{"id":"https://openalex.org/W7225828546","doi":"https://doi.org/10.64898/2026.11.10.765736","title":"Differential regulation of myeloid Scavenger Receptor A (CD204) expression in humans versus mice in response to sepsis","display_name":"Differential regulation of myeloid Scavenger Receptor A (CD204) expression in humans versus mice in response to sepsis","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225828546","doi":"https://doi.org/10.64898/2026.11.10.765736"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.10.765736","doi":"https://doi.org/10.64898/2026.11.10.765736","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.11.10.765736","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040254279","display_name":"Tammy R. Ozment","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tammy R Ozment","raw_affiliation_strings":["East Tennessee State University;"],"raw_orcid":"https://orcid.org/0000-0003-3623-9745","affiliations":[{"raw_affiliation_string":"East Tennessee State University;","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161461027","display_name":"Melanie McGlothlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melanie McGlothlin","raw_affiliation_strings":["East Tennessee State University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East Tennessee State University;","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111503275","display_name":"John B. Schweitzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Schweitzer","raw_affiliation_strings":["East Tennessee State University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East Tennessee State University;","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045345310","display_name":"James L. Adkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Adkins","raw_affiliation_strings":["East Tennessee State University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East Tennessee State University;","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161486486","display_name":"Nikolas Hopkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikolas Hopkins","raw_affiliation_strings":["University of Alabama at Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033677559","display_name":"David L. Williams","orcid":"https://orcid.org/0000-0002-4586-9290","observed_orcids":["https://orcid.org/0000-0002-4586-9290"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L Williams","raw_affiliation_strings":["East Tennessee State University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East Tennessee State University;","institution_ids":["https://openalex.org/I119443389"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.7666000127792358,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.7666000127792358,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.14669999480247498,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.06400000303983688,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.8367000222206116},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.689300000667572},{"id":"https://openalex.org/C41443022","wikidata":"https://www.wikidata.org/wiki/Q27796666","display_name":"Scavenger receptor","level":4,"score":0.679099977016449},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.612500011920929},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5841000080108643},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48899999260902405},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4742000102996826},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4740000069141388},{"id":"https://openalex.org/C2993002077","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Receptor expression","level":3,"score":0.4636000096797943},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.4262000024318695},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3700000047683716},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.36489999294281006},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3628999888896942},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.34869998693466187},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.34549999237060547},{"id":"https://openalex.org/C2994430510","wikidata":"https://www.wikidata.org/wiki/Q3270846","display_name":"Myeloid cells","level":3,"score":0.3158999979496002},{"id":"https://openalex.org/C101666144","wikidata":"https://www.wikidata.org/wiki/Q2587862","display_name":"CCL2","level":4,"score":0.31130000948905945},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.3091999888420105},{"id":"https://openalex.org/C2778923028","wikidata":"https://www.wikidata.org/wiki/Q974869","display_name":"Leukocytosis","level":2,"score":0.3043999969959259},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.30379998683929443},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.3003999888896942},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.29109999537467957},{"id":"https://openalex.org/C108634530","wikidata":"https://www.wikidata.org/wiki/Q7863610","display_name":"U937 cell","level":3,"score":0.2888000011444092},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.28439998626708984},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.28360000252723694},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.28290000557899475},{"id":"https://openalex.org/C2781090800","wikidata":"https://www.wikidata.org/wiki/Q776030","display_name":"Systemic inflammatory response syndrome","level":3,"score":0.27720001339912415},{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.2721000015735626},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.26010000705718994},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.25619998574256897}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.10.765736","doi":"https://doi.org/10.64898/2026.11.10.765736","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.11.10.765736","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Sepsis":[0],"is":[1,18,26,195,215],"the":[2,9,57,208,244],"number":[3],"one":[4],"cause":[5],"of":[6,16,30,59,153,162,246],"mortality":[7,47],"in":[8,48,65,197,207,218,243],"critically":[10],"ill":[11],"patient.":[12],"The":[13,51],"underlying":[14],"pathophysiology":[15,245],"sepsis":[17,60,72,89,144],"not":[19,136,174,216,225,236],"fully":[20],"understood.":[21],"Scavenger":[22],"Receptor":[23],"A":[24],"(SR-A)":[25],"a":[27,204,241],"promiscuous":[28],"receptor":[29],"myeloid":[31,62,232],"cells":[32,92],"that":[33,44],"binds":[34],"multiple":[35],"pathogen":[36],"associated":[37],"molecular":[38],"patterns":[39],"(PAMPs).":[40],"We":[41],"have":[42],"demonstrated":[43],"SR-A":[45,63,109,118,133,167,171,187,193,213,233],"promotes":[46],"murine":[49,154],"sepsis.":[50,248],"present":[52],"study":[53],"sought":[54],"to":[55,71,122,148,210,238],"examine":[56],"effect":[58],"on":[61,126,138,189],"expression":[64,110,119,134,172,188,194,214,234],"septic":[66,198,221],"mice":[67,78,97],"and":[68,82,101,108,129,156,160,179,200,223],"compare":[69],"it":[70],"patients.":[73,90],"Leukocytes":[74],"were":[75,86,93,102,111],"isolated":[76,87,94],"from":[77,88,95,143,220],"after":[79],"cecal":[80],"ligation":[81],"puncture.":[83],"Blood":[84],"leukocytes":[85,219],"Myeloid":[91,192],"healthy":[96,149],"or":[98,141],"human":[99,190,247],"subjects":[100],"treated":[103],"with":[104,158,164,182,227],"PAMPs.":[105],"Leukocyte":[106],"phenotype":[107],"determined":[112],"by":[113,176],"flow":[114],"cytometry.":[115],"CLP":[116],"increased":[117,166,186,196],"when":[120,146],"compared":[121,147],"sham":[123],"operated":[124],"animals":[125],"both":[127],"neutrophils":[128,140,155],"monocytes/macrophages.":[130],"In":[131],"contrast,":[132],"was":[135,173],"changed":[137,217],"either":[139],"monocytes":[142],"patients":[145,222],"control":[150],"subjects.":[151],"Treatment":[152],"macrophages":[157,163],"Pam3CSK4":[159],"treatment":[161,181],"LPS":[165],"expression.":[168],"Human":[169],"neutrophil":[170],"altered":[175],"any":[177],"PAMPs,":[178],"only":[180],"C.":[183],"albicans":[184],"glucan":[185],"monocytes.":[191],"mice,":[199],"this":[201],"increase":[202],"plays":[203],"detrimental":[205],"role":[206,242],"response":[209],"sepsis,":[211],"while":[212],"does":[224,235],"correlate":[226],"SOFA":[228],"II":[229],"scores.":[230],"Thus,":[231],"appear":[237],"play":[239],"significant":[240]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
