{"id":"https://openalex.org/W7225826626","doi":"https://doi.org/10.1021/jacs.6c14020","title":"Unifying Polar and Hydrophobic Models of Ice Recognition by Antifreeze Glycoproteins","display_name":"Unifying Polar and Hydrophobic Models of Ice Recognition by Antifreeze Glycoproteins","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225826626","doi":"https://doi.org/10.1021/jacs.6c14020"},"language":"en","primary_location":{"id":"doi:10.1021/jacs.6c14020","doi":"https://doi.org/10.1021/jacs.6c14020","is_oa":true,"landing_page_url":"https://doi.org/10.1021/jacs.6c14020","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/jacs.6c14020","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003436106","display_name":"Alejandro Villacampa","orcid":"https://orcid.org/0000-0001-7514-9991","observed_orcids":["https://orcid.org/0000-0001-7514-9991"]},"institutions":[{"id":"https://openalex.org/I4210162082","display_name":"Instituto de Qu\u00edmica Org\u00e1nica General","ror":"https://ror.org/05e0q7s59","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210162082"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alejandro Villacampa","raw_affiliation_strings":["Instituto de Qui\u0301mica Orga\u0301nica General (IQOG-CSIC) , Juan de la Cierva 3 , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Qui\u0301mica Orga\u0301nica General (IQOG-CSIC) , Juan de la Cierva 3 , ,","institution_ids":["https://openalex.org/I4210162082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161456212","display_name":"Julio Zabalza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168974976","display_name":"Universidad de La Rioja","ror":"https://ror.org/0553yr311","country_code":"ES","type":"education","lineage":["https://openalex.org/I168974976"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Julio Zabalza","raw_affiliation_strings":["Universidad de La Rioja , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de La Rioja , , ,","institution_ids":["https://openalex.org/I168974976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083448029","display_name":"Alba Nin\u2010Hill","orcid":"https://orcid.org/0000-0002-8670-9031","observed_orcids":["https://orcid.org/0000-0002-8670-9031"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alba Nin-Hill","raw_affiliation_strings":["Universitat de Barcelona , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitat de Barcelona , , ,","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068424602","display_name":"Akari Yamauchi","orcid":"https://orcid.org/0000-0002-8973-4443","observed_orcids":["https://orcid.org/0000-0002-8973-4443"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akari Yamauchi","raw_affiliation_strings":["Hokkaido University , , N19, W8, Kita-ku , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hokkaido University , , N19, W8, Kita-ku , ,","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040251199","display_name":"Alicia As\u00edn","orcid":"https://orcid.org/0000-0001-6030-5752","observed_orcids":["https://orcid.org/0000-0001-6030-5752","https://orcid.org/0000-0003-2520-722X"]},"institutions":[{"id":"https://openalex.org/I168974976","display_name":"Universidad de La Rioja","ror":"https://ror.org/0553yr311","country_code":"ES","type":"education","lineage":["https://openalex.org/I168974976"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alicia Asi\u0301n","raw_affiliation_strings":["Universidad de La Rioja , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de La Rioja , , ,","institution_ids":["https://openalex.org/I168974976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047657328","display_name":"Andr\u00e9s G. Santana","orcid":"https://orcid.org/0000-0003-3568-7714","observed_orcids":["https://orcid.org/0000-0003-3568-7714","https://orcid.org/0000-0002-8711-9543"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210112570","display_name":"Instituto de Productos Naturales y Agrobiolog\u00eda","ror":"https://ror.org/028ev2d94","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210112570"]},{"id":"https://openalex.org/I4210162082","display_name":"Instituto de Qu\u00edmica Org\u00e1nica General","ror":"https://ror.org/05e0q7s59","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210162082"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Andre\u0301s G. Santana","raw_affiliation_strings":["Instituto de Productos