{"id":"https://openalex.org/W7225827397","doi":"https://doi.org/10.3390/plants15223513","title":"CabHLH55 Negatively Regulates Cold Tolerance in Pepper by Modulating Reactive Oxygen Species Homeostasis and Cold-Responsive Gene Expression","display_name":"CabHLH55 Negatively Regulates Cold Tolerance in Pepper by Modulating Reactive Oxygen Species Homeostasis and Cold-Responsive Gene Expression","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225827397","doi":"https://doi.org/10.3390/plants15223513"},"language":"en","primary_location":{"id":"doi:10.3390/plants15223513","doi":"https://doi.org/10.3390/plants15223513","is_oa":true,"landing_page_url":"https://doi.org/10.3390/plants15223513","pdf_url":null,"source":{"id":"https://openalex.org/S4210230202","display_name":"Plants","issn_l":"2223-7747","issn":["2223-7747"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plants","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/plants15223513","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5121691251","display_name":"Jianwei Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119635","display_name":"Kaili University","ror":"https://ror.org/02hzqbc55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210119635"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianwei Zhang","raw_affiliation_strings":["Guizhou Key Laboratory of Molecular Breeding for Characteristic Horticultural Crops, Kaili 556011, China","School of Life and Health Science, Kaili University, Kaili 556011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guizhou Key Laboratory of Molecular Breeding for Characteristic Horticultural Crops, Kaili 556011, China","institution_ids":[]},{"raw_affiliation_string":"School of Life and Health Science, Kaili University, Kaili 556011, China","institution_ids":["https://openalex.org/I4210119635"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161490958","display_name":"Rong Ning","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119635","display_name":"Kaili University","ror":"https://ror.org/02hzqbc55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210119635"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Ning","raw_affiliation_strings":["School of Life and Health Science, Kaili University, Kaili 556011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life and Health Science, Kaili University, Kaili 556011, China","institution_ids":["https://openalex.org/I4210119635"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161429447","display_name":"Jiaxiang Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119635","display_name":"Kaili University","ror":"https://ror.org/02hzqbc55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210119635"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaxiang Luo","raw_affiliation_strings":["School of Life and Health Science, Kaili University, Kaili 556011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life and Health Science, Kaili University, Kaili 556011, China","institution_ids":["https://openalex.org/I4210119635"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161482873","display_name":"Liwei Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092582","display_name":"Guizhou Academy of Agricultural Sciences","ror":"https://ror.org/00ev3nz67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092582"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liwei Bai","raw_affiliation_strings":["Chili Pepper Research Institute, Guizhou Academy of Agricultural Sciences, Guiyang 550006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chili Pepper Research Institute, Guizhou Academy of Agricultural Sciences, Guiyang 550006, China","institution_ids":["https://openalex.org/I4210092582"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161438053","display_name":"Fenglian Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fenglian Wu","raw_affiliation_strings":["Vegetable Research Institute, Qiandongnan Academy of Agricultural Sciences, Kaili 556000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vegetable Research Institute, Qiandongnan Academy of Agricultural Sciences, Kaili 556000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161433503","display_name":"Qin Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Qin Yang","raw_affiliation_strings":["Guizhou Key Laboratory of Molecular Breeding for Characteristic Horticultural Crops, Kaili 556011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guizhou Key Laboratory of Molecular Breeding for Characteristic Horticultural Crops, Kaili 556011, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124142339","display_name":"Jianwen He","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jianwen He","raw_affiliation_strings":["Vegetable Research Institute, Qiandongnan Academy of Agricultural Sciences, Kaili 556000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vegetable Research Institute, Qiandongnan Academy of