{"id":"https://openalex.org/W7225831941","doi":"https://doi.org/10.64898/2026.11.10.765652","title":"Evolutionarily distinct dengue virus type 2 with a unique type-specific neutralization determinant","display_name":"Evolutionarily distinct dengue virus type 2 with a unique type-specific neutralization determinant","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225831941","doi":"https://doi.org/10.64898/2026.11.10.765652"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.10.765652","doi":"https://doi.org/10.64898/2026.11.10.765652","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.10.765652","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.11.10.765652","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161453456","display_name":"Sandra Mayer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Mayer","raw_affiliation_strings":["Walter Reed Army Institute of Research, Silver Spring, MD, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Walter Reed Army Institute of Research, Silver Spring, MD, United States;","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161483419","display_name":"Evandro Winkelmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evandro Winkelmann","raw_affiliation_strings":["Walter Reed Army Institute of Research, Silver Spring, MD, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Walter Reed Army Institute of Research, Silver Spring, MD, United States;","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013909216","display_name":"Ana Coello Escoto","orcid":"https://orcid.org/0000-0002-9634-5091","observed_orcids":["https://orcid.org/0000-0002-9634-5091"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana Coello Escoto","raw_affiliation_strings":["Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012430532","display_name":"Jack Dorman","orcid":"https://orcid.org/0009-0003-9776-9069","observed_orcids":["https://orcid.org/0009-0003-9776-9069"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack Dorman","raw_affiliation_strings":["Quantitative Virology and Evolution Unit, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Virology and Evolution Unit, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031439855","display_name":"Michael K. McCracken","orcid":"https://orcid.org/0000-0002-4035-5485","observed_orcids":["https://orcid.org/0000-0002-4035-5485"]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael McCracken","raw_affiliation_strings":["Walter Reed Army Institute of Research, Silver Spring, MD, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Walter Reed Army Institute of Research, Silver Spring, MD, United States;","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019880941","display_name":"Douglas Fritz","orcid":"https://orcid.org/0000-0001-8822-4639","observed_orcids":["https://orcid.org/0000-0001-8822-4639"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas Fritz","raw_affiliation_strings":["Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017501496","display_name":"Ralph Steven Baric","orcid":"https://orcid.org/0000-0001-6827-8701","observed_orcids":["https://orcid.org/0000-0001-6827-8701"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph Baric","raw_affiliation_strings":["Department of Epidemiology, Gillings School of Public Health, University of North Carolina, Chapel Hill, Chapel Hill, NC, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Gillings School of Public Health, University of North Carolina, Chapel Hill, Chapel Hill, NC, United States;","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161466652","display_name":"Longping Tse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Longping Tse","raw_affiliation_strings":["Department of Molecular Microbiology & Immunology, Saint Louis University, St. Louis, MO, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology & Immunology, Saint Louis University, St. Louis, MO, United States;","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040212218","display_name":"Richard L. Herbert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Herbert","raw_affiliation_strings":["Experimental Primate Virology Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Primate Virology Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129356017","display_name":"Derek Cummings","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek Cummings","raw_affiliation_strings":["Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States;","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044951472","display_name":"Stephen S. Whitehead","orcid":"https://orcid.org/0000-0001-6707-482X","observed_orcids":["https://orcid.org/0000-0001-6707-482X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Whitehead","raw_affiliation_strings":["Arbovirus Vaccine Research Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arbovirus Vaccine Research Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161426174","display_name":"Sonja Best","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonja Best","raw_affiliation_strings":["Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022164242","display_name":"Patrick Dolan","orcid":"https://orcid.org/0000-0002-4169-0058","observed_orcids":["https://orcid.org/0000-0002-4169-0058"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Dolan","raw_affiliation_strings":["Quantitative Virology and Evolution Unit, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Virology and Evolution Unit, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089496232","display_name":"John Aaskov","orcid":"https://orcid.org/0000-0003-1998-4575","observed_orcids":["https://orcid.org/0000-0003-1998-4575"]},"institutions":[{"id":"https://openalex.org/I160993911","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752","country_code":"AU","type":"education","lineage":["https://openalex.org/I160993911"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"John Aaskov","raw_affiliation_strings":["Queensland University of Technology, Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queensland University of Technology, Brisbane, Australia","institution_ids":["https://openalex.org/I160993911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039786822","display_name":"Gregory D. Gromowski","orcid":"https://orcid.org/0000-0003-4576-4277","observed_orcids":["https://orcid.org/0000-0003-4576-4277"]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Gromowski","raw_affiliation_strings":["Walter