{"id":"https://openalex.org/W7225830227","doi":"https://doi.org/10.64898/2026.11.08.765212","title":"Endogenous Mechanical Reporters Encode the Global Mechanical Landscape of Morphogenesis","display_name":"Endogenous Mechanical Reporters Encode the Global Mechanical Landscape of Morphogenesis","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225830227","doi":"https://doi.org/10.64898/2026.11.08.765212"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.08.765212","doi":"https://doi.org/10.64898/2026.11.08.765212","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.11.08.765212","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112974786","display_name":"Ruoqing Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruoqing Xu","raw_affiliation_strings":["Westlake University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westlake University","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161433089","display_name":"Han Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Gao","raw_affiliation_strings":["Westlake University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westlake University","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161454551","display_name":"Fancheng Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fancheng Li","raw_affiliation_strings":["Westlake University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westlake University","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5155597813","display_name":"Lei-Han Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei-han Tang","raw_affiliation_strings":["Westlake University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westlake University","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103256380","display_name":"Hai Zhu","orcid":"https://orcid.org/0000-0002-0810-7764","observed_orcids":["https://orcid.org/0000-0002-0810-7764"]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai Zhu","raw_affiliation_strings":["Westlake University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westlake University","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130237063","display_name":"Zhennan Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhennan Zhou","raw_affiliation_strings":["Westlake University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westlake University","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101090752","display_name":"Hanqing Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hanqing Guo","raw_affiliation_strings":["Westlake University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westlake University","institution_ids":["https://openalex.org/I3133055985"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101090752"],"corresponding_institution_ids":["https://openalex.org/I3133055985"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11737","display_name":"Advanced Materials and Mechanics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C171912257","wikidata":"https://www.wikidata.org/wiki/Q11019","display_name":"Mechanical system","level":2,"score":0.5565000176429749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.484499990940094},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4699000120162964},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.45680001378059387},{"id":"https://openalex.org/C66746571","wikidata":"https://www.wikidata.org/wiki/Q1134833","display_name":"ENCODE","level":3,"score":0.4390999972820282},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.41620001196861267},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3889000117778778},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36890000104904175},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36660000681877136},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3578999936580658},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.35740000009536743},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.32280001044273376},{"id":"https://openalex.org/C2780980858","wikidata":"https://www.wikidata.org/wiki/Q110022","display_name":"Dual (grammatical number)","level":2,"score":0.30250000953674316},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3003999888896942},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.27379998564720154},{"id":"https://openalex.org/C15526883","wikidata":"https://www.wikidata.org/wiki/Q6657126","display_name":"Live cell imaging","level":3,"score":0.26080000400543213},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.25920000672340393},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.2538999915122986}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.08.765212","doi":"https://doi.org/10.64898/2026.11.08.765212","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.11.08.765212","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Developmental":[0],"systems":[1],"usually":[2],"comprise":[3],"multiple":[4],"genetically":[5],"programmed":[6],"morphogenetic":[7],"events":[8],"within":[9],"a":[10,55,88,94,124,147],"mechanically":[11],"continuous":[12],"environment,":[13],"yet":[14],"how":[15],"individual":[16],"processes":[17],"interact":[18],"and":[19,64,78,153],"contribute":[20],"to":[21,96,131],"the":[22,31,44,72,99,111,135,141],"overall":[23],"mechanical":[24,34,46,56,80,85,112,137,144,156],"landscape":[25,86,113],"remains":[26],"unknown.":[27],"Here,":[28],"we":[29,66,92,106,122],"introduce":[30],"concept":[32,142],"of":[33,43,75,143],"reporter:":[35],"endogenous":[36],"tissues":[37],"function":[38],"as":[39,54],"in":[40,58,110,117,134,158],"situ":[41],"probes":[42],"embedded":[45],"landscape.":[47,138],"We":[48],"exemplified":[49],"cephalic":[50],"furrow":[51],"(CF)":[52],"migration":[53],"reporter":[57,100,145],"gastrulating":[59,118],"Drosophila":[60,119],".":[61,120],"Using":[62,102],"optogenetics":[63],"genetics,":[65],"revealed":[67],"that":[68,127],"CF":[69,115,129],"displacement":[70],"reflects":[71],"combined":[73],"effect":[74],"both":[76],"force":[77],"tissue":[79],"properties.":[81],"By":[82],"incorporating":[83],"condition-specific":[84],"into":[87],"continuum":[89],"minimal-response":[90],"model,":[91],"developed":[93],"framework":[95,126],"quantitatively":[97],"predict":[98],"dynamics.":[101],"different":[103],"genetic":[104],"mutants,":[105],"successfully":[107],"decoded":[108],"changes":[109,133],"from":[114],"dynamics":[116,130],"Overall,":[121],"established":[123],"predictive":[125],"uses":[128],"infer":[132],"global":[136],"Beyond":[139],"this,":[140],"provides":[146],"general":[148],"strategy":[149],"for":[150],"systematically":[151],"understanding":[152],"decoding":[154],"complex":[155],"environments":[157],"living":[159],"systems.":[160]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
