{"id":"https://openalex.org/W7225829215","doi":"https://doi.org/10.66789/tjcvd.2026.839","title":"Immune thrombotic thrombocytopenic purpura associated with acute large vessel occlusion","display_name":"Immune thrombotic thrombocytopenic purpura associated with acute large vessel occlusion","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225829215","doi":"https://doi.org/10.66789/tjcvd.2026.839"},"language":"en","primary_location":{"id":"doi:10.66789/tjcvd.2026.839","doi":"https://doi.org/10.66789/tjcvd.2026.839","is_oa":true,"landing_page_url":"https://doi.org/10.66789/tjcvd.2026.839","pdf_url":null,"source":{"id":"https://openalex.org/S5407047893","display_name":"Turkish Journal of Cerebrovascular Diseases","issn_l":"1301-1375","issn":["1301-1375","2146-9113","3062-3707"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":"https://openalex.org/P4310318333","host_organization_name":"Turkish Society of Cerebrovascular Diseases","host_organization_lineage":["https://openalex.org/P4310318333"],"host_organization_lineage_names":["Turkish Society of Cerebrovascular Diseases"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Cerebrovascular Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.66789/tjcvd.2026.839","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161441018","display_name":"\u015eevda Karakoyunlu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123466251","display_name":"Dicle University","ror":"https://ror.org/0257dtg16","country_code":"TR","type":"education","lineage":["https://openalex.org/I123466251"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u015eevda Karakoyunlu","raw_affiliation_strings":["Department of Neurology, Faculty of Medicine, Dicle University, Diyarbak\u0131r, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Faculty of Medicine, Dicle University, Diyarbak\u0131r, T\u00fcrkiye","institution_ids":["https://openalex.org/I123466251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116767912","display_name":"M\u00fcttalip \u00d6zbek","orcid":"https://orcid.org/0000-0001-7413-0965","observed_orcids":["https://orcid.org/0000-0001-7413-0965"]},"institutions":[{"id":"https://openalex.org/I123466251","display_name":"Dicle University","ror":"https://ror.org/0257dtg16","country_code":"TR","type":"education","lineage":["https://openalex.org/I123466251"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Muttalip \u00d6zbek","raw_affiliation_strings":["Department of Neurology, Faculty of Medicine, Dicle University, Diyarbak\u0131r, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Faculty of Medicine, Dicle University, Diyarbak\u0131r, T\u00fcrkiye","institution_ids":["https://openalex.org/I123466251"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091352458","display_name":"E\u015fref Ak\u0131l","orcid":"https://orcid.org/0000-0001-9669-6804","observed_orcids":["https://orcid.org/0000-0001-9669-6804"]},"institutions":[{"id":"https://openalex.org/I123466251","display_name":"Dicle University","ror":"https://ror.org/0257dtg16","country_code":"TR","type":"education","lineage":["https://openalex.org/I123466251"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"E\u015fref Ak\u0131l","raw_affiliation_strings":["Department of Neurology, Faculty of Medicine, Dicle University, Diyarbak\u0131r, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Faculty of Medicine, Dicle University, Diyarbak\u0131r, T\u00fcrkiye","institution_ids":["https://openalex.org/I123466251"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I123466251"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"Supplement 1","first_page":"46","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9817000031471252},{"id":"https://openalex.org/C2778585876","wikidata":"https://www.wikidata.org/wiki/Q1426491","display_name":"Thrombotic thrombocytopenic purpura","level":3,"score":0.6353999972343445},{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.6000999808311462},{"id":"https://openalex.org/C65245452","wikidata":"https://www.wikidata.org/wiki/Q623225","display_name":"Schistocyte","level":4,"score":0.5909000039100647},{"id":"https://openalex.org/C2777878052","wikidata":"https://www.wikidata.org/wiki/Q3312044","display_name":"Thrombotic