{"id":"https://openalex.org/W7225833687","doi":"https://doi.org/10.1186/s12877-026-08642-w","title":"Orthogeriatric admission biomarker profiles across hip fragility fracture phenotypes: a real-world cohort study","display_name":"Orthogeriatric admission biomarker profiles across hip fragility fracture phenotypes: a real-world cohort study","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225833687","doi":"https://doi.org/10.1186/s12877-026-08642-w"},"language":"en","primary_location":{"id":"doi:10.1186/s12877-026-08642-w","doi":"https://doi.org/10.1186/s12877-026-08642-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12877-026-08642-w","pdf_url":null,"source":{"id":"https://openalex.org/S14643628","display_name":"BMC Geriatrics","issn_l":"1471-2318","issn":["1471-2318"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Geriatrics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12877-026-08642-w","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030121254","display_name":"Jos\u00e9 Luis Dinamarca\u2010Montecinos","orcid":"https://orcid.org/0000-0002-0186-5992","observed_orcids":["https://orcid.org/0000-0002-0186-5992"]},"institutions":[{"id":"https://openalex.org/I4210145000","display_name":"Hospital Dr. Gustavo Fricke","ror":"https://ror.org/04dr2j587","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I4210145000"]},{"id":"https://openalex.org/I79274474","display_name":"University of Valpara\u00edso","ror":"https://ror.org/00h9jrb69","country_code":"CL","type":"education","lineage":["https://openalex.org/I79274474"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Jos\u00e9 Luis Dinamarca-Montecinos","raw_affiliation_strings":["Orthogeriatric Program, Adult Orthopaedics and Traumatology Department, Dr. Gustavo Fricke Hospital, Vi\u00f1a del Mar, \u00c1lvarez, 1532, Chile","School of Medicine, University of Valpara\u00edso, Angamos 655, Vi\u00f1a del Mar, Chile"],"raw_orcid":"https://orcid.org/0000-0002-0186-5992","affiliations":[{"raw_affiliation_string":"Orthogeriatric Program, Adult Orthopaedics and Traumatology Department, Dr. Gustavo Fricke Hospital, Vi\u00f1a del Mar, \u00c1lvarez, 1532, Chile","institution_ids":["https://openalex.org/I4210145000"]},{"raw_affiliation_string":"School of Medicine, University of Valpara\u00edso, Angamos 655, Vi\u00f1a del Mar, Chile","institution_ids":["https://openalex.org/I79274474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117136686","display_name":"Miguel Y\u00e1nez","orcid":"https://orcid.org/0009-0009-2965-5629","observed_orcids":["https://orcid.org/0009-0009-2965-5629"]},"institutions":[{"id":"https://openalex.org/I79274474","display_name":"University of Valpara\u00edso","ror":"https://ror.org/00h9jrb69","country_code":"CL","type":"education","lineage":["https://openalex.org/I79274474"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Miguel Y\u00e1\u00f1ez","raw_affiliation_strings":["Escuela de Ingenier\u00eda Inform\u00e1tica, Universidad de Valpara\u00edso, General Cruz 222, Valpara\u00edso, Chile"],"raw_orcid":"https://orcid.org/0009-0009-2965-5629","affiliations":[{"raw_affiliation_string":"Escuela de Ingenier\u00eda Inform\u00e1tica, Universidad de Valpara\u00edso, General Cruz 222, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027450937","display_name":"Diego Mellado","orcid":"https://orcid.org/0000-0001-8078-253X","observed_orcids":["https://orcid.org/0000-0001-8078-253X"]},"institutions":[{"id":"https://openalex.org/I79274474","display_name":"University of Valpara\u00edso","ror":"https://ror.org/00h9jrb69","country_code":"CL","type":"education","lineage":["https://openalex.org/I79274474"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Diego Mellado","raw_affiliation_strings":["Doctorado de Ciencias e Ingenier\u00eda para la Salud, Universidad de Valpara\u00edso, General Cruz 222, Valpara\u00edso, Chile"],"raw_orcid":"https://orcid.org/0000-0001-8078-253X","affiliations":[{"raw_affiliation_string":"Doctorado de Ciencias e Ingenier\u00eda para la Salud, Universidad de Valpara\u00edso, General Cruz 222, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137090227","display_name":"Constanza Toloza Zamora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145000","display_name":"Hospital Dr. Gustavo Fricke","ror":"https://ror.org/04dr2j587","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I4210145000"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Constanza Toloza Zamora","raw_affiliation_strings":["Clinic Laboratory Unit, Hospital Dr. Gustavo Fricke, Vi\u00f1a del Mar, Chile"],"raw_orcid":"https://orcid.org/0009-0003-8320-2803","affiliations":[{"raw_affiliation_string":"Clinic Laboratory Unit, Hospital Dr. Gustavo Fricke, Vi\u00f1a del Mar, Chile","institution_ids":["https://openalex.org/I4210145000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060109964","display_name":"Ana