{"id":"https://openalex.org/W7225829808","doi":"https://doi.org/10.3390/cimb48111193","title":"Analysis of the Differential Expression of Genes Involved in Pathways of Cell Proliferation, Differentiation and Inflammatory Responses in the Eutopic Endometrium of Patients with and Without Endometriosis","display_name":"Analysis of the Differential Expression of Genes Involved in Pathways of Cell Proliferation, Differentiation and Inflammatory Responses in the Eutopic Endometrium of Patients with and Without Endometriosis","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225829808","doi":"https://doi.org/10.3390/cimb48111193"},"language":"en","primary_location":{"id":"doi:10.3390/cimb48111193","doi":"https://doi.org/10.3390/cimb48111193","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb48111193","pdf_url":null,"source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/cimb48111193","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027777259","display_name":"J\u00falia Kefal\u00e1s Troncon","orcid":"https://orcid.org/0000-0002-1819-622X","observed_orcids":["https://orcid.org/0000-0002-1819-622X"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"J\u00falia Kefal\u00e1s Troncon","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Av. Bandeirantes, 3900, Ribeir\u00e3o Preto 14049-900, SP, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-1819-622X","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Av. Bandeirantes, 3900, Ribeir\u00e3o Preto 14049-900, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044414110","display_name":"Juliana Meola","orcid":"https://orcid.org/0000-0003-2514-4011","observed_orcids":["https://orcid.org/0000-0003-2514-4011"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Juliana Meola","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Av. Bandeirantes, 3900, Ribeir\u00e3o Preto 14049-900, SP, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-2514-4011","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Av. Bandeirantes, 3900, Ribeir\u00e3o Preto 14049-900, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036552780","display_name":"Carla de Azevedo Piccinato","orcid":"https://orcid.org/0000-0002-2872-5957","observed_orcids":["https://orcid.org/0000-0002-2872-5957"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carla de Azevedo Piccinato","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Av. Bandeirantes, 3900, Ribeir\u00e3o Preto 14049-900, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Av. Bandeirantes, 3900, Ribeir\u00e3o Preto 14049-900, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161457603","display_name":"Isabela Nardo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Isabela Nardo","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Av. Bandeirantes, 3900, Ribeir\u00e3o Preto 14049-900, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Av. Bandeirantes, 3900, Ribeir\u00e3o Preto 14049-900, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089553098","display_name":"Omero Benedicto Poli\u2010Neto","orcid":"https://orcid.org/0000-0003-0270-5496","observed_orcids":["https://orcid.org/0000-0003-0270-5496"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Omero Benedicto Poli-Neto","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Av. Bandeirantes, 3900, Ribeir\u00e3o Preto 14049-900, SP, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-0270-5496","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Av. Bandeirantes, 3900, Ribeir\u00e3o Preto 14049-900, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004632603","display_name":"J\u00falio Dos Santos Silva","orcid":"https://orcid.org/0000-0001-8212-7440","observed_orcids":["https://orcid.org/0000-0001-8212-7440","https://orcid.org/0000-0001-6930-1328"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"J\u00falio C\u00e9sar Rosa e Silva","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Av. Bandeirantes, 3900, Ribeir\u00e3o Preto 14049-900, SP, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-6930-1328","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Av. Bandeirantes, 3900, Ribeir\u00e3o Preto 14049-900, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004632603"],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2654},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2654},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":"11","first_page":"1193","last_page":"1193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12096","display_name":"Ectopic Pregnancy Diagnosis and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2779522080","wikidata":"https://www.wikidata.org/wiki/Q205764","display_name":"Endometriosis","level":2,"score":0.9466000199317932},{"id":"https://openalex.org/C2781085546","wikidata":"https://www.wikidata.org/wiki/Q18028096","display_name":"JUNB","level":4,"score":0.6955999732017517},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5659000277519226},{"id":"https://openalex.org/C2777099045","wikidata":"https://www.wikidata.org/wiki/Q17929096","display_name":"FOSB","level":4,"score":0.5637000203132629},{"id":"https://openalex.org/C2779742232","wikidata":"https://www.wikidata.org/wiki/Q839508","display_name":"Endometrium","level":2,"score":0.4968999922275543},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47099998593330383},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.42160001397132874},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41780000925064087},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3873000144958496},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3853999972343445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38420000672340393},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.383899986743927},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.38359999656677246},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.3709000051021576},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3596000075340271},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3571000099182129},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.328900009393692},{"id":"https://openalex.org/C2779066055","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Uterus","level":2,"score":0.3280999958515167},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.31679999828338623},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.31139999628067017},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.30820000171661377},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.30090001225471497},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.29750001430511475},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2827000021934509},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2786000072956085},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.27639999985694885},{"id":"https://openalex.org/C3018023364","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Significant