Naturales y Agrobiologi\u0301a (IPNA-CSIC) , Av. Astrofi\u0301sico Fco. Sa\u0301nchez 3 , , ,","Instituto de Qui\u0301mica Orga\u0301nica General (IQOG-CSIC) , Juan de la Cierva 3 , ,"],"raw_orcid":"https://orcid.org/0000-0003-3568-7714","affiliations":[{"raw_affiliation_string":"Instituto de Productos Naturales y Agrobiologi\u0301a (IPNA-CSIC) , Av. Astrofi\u0301sico Fco. Sa\u0301nchez 3 , , ,","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210112570"]},{"raw_affiliation_string":"Instituto de Qui\u0301mica Orga\u0301nica General (IQOG-CSIC) , Juan de la Cierva 3 , ,","institution_ids":["https://openalex.org/I4210162082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048472425","display_name":"Mattia Ghirardello","orcid":"https://orcid.org/0000-0002-2855-4801","observed_orcids":["https://orcid.org/0000-0002-2855-4801"]},"institutions":[{"id":"https://openalex.org/I168974976","display_name":"Universidad de La Rioja","ror":"https://ror.org/0553yr311","country_code":"ES","type":"education","lineage":["https://openalex.org/I168974976"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mattia Ghirardello","raw_affiliation_strings":["Universidad de La Rioja , , ,"],"raw_orcid":"https://orcid.org/0000-0002-2855-4801","affiliations":[{"raw_affiliation_string":"Universidad de La Rioja , , ,","institution_ids":["https://openalex.org/I168974976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161457277","display_name":"Ismael Compan\u0303o\u0301n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168974976","display_name":"Universidad de La Rioja","ror":"https://ror.org/0553yr311","country_code":"ES","type":"education","lineage":["https://openalex.org/I168974976"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ismael Compan\u0303o\u0301n","raw_affiliation_strings":["Universidad de La Rioja , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de La Rioja , , ,","institution_ids":["https://openalex.org/I168974976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101813998","display_name":"Tatsuya J. Arai","orcid":"https://orcid.org/0000-0002-2328-9519","observed_orcids":["https://orcid.org/0000-0002-2328-9519","https://orcid.org/0000-0002-8045-1359","https://orcid.org/0000-0001-5726-2309"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuya Arai","raw_affiliation_strings":["Hokkaido University , , N10 W8 Kitaku , ,"],"raw_orcid":"https://orcid.org/0000-0002-2328-9519","affiliations":[{"raw_affiliation_string":"Hokkaido University , , N10 W8 Kitaku , ,","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033115148","display_name":"Qinghua Liao","orcid":"https://orcid.org/0000-0002-2260-8493","observed_orcids":["https://orcid.org/0000-0002-2260-8493"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Qinghua Liao","raw_affiliation_strings":["Universitat de Barcelona , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitat de Barcelona , , ,","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044250918","display_name":"Laura D\u00edaz\u2010Casado","orcid":"https://orcid.org/0000-0003-0333-8624","observed_orcids":["https://orcid.org/0000-0003-0333-8624"]},"institutions":[{"id":"https://openalex.org/I4210162082","display_name":"Instituto de Qu\u00edmica Org\u00e1nica General","ror":"https://ror.org/05e0q7s59","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210162082"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laura Di\u0301az-Casado","raw_affiliation_strings":["Instituto de Qui\u0301mica Orga\u0301nica General (IQOG-CSIC) , Juan de la Cierva 3 , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Qui\u0301mica Orga\u0301nica General (IQOG-CSIC) , Juan de la Cierva 3 , ,","institution_ids":["https://openalex.org/I4210162082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114265084","display_name":"Claudia S\u00e1nchez-Garc\u00eda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162082","display_name":"Instituto de Qu\u00edmica Org\u00e1nica General","ror":"https://ror.org/05e0q7s59","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210162082"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Claudia Sanchez-Garci\u0301a","raw_affiliation_strings":["Instituto de Qui\u0301mica Orga\u0301nica General (IQOG-CSIC) , Juan de la Cierva 3 , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Qui\u0301mica Orga\u0301nica General (IQOG-CSIC) , Juan de la Cierva 3 , ,","institution_ids":["https://openalex.org/I4210162082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060944562","display_name":"Hiroshi Hinou","orcid":"https://orcid.org/0000-0003-2223-7300","observed_orcids":["https://orcid.org/0000-0003-2223-7300"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Hinou","raw_affiliation_strings":["Hokkaido University , , ,"],"raw_orcid":"https://orcid.org/0000-0003-2223-7300","affiliations":[{"raw_affiliation_string":"Hokkaido University , , ,","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083667558","display_name":"Pierre \u00c7ar\u00e7abal","orcid":"https://orcid.org/0000-0002-4738-115X","observed_orcids":["https://orcid.org/0000-0002-4738-115X"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre C\u0327arc\u0327abal","raw_affiliation_strings":["CNRS, Universite\u0301 Paris Sud XI , , Ba\u0302timent 210 , ,"],"raw_orcid":"https://orcid.org/0000-0002-4738-115X","affiliations":[{"raw_affiliation_string":"CNRS, Universite\u0301 Paris Sud XI , , Ba\u0302timent 210 , ,","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102903531","display_name":"Emilio J. Cocinero","orcid":"https://orcid.org/0000-0001-7632-3728","observed_orcids":["https://orcid.org/0000-0001-7632-3728"]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210118072","display_name":"Instituto Biofisika","ror":"https://ror.org/01pf2cj55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I169108374","https://openalex.org/I4210118072"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Emilio J. Cocinero","raw_affiliation_strings":["Biofisika Institute (CSIC\u2013EHU) , ,","University of the Basque Country (EHU) , , ,"],"raw_orcid":"https://orcid.org/0000-0001-7632-3728","affiliations":[{"raw_affiliation_string":"Biofisika Institute (CSIC\u2013EHU) , ,","institution_ids":["https://openalex.org/I4210118072"]},{"raw_affiliation_string":"University of the Basque Country (EHU) , , ,","institution_ids":["https://openalex.org/I169108374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055399781","display_name":"Fayna Garc\u00eda Mart\u00edn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168974976","display_name":"Universidad de La Rioja","ror":"https://ror.org/0553yr311","country_code":"ES","type":"education","lineage":["https://openalex.org/I168974976"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Fayna Garci\u0301a Marti\u0301n","raw_affiliation_strings":["Universidad de La Rioja , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de La Rioja , , ,","institution_ids":["https://openalex.org/I168974976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085119719","display_name":"Alberto Avenoza","orcid":"https://orcid.org/0000-0002-5465-3555","observed_orcids":["https://orcid.org/0000-0002-5465-3555"]},"institutions":[{"id":"https://openalex.org/I168974976","display_name":"Universidad de La Rioja","ror":"https://ror.org/0553yr311","country_code":"ES","type":"education","lineage":["https://openalex.org/I168974976"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alberto Avenoza","raw_affiliation_strings":["Universidad de La Rioja , , ,"],"raw_orcid":"https://orcid.org/0000-0002-5465-3555","affiliations":[{"raw_affiliation_string":"Universidad de La Rioja , , ,","institution_ids":["https://openalex.org/I168974976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069781060","display_name":"Jes\u00fas H. Busto","orcid":"https://orcid.org/0000-0003-4403-4790","observed_orcids":["https://orcid.org/0000-0003-4403-4790"]},"institutions":[{"id":"https://openalex.org/I168974976","display_name":"Universidad de La Rioja","ror":"https://ror.org/0553yr311","country_code":"ES","type":"education","lineage":["https://openalex.org/I168974976"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jesu\u0301s H. Busto","raw_affiliation_strings":["Universidad de La Rioja , , ,"],"raw_orcid":"https://orcid.org/0000-0003-4403-4790","affiliations":[{"raw_affiliation_string":"Universidad de La Rioja , , ,","institution_ids":["https://openalex.org/I168974976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076683231","display_name":"Ram\u00f3n Hurtado\u2010Guerrero","orcid":"https://orcid.org/0000-0002-3122-9401","observed_orcids":["https://orcid.org/0000-0002-3122-9401"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I4210085944","display_name":"Fundacion Agencia Aragonesa para la Investigacion