":[204],"\u2010hexosaminidase":[207],"levels,":[208],"while":[209],"ameliorating":[210],"jejunal":[211],"damage":[212],"mast":[214],"cell":[215],"degranulation":[216],"(":[217,230],"P":[218,231],"<":[219,232],"0.05).":[220,233],"also":[222],"increased":[223],"Richness,":[225],"ACE,":[226],"Chao1":[228],"indices":[229],"Conclusion":[234],"alleviated":[238],"attenuating":[242],"systemic":[243],"responses,":[245],"reducing":[246],"mast\u2010cell":[247],"activation":[248],"mediator":[251],"release,":[252],"partially":[254],"restoring":[255],"microbial":[257],"richness":[258],"diversity,":[260],"supporting":[261],"ingredient.":[268],"\u00a9":[269],"2026":[270],"Society":[271],"Chemical":[273],"Industry.":[274]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}