{"id":"https://openalex.org/W7225827810","doi":"https://doi.org/10.5281/zenodo.24128871","title":"Driving the Vaginal Microecology towards Lactobacillus Dominance by Autologous Microbiota Transplantation: Paired Metagenomic Observations in Three Subjects","display_name":"Driving the Vaginal Microecology towards Lactobacillus Dominance by Autologous Microbiota Transplantation: Paired Metagenomic Observations in Three Subjects","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225827810","doi":"https://doi.org/10.5281/zenodo.24128871"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.24128871","doi":"https://doi.org/10.5281/zenodo.24128871","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24128871","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.24128871","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161494658","display_name":"Xue-Jiao Yang","orcid":"https://orcid.org/0009-0000-7360-5295","observed_orcids":["https://orcid.org/0009-0000-7360-5295"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang, Xue-Jiao","raw_affiliation_strings":["Beijing Fumate Biotechnology Co., Ltd., Beijing, China"],"raw_orcid":"https://orcid.org/0009-0000-7360-5295","affiliations":[{"raw_affiliation_string":"Beijing Fumate Biotechnology Co., Ltd., Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362621","display_name":"Wenhao Li","orcid":"https://orcid.org/0000-0002-4398-4586","observed_orcids":["https://orcid.org/0000-0002-4398-4586"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li, Wen-Hao","raw_affiliation_strings":["Beijing Fumate Biotechnology Co., Ltd., Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-4398-4586","affiliations":[{"raw_affiliation_string":"Beijing Fumate Biotechnology Co., Ltd., Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088547332","display_name":"Xiaochen Du","orcid":"https://orcid.org/0000-0003-1204-2665","observed_orcids":["https://orcid.org/0000-0003-1204-2665"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Du, Xiao-Chen","raw_affiliation_strings":["Beijing Fumate Biotechnology Co., Ltd., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Fumate Biotechnology Co., Ltd., Beijing, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161489576","display_name":"Jia-Shu Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhang, Jia-Shu","raw_affiliation_strings":["Beijing Fumate Biotechnology Co., Ltd., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Fumate Biotechnology Co., Ltd., Beijing, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7695000171661377},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.6370999813079834},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.6082000136375427},{"id":"https://openalex.org/C2777385719","wikidata":"https://www.wikidata.org/wiki/Q1061265","display_name":"Bacteroidetes","level":4,"score":0.4490000009536743},{"id":"https://openalex.org/C2780236403","wikidata":"https://www.wikidata.org/wiki/Q2355641","display_name":"Lactobacillus crispatus","level":4,"score":0.44769999384880066},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4327000081539154},{"id":"https://openalex.org/C151913843","wikidata":"https://www.wikidata.org/wiki/Q3454555","display_name":"Dominance (genetics)","level":3,"score":0.4203000068664551},{"id":"https://openalex.org/C120667501","wikidata":"https://www.wikidata.org/wiki/Q6839493","display_name":"Microecology","level":2,"score":0.39809998869895935},{"id":"https://openalex.org/C30968088","wikidata":"https://www.wikidata.org/wiki/Q1230601","display_name":"Diversity index","level":3,"score":0.3758000135421753},{"id":"https://openalex.org/C2779952448","wikidata":"https://www.wikidata.org/wiki/Q804521","display_name":"Bacterial vaginosis","level":2,"score":0.352400004863739},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.3495999872684479},{"id":"https://openalex.org/C2778536940","wikidata":"https://www.wikidata.org/wiki/Q1975869","display_name":"Lactobacillus gasseri","level":4,"score":0.3384999930858612},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.33009999990463257},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.31790000200271606},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.3107999861240387},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3100000023841858},{"id":"https://openalex.org/C2777221637","wikidata":"https://www.wikidata.org/wiki/Q132644","display_name":"Lactobacillus acidophilus","level":4,"score":0.30379998683929443},{"id":"https://openalex.org/C23913935","wikidata":"https://www.wikidata.org/wiki/Q2650881","display_name":"Alpha diversity","level":3,"score":0.30250000953674316},{"id":"https://openalex.org/C2780018483","wikidata":"https://www.wikidata.org/wiki/Q127375","display_name":"Gardnerella vaginalis","level":3,"score":0.3010999858379364},{"id":"https://openalex.org/C2777744392","wikidata":"https://www.wikidata.org/wiki/Q5880","display_name":"Vagina","level":2,"score":0.29429998993873596},{"id":"https://openalex.org/C2780423288","wikidata":"https://www.wikidata.org/wiki/Q7242440","display_name":"Prevotella","level":3,"score":0.2928999960422516},{"id":"https://openalex.org/C2778265057","wikidata":"https://www.wikidata.org/wiki/Q537299","display_name":"Axenic","level":3,"score":0.27570000290870667},{"id":"https://openalex.org/C2779433226","wikidata":"https://www.wikidata.org/wiki/Q1799829","display_name":"Lactobacillus