y el Desarrollo","ror":"https://ror.org/007bpwb04","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210085944"]}],"countries":["DK","ES"],"is_corresponding":false,"raw_author_name":"Ramo\u0301n Hurtado-Guerrero","raw_affiliation_strings":["Fundacio\u0301n ARAID , ,","University of Copenhagen , , ,","University of Zaragoza , , Mariano Esquillor s/n, Campus Rio Ebro, Edificio I+D , ,"],"raw_orcid":"https://orcid.org/0000-0002-3122-9401","affiliations":[{"raw_affiliation_string":"Fundacio\u0301n ARAID , ,","institution_ids":["https://openalex.org/I4210085944"]},{"raw_affiliation_string":"University of Copenhagen , , ,","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"University of Zaragoza , , Mariano Esquillor s/n, Campus Rio Ebro, Edificio I+D , ,","institution_ids":["https://openalex.org/I255234318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017576648","display_name":"Jes\u00fas Manuel Peregrina","orcid":"https://orcid.org/0000-0003-3778-7065","observed_orcids":["https://orcid.org/0000-0003-3778-7065"]},"institutions":[{"id":"https://openalex.org/I168974976","display_name":"Universidad de La Rioja","ror":"https://ror.org/0553yr311","country_code":"ES","type":"education","lineage":["https://openalex.org/I168974976"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jesu\u0301s M. Peregrina","raw_affiliation_strings":["Universidad de La Rioja , , ,"],"raw_orcid":"https://orcid.org/0000-0003-3778-7065","affiliations":[{"raw_affiliation_string":"Universidad de La Rioja , , ,","institution_ids":["https://openalex.org/I168974976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101752138","display_name":"Ana Mar\u00eda G\u00f3mez","orcid":"https://orcid.org/0000-0002-8703-3360","observed_orcids":["https://orcid.org/0000-0002-8703-3360"]},"institutions":[{"id":"https://openalex.org/I4210162082","display_name":"Instituto de Qu\u00edmica Org\u00e1nica General","ror":"https://ror.org/05e0q7s59","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210162082"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana M. Go\u0301mez","raw_affiliation_strings":["Instituto de Qui\u0301mica Orga\u0301nica General (IQOG-CSIC) , Juan de la Cierva 3 , ,"],"raw_orcid":"https://orcid.org/0000-0002-8703-3360","affiliations":[{"raw_affiliation_string":"Instituto de Qui\u0301mica Orga\u0301nica General (IQOG-CSIC) , Juan de la Cierva 3 , ,","institution_ids":["https://openalex.org/I4210162082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074428939","display_name":"Shin\u2010Ichiro Nishimura","orcid":"https://orcid.org/0000-0002-6608-8418","observed_orcids":["https://orcid.org/0000-0002-6608-8418"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shin-Ichiro Nishimura","raw_affiliation_strings":["Hokkaido University , , ,"],"raw_orcid":"https://orcid.org/0000-0002-6608-8418","affiliations":[{"raw_affiliation_string":"Hokkaido University , , ,","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063186779","display_name":"Jes\u00fas Jim\u00e9nez\u2010Barbero","orcid":"https://orcid.org/0000-0001-5421-8513","observed_orcids":["https://orcid.org/0000-0001-5421-8513"]},"institutions":[{"id":"https://openalex.org/I110594554","display_name":"Ikerbasque","ror":"https://ror.org/01cc3fy72","country_code":"ES","type":"other","lineage":["https://openalex.org/I110594554"]},{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210099160","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias","ror":"https://ror.org/0119pby33","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210099160","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jesu\u0301s Jime\u0301nez-Barbero","raw_affiliation_strings":["Basque Research and Technology Alliance (BRTA) Derio , , ,","Centro de Investigacio\u0301n Biome\u0301dica En Red de Enfermedades Respiratorias , ,","Ikerbasque, Basque Foundation for Science , Plaza Euskadi 5 , ,","University of the Basque Country , , EHU-UPV , ,"],"raw_orcid":"https://orcid.org/0000-0001-5421-8513","affiliations":[{"raw_affiliation_string":"Basque Research and Technology Alliance (BRTA) Derio , , ,","institution_ids":[]},{"raw_affiliation_string":"Centro de Investigacio\u0301n Biome\u0301dica En Red de Enfermedades Respiratorias , ,","institution_ids":["https://openalex.org/I4210099160"]},{"raw_affiliation_string":"Ikerbasque, Basque Foundation for Science , Plaza Euskadi 5 , ,","institution_ids":["https://openalex.org/I110594554"]},{"raw_affiliation_string":"University of the Basque Country , , EHU-UPV , ,","institution_ids":["https://openalex.org/I169108374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081831378","display_name":"Carme Rovira","orcid":"https://orcid.org/0000-0003-1477-5010","observed_orcids":["https://orcid.org/0000-0003-1477-5010"]},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carme Rovira","raw_affiliation_strings":["Institucio\u0301 Catalana de Recerca i Estudis Avanc\u0327ats (ICREA) , ,","Universitat de Barcelona , , ,"],"raw_orcid":"https://orcid.org/0000-0003-1477-5010","affiliations":[{"raw_affiliation_string":"Institucio\u0301 Catalana de Recerca i Estudis Avanc\u0327ats (ICREA) , ,","institution_ids":["https://openalex.org/I11932220"]},{"raw_affiliation_string":"Universitat de Barcelona , , ,","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043732814","display_name":"Benjamin G. Davis","orcid":"https://orcid.org/0000-0002-5056-407X","observed_orcids":["https://orcid.org/0000-0002-5056-407X"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210103985","display_name":"Rosalind Franklin Institute","ror":"https://ror.org/01djcs087","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210103985"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Benjamin G. Davis","raw_affiliation_strings":["The Rosalind Franklin Institute , ,","University of Oxford , , ,"],"raw_orcid":"https://orcid.org/0000-0002-5056-407X","affiliations":[{"raw_affiliation_string":"The Rosalind Franklin Institute , ,","institution_ids":["https://openalex.org/I4210103985"]},{"raw_affiliation_string":"University of Oxford , , ,","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073395023","display_name":"Ester Jim\u00e9nez\u2010Moreno","orcid":"https://orcid.org/0000-0002-5045-433X","observed_orcids":["https://orcid.org/0000-0002-5045-433X"]},"institutions":[{"id":"https://openalex.org/I168974976","display_name":"Universidad de La Rioja","ror":"https://ror.org/0553yr311","country_code":"ES","type":"education","lineage":["https://openalex.org/I168974976"]},{"id":"https://openalex.org/I4210162082","display_name":"Instituto de Qu\u00edmica Org\u00e1nica General","ror":"https://ror.org/05e0q7s59","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210162082"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Ester Jime\u0301nez-Moreno","raw_affiliation_strings":["Instituto de Qui\u0301mica Orga\u0301nica General (IQOG-CSIC) , Juan de la Cierva 3 , ,","Universidad de La Rioja , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Qui\u0301mica Orga\u0301nica General (IQOG-CSIC) , Juan de la Cierva 3 , ,","institution_ids":["https://openalex.org/I4210162082"]},{"raw_affiliation_string":"Universidad de La Rioja , , ,","institution_ids":["https://openalex.org/I168974976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037303223","display_name":"Sakae Tsuda","orcid":"https://orcid.org/0000-0002-1399-0619","observed_orcids":["https://orcid.org/0000-0002-1399-0619"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Sakae Tsuda","raw_affiliation_strings":["Hokkaido University , , N10 W8 Kitaku , ,"],"raw_orcid":"https://orcid.org/0000-0002-1399-0619","affiliations":[{"raw_affiliation_string":"Hokkaido University , , N10 W8 Kitaku , ,","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078435865","display_name":"Francisco Corzana","orcid":"https://orcid.org/0000-0001-5597-8127","observed_orcids":["https://orcid.org/0000-0001-5597-8127"]},"institutions":[{"id":"https://openalex.org/I168974976","display_name":"Universidad de La Rioja","ror":"https://ror.org/0553yr311","country_code":"ES","type":"education","lineage":["https://openalex.org/I168974976"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Francisco Corzana","raw_affiliation_strings":["Universidad de La Rioja , , ,"],"raw_orcid":"https://orcid.org/0000-0001-5597-8127","affiliations":[{"raw_affiliation_string":"Universidad de La Rioja , , ,","institution_ids":["https://openalex.org/I168974976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059584574","display_name":"Juan Luis Asensio","orcid":"https://orcid.org/0000-0001-7536-5221","observed_orcids":["https://orcid.org/0000-0001-7536-5221"]},"institutions":[{"id":"https://openalex.org/I4210162082","display_name":"Instituto de Qu\u00edmica Org\u00e1nica