{"id":"https://openalex.org/W7225831202","doi":"https://doi.org/10.3390/molecules31224052","title":"Lomerizine Suppresses JAK2/STAT3 Pathway Activation via CACNA1B in HNSCC","display_name":"Lomerizine Suppresses JAK2/STAT3 Pathway Activation via CACNA1B in HNSCC","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225831202","doi":"https://doi.org/10.3390/molecules31224052"},"language":"en","primary_location":{"id":"doi:10.3390/molecules31224052","doi":"https://doi.org/10.3390/molecules31224052","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules31224052","pdf_url":null,"source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/molecules31224052","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160822896","display_name":"Yashu Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yashu Liu","raw_affiliation_strings":["State Key Laboratory of Medicinal Biology, College of Pharmacy, Nankai University, Tianjin 300353, China","Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300353, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Medicinal Biology, College of Pharmacy, Nankai University, Tianjin 300353, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300353, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091296954","display_name":"Zihui Zhang","orcid":"https://orcid.org/0000-0001-9733-6448","observed_orcids":["https://orcid.org/0000-0001-9733-6448"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zihui Zhang","raw_affiliation_strings":["State Key Laboratory of Medicinal Biology, College of Pharmacy, Nankai University, Tianjin 300353, China","Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300353, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Medicinal Biology, College of Pharmacy, Nankai University, Tianjin 300353, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300353, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161431655","display_name":"Yan Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]},{"id":"https://openalex.org/I4210136021","display_name":"Tianjin Stomatological Hospital","ror":"https://ror.org/047rxfg53","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136021"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Zhao","raw_affiliation_strings":["Department of Oromaxillofacial-Head and Neck Oncology, Tianjin Stomatological Hospital, School of Medicine, Nankai University, 75 Dagu Road, Heping District, Tianjin 300041, China","State Key Laboratory of Medicinal Biology, College of Pharmacy, Nankai University, Tianjin 300353, China","Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300353, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oromaxillofacial-Head and Neck Oncology, Tianjin Stomatological Hospital, School of Medicine, Nankai University, 75 Dagu Road, Heping District, Tianjin 300041, China","institution_ids":["https://openalex.org/I205237279","https://openalex.org/I4210136021"]},{"raw_affiliation_string":"State Key Laboratory of Medicinal Biology, College of Pharmacy, Nankai University, Tianjin 300353, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300353, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086981720","display_name":"Chaoge Liu","orcid":"https://orcid.org/0000-0002-8023-3941","observed_orcids":["https://orcid.org/0000-0002-8023-3941"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]},{"id":"https://openalex.org/I4210136021","display_name":"Tianjin Stomatological Hospital","ror":"https://ror.org/047rxfg53","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136021"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chaoge Liu","raw_affiliation_strings":["Department of Oromaxillofacial-Head and Neck Oncology, Tianjin Stomatological Hospital, School of Medicine, Nankai University, 75 Dagu Road, Heping District, Tianjin 300041, China","State Key Laboratory of Medicinal Biology, College of Pharmacy, Nankai University, Tianjin 300353, China","Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300353, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oromaxillofacial-Head and Neck Oncology, Tianjin Stomatological Hospital, School of Medicine, Nankai University, 75 Dagu Road, Heping District, Tianjin 300041, China","institution_ids":["https://openalex.org/I205237279","https://openalex.org/I4210136021"]},{"raw_affiliation_string":"State Key Laboratory of Medicinal Biology, College of Pharmacy, Nankai University, Tianjin 300353, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300353, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113384983","display_name":"Yutian Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yutian Cai","raw_affiliation_strings":["State Key Laboratory of Medicinal Biology, College of Pharmacy, Nankai University, Tianjin 300353, China","Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300353, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Medicinal