{"id":"https://openalex.org/W7225833336","doi":"https://doi.org/10.3390/ijms272210102","title":"Targeted Quantitative Phenolic Profiling and In Vitro Biological Activities of Onosma erecta Sm. Extracts Obtained by Ultrasound-Assisted Extraction","display_name":"Targeted Quantitative Phenolic Profiling and In Vitro Biological Activities of Onosma erecta Sm. Extracts Obtained by Ultrasound-Assisted Extraction","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225833336","doi":"https://doi.org/10.3390/ijms272210102"},"language":"en","primary_location":{"id":"doi:10.3390/ijms272210102","doi":"https://doi.org/10.3390/ijms272210102","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms272210102","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms272210102","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083342014","display_name":"Cengiz Sar\u0131k\u00fcrk\u00e7\u00fc","orcid":"https://orcid.org/0000-0001-5094-2520","observed_orcids":["https://orcid.org/0000-0001-5094-2520"]},"institutions":[{"id":"https://openalex.org/I4387154071","display_name":"Afyonkarahisar Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","ror":"https://ror.org/00sfg6g55","country_code":"TR","type":"education","lineage":["https://openalex.org/I4387154071"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Cengiz Sarikurkcu","raw_affiliation_strings":["Department of Analytical Chemistry, Faculty of Pharmacy, Afyonkarahisar Health Sciences University, Afyonkarahisar 03030, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0001-5094-2520","affiliations":[{"raw_affiliation_string":"Department of Analytical Chemistry, Faculty of Pharmacy, Afyonkarahisar Health Sciences University, Afyonkarahisar 03030, T\u00fcrkiye","institution_ids":["https://openalex.org/I4387154071"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161421743","display_name":"Bahtiyar Nar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387154071","display_name":"Afyonkarahisar Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","ror":"https://ror.org/00sfg6g55","country_code":"TR","type":"education","lineage":["https://openalex.org/I4387154071"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Bahtiyar Nar","raw_affiliation_strings":["Department of Analytical Chemistry, Faculty of Pharmacy, Afyonkarahisar Health Sciences University, Afyonkarahisar 03030, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Analytical Chemistry, Faculty of Pharmacy, Afyonkarahisar Health Sciences University, Afyonkarahisar 03030, T\u00fcrkiye","institution_ids":["https://openalex.org/I4387154071"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5083342014"],"corresponding_institution_ids":["https://openalex.org/I4387154071"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"22","first_page":"10102","last_page":"10102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.6923999786376953,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.6923999786376953,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.1858000010251999,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.10339999943971634,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2780117898","wikidata":"https://www.wikidata.org/wiki/Q421964","display_name":"Chlorogenic acid","level":2,"score":0.8054999709129333},{"id":"https://openalex.org/C2778771215","wikidata":"https://www.wikidata.org/wiki/Q50380051","display_name":"Rosmarinic acid","level":3,"score":0.7785000205039978},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7753000259399414},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.6567000150680542},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5551999807357788},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4860000014305115},{"id":"https://openalex.org/C2778778762","wikidata":"https://www.wikidata.org/wiki/Q419836","display_name":"Phenolic acid","level":3,"score":0.48420000076293945},{"id":"https://openalex.org/C2777728882","wikidata":"https://www.wikidata.org/wiki/Q407142","display_name":"Phenols","level":2,"score":0.4699000120162964},{"id":"https://openalex.org/C2776617576","wikidata":"https://www.wikidata.org/wiki/Q338005","display_name":"Acarbose","level":3,"score":0.42649999260902405},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4117000102996826},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.38909998536109924},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38670000433921814},{"id":"https://openalex.org/C2778224086","wikidata":"https://www.wikidata.org/wiki/Q414116","display_name":"Caffeic acid","level":3,"score":0.3716000020503998},{"id":"https://openalex.org/C2776586676","wikidata":"https://www.wikidata.org/wiki/Q5242815","display_name":"Hyperoside","level":4,"score":0.3662000000476837},{"id":"https://openalex.org/C2779607525","wikidata":"https://www.wikidata.org/wiki/Q14982","display_name":"Methanol","level":2,"score":0.35109999775886536},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.34709998965263367},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.34459999203681946},{"id":"https://openalex.org/C2777781930","wikidata":"https://www.wikidata.org/wiki/Q1074417","display_name":"Mangiferin","level":2,"score":0.3409999907016754},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.3330000042915344},{"id":"https://openalex.org/C2779431889","wikidata":"https://www.wikidata.org/wiki/Q415007","display_name":"Catechin","level":4,"score":0.32760000228881836},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.3140999972820282},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.3082999885082245},{"id":"https://openalex.org/C2778362808","wikidata":"https://www.wikidata.org/wiki/Q375837","display_name":"Gallic