Aguilera","orcid":"https://orcid.org/0000-0003-0726-1759","observed_orcids":["https://orcid.org/0000-0003-0726-1759"]},"institutions":[{"id":"https://openalex.org/I79274474","display_name":"University of Valpara\u00edso","ror":"https://ror.org/00h9jrb69","country_code":"CL","type":"education","lineage":["https://openalex.org/I79274474"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Ana Aguilera","raw_affiliation_strings":["Doctorado de Ciencias e Ingenier\u00eda para la Salud, Universidad de Valpara\u00edso, General Cruz 222, Valpara\u00edso, Chile","Interdisciplinary Centre for Biomedical Research and Health Engineering \u201cMEDING\u201d, Universidad de Valpara\u00edso, Vi\u00f1a del Mar, Chile"],"raw_orcid":"https://orcid.org/0000-0003-0726-1759","affiliations":[{"raw_affiliation_string":"Doctorado de Ciencias e Ingenier\u00eda para la Salud, Universidad de Valpara\u00edso, General Cruz 222, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]},{"raw_affiliation_string":"Interdisciplinary Centre for Biomedical Research and Health Engineering \u201cMEDING\u201d, Universidad de Valpara\u00edso, Vi\u00f1a del Mar, Chile","institution_ids":["https://openalex.org/I79274474"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043771064","display_name":"Jean-Gabriel Minonzio","orcid":"https://orcid.org/0000-0003-1364-0560","observed_orcids":["https://orcid.org/0000-0003-1364-0560"]},"institutions":[{"id":"https://openalex.org/I79274474","display_name":"University of Valpara\u00edso","ror":"https://ror.org/00h9jrb69","country_code":"CL","type":"education","lineage":["https://openalex.org/I79274474"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Jean-Gabriel Minonzio","raw_affiliation_strings":["Doctorado de Ciencias e Ingenier\u00eda para la Salud, Universidad de Valpara\u00edso, General Cruz 222, Valpara\u00edso, Chile","Escuela de Ingenier\u00eda Inform\u00e1tica, Universidad de Valpara\u00edso, General Cruz 222, Valpara\u00edso, Chile"],"raw_orcid":"https://orcid.org/0000-0003-1364-0560","affiliations":[{"raw_affiliation_string":"Doctorado de Ciencias e Ingenier\u00eda para la Salud, Universidad de Valpara\u00edso, General Cruz 222, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]},{"raw_affiliation_string":"Escuela de Ingenier\u00eda Inform\u00e1tica, Universidad de Valpara\u00edso, General Cruz 222, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030121254"],"corresponding_institution_ids":["https://openalex.org/I4210145000","https://openalex.org/I79274474"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11509","display_name":"Hip and Femur Fractures","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11509","display_name":"Hip and Femur Fractures","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9340000152587891},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7626000046730042},{"id":"https://openalex.org/C2778885795","wikidata":"https://www.wikidata.org/wiki/Q240856","display_name":"Hip fracture","level":3,"score":0.6963000297546387},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5907999873161316},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4828999936580658},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.48100000619888306},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.4648999869823456},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.44909998774528503},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.44609999656677246},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4433000087738037},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.3788999915122986},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.3571999967098236},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.337799996137619},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.3343999981880188},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.31029999256134033},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.305400013923645},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.3050999939441681},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.29409998655319214},{"id":"https://openalex.org/C80191262","wikidata":"https://www.wikidata.org/wiki/Q5477668","display_name":"Fragility","level":2,"score":0.2915000021457672},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.2639999985694885},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.25600001215934753},{"id":"https://openalex.org/C68312169","wikidata":"https://www.wikidata.org/wiki/Q216685","display_name":"Orthopedic surgery","level":2,"score":0.25189998745918274}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12877-026-08642-w","doi":"https://doi.org/10.1186/s12877-026-08642-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12877-026-08642-w","pdf_url":null,"source":{"id":"https://openalex.org/S14643628","display_name":"BMC