Biology, College of Pharmacy, Nankai University, Tianjin 300353, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300353, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087153998","display_name":"Xiaoting Gu","orcid":"https://orcid.org/0000-0002-9236-5941","observed_orcids":["https://orcid.org/0000-0002-9236-5941"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoting Gu","raw_affiliation_strings":["State Key Laboratory of Medicinal Biology, College of Pharmacy, Nankai University, Tianjin 300353, China","Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300353, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Medicinal Biology, College of Pharmacy, Nankai University, Tianjin 300353, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300353, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159540694","display_name":"Yingbin Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]},{"id":"https://openalex.org/I4210136021","display_name":"Tianjin Stomatological Hospital","ror":"https://ror.org/047rxfg53","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136021"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yingbin Yan","raw_affiliation_strings":["Department of Oromaxillofacial-Head and Neck Oncology, Tianjin Stomatological Hospital, School of Medicine, Nankai University, 75 Dagu Road, Heping District, Tianjin 300041, China","State Key Laboratory of Medicinal Biology, College of Pharmacy, Nankai University, Tianjin 300353, China","Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300353, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oromaxillofacial-Head and Neck Oncology, Tianjin Stomatological Hospital, School of Medicine, Nankai University, 75 Dagu Road, Heping District, Tianjin 300041, China","institution_ids":["https://openalex.org/I205237279","https://openalex.org/I4210136021"]},{"raw_affiliation_string":"State Key Laboratory of Medicinal Biology, College of Pharmacy, Nankai University, Tianjin 300353, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300353, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085610505","display_name":"Honggang Zhou","orcid":"https://orcid.org/0000-0003-2987-3422","observed_orcids":["https://orcid.org/0000-0003-2987-3422"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]},{"id":"https://openalex.org/I4210112130","display_name":"Tianjin International Joint Academy of Biomedicine","ror":"https://ror.org/01v11cc68","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210112130"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Honggang Zhou","raw_affiliation_strings":["State Key Laboratory of Medicinal Biology, College of Pharmacy, Nankai University, Tianjin 300353, China","Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300353, China","Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China"],"raw_orcid":"https://orcid.org/0000-0003-2987-3422","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Medicinal Biology, College of Pharmacy, Nankai University, Tianjin 300353, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300353, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China","institution_ids":["https://openalex.org/I4210112130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064700970","display_name":"Ting Xiao","orcid":"https://orcid.org/0000-0002-3489-4124","observed_orcids":["https://orcid.org/0000-0002-3489-4124"]},"institutions":[{"id":"https://openalex.org/I198091727","display_name":"Tiangong University","ror":"https://ror.org/00xsr9m91","country_code":"CN","type":"education","lineage":["https://openalex.org/I198091727"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ting Xiao","raw_affiliation_strings":["School of Pharmaceutical Sciences, Tiangong University, Tianjin 300387, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Tiangong University, Tianjin 300387, China","institution_ids":["https://openalex.org/I198091727"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5064700970","https://openalex.org/A5085610505","https://openalex.org/A5159540694"],"corresponding_institution_ids":["https://openalex.org/I198091727","https://openalex.org/I205237279","https://openalex.org/I4210112130","https://openalex.org/I4210136021"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"22","first_page":"4052","last_page":"4052"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0272000003606081,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.7724999785423279},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6697999835014343},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6500999927520752},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6396999955177307},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6216999888420105},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5795999765396118},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4390999972820282},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.38530001044273376},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.3693999946117401},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3666999936103821},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3479999899864197},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.3407000005245209},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3328000009059906},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.3102000057697296},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.3077000081539154},{"id":"https://openalex.org/C85520022","wikidata":"https://www.wikidata.org/wiki/Q15322916","display_name":"Calcium