Agricultural Sciences, Kaili 556000, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108703477","display_name":"Huanxiu Li","orcid":"https://orcid.org/0000-0002-4040-3774","observed_orcids":["https://orcid.org/0000-0002-4040-3774","https://orcid.org/0000-0002-4702-0936"]},"institutions":[{"id":"https://openalex.org/I37574244","display_name":"Sichuan Agricultural University","ror":"https://ror.org/0388c3403","country_code":"CN","type":"education","lineage":["https://openalex.org/I37574244"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huanxiu Li","raw_affiliation_strings":["College of Horticulture, Sichuan Agricultural University, Chengdu 611130, China"],"raw_orcid":"https://orcid.org/0000-0002-4040-3774","affiliations":[{"raw_affiliation_string":"College of Horticulture, Sichuan Agricultural University, Chengdu 611130, China","institution_ids":["https://openalex.org/I37574244"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5108703477","https://openalex.org/A5124142339","https://openalex.org/A5161433503"],"corresponding_institution_ids":["https://openalex.org/I37574244"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"22","first_page":"3513","last_page":"3513"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10014","display_name":"Plant Stress Responses and Tolerance","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10014","display_name":"Plant Stress Responses and Tolerance","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11237","display_name":"Plant Gene Expression Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2776242653","wikidata":"https://www.wikidata.org/wiki/Q22907699","display_name":"Pepper","level":2,"score":0.7483000159263611},{"id":"https://openalex.org/C89519541","wikidata":"https://www.wikidata.org/wiki/Q4667893","display_name":"Abiotic stress","level":3,"score":0.6013000011444092},{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.5807999968528748},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.550000011920929},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5338000059127808},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.5220999717712402},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5131000280380249},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5120000243186951},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49140000343322754},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46070000529289246},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.45879998803138733},{"id":"https://openalex.org/C162008176","wikidata":"https://www.wikidata.org/wiki/Q419305","display_name":"Peroxidase","level":3,"score":0.4296000003814697},{"id":"https://openalex.org/C79877727","wikidata":"https://www.wikidata.org/wiki/Q24786020","display_name":"WRKY protein domain","level":5,"score":0.4156000018119812},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.3928000032901764},{"id":"https://openalex.org/C108305142","wikidata":"https://www.wikidata.org/wiki/Q3062286","display_name":"Heterologous expression","level":4,"score":0.3849000036716461},{"id":"https://openalex.org/C132215390","wikidata":"https://www.wikidata.org/wiki/Q461335","display_name":"Abiotic component","level":2,"score":0.3434000015258789},{"id":"https://openalex.org/C2776879804","wikidata":"https://www.wikidata.org/wiki/Q7630919","display_name":"Subcellular localization","level":3,"score":0.3431999981403351},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33489999175071716},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.33059999346733093},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3280999958515167},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3174000084400177},{"id":"https://openalex.org/C2780118905","wikidata":"https://www.wikidata.org/wiki/Q16949811","display_name":"Cold sensitivity","level":4,"score":0.3154999911785126},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.3009999990463257},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.29260000586509705},{"id":"https://openalex.org/C161221295","wikidata":"https://www.wikidata.org/wiki/Q185973","display_name":"Plant physiology","level":2,"score":0.2897000014781952},{"id":"https://openalex.org/C2993964980","wikidata":"https://www.wikidata.org/wiki/Q913343","display_name":"Cold tolerance","level":2,"score":0.289000004529953},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.28369998931884766},{"id":"https://openalex.org/C2778778573","wikidata":"https://www.wikidata.org/wiki/Q421976","display_name":"Brassinosteroid","level":5,"score":0.28349998593330383},{"id":"https://openalex.org/C2992529232","wikidata":"https://www.wikidata.org/wiki/Q1036696","display_name":"Cold