{"id":"https://openalex.org/W7225834246","doi":"https://doi.org/10.1002/exp2.70250","title":"A Cuproptosis Nanoparticle Reverses Lung Adenocarcinoma Drug Resistance","display_name":"A Cuproptosis Nanoparticle Reverses Lung Adenocarcinoma Drug Resistance","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225834246","doi":"https://doi.org/10.1002/exp2.70250"},"language":"en","primary_location":{"id":"doi:10.1002/exp2.70250","doi":"https://doi.org/10.1002/exp2.70250","is_oa":true,"landing_page_url":"https://doi.org/10.1002/exp2.70250","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/exp2.70250","source":{"id":"https://openalex.org/S4210208535","display_name":"Exploration","issn_l":"2766-2098","issn":["2766-2098","2766-8509"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","oarl"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exploration","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/exp2.70250","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161454724","display_name":"Leilei Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Leilei Wu","raw_affiliation_strings":["Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai P. R. China","Department of Thoracic Surgery Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai P. R. China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]},{"raw_affiliation_string":"Department of Thoracic Surgery Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou P. R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210098734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161491659","display_name":"Kun Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Li","raw_affiliation_strings":["Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai P. R. China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100452757","display_name":"Han Wang","orcid":"https://orcid.org/0000-0003-3102-4235","observed_orcids":["https://orcid.org/0000-0003-3102-4235"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Han Wang","raw_affiliation_strings":["Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153012047","display_name":"Shangshang Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shangshang Ma","raw_affiliation_strings":["Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai P. R. China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058843753","display_name":"Rangrang Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rangrang Wang","raw_affiliation_strings":["Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai P. R. China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122029585","display_name":"Yongfei Fan","orcid":"https://orcid.org/0000-0002-7759-2505","observed_orcids":["https://orcid.org/0000-0002-7759-2505"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongfei Fan","raw_affiliation_strings":["Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai P. R. China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050555102","display_name":"Xichun Qin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xichun Qin","raw_affiliation_strings":["Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai P. R. China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149981332","display_name":"Mingjun Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingjun Li","raw_affiliation_strings":["Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai P. R. China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008465406","display_name":"Diego Gonz\u00e1lez-Rivas","orcid":"https://orcid.org/0000-0002-2436-2570","observed_orcids":["https://orcid.org/0000-0002-2436-2570","https://orcid.org/0009-0004-6026-0274"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Diego Gonzalez\u2010Rivas","raw_affiliation_strings":["Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai P. R. China","Department of Thoracic Surgery and Minimally Invasive Thoracic Surgery Unit Coru\u00f1a University Hospital  Coru\u00f1a Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai P. R. China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]},{"raw_affiliation_string":"Department of Thoracic Surgery and Minimally Invasive Thoracic Surgery Unit Coru\u00f1a University Hospital  Coru\u00f1a Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065250460","display_name":"Xiuru Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiuru Ji","raw_affiliation_strings":["Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052184500","display_name":"Ni Dalong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]},{"id":"https://openalex.org/I4210092817","display_name":"Suzhou Institute of Biomedical Engineering and Technology","ror":"https://ror.org/00f58mx93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210092817"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dalong Ni","raw_affiliation_strings":["Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China","Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences  Suzhou P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]},{"raw_affiliation_string":"Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences  Suzhou P. R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210092817"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161424072","display_name":"Dong Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dong Xie","raw_affiliation_strings":["Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai P. R. China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5052184500","https://openalex.org/A5100452757","https://openalex.org/A5161424072"],"corresponding_institution_ids":["https://openalex.org/I116953780","https://openalex.org/I183067930","https://openalex.org/I19820366","https://openalex.org/I2801556517","https://openalex.org/I4210092817","https://openalex.org/I4210127126"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.5268999934196472,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.5268999934196472,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.21369999647140503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.09629999846220016,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7297999858856201},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6291000247001648},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5885000228881836},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5791000127792358},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.46619999408721924},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.46