Geriatrics","issn_l":"1471-2318","issn":["1471-2318"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Geriatrics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12877-026-08642-w","doi":"https://doi.org/10.1186/s12877-026-08642-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12877-026-08642-w","pdf_url":null,"source":{"id":"https://openalex.org/S14643628","display_name":"BMC Geriatrics","issn_l":"1471-2318","issn":["1471-2318"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Geriatrics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Hip":[0],"fragility":[1,50,253],"fractures":[2,51,170],"are":[3,264,332],"traditionally":[4],"managed":[5],"as":[6,85,105],"a":[7,191],"single":[8],"clinical":[9,111],"entity,":[10],"despite":[11],"long-standing":[12],"anatomical,":[13],"epidemiological":[14],"and":[15,20,61,68,80,107,112,127,138,155,176,180,211,220,236,250,272,279,328,339],"prognostic":[16],"differences":[17,306],"between":[18,30,134,207,246,269],"intra-":[19,249],"extracapsular":[21,108,167,251],"fractures.":[22],"Whether":[23],"routinely":[24,77],"collected":[25],"admission":[26,82,135,193,242],"biomarker":[27,116,136,194,238,243,321],"profiles":[28,137,244],"differ":[29,245],"these":[31,261],"fracture":[32,142,198,254,270,294],"phenotypes":[33,213,271],"remains":[34],"insufficiently":[35],"explored.":[36],"The":[37,144,200],"prospective":[38],"cohort":[39],"comprised":[40],"743":[41],"consecutive":[42],"patients":[43],"aged":[44],"\u2265":[45],"60":[46],"years":[47],"with":[48,166,197,266,324],"hip":[49,252],"admitted":[52],"during":[53],"2023\u20132024,":[54],"of":[55,146],"whom":[56],"644":[57],"had":[58],"complete":[59],"data":[60],"constituted":[62],"the":[63,139,156,159,258,289,296,304],"analytical":[64],"sample":[65],"(266":[66],"ICF":[67,210,278],"378":[69],"ECF).":[70],"No":[71],"missing":[72],"values":[73],"were":[74,99,120,291],"imputed.":[75],"Eighteen":[76],"assessed":[78,151],"haematological":[79],"biochemical":[81],"biomarkers,":[83],"used":[84],"proxies":[86],"for":[87,95],"biological":[88,267,309],"domains":[89],"related":[90],"to":[91,131,231,301,334],"Chronic":[92],"Risk":[93],"Factors":[94],"Bone":[96],"Damage":[97],"(CRiF-BD),":[98],"analysed.":[100],"Fracture":[101],"phenotype":[102],"was":[103,150],"established":[104,141,209,248],"intracapsular":[106,169],"by":[109,122],"standard":[110],"radiographic":[113],"criteria":[114],"before":[115],"analysis.":[117],"Group":[118],"comparisons":[119,323],"followed":[121],"correlation":[123],"analysis,":[124],"hierarchical":[125,221],"clustering":[126,222],"multivariable":[128,147,201,227],"logistic":[129],"regression":[130],"assess":[132],"associations":[133,263],"radiographically":[140,208,247],"phenotype.":[143,199],"robustness":[145],"statistical":[148,205],"separation":[149,206],"using":[152],"10-fold":[153],"cross-validation":[154],"area":[157],"under":[158],"receiver":[160],"operating":[161],"characteristic":[162],"curve":[163],"(AUC).":[164],"Compared":[165],"fractures,":[168],"showed":[171,203],"higher":[172],"haematocrit,":[173],"haemoglobin,":[174],"albumin":[175],"free":[177],"thyroxine":[178],"levels,":[179],"lower":[181],"potassium":[182],"levels":[183],"(all":[184],"p":[185],"<":[186],"0.05).":[187],"Multivariable":[188],"analysis":[189],"identified":[190],"combined":[192],"profile":[195],"associated":[196],"model":[202],"moderate":[204],"ECF":[212,280],"(AUC":[214],"0.72":[215],"[95%":[216],"CI":[217],"0.67\u20130.76]).":[218],"Correlation":[219],"analyses":[223],"revealed":[224],"an":[225],"exploratory":[226,262],"structure":[228],"broadly":[229],"corresponding":[230],"haematological,":[232],"transport/coagulation,":[233],"renal,":[234],"endocrine":[235],"metabolic":[237],"domains.":[239],"Routinely":[240],"available":[241],"phenotypes.":[255],"Interpreted":[256],"within":[257],"CRiF-BD":[259],"framework,":[260],"consistent":[265],"heterogeneity":[268],"support":[273],"further":[274],"investigation":[275],"into":[276],"whether":[277],"reflect":[281,307],"distinct":[282],"or":[283,311,319],"partially":[284],"overlapping":[285],"pathophysiological":[286,340],"processes.":[287],"Because":[288],"biomarkers":[290],"measured":[292],"after":[293],"occurrence,":[295],"present":[297],"study":[298],"cannot":[299],"determine":[300],"what":[302],"extent":[303],"observed":[305],"pre-existing":[308],"characteristics":[310],"acute":[312],"fracture-related":[313],"changes.":[314],"Future":[315],"studies":[316],"incorporating":[317],"pre-fracture":[318],"longitudinal":[320],"data,":[322],"non-fractured":[325],"older":[326],"populations":[327],"direct":[329],"bone":[330],"assessment":[331],"needed":[333],"clarify":[335],"their":[336],"temporal":[337],"origin":[338],"significance.":[341]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
