{"id":"https://openalex.org/W7225830431","doi":"https://doi.org/10.21203/rs.3.rs-11322431/v1","title":"The Impact of the COVID-19 Pandemic on Adverse Pathological Outcomes After Radical Prostatectomy: Pre- and Post-Pandemic Comparison in a Brazilian Public Healthcare Setting","display_name":"The Impact of the COVID-19 Pandemic on Adverse Pathological Outcomes After Radical Prostatectomy: Pre- and Post-Pandemic Comparison in a Brazilian Public Healthcare Setting","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225830431","doi":"https://doi.org/10.21203/rs.3.rs-11322431/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11322431/v1","doi":"https://doi.org/10.21203/rs.3.rs-11322431/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11322431/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.21203/rs.3.rs-11322431/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001775611","display_name":"Tiago Aparecido Silva","orcid":"https://orcid.org/0000-0001-6796-3491","observed_orcids":["https://orcid.org/0000-0001-6796-3491"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Tiago Aparecido Silva","raw_affiliation_strings":["Federal University of S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of S\u00e3o Paulo","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114464820","display_name":"Luciana Saboya Dal Col","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luciana Saboya Dal Col","raw_affiliation_strings":["Federal University of S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of S\u00e3o Paulo","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104196185","display_name":"Renato Meirelles Mariano Da Costa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Renato Meirelles Mariano Costa","raw_affiliation_strings":["Federal University of S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of S\u00e3o Paulo","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025813943","display_name":"Pedro Rodrigues Beal","orcid":"https://orcid.org/0000-0001-8949-4921","observed_orcids":["https://orcid.org/0000-0001-8949-4921"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Pedro Rodrigues Beal","raw_affiliation_strings":["Federal University of S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of S\u00e3o Paulo","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161456233","display_name":"Jose Arnaldo Shiomi Cruz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jose Arnaldo Shiomi Cruz","raw_affiliation_strings":["Federal University of S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of S\u00e3o Paulo","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007828886","display_name":"Monique Sampaio Rodrigues","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Monique Sampaio Rodrigues","raw_affiliation_strings":["Federal University of S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of S\u00e3o Paulo","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027897438","display_name":"Thiago Lobo Andrade Moraes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Thiago Lobo Andrade Moraes","raw_affiliation_strings":["Federal University of S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of S\u00e3o Paulo","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077818094","display_name":"Vitor Bonadia Buonfiglio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vitor Bonadia Buonfiglio","raw_affiliation_strings":["Federal University of S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of S\u00e3o Paulo","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021087019","display_name":"Marcus Vinicius Sadi","orcid":"https://orcid.org/0000-0001-8332-9343","observed_orcids":["https://orcid.org/0000-0001-8332-9343"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcus Vinicius Sadi","raw_affiliation_strings":["Federal University of S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of S\u00e3o Paulo","institution_ids":["https://openalex.org/I88273585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I88273585"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11296","display_name":"COVID-19 and healthcare impacts","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11296","display_name":"COVID-19 and healthcare impacts","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.04430000111460686,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8996999859809875},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.6977999806404114},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.5770999789237976},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5274999737739563},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.5206000208854675},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5187000036239624},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43860000371932983},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.43220001459121704},{"id":"https://openalex.org/C2779466945","wikidata":"https://www.wikidata.org/wiki/Q1765251","display_name":"Prostatectomy","level":4,"score":0.4092999994754791},{"id":"https://openalex.org/C2777363581","wikidata":"https://www.wikidata.org/wiki/Q15098235","display_name":"Harm","level":2,"score":0.397599995136261},{"id":"https://openalex.org/C14331377","wikidata":"https://www.wikidata.org/wiki/Q2340208","display_name":"Contingency plan","level":2,"score":0.3928999900817871},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3788999915122986},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3368000090122223},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.33500000834465027},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33160001039505005},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.32760000228881836},{"id":"https://openalex.org/C61434518","wikidata":"https://www.wikidata.org/wiki/Q932510","display_name":"General