stress","level":3,"score":0.2572999894618988}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/plants15223513","doi":"https://doi.org/10.3390/plants15223513","is_oa":true,"landing_page_url":"https://doi.org/10.3390/plants15223513","pdf_url":null,"source":{"id":"https://openalex.org/S4210230202","display_name":"Plants","issn_l":"2223-7747","issn":["2223-7747"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plants","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/plants15223513","doi":"https://doi.org/10.3390/plants15223513","is_oa":true,"landing_page_url":"https://doi.org/10.3390/plants15223513","pdf_url":null,"source":{"id":"https://openalex.org/S4210230202","display_name":"Plants","issn_l":"2223-7747","issn":["2223-7747"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plants","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1484403819","https://openalex.org/W1594526056","https://openalex.org/W1981611178","https://openalex.org/W2048737180","https://openalex.org/W2074149304","https://openalex.org/W2107277218","https://openalex.org/W2116122104","https://openalex.org/W2119078782","https://openalex.org/W2121665941","https://openalex.org/W2150900054","https://openalex.org/W2162413931","https://openalex.org/W2322133405","https://openalex.org/W2790450027","https://openalex.org/W2884411658","https://openalex.org/W2912513382","https://openalex.org/W2927774627","https://openalex.org/W2999158345","https://openalex.org/W3036319615","https://openalex.org/W3087397141","https://openalex.org/W3150167015","https://openalex.org/W3170073984","https://openalex.org/W4214506997","https://openalex.org/W4220705238","https://openalex.org/W4225160906","https://openalex.org/W4294733682","https://openalex.org/W4308181383","https://openalex.org/W4313611824","https://openalex.org/W4327601346","https://openalex.org/W4380422131","https://openalex.org/W4383092961","https://openalex.org/W4387935471","https://openalex.org/W4389862043","https://openalex.org/W4391359149","https://openalex.org/W4404121469","https://openalex.org/W4404692332","https://openalex.org/W4405924372","https://openalex.org/W4409875822"],"related_works":[],"abstract_inverted_index":{"Low":[0],"temperature":[1],"is":[2],"a":[3,77,82,192,212],"major":[4],"abiotic":[5,106],"stress":[6,29,53,96,219],"that":[7,101,188],"constrains":[8],"the":[9,165,168,226],"early-spring":[10],"and":[11,47,68,95,108,125,130,156,159,173,205,223],"late-season":[12],"cultivation":[13],"of":[14,167,195,229],"pepper":[15,35,146,222,231],"(Capsicum":[16],"annuum":[17],"L.).":[18],"Basic":[19],"helix\u2013loop\u2013helix":[20],"(bHLH)":[21],"transcription":[22,61],"factors":[23],"play":[24],"important":[25],"roles":[26],"in":[27,34,51,66,73,145,178,198,221],"plant":[28],"responses;":[30],"however,":[31],"their":[32],"functions":[33,190],"cold":[36,52,113,116,148,182,196,218],"tolerance":[37,197],"remain":[38],"poorly":[39],"understood.":[40],"In":[41],"this":[42],"study,":[43],"we":[44],"characterized":[45],"CabHLH55":[46,75,102,144,189],"investigated":[48],"its":[49],"role":[50],"through":[54],"bioinformatic":[55],"analysis,":[56],"subcellular":[57],"localization,":[58],"quantitative":[59],"reverse":[60],"PCR":[62],"(RT-qPCR),":[63],"heterologous":[64],"overexpression":[65],"Arabidopsis,":[67],"virus-induced":[69],"gene":[70,207],"silencing":[71,143],"(VIGS)":[72],"pepper.":[74],"encodes":[76],"257-amino-acid":[78],"nuclear":[79],"protein":[80],"containing":[81],"conserved":[83],"bHLH":[84],"domain.":[85],"Its":[86],"promoter":[87],"contains":[88],"multiple":[89,105],"cis-acting":[90],"elements":[91],"associated":[92],"with":[93,135],"phytohormone":[94],"responses.":[97],"Expression":[98],"analysis":[99],"showed":[100],"responded":[103],"to":[104],"stresses":[107],"was":[109,175],"markedly":[110],"downregulated":[111],"under":[112,181],"stress.":[114,183],"Under":[115],"conditions,":[117],"CabHLH55-overexpressing":[118],"Arabidopsis":[119],"plants":[120,180],"exhibited":[121],"reduced":[122,150],"chlorophyll":[123],"content":[124],"increased":[126,160,177],"relative":[127],"electrolyte":[128],"leakage":[129],"malondialdehyde":[131],"(MDA)":[132],"levels":[133],"compared":[134],"WT":[136],"plants,":[137],"indicating":[138],"enhanced":[139],"cold-induced":[140],"damage.":[141],"Conversely,":[142],"alleviated":[147],"injury,":[149],"reactive":[151],"oxygen":[152],"species":[153],"(ROS)":[154],"accumulation":[155],"MDA":[157],"levels,":[158],"peroxidase":[161],"(POD)":[162],"activity.":[163],"Moreover,":[164],"expression":[166],"cold-responsive":[169,206],"genes":[170],"CaCBF1a,":[171],"CaKIN,":[172],"CaCOR47":[174],"significantly":[176],"CabHLH55-silenced":[179],"Collectively,":[184],"these":[185],"results":[186],"indicate":[187],"as":[191],"negative":[193],"regulator":[194],"pepper,":[199],"potentially":[200],"by":[201],"affecting":[202],"ROS":[203],"homeostasis":[204],"expression.":[208],"This":[209],"study":[210],"provides":[211],"basis":[213],"for":[214],"further":[215],"elucidating":[216],"bHLH-mediated":[217],"responses":[220],"may":[224],"facilitate":[225],"molecular":[227],"breeding":[228],"cold-tolerant":[230],"cultivars.":[232]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}