{"id":"https://openalex.org/W7225826869","doi":"https://doi.org/10.64898/2026.11.10.765580","title":"Structural signatures of salinity adaptation in Microviricetes capsids","display_name":"Structural signatures of salinity adaptation in Microviricetes capsids","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225826869","doi":"https://doi.org/10.64898/2026.11.10.765580"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.10.765580","doi":"https://doi.org/10.64898/2026.11.10.765580","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.10.765580","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.11.10.765580","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087327383","display_name":"Varada Khot","orcid":"https://orcid.org/0000-0003-4664-6678","observed_orcids":["https://orcid.org/0000-0003-4664-6678"]},"institutions":[{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Varada Milind Khot","raw_affiliation_strings":["Friedrich Schiller University Jena;"],"raw_orcid":"https://orcid.org/0000-0003-4664-6678","affiliations":[{"raw_affiliation_string":"Friedrich Schiller University Jena;","institution_ids":["https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028591015","display_name":"Mart Krupov\u00ec\u010d","orcid":"https://orcid.org/0000-0001-5486-0098","observed_orcids":["https://orcid.org/0000-0001-5486-0098"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mart Krupovic","raw_affiliation_strings":["Institut Pasteur"],"raw_orcid":"https://orcid.org/0000-0001-5486-0098","affiliations":[{"raw_affiliation_string":"Institut Pasteur","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084321697","display_name":"Bas E. Dutilh","orcid":"https://orcid.org/0000-0003-2329-7890","observed_orcids":["https://orcid.org/0000-0003-2329-7890"]},"institutions":[{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bas E Dutilh","raw_affiliation_strings":["Friedrich Schiller University Jena;"],"raw_orcid":"https://orcid.org/0000-0003-2329-7890","affiliations":[{"raw_affiliation_string":"Friedrich Schiller University Jena;","institution_ids":["https://openalex.org/I76198965"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087327383"],"corresponding_institution_ids":["https://openalex.org/I76198965"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.8417999744415283,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.8417999744415283,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.10970000177621841,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.031300000846385956,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.9088000059127808},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6819000244140625},{"id":"https://openalex.org/C30765947","wikidata":"https://www.wikidata.org/wiki/Q899119","display_name":"Salt bridge","level":4,"score":0.5478000044822693},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5472000241279602},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4973999857902527},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.49000000953674316},{"id":"https://openalex.org/C129513315","wikidata":"https://www.wikidata.org/wiki/Q179615","display_name":"Salinity","level":2,"score":0.4221999943256378},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4025000035762787},{"id":"https://openalex.org/C2994376932","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Amino acid residue","level":4,"score":0.40209999680519104},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.3952000141143799},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37209999561309814},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.36340001225471497},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.3560999929904938},{"id":"https://openalex.org/C204323151","wikidata":"https://www.wikidata.org/wiki/Q905424","display_name":"Range (aeronautics)","level":2,"score":0.3384999930858612},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3028999865055084},{"id":"https://openalex.org/C2776371256","wikidata":"https://www.wikidata.org/wiki/Q12370","display_name":"Salt (chemistry)","level":2,"score":0.30160000920295715},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.29249998927116394},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.2867000102996826},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.2689000070095062},{"id":"https://openalex.org/C2991991741","wikidata":"https://www.wikidata.org/wiki/Q188025","display_name":"Salt lake","level":3,"score":0.2628999948501587},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.2556999921798706},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.2533000111579895}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.10.765580","doi":"https://doi.org/10.64898/2026.11.10.765580","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.10.765580","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.10.765580","doi":"https://doi.org/10.64898/2026.11.10.765580","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.10.765580","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Phages,":[0],"like":[1],"their":[2,25],"bacterial":[3],"hosts,":[4],"have":[5],"evolved":[6],"to":[7,51,57,63,137,174],"proliferate":[8],"across":[9],"the":[10,18,76,119,164,195],"full":[11],"range":[12],"of":[13,128,199],"environments":[14,176],"on":[15,94],"Earth,":[16],"but":[17],"specific":[19,58],"amino":[20,53,158],"acid":[21,54,146],"residues":[22,55,93,147],"that":[23,36,83,170],"underlie":[24],"environmental":[26,205],"adaptations":[27],"remain":[28],"elusive.":[29],"Here,":[30],"we":[31,67,188],"developed":[32],"a":[33,42,47,190],"computational":[34],"framework":[35,62],"uses":[37],"structure-based":[38],"multiple":[39],"sequence":[40],"alignments,":[41],"random":[43],"forest":[44],"classifier,":[45],"and":[46,78,81,96,109,130,142,182,197],"phylogeny-aware":[48],"regression":[49],"model":[50],"find":[52],"linked":[56],"environments.":[59],"Applying":[60],"this":[61],"public":[64],"metagenomic":[65],"data,":[66],"analyzed":[68],"1,110":[69],"Microviricetes":[70],"major":[71],"capsid":[72],"proteins":[73],"(MCPs)":[74],"from":[75],"lake":[77,149],"ocean":[79,84,124,161],"biomes,":[80],"found":[82],"virus":[85],"capsids":[86,125,150,162,172],"were":[87,151],"highly":[88],"enriched":[89],"in":[90,148,160,179],"negatively":[91],"charged":[92,116],"internal":[95],"external":[97],"surfaces.":[98],"This":[99],"adaptation":[100,196],"likely":[101],"helps":[102],"maintain":[103],"solubility":[104],"at":[105],"high":[106],"salt":[107,140],"concentrations":[108],"stabilizes":[110],"ssDNA-capsid":[111],"interactions":[112],"by":[113,155],"sequestering":[114],"positively":[115],"ions":[117],"inside":[118],"capsid.":[120],"At":[121],"intersubunit":[122,185],"interfaces,":[123],"showed":[126],"enrichment":[127],"cation-\u03c0":[129],"\u03c0-\u03c0":[131],"interactions,":[132],"which":[133],"are":[134],"more":[135,152],"resistant":[136],"solvation":[138],"than":[139,163],"bridges":[141],"hydrogen":[143],"bonds.":[144],"Amino":[145],"often":[153],"substituted":[154],"biochemically":[156],"dissimilar":[157],"acids":[159],"reverse.":[165],"Together,":[166],"these":[167],"results":[168],"show":[169],"microvirus":[171],"adapt":[173],"high-salt":[175],"through":[177],"changes":[178],"surface":[180],"charge":[181],"substitutions":[183],"affecting":[184],"interactions.":[186],"Further,":[187],"describe":[189],"general":[191],"approach":[192],"for":[193],"studying":[194],"stability":[198],"any":[200],"protein":[201],"family":[202],"under":[203],"complementary":[204],"or":[206],"phenotypic":[207],"conditions.":[208]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