surgery","level":1,"score":0.31769999861717224},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.3116999864578247},{"id":"https://openalex.org/C2988170871","wikidata":"https://www.wikidata.org/wiki/Q11000047","display_name":"Healthcare system","level":3,"score":0.3061999976634979},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29499998688697815},{"id":"https://openalex.org/C2775860198","wikidata":"https://www.wikidata.org/wiki/Q7257872","display_name":"Public hospital","level":2,"score":0.2818000018596649},{"id":"https://openalex.org/C2992528526","wikidata":"https://www.wikidata.org/wiki/Q1752284","display_name":"Pathological staging","level":3,"score":0.2736000120639801},{"id":"https://openalex.org/C2779328685","wikidata":"https://www.wikidata.org/wiki/Q1475557","display_name":"Patient safety","level":3,"score":0.27140000462532043},{"id":"https://openalex.org/C2989236134","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Patient care","level":2,"score":0.25850000977516174},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.25369998812675476},{"id":"https://openalex.org/C2779377019","wikidata":"https://www.wikidata.org/wiki/Q956131","display_name":"Overdiagnosis","level":2,"score":0.25279998779296875},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2515000104904175}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11322431/v1","doi":"https://doi.org/10.21203/rs.3.rs-11322431/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11322431/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11322431/v1","doi":"https://doi.org/10.21203/rs.3.rs-11322431/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11322431/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1827112513","https://openalex.org/W2121836977","https://openalex.org/W3009221479","https://openalex.org/W3024734235","https://openalex.org/W3042226836","https://openalex.org/W3042357937","https://openalex.org/W3046581048","https://openalex.org/W3088645878","https://openalex.org/W3095393026","https://openalex.org/W3113100123","https://openalex.org/W3119214553","https://openalex.org/W3164584310","https://openalex.org/W4321748436","https://openalex.org/W4361284304","https://openalex.org/W4378232608","https://openalex.org/W4387014443","https://openalex.org/W4389137223","https://openalex.org/W4399299862","https://openalex.org/W4400363658","https://openalex.org/W4400526530","https://openalex.org/W4400788340","https://openalex.org/W4401385191","https://openalex.org/W4401754986","https://openalex.org/W4412493284"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"The":[2,91],"COVID-19":[3],"pandemic":[4],"severely":[5],"disrupted":[6],"healthcare":[7],"systems,":[8],"delaying":[9],"essential":[10],"oncological":[11,222],"treatments.":[12],"We":[13,69],"evaluated":[14],"how":[15],"pandemic-related":[16],"surgical":[17,185],"delays":[18,186],"affected":[19],"pathological":[20,74,190],"outcomes\u2014such":[21],"as":[22],"staging":[23],"and":[24,53,62,79,87,149,166,176,187,219],"grading\u2014in":[25],"patients":[26,48],"undergoing":[27,49],"radical":[28],"prostatectomy":[29],"(RP)":[30],"for":[31,210],"localized":[32],"prostate":[33],"cancer":[34,217],"within":[35],"a":[36],"Brazilian":[37],"public":[38,226],"university":[39],"hospital.":[40],"Methods":[41],"This":[42],"retrospective,":[43,163],"single-center":[44,164],"study":[45],"analyzed":[46],"382":[47],"RP":[50],"between":[51],"2016":[52],"2025,":[54],"divided":[55],"into":[56],"pre-pandemic":[57],"(2016\u20132019;":[58],"n":[59,65],"=":[60,66,115],"155)":[61],"pandemic/post-pandemic":[63],"(2020\u20132025;":[64],"227)":[67],"cohorts.":[68],"compared":[70],"clinicopathological":[71],"variables,":[72],"including":[73],"staging,":[75],"ISUP":[76,140],"grade":[77,141],"groups,":[78],"biopsy-to-surgery":[80,93],"intervals,":[81],"using":[82],"Mann-Whitney":[83],"U,":[84],"Student's":[85],"t,":[86],"Chi-square":[88],"tests.":[89],"Results":[90],"median":[92],"interval":[94],"rose":[95,152],"from":[96,127,133,153],"245":[97,102],"to":[98,103,129,135,147,155,214],"340":[99],"days":[100],"(mean:":[101],"383":[104],"days;":[105],"p":[106,137],"<":[107,138,158],"0.01).":[108,139,159],"While":[109],"baseline":[110],"PSA":[111],"remained":[112],"stable":[113],"(p":[114,157],"0.7),":[116],"we":[117],"observed":[118],"significant":[119],"migration":[120],"toward":[121],"locally":[122],"advanced":[123],"disease":[124],"(pT2":[125],"decreased":[126],"63.2%":[128],"42.3%;":[130],"pT3a/b":[131],"increased":[132],"36.8%":[134],"57.7%;":[136],"5":[142],"tumors":[143],"nearly":[144],"doubled":[145],"(14.2%":[146],"27.7%),":[148],"histological":[150],"upgrading":[151],"32.9%":[154],"55.9%":[156],"Limitations":[160],"include":[161],"the":[162,194,201,207],"design,":[165],"lack":[167],"of":[168,196],"long-term":[169,221],"biochemical":[170],"recurrence":[171],"or":[172],"survival":[173],"data.":[174],"Conclusions":[175],"Clinical":[177],"Implications:":[178],"Pandemic-related":[179],"disruptions":[180],"were":[181],"associated":[182],"with":[183],"prolonged":[184],"significantly":[188],"worse":[189],"outcomes,":[191],"strongly":[192],"supporting":[193],"hypothesis":[195],"true":[197],"tumor":[198],"progression":[199],"during":[200,224],"waiting":[202],"period.":[203],"These":[204],"findings":[205],"emphasize":[206],"critical":[208],"need":[209],"robust":[211],"contingency":[212],"strategies":[213],"preserve":[215],"timely":[216],"surgery":[218],"mitigate":[220],"harm":[223],"future":[225],"health":[227],"crises.":[228]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