channel","level":3,"score":0.2985999882221222},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2973000109195709},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.273499995470047},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.272599995136261},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.26980000734329224}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/molecules31224052","doi":"https://doi.org/10.3390/molecules31224052","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules31224052","pdf_url":null,"source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/molecules31224052","doi":"https://doi.org/10.3390/molecules31224052","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules31224052","pdf_url":null,"source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1603491949","https://openalex.org/W2130479394","https://openalex.org/W2135454149","https://openalex.org/W2138512826","https://openalex.org/W2148574613","https://openalex.org/W2157745198","https://openalex.org/W2162011385","https://openalex.org/W2562543505","https://openalex.org/W2625511450","https://openalex.org/W2774925816","https://openalex.org/W2788371883","https://openalex.org/W2883276664","https://openalex.org/W2896002881","https://openalex.org/W2946412700","https://openalex.org/W2946657092","https://openalex.org/W2955341169","https://openalex.org/W2987694037","https://openalex.org/W2998322952","https://openalex.org/W3080773873","https://openalex.org/W3087992083","https://openalex.org/W3094100586","https://openalex.org/W3094875479","https://openalex.org/W3107533236","https://openalex.org/W3115235573","https://openalex.org/W3175064583","https://openalex.org/W3178563513","https://openalex.org/W3185746646","https://openalex.org/W3189599812","https://openalex.org/W4213206479","https://openalex.org/W4220661303","https://openalex.org/W4224248664","https://openalex.org/W4282833750","https://openalex.org/W4283795283","https://openalex.org/W4286253973","https://openalex.org/W4290010934","https://openalex.org/W4291278868","https://openalex.org/W4306173356","https://openalex.org/W4308158649","https://openalex.org/W4311857661","https://openalex.org/W4313272502","https://openalex.org/W4316494556","https://openalex.org/W4317759314","https://openalex.org/W4367610420","https://openalex.org/W4380681798","https://openalex.org/W4385660961","https://openalex.org/W4404511389"],"related_works":[],"abstract_inverted_index":{"The":[0],"JAK2/STAT3":[1,110],"pathway":[2],"contributes":[3],"to":[4],"head":[5],"and":[6,25,47,53,64,79,98,120],"neck":[7],"squamous":[8],"cell":[9,59,83],"carcinoma":[10],"(HNSCC)":[11],"progression.":[12],"Using":[13],"a":[14,20,28,105],"STAT3":[15,48],"reporter":[16,42],"assay,":[17],"we":[18],"screened":[19],"panel":[21],"of":[22,41,108,130],"79":[23],"compounds":[24],"identified":[26],"lomerizine,":[27],"calcium":[29],"channel":[30],"blocker":[31],"approved":[32],"in":[33,50,56,69,118,132],"Japan":[34],"for":[35],"migraine":[36],"prophylaxis,":[37],"as":[38,104],"an":[39],"inhibitor":[40],"activity.":[43],"Lomerizine":[44,112],"reduced":[45,82,115],"JAK2":[46],"phosphorylation":[49],"CAL-27":[51,70,121],"cells":[52],"suppressed":[54],"proliferation":[55],"the":[57],"HNSCC":[58,71],"models":[60],"tested.":[61],"Ferroptosis-associated":[62],"readouts":[63],"EMT-marker":[65],"changes":[66],"were":[67],"observed":[68],"cells.":[72],"In":[73],"cisplatin-resistant":[74],"CAL-27-DDP":[75],"cells,":[76],"combined":[77],"lomerizine":[78,131],"cisplatin":[80,87],"treatment":[81,113],"viability":[84],"compared":[85],"with":[86],"alone.":[88],"Target":[89],"prediction,":[90],"molecular":[91],"docking,":[92],"cellular":[93],"thermal":[94],"shift":[95],"assay":[96],"(CETSA),":[97],"CACNA1B":[99,103],"knockdown":[100],"results":[101],"implicate":[102],"candidate":[106],"mediator":[107],"lomerizine-associated":[109],"changes.":[111],"also":[114],"tumor":[116],"growth":[117],"PDX":[119],"xenograft":[122],"models.":[123],"These":[124],"findings":[125],"support":[126],"further":[127],"preclinical":[128],"evaluation":[129],"HNSCC.":[133]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}