Reed Army Institute of Research, Silver Spring, MD, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Walter Reed Army Institute of Research, Silver Spring, MD, United States;","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036332609","display_name":"Leah C. Katzelnick","orcid":"https://orcid.org/0000-0003-1033-6758","observed_orcids":["https://orcid.org/0000-0003-1033-6758"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leah Katzelnick","raw_affiliation_strings":["Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C14086860","wikidata":"https://www.wikidata.org/wiki/Q337120","display_name":"Neutralization","level":3,"score":0.8783000111579895},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.8184000253677368},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7888000011444092},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6937999725341797},{"id":"https://openalex.org/C533803919","wikidata":"https://www.wikidata.org/wiki/Q30953","display_name":"Dengue fever","level":2,"score":0.6121000051498413},{"id":"https://openalex.org/C10389963","wikidata":"https://www.wikidata.org/wiki/Q848328","display_name":"Serotype","level":2,"score":0.5939000248908997},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.5817999839782715},{"id":"https://openalex.org/C2779635636","wikidata":"https://www.wikidata.org/wiki/Q476209","display_name":"Dengue virus","level":3,"score":0.5587000250816345},{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.5364999771118164},{"id":"https://openalex.org/C191942190","wikidata":"https://www.wikidata.org/wiki/Q4774739","display_name":"Antigenic variation","level":3,"score":0.448199987411499},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.42010000348091125},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.40959998965263367},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.40790000557899475},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.3944000005722046},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3702000081539154},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.335999995470047},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.3118000030517578},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.31029999256134033},{"id":"https://openalex.org/C180915046","wikidata":"https://www.wikidata.org/wiki/Q575264","display_name":"Original antigenic sin","level":5,"score":0.298799991607666},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.29589998722076416},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.28540000319480896},{"id":"https://openalex.org/C2780568436","wikidata":"https://www.wikidata.org/wiki/Q1165479","display_name":"Flavivirus","level":3,"score":0.26589998602867126},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.25110000371932983}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.10.765652","doi":"https://doi.org/10.64898/2026.11.10.765652","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.10.765652","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.10.765652","doi":"https://doi.org/10.64898/2026.11.10.765652","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.10.765652","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Dengue":[0],"viruses":[1],"1-4":[2],"(DENV1-4)":[3],"mostly":[4],"circulate":[5],"in":[6,67,137,151,163,255],"endemic":[7,35,109,179,191],"cycles":[8],"involving":[9],"humans":[10],"and":[11,111,120,185,190,248,277],"Aedes":[12],"mosquitoes.":[13],"However,":[14],"rare":[15],"dengue":[16],"outbreaks":[17],"originate":[18],"from":[19,117,198],"non-human":[20,199],"primates.":[21],"These":[22,267],"spillovers":[23],"are":[24,31,43,65],"caused":[25,44],"by":[26,45,105,115],"sylvatic":[27],"virus":[28],"genotypes":[29],"that":[30,47,159,249],"closely":[32,83],"related":[33,84],"to":[34,85,193,229,244,259],"strains":[36,46,125,192],"of":[37,77,126,132,140,166,175,264,275,281],"the":[38,50,74,141,152,167,212,235,260,272,278],"same":[39],"serotype,":[40],"but":[41,219],"some":[42],"fall":[48],"between":[49],"four":[51],"canonical":[52],"serotypes":[53],"on":[54],"phylogenetic":[55],"trees.":[56],"It":[57],"is":[58],"not":[59,101],"clear":[60],"whether":[61],"these":[62],"genotypic":[63],"differences":[64],"reflected":[66],"corresponding":[68],"antigenic":[69,75,89,273],"differences.":[70],"Here,":[71],"we":[72],"characterized":[73],"features":[76],"QML-22,":[78],"a":[79,130],"divergent":[80],"strain":[81,207],"most":[82],"DENV2.":[86,127,266],"On":[87],"an":[88],"map,":[90],"QML-22":[91,99,128,176,189,203,250],"clustered":[92],"with":[93,145,202,211],"other":[94,124,178,183,245],"globally":[95],"representative":[96],"DENV2":[97,110,180,205],"strains.":[98],"was":[100,112,217,222,227,238],"as":[102],"well":[103],"neutralized":[104,114,188],"antisera":[106,116,197],"raised":[107],"against":[108],"better":[113],"DENV1,":[118],"3,":[119],"4":[121],"infections":[122],"than":[123,177],"had":[129,171,251],"cluster":[131],"distinct":[133,230],"amino":[134,253],"acid":[135],"residues":[136],"domain":[138,164],"I":[139,165],"envelope":[142],"(E)":[143],"protein,":[144,169],"only":[146],"scattered":[147],"point":[148],"mutations":[149],"elsewhere":[150],"envelope.":[153],"A":[154],"potently":[155],"neutralizing":[156,246],"anti-DENV2":[157],"antibody":[158],"targets":[160],"this":[161,256],"site":[162],"E":[168],"3F9,":[170],">1000-fold":[172],"lower":[173],"neutralization":[174,216,221,226],"strains,":[181],"whereas":[182],"cross-reactive":[184],"DENV2-specific":[186],"antibodies":[187],"similar":[194],"titers.":[195],"When":[196],"primates":[200],"infected":[201],"or":[204],"reference":[206],"S16803":[208],"were":[209],"depleted":[210],"heterologous":[213,220],"virions,":[214],"homologous":[215,225],"unaffected":[218],"reduced,":[223],"suggesting":[224],"due":[228],"epitopes.":[231],"Evolutionary":[232],"analyses":[233],"showed":[234],"3F9":[236],"epitope":[237,257],"under":[239],"relaxed":[240],"selection":[241],"pressure":[242],"compared":[243],"epitopes":[247],"unique":[252],"acids":[254],"relative":[258],"likely":[261],"common":[262],"ancestor":[263],"all":[265],"findings":[268],"provide":[269],"insight":[270],"into":[271],"diversification":[274],"DENV":[276],"possible":[279],"evolution":[280],"new":[282],"serotypes.":[283]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