microangiopathy","level":3,"score":0.5519000291824341},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5479999780654907},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.46320000290870667},{"id":"https://openalex.org/C2780921031","wikidata":"https://www.wikidata.org/wiki/Q14873945","display_name":"ADAMTS13","level":4,"score":0.4528999924659729},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.38339999318122864},{"id":"https://openalex.org/C2781127562","wikidata":"https://www.wikidata.org/wiki/Q2063651","display_name":"Microangiopathic hemolytic anemia","level":4,"score":0.34470000863075256},{"id":"https://openalex.org/C2780643987","wikidata":"https://www.wikidata.org/wiki/Q468414","display_name":"Angiography","level":2,"score":0.33739998936653137},{"id":"https://openalex.org/C2776513394","wikidata":"https://www.wikidata.org/wiki/Q1412400","display_name":"Microangiopathy","level":3,"score":0.3303999900817871},{"id":"https://openalex.org/C2776882386","wikidata":"https://www.wikidata.org/wiki/Q2291130","display_name":"Hemiparesis","level":3,"score":0.313400000333786},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.31310001015663147},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.311599999666214},{"id":"https://openalex.org/C2780022809","wikidata":"https://www.wikidata.org/wiki/Q5786759","display_name":"Lupus anticoagulant","level":3,"score":0.3093000054359436},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.30559998750686646},{"id":"https://openalex.org/C2779771385","wikidata":"https://www.wikidata.org/wiki/Q6132707","display_name":"Thrombocytopenic purpura","level":3,"score":0.28870001435279846},{"id":"https://openalex.org/C2777121669","wikidata":"https://www.wikidata.org/wiki/Q148881","display_name":"Purpura (gastropod)","level":2,"score":0.2881999909877777},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2815999984741211},{"id":"https://openalex.org/C2776874634","wikidata":"https://www.wikidata.org/wiki/Q582207","display_name":"Antiphospholipid syndrome","level":3,"score":0.2800999879837036},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.25189998745918274}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.66789/tjcvd.2026.839","doi":"https://doi.org/10.66789/tjcvd.2026.839","is_oa":true,"landing_page_url":"https://doi.org/10.66789/tjcvd.2026.839","pdf_url":null,"source":{"id":"https://openalex.org/S5407047893","display_name":"Turkish Journal of Cerebrovascular Diseases","issn_l":"1301-1375","issn":["1301-1375","2146-9113","3062-3707"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":"https://openalex.org/P4310318333","host_organization_name":"Turkish Society of Cerebrovascular Diseases","host_organization_lineage":["https://openalex.org/P4310318333"],"host_organization_lineage_names":["Turkish Society of Cerebrovascular Diseases"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Cerebrovascular Diseases","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.66789/tjcvd.2026.839","doi":"https://doi.org/10.66789/tjcvd.2026.839","is_oa":true,"landing_page_url":"https://doi.org/10.66789/tjcvd.2026.839","pdf_url":null,"source":{"id":"https://openalex.org/S5407047893","display_name":"Turkish Journal of Cerebrovascular Diseases","issn_l":"1301-1375","issn":["1301-1375","2146-9113","3062-3707"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":"https://openalex.org/P4310318333","host_organization_name":"Turkish Society of Cerebrovascular Diseases","host_organization_lineage":["https://openalex.org/P4310318333"],"host_organization_lineage_names":["Turkish Society of Cerebrovascular Diseases"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Cerebrovascular