{"id":"https://openalex.org/W7225834732","doi":"https://doi.org/10.64898/2026.11.09.765501","title":"Sleep deprivation differentially recruits amygdala subregions in male and female mice","display_name":"Sleep deprivation differentially recruits amygdala subregions in male and female mice","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225834732","doi":"https://doi.org/10.64898/2026.11.09.765501"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.09.765501","doi":"https://doi.org/10.64898/2026.11.09.765501","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.11.09.765501","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090574545","display_name":"Nikita K. Koziel Ly","orcid":"https://orcid.org/0000-0002-2889-9973","observed_orcids":["https://orcid.org/0000-0002-2889-9973"]},"institutions":[{"id":"https://openalex.org/I67031392","display_name":"Carleton University","ror":"https://ror.org/02qtvee93","country_code":"CA","type":"education","lineage":["https://openalex.org/I67031392"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nikita K Koziel Ly","raw_affiliation_strings":["Department of Neuroscience, Carleton University, Ottawa, ON, K1S 5B6, Canada;"],"raw_orcid":"https://orcid.org/0000-0002-2889-9973","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Carleton University, Ottawa, ON, K1S 5B6, Canada;","institution_ids":["https://openalex.org/I67031392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108145150","display_name":"Chia-Luen Leu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Chia-Luen Leu","raw_affiliation_strings":["Institute of Neurogenomics, Helmholtz Zentrum M\u00fcnchen, 85764 Neuherberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurogenomics, Helmholtz Zentrum M\u00fcnchen, 85764 Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003094513","display_name":"Daniel D. Lam","orcid":"https://orcid.org/0000-0001-8593-3157","observed_orcids":["https://orcid.org/0000-0001-8593-3157"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel D Lam","raw_affiliation_strings":["Institute of Neurogenomics, Helmholtz Zentrum M\u00fcnchen, 85764 Neuherberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurogenomics, Helmholtz Zentrum M\u00fcnchen, 85764 Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080124435","display_name":"Violetta Molokopoy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67031392","display_name":"Carleton University","ror":"https://ror.org/02qtvee93","country_code":"CA","type":"education","lineage":["https://openalex.org/I67031392"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Violetta Molokopoy","raw_affiliation_strings":["Department of Neuroscience, Carleton University, Ottawa, ON, K1S 5B6, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Carleton University, Ottawa, ON, K1S 5B6, Canada;","institution_ids":["https://openalex.org/I67031392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026354741","display_name":"Rh\u00eeannan H. Williams","orcid":"https://orcid.org/0000-0002-3667-706X","observed_orcids":["https://orcid.org/0000-0002-3667-706X"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rh\u00eeannan H Williams","raw_affiliation_strings":["Institute of Neurogenomics, Helmholtz Zentrum M\u00fcnchen, 85764 Neuherberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurogenomics, Helmholtz Zentrum M\u00fcnchen, 85764 Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010229707","display_name":"Melissa J. S. Chee","orcid":"https://orcid.org/0000-0003-3815-9095","observed_orcids":["https://orcid.org/0000-0003-3815-9095"]},"institutions":[{"id":"https://openalex.org/I67031392","display_name":"Carleton University","ror":"https://ror.org/02qtvee93","country_code":"CA","type":"education","lineage":["https://openalex.org/I67031392"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Melissa J Chee","raw_affiliation_strings":["Department of Neuroscience, Carleton University, Ottawa, ON, K1S 5B6, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Carleton University, Ottawa, ON, K1S 5B6, Canada;","institution_ids":["https://openalex.org/I67031392"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.9208999872207642},{"id":"https://openalex.org/C2780451725","wikidata":"https://www.wikidata.org/wiki/Q4867818","display_name":"Basolateral amygdala","level":3,"score":0.8111000061035156},{"id":"https://openalex.org/C2778329153","wikidata":"https://www.wikidata.org/wiki/Q1364801","display_name":"Sleep deprivation","level":3,"score":0.6686999797821045},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.5990999937057495},{"id":"https://openalex.org/C2779213384","wikidata":"https://www.wikidata.org/wiki/Q211402","display_name":"Rapid eye movement sleep","level":3,"score":0.47130000591278076},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.46950000524520874},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41589999198913574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4066999852657318},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4036000072956085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3321000039577484},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.30720001459121704},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27570000290870667},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2615000009536743},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.2583000063896179},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.2574999928474426}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.09.765501","doi":"https://doi.org/10.64898/2026.11.09.765501","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.11.09.765501","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Sleep":[0],"deprivation":[1],"(SD)":[2],"acutely":[3],"increases":[4],"negative":[5],"affect,":[6],"and":[7,26,28,101,116,134,183,187,216],"chronic":[8],"insufficient":[9],"sleep":[10,37,62,95,214],"is":[11],"associated":[12],"with":[13,92,167,193],"an":[14],"increased":[15,106,157,174],"risk":[16],"of":[17,60,68,98,113,201],"depression.":[18],"Since":[19],"the":[20,46,58,65,75,110,126,179,184],"amygdala":[21,33,127,182,203],"regulates":[22],"both":[23,114,188],"emotional":[24,40,211],"processing":[25,212],"sleep,":[27],"SD":[29,91,156,171],"dysregulates":[30],"amygdalar":[31,49,70,123,140,162],"function,":[32],"functionality":[34],"may":[35,206],"link":[36],"loss":[38,63,215],"to":[39,52,122,208],"outcomes.":[41],"To":[42,56],"better":[43],"understand":[44],"this,":[45],"specific":[47,69],"sleep-impacted":[48],"nuclei":[50],"need":[51],"be":[53],"fully":[54],"defined.":[55],"determine":[57],"impact":[59],"acute":[61],"on":[64],"relative":[66],"activation":[67],"regions,":[71],"we":[72,132,143],"screened":[73],"for":[74,221],"neuronal":[76],"activity":[77],"marker":[78],"c-Fos":[79,107,136,148,158,175],"in":[80,172,178,210],"wildtype":[81],"mice":[82,118],"that":[83,119,145],"slept":[84],"undisturbed,":[85],"underwent":[86],"4-h":[87,90],"SD,":[88],"or":[89],"2-h":[93],"recovery":[94],"(RS).":[96],"Application":[97],"whole-brain":[99],"clearing":[100],"automated":[102],"cell":[103],"counting":[104],"identified":[105],"expression":[108,137,149,159,176],"within":[109,138],"cortical":[111],"subplate":[112],"male":[115,154],"female":[117],"was":[120],"localized":[121],"regions.":[124],"As":[125],"comprises":[128],"multiple":[129],"distinct":[130],"subnuclei,":[131,163],"parcellated":[133],"quantified":[135],"each":[139],"subnucleus.":[141],"Interestingly,":[142],"found":[144],"SD-induced":[146],"differential":[147],"patterns":[150],"between":[151],"sexes.":[152],"In":[153],"mice,":[155],"across":[160],"several":[161],"which":[164,205],"largely":[165],"reversed":[166],"RS.":[168,194],"By":[169],"contrast,":[170],"females":[173],"only":[177],"anterior":[180],"basolateral":[181],"intercalated":[185],"amygdala,":[186],"subnuclei":[189],"remained":[190],"activated":[191],"even":[192],"These":[195],"findings":[196],"highlight":[197],"sex-specific":[198],"spatial":[199],"distribution":[200],"SD-activated":[202],"cells,":[204],"contribute":[207],"differences":[209],"following":[213],"offer":[217],"potential":[218],"anatomical":[219],"targets":[220],"mitigating":[222],"SD-related":[223],"mood":[224],"deficits.":[225]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}