acid","level":3,"score":0.29760000109672546},{"id":"https://openalex.org/C2910589225","wikidata":"https://www.wikidata.org/wiki/Q5955538","display_name":"Hydroxybenzoic acid","level":2,"score":0.2870999872684479},{"id":"https://openalex.org/C17857428","wikidata":"https://www.wikidata.org/wiki/Q533025","display_name":"Nutraceutical","level":2,"score":0.28139999508857727},{"id":"https://openalex.org/C2778395939","wikidata":"https://www.wikidata.org/wiki/Q2160967","display_name":"Water extraction","level":3,"score":0.28040000796318054},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.2784999907016754},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2773999869823456},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.2621000111103058},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.2581999897956848},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.2524999976158142}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/ijms272210102","doi":"https://doi.org/10.3390/ijms272210102","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms272210102","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/ijms272210102","doi":"https://doi.org/10.3390/ijms272210102","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms272210102","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1971048984","https://openalex.org/W1985119065","https://openalex.org/W1989705993","https://openalex.org/W1992544322","https://openalex.org/W2012991711","https://openalex.org/W2013560821","https://openalex.org/W2017186389","https://openalex.org/W2031596649","https://openalex.org/W2040622874","https://openalex.org/W2077013120","https://openalex.org/W2089198231","https://openalex.org/W2165292984","https://openalex.org/W2321528849","https://openalex.org/W2322580831","https://openalex.org/W2471898040","https://openalex.org/W2614605940","https://openalex.org/W2794014852","https://openalex.org/W2810310715","https://openalex.org/W2890998214","https://openalex.org/W2900994627","https://openalex.org/W2992255612","https://openalex.org/W3049091887","https://openalex.org/W3081632915","https://openalex.org/W3088986342","https://openalex.org/W3145954797","https://openalex.org/W3162581364","https://openalex.org/W3164037990","https://openalex.org/W3178286539","https://openalex.org/W4282939138","https://openalex.org/W4306362341","https://openalex.org/W4311959957","https://openalex.org/W4313489330","https://openalex.org/W4362692205","https://openalex.org/W4389042268","https://openalex.org/W4389836842","https://openalex.org/W4399708551","https://openalex.org/W4405291239","https://openalex.org/W4407031642","https://openalex.org/W4409413169","https://openalex.org/W4411468525","https://openalex.org/W4412178743","https://openalex.org/W4415251765","https://openalex.org/W7119640604","https://openalex.org/W7125998930","https://openalex.org/W7133323518","https://openalex.org/W7152703307","https://openalex.org/W7164655475"],"related_works":[],"abstract_inverted_index":{"Onosma":[0],"erecta":[1],"remains":[2],"insufficiently":[3],"characterized":[4],"in":[5,46,65,87,104],"terms":[6],"of":[7,22,106,133,164],"quantitative":[8],"phenolic":[9,55,97],"composition":[10],"and":[11,19,38,71,81,98,101,171,173],"solvent-dependent":[12],"bioactivity.":[13],"This":[14],"study":[15],"compared":[16],"ultrasound-assisted":[17],"water":[18,89],"methanol":[20,61,92],"extracts":[21,142],"its":[23,124],"aerial":[24],"parts":[25],"using":[26],"targeted":[27,54],"liquid":[28],"chromatography\u2013tandem":[29],"mass":[30],"spectrometry":[31],"(LC\u2013MS/MS),":[32],"antioxidant":[33,108],"assays,":[34],"enzyme":[35],"inhibition":[36],"tests,":[37],"the":[39,88,138],"water-soluble":[40],"tetrazolium-1":[41],"(WST-1)":[42],"cell":[43],"viability":[44],"assay":[45,139],"A549":[47],"human":[48],"lung":[49],"carcinoma":[50],"cells.":[51],"Of":[52],"30":[53],"compounds,":[56],"21":[57],"were":[58,84],"quantified.":[59],"The":[60,91],"extract":[62,93,166],"was":[63,129],"enriched":[64],"chlorogenic":[66],"acid":[67,73],"(16,430":[68],"\u00b5g/g":[69,75],"extract)":[70],"rosmarinic":[72],"(2474":[74],"extract),":[76],"whereas":[77],"selected":[78],"hydroxybenzoic":[79],"acids":[80],"flavonoid":[82,99],"aglycones":[83],"more":[85],"abundant":[86],"extract.":[90],"exhibited":[94],"higher":[95],"total":[96],"contents":[100],"stronger":[102],"responses":[103],"four":[105],"six":[107],"assays.":[109],"It":[110],"also":[111],"showed":[112],"lower":[113,130],"half-maximal":[114],"inhibitory":[115],"concentrations":[116],"(IC50)":[117],"against":[118],"all":[119],"five":[120],"tested":[121],"enzymes.":[122],"Notably,":[123],"\u03b1-glucosidase":[125],"IC50":[126],"(1.12":[127],"mg/mL)":[128,136],"than":[131],"that":[132],"acarbose":[134],"(1.26":[135],"under":[137],"conditions.":[140],"Both":[141],"produced":[143],"elevated":[144],"WST-1":[145],"signals":[146],"at":[147],"intermediate":[148],"concentrations,":[149],"which":[150],"do":[151],"not":[152],"establish":[153],"enhanced":[154],"proliferation":[155],"or":[156],"safety.":[157],"As":[158],"results":[159],"derive":[160],"from":[161],"technical":[162],"triplicates":[163],"single":[165],"preparations,":[167],"further":[168],"independent":[169],"replication":[170],"mechanistic":[172],"toxicological":[174],"validation":[175],"are":[176],"warranted.":[177]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}