Diseases","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Introduction:":[0],"Thrombotic":[1],"thrombocytopenic":[2],"purpura":[3],"(TTP)":[4],"is":[5,35,246,320],"a":[6,44,96,202,231,248,349,372],"life-threatening":[7],"thrombotic":[8,308,333,363],"microangiopathy":[9],"caused":[10],"by":[11,16,275],"ADAMTS13":[12,157,283],"deficiency":[13],"and":[14,29,55,84,95,104,118,152,162,169,174,189,209,214,238,287,341],"characterized":[15],"platelet-rich":[17],"microthrombi.":[18],"Neurological":[19],"findings":[20],"are":[21],"common,":[22],"but":[23,278],"presentation":[24],"with":[25,31,59,65,73,86,135,258],"acute":[26,52],"ischemic":[27],"stroke,":[28],"particularly":[30],"large":[32,232,259,350],"vessel":[33,260,328,351],"occlusion,":[34],"rare.":[36],"This":[37,318],"report":[38],"describes":[39],"the":[40,127,131,163,186,215,228,267,295,306,315,327,332,376],"clinical":[41,199,240,377],"course":[42],"of":[43,154,183,198,204,230,250,297],"young":[45,338],"patient":[46,222],"who":[47],"underwent":[48],"mechanical":[49,114,276],"thrombectomy":[50,115],"for":[51,359],"MCA":[53,112,234,270],"occlusion":[54,261,271,352],"was":[56,81,102,106,116,122,133,159,165,272],"subsequently":[57],"diagnosed":[58],"immune":[60,205,298],"TTP.Case:":[61],"A":[62,361],"27-year-old":[63],"woman":[64],"no":[66,178],"chronic":[67],"illness":[68],"or":[69],"regular":[70],"medication":[71],"presented":[72],"acute-onset":[74],"focal":[75],"neurological":[76],"deficit.":[77],"On":[78],"examination":[79],"she":[80],"alert,":[82],"oriented,":[83],"cooperative,":[85],"left":[87,91,97],"central":[88],"facial":[89],"paralysis,":[90],"hemiparesis":[92],"(1/5),":[93],"dysarthria,":[94],"plantar":[98],"extensor":[99],"response.":[100],"NIHSS":[101],"20":[103],"ASPECTS":[105],"8.":[107],"CT":[108],"angiography":[109],"showed":[110,150,177],"right":[111,190,233,269],"occlusion;":[113],"performed,":[117],"TICI":[119],"3":[120],"reperfusion":[121,369],"achieved.":[123],"Contrast":[124],"extravasation":[125],"at":[126,142,185],"ICA":[128],"terminus":[129],"during":[130,291,346],"procedure":[132],"controlled":[134],"endovascular":[136],"methods.":[137],"The":[138,147,221,300],"platelet":[139,216],"count,":[140],"166,000":[141],"baseline,":[143],"fell":[144],"to":[145,219,294,314],"24,000.":[146],"peripheral":[148],"smear":[149],"schistocytes":[151],"signs":[153],"microangiopathic":[155,281,342],"hemolysis.":[156],"activity":[158,284],"6":[160],"IU/dL,":[161],"inhibitor":[164,288],"positive.":[166],"Antiphospholipid":[167],"antibodies":[168],"lupus":[170],"anticoagulant":[171],"were":[172,212],"negative,":[173],"blood":[175],"cultures":[176],"growth.":[179],"Echocardiography":[180],"raised":[181],"suspicion":[182],"thrombus":[184,303],"mitral":[187],"valve":[188],"atrium;":[191],"TEE":[192],"could":[193],"not":[194,311,330],"be":[195,256,312,354,371],"performed":[196],"because":[197,322],"instability.":[200],"With":[201],"diagnosis":[203,296],"TTP,":[206],"plasma":[207],"exchange":[208],"steroid":[210],"therapy":[211],"started,":[213],"count":[217],"rose":[218],"37,000.":[220],"died":[223],"within":[224],"one":[225],"month":[226],"in":[227],"setting":[229],"infarct,":[235],"hemorrhagic":[236],"transformation,":[237],"systemic":[239,307,362],"deterioration":[241],"(Figure":[242],"1\u20134).Discussion/Conclusion:":[243],"Although":[244],"TTP":[245],"fundamentally":[247],"disease":[249],"microvascular":[251,316],"thrombosis,":[252],"it":[253,323],"may":[254,310,370],"rarely":[255],"associated":[257],"as":[262],"well.":[263],"In":[264,337],"our":[265],"patient,":[266],"embolic":[268],"successfully":[273],"opened":[274],"thrombectomy,":[277],"severe":[279],"thrombocytopenia,":[280],"hemolysis,":[282],"below":[285],"10%,":[286],"positivity":[289],"developed":[290],"follow-up,":[292],"leading":[293],"TTP.":[299,360],"suspected":[301],"cardiac":[302],"suggested":[304],"that":[305,325,344,365],"process":[309,334,364],"confined":[313],"bed.":[317],"case":[319],"noteworthy":[321],"shows":[324],"opening":[326],"does":[329],"mean":[331],"has":[335],"ended.":[336],"patients,":[339],"thrombocytopenia":[340],"hemolysis":[343],"develop":[345],"follow-up":[347],"after":[348],"should":[353],"an":[355],"important":[356],"warning":[357],"sign":[358],"continues":[366],"despite":[367],"successful":[368],"critical":[373],"factor":[374],"determining":[375],"course.Keywords:":[378]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}