paracasei","level":4,"score":0.27309998869895935},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.26510000228881836},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.2605000138282776}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.24128871","doi":"https://doi.org/10.5281/zenodo.24128871","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24128871","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.5281/zenodo.24128872","doi":"https://doi.org/10.5281/zenodo.24128872","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24128872","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.5281/zenodo.24128871","doi":"https://doi.org/10.5281/zenodo.24128871","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24128871","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Vaginal":[1],"microbiota":[2,280],"transplantation":[3],"(VMT)":[4],"is":[5,256,265],"used":[6],"to":[7,86,97,105,118,129,142,147,154,159,164,176,323,363],"restore":[8],"a":[9,63,165,240,283],"Lactobacillus\u2011dominated":[10,241],"vaginal":[11,38,237,279],"microecology":[12],"in":[13,88,107,120,138,150,172,190,215,224],"women":[14],"whose":[15],"communities":[16],"have":[17],"shifted":[18],"into":[19,239],"dysbiosis.":[20],"In":[21],"this":[22],"pilot":[23],"descriptive":[24,333],"study,":[25],"three":[26,75,192,275],"subjects":[27,76,193,276],"(VT10,":[28],"VT12":[29,108,151,225],"and":[30,35,43,54,115,149,169,184,205,217,226,260,300,319,336],"VT13)":[31],"received":[32],"autologous":[33,278],"VMT,":[34],"six":[36],"paired":[37],"samples":[39,320],"collected":[40],"immediately":[41],"before":[42,252],"after":[44],"the":[45,67,78,220,236,310],"intervention":[46],"were":[47,211],"profiled":[48],"by":[49,125,324],"shotgun":[50],"metagenomics":[51],"with":[52,92,100,162,194,246,282,357],"Kraken2":[53],"Bracken":[55],"species\u2011level":[56],"annotation.":[57],"The":[58,80,270,329],"predefined":[59],"ecological":[60],"endpoint":[61],"was":[62,181,292],"relative":[64],"abundance":[65],"of":[66,70,219,309,349],"Lactobacillus":[68,81,167,223],"complex":[69,82],"at":[71],"least":[72],"50%.":[73],"All":[74,312],"reached":[77],"endpoint.":[79],"rose":[83],"from":[84,103,116],"45.4%":[85],"94.2%":[87],"VT10":[89,139],"(CST":[90,109,122],"IV":[91,123],"L.":[93,101,112,131],"iners":[94],"dominance":[95],"converted":[96,128],"CST":[98],"I":[99,110],"crispatus),":[102],"69.1%":[104],"98.8%":[106],"maintained,":[111],"crispatus":[113],"expanded),":[114],"19.3%":[117],"82.2%":[119],"VT13":[121,173],"dominated":[124],"Gardnerella":[126],"vaginalis":[127],"an":[130,266],"acidophilus\u2011dominated":[132],"community).":[133],"Alpha":[134],"diversity":[135],"decreased":[136,189],"sharply":[137],"(richness":[140,152,174],"1,311":[141],"148;":[143],"Shannon":[144,156],"index":[145,157],"2.79":[146],"1.14)":[148],"136":[153],"127;":[155],"1.27":[158],"0.19),":[160],"consistent":[161],"convergence":[163],"low\u2011diversity":[166],"monoculture,":[168],"increased":[170],"slightly":[171],"173":[175],"206).":[177],"Paired":[178],"Bray\u2011Curtis":[179],"dissimilarity":[180],"0.516,":[182],"0.299":[183],"0.695":[185],"respectively.":[186],"Fifteen":[187],"taxa":[188],"all":[191],"|log2FC|":[195],">=":[196],"1,":[197],"predominantly":[198],"Prevotella":[199],"species,":[200],"G.":[201],"vaginalis,":[202],"Hoylesella":[203],"buccalis":[204],"Fenollaria":[206],"massiliensis.":[207],"Two":[208],"engraftment":[209],"modes":[210],"observed:":[212],"species":[213],"replacement":[214],"VT10,":[216],"expansion":[218],"pre\u2011existing":[221],"dominant":[222],"VT13.":[227],"These":[228],"hypothesis\u2011generating":[229],"observations":[230,330],"indicate":[231],"that":[232],"VMT":[233],"can":[234],"move":[235],"community":[238],"state;":[242],"adequately":[243,354],"powered":[244,355],"studies":[245,356],"formal":[247,296,358],"ethical":[248,359],"approval":[249,299],"are":[250,321,331,361],"required":[251,362],"any":[253],"clinical":[254,340],"claim":[255],"made.":[257],"Important":[258],"Limitation":[259],"Ethics":[261],"Statement":[262],"This":[263,290],"work":[264,291],"exploratory":[267],"working":[268],"paper.":[269],"empirical":[271],"part":[272],"includes":[273],"only":[274],"receiving":[277],"transplantation,":[281],"single":[284],"post\u2011intervention":[285],"sampling":[286],"point":[287],"per":[288],"subject.":[289],"conducted":[293],"without":[294,301],"prior":[295],"institutional":[297],"ethics\u2011committee":[298],"documented":[302],"written":[303],"informed":[304],"consent":[305],"for":[306],"research":[307],"use":[308],"samples.":[311],"subject\u2011identifying":[313],"information":[314],"has":[315],"been":[316],"fully":[317],"de\u2011identified,":[318],"referred":[322],"laboratory":[325],"serial":[326],"numbers":[327],"only.":[328],"purely":[332],"preliminary":[334],"findings":[335],"cannot":[337],"serve":[338],"as":[339,347],"evidence,":[341],"nor":[342],"should":[343],"they":[344],"be":[345],"cited":[346],"evidence":[348],"efficacy":[350],"or":[351],"safety.":[352],"Further":[353],"review":[360],"validate":[364],"these":[365],"results.":[366]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}