399998664855957},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4077000021934509},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4023999869823456},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38339999318122864},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.37790000438690186},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.37770000100135803},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3684000074863434},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.3537999987602234},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.3537999987602234},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.337799996137619},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.3359000086784363},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3357999920845032},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.32589998841285706},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.2897000014781952},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2802000045776367},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.2574999928474426}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/exp2.70250","doi":"https://doi.org/10.1002/exp2.70250","is_oa":true,"landing_page_url":"https://doi.org/10.1002/exp2.70250","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/exp2.70250","source":{"id":"https://openalex.org/S4210208535","display_name":"Exploration","issn_l":"2766-2098","issn":["2766-2098","2766-8509"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","oarl"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exploration","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/exp2.70250","doi":"https://doi.org/10.1002/exp2.70250","is_oa":true,"landing_page_url":"https://doi.org/10.1002/exp2.70250","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/exp2.70250","source":{"id":"https://openalex.org/S4210208535","display_name":"Exploration","issn_l":"2766-2098","issn":["2766-2098","2766-8509"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","oarl"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exploration","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225834246.pdf","grobid_xml":"https://content.openalex.org/works/W7225834246.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1987225761","https://openalex.org/W2095761326","https://openalex.org/W2128339707","https://openalex.org/W2766755551","https://openalex.org/W2971095732","https://openalex.org/W2980109711","https://openalex.org/W2999810289","https://openalex.org/W3011410517","https://openalex.org/W3028421969","https://openalex.org/W3081154089","https://openalex.org/W3087210493","https://openalex.org/W3087229737","https://openalex.org/W3120172300","https://openalex.org/W3157480760","https://openalex.org/W3165760432","https://openalex.org/W3173190061","https://openalex.org/W3183709015","https://openalex.org/W3202865057","https://openalex.org/W4205552366","https://openalex.org/W4205714528","https://openalex.org/W4206804220","https://openalex.org/W4220757518","https://openalex.org/W4221115671","https://openalex.org/W4221126430","https://openalex.org/W4294316884","https://openalex.org/W4309477688","https://openalex.org/W4310045066","https://openalex.org/W4312220285","https://openalex.org/W4319337483","https://openalex.org/W4324017473","https://openalex.org/W4366261694","https://openalex.org/W4386694117","https://openalex.org/W4389778502","https://openalex.org/W4390341514","https://openalex.org/W4390584866","https://openalex.org/W4391814898","https://openalex.org/W4392243634","https://openalex.org/W4392354672","https://openalex.org/W4401170002","https://openalex.org/W4401824769","https://openalex.org/W4402204513","https://openalex.org/W4402323174","https://openalex.org/W4402646488","https://openalex.org/W4404769339","https://openalex.org/W4404928863","https://openalex.org/W4405728678","https://openalex.org/W4406081169","https://openalex.org/W4406338100","https://openalex.org/W7122861802","https://openalex.org/W7160632429","https://openalex.org/W7220726438"],"related_works":[],"abstract_inverted_index":{"ABSTRACT":[0],"Residual":[1],"tumors":[2],"that":[3,27,91,143],"received":[4],"targeted":[5,113],"therapy":[6],"often":[7],"evolve":[8],"into":[9],"drug":[10,44,60,78,187],"resistance,":[11],"with":[12,84,168],"an":[13,150],"increasing":[14],"risk":[15],"of":[16,67,97],"recurrence":[17],"and":[18,75,138,153],"metastasis.":[19],"By":[20,80],"analyzing":[21],"patient":[22],"data,":[23],"it":[24],"is":[25,56],"found":[26],"KRAS":[28],"\u2010mutated":[29,52],"lung":[30,178],"adenocarcinoma":[31,179],"(LUAD)":[32],"exhibits":[33],"a":[34,63,94,112,122,169,182],"worse":[35],"survival":[36],"rate":[37],"than":[38],"wild\u2010type":[39],"LUAD.":[40],"Although":[41],"the":[42,154],"clinical":[43],"AMG\u2010510":[45,166],"has":[46],"been":[47],"approved":[48],"to":[49,87,105,109,185],"treat":[50],"KRAS(G12C)":[51],"LUAD,":[53],"its":[54],"effectiveness":[55],"still":[57],"limited":[58],"by":[59],"resistance.":[61,79,188],"Cuproptosis,":[62],"newly":[64],"identified":[65],"mode":[66],"cellular":[68],"death,":[69],"shows":[70],"promise":[71],"in":[72,76,101,136,139,149,176],"cancer":[73],"treatment":[74],"reversing":[77],"comparing":[81],"cell":[82,103],"lines":[83,104],"different":[85],"sensitivities":[86],"AMG\u2010510,":[88],"we":[89],"discovered":[90],"ATP7B":[92,161],",":[93,162],"key":[95],"regulator":[96],"cuproptosis,":[98],"was":[99,119],"up\u2010regulated":[100],"AMG\u2010510\u2010resistant":[102],"decrease":[106],"their":[107],"sensitivity":[108],"cuproptosis.":[110],"Therefore,":[111],"sensitization":[114],"strategy":[115,184],"focused":[116],"on":[117,126],"cuproptosis":[118,157,175],"proposed":[120],"using":[121],"single":[123],"nanoparticle":[124],"based":[125],"bovine":[127],"serum":[128],"albumin":[129],"encapsulating":[130],"copper":[131,147],"ions":[132,148],"(termed":[133],"CuNPs).":[134],"Both":[135],"vitro":[137],"vivo":[140],"results":[141],"demonstrated":[142],"these":[144],"nanoparticles":[145],"released":[146],"acidic":[151],"environment,":[152],"following":[155],"CuNP\u2010triggered":[156],"could":[158],"effectively":[159],"down\u2010regulated":[160],"which":[163],"successfully":[164],"overcame":[165],"resistance":[167],"synergistic":[170],"antitumor":[171],"effect.":[172],"Collectively,":[173],"targeting":[174],"KRAS\u2010mutated":[177],"emerges":[180],"as":[181],"compelling":[183],"address":[186]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}