difference","level":2,"score":0.2671999931335449},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.26339998841285706},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.2599000036716461},{"id":"https://openalex.org/C16156107","wikidata":"https://www.wikidata.org/wiki/Q4875786","display_name":"Beach morphodynamics","level":4,"score":0.25850000977516174}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/cimb48111193","doi":"https://doi.org/10.3390/cimb48111193","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb48111193","pdf_url":null,"source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/cimb48111193","doi":"https://doi.org/10.3390/cimb48111193","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb48111193","pdf_url":null,"source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1963892494","https://openalex.org/W1976506071","https://openalex.org/W1983357242","https://openalex.org/W2007347214","https://openalex.org/W2009139525","https://openalex.org/W2011696346","https://openalex.org/W2017734786","https://openalex.org/W2019599115","https://openalex.org/W2035644133","https://openalex.org/W2036224418","https://openalex.org/W2052734212","https://openalex.org/W2057582406","https://openalex.org/W2061096783","https://openalex.org/W2072319964","https://openalex.org/W2077121523","https://openalex.org/W2078551011","https://openalex.org/W2093350076","https://openalex.org/W2097174302","https://openalex.org/W2101648602","https://openalex.org/W2107277218","https://openalex.org/W2117993574","https://openalex.org/W2141020709","https://openalex.org/W2164002837","https://openalex.org/W2165696199","https://openalex.org/W2203749559","https://openalex.org/W2233670447","https://openalex.org/W2765750028","https://openalex.org/W2986294785","https://openalex.org/W3000127458","https://openalex.org/W3028412883","https://openalex.org/W3106204292","https://openalex.org/W3116156571","https://openalex.org/W3149429548","https://openalex.org/W3150222876","https://openalex.org/W3198929167","https://openalex.org/W4211092896","https://openalex.org/W4234160457","https://openalex.org/W4297988543","https://openalex.org/W4321787636","https://openalex.org/W4360603678","https://openalex.org/W4394857494","https://openalex.org/W4399321469","https://openalex.org/W4403404797","https://openalex.org/W4406605720","https://openalex.org/W4410079655","https://openalex.org/W4410541673","https://openalex.org/W7163904745"],"related_works":[],"abstract_inverted_index":{"An":[0],"observational":[1],"cross-sectional":[2],"study":[3],"was":[4,36,77,124],"conducted":[5],"in":[6,54,83,116,130,154,158,175,217],"a":[7,18,102,151],"university":[8],"hospital":[9],"to":[10,66,93,228],"evaluate":[11],"eutopic":[12,192],"endometria":[13],"from":[14],"women":[15,107],"who":[16],"underwent":[17],"laparoscopy,":[19],"comprising":[20],"20":[21],"patients":[22,115,162],"with":[23,91,160],"endometriosis":[24,71,109,161,203],"and":[25,49,60,62,80,178,180,216],"25":[26],"without":[27],"the":[28,39,44,63,70,73,84,98,113,128,131,155,170,191,199,202,206,214,218,231],"disease":[29],"(control":[30],"group).":[31],"The":[32,87],"differential":[33],"gene":[34],"expression":[35,132,153],"analyzed":[37],"between":[38,127],"groups":[40,88,118,129],"by":[41],"RT-qPCR":[42],"for":[43,97],"genes":[45],"FOS,":[46],"FOSB,":[47],"JUNB,":[48,148],"EGR1,":[50],"which":[51,100],"are":[52],"involved":[53],"common":[55],"pathways":[56],"regulating":[57],"cell":[58],"differentiation":[59],"proliferation":[61,177],"early":[64],"response":[65],"inflammatory":[67],"insults.":[68],"In":[69],"group,":[72],"mean":[74],"patient\u2019s":[75],"age":[76],"36.4":[78],"years,":[79],"34.4":[81],"years":[82],"control":[85,156],"group.":[86],"were":[89,119],"homogeneous":[90],"respect":[92],"clinical":[94],"variables,":[95],"except":[96],"parity,":[99],"showed":[101],"higher":[103,152],"frequency":[104],"of":[105,112,133,173,201,220,237],"nulliparous":[106],"among":[108,185],"patients.":[110],"Most":[111],"included":[114],"both":[117],"on":[120,198],"hormonal":[121],"medications.":[122],"There":[123],"no":[125],"difference":[126],"EGR1":[134],"(p":[135,139,144,163],"=":[136,140,145,164],"0.9231),":[137],"FOS":[138],"0.1261),":[141],"or":[142],"FOSB":[143],"0.8249).":[146],"Concerning":[147],"we":[149],"observed":[150],"group":[157],"comparison":[159],"0.0417).":[165],"These":[166],"results":[167],"may":[168,194],"reflect":[169],"paradoxical":[171],"role":[172],"JUNB":[174],"modulating":[176],"apoptosis":[179],"highlight":[181],"possible":[182],"biological":[183],"variability":[184],"different":[186],"populations.":[187],"Finally,":[188],"analyzing":[189],"only":[190],"endometrium":[193,207],"not":[195],"shed":[196],"light":[197],"complexity":[200],"pathophysiology,":[204],"since":[205],"undergoes":[208],"critical":[209],"modifications":[210],"when":[211],"present":[212],"outside":[213],"uterus":[215],"context":[219],"already":[221],"established":[222],"disease.":[223],"Future":[224],"studies":[225],"should":[226],"aim":[227],"better":[229],"understand":[230],"peritoneal":[232],"microenvironment,":[233],"prioritizing":[234],"broader":[235],"evaluations":[236],"post-transcriptional":[238],"factors.":[239]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}