General","ror":"https://ror.org/05e0q7s59","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210162082"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Juan L. Asensio","raw_affiliation_strings":["Instituto de Qui\u0301mica Orga\u0301nica General (IQOG-CSIC) , Juan de la Cierva 3 , ,"],"raw_orcid":"https://orcid.org/0000-0001-7536-5221","affiliations":[{"raw_affiliation_string":"Instituto de Qui\u0301mica Orga\u0301nica General (IQOG-CSIC) , Juan de la Cierva 3 , ,","institution_ids":["https://openalex.org/I4210162082"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":18,"corresponding_author_ids":["https://openalex.org/A5037303223","https://openalex.org/A5059584574","https://openalex.org/A5073395023","https://openalex.org/A5078435865"],"corresponding_institution_ids":["https://openalex.org/I168974976","https://openalex.org/I205349734","https://openalex.org/I4210162082"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.5307999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.5307999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12202","display_name":"nanoparticles nucleation surface interactions","score":0.31450000405311584,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8996999859809875},{"id":"https://openalex.org/C29705727","wikidata":"https://www.wikidata.org/wiki/Q294562","display_name":"Polar","level":2,"score":0.7623000144958496},{"id":"https://openalex.org/C141734981","wikidata":"https://www.wikidata.org/wiki/Q421541","display_name":"Antifreeze protein","level":2,"score":0.6804999709129333},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.599399983882904},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5985000133514404},{"id":"https://openalex.org/C2776170207","wikidata":"https://www.wikidata.org/wiki/Q503288","display_name":"Antifreeze","level":2,"score":0.5975000262260437},{"id":"https://openalex.org/C178910836","wikidata":"https://www.wikidata.org/wiki/Q2196961","display_name":"Molecular model","level":2,"score":0.4984000027179718},{"id":"https://openalex.org/C179303850","wikidata":"https://www.wikidata.org/wiki/Q4300362","display_name":"Molecular recognition","level":3,"score":0.47909998893737793},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.44040000438690186},{"id":"https://openalex.org/C90260826","wikidata":"https://www.wikidata.org/wiki/Q899157","display_name":"Hydrophobic effect","level":2,"score":0.40869998931884766},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.38519999384880066},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.3684999942779541},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.357699990272522},{"id":"https://openalex.org/C204921945","wikidata":"https://www.wikidata.org/wiki/Q899689","display_name":"Side chain","level":3,"score":0.34360000491142273},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.34060001373291016},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.32010000944137573},{"id":"https://openalex.org/C61978335","wikidata":"https://www.wikidata.org/wiki/Q506623","display_name":"Chemical polarity","level":3,"score":0.30140000581741333},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.30059999227523804},{"id":"https://openalex.org/C49853544","wikidata":"https://www.wikidata.org/wiki/Q206229","display_name":"Biomolecule","level":2,"score":0.2888000011444092},{"id":"https://openalex.org/C2778977261","wikidata":"https://www.wikidata.org/wiki/Q11358","display_name":"Carbohydrate","level":2,"score":0.28769999742507935},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.26750001311302185},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.26649999618530273}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/jacs.6c14020","doi":"https://doi.org/10.1021/jacs.6c14020","is_oa":true,"landing_page_url":"https://doi.org/10.1021/jacs.6c14020","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1021/jacs.6c14020","doi":"https://doi.org/10.1021/jacs.6c14020","is_oa":true,"landing_page_url":"https://doi.org/10.1021/jacs.6c14020","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W51383163","https://openalex.org/W86722686","https://openalex.org/W1031578623","https://openalex.org/W1528606800","https://openalex.org/W1561303451","https://openalex.org/W1976499671","https://openalex.org/W1979275471","https://openalex.org/W1982782097","https://openalex.org/W1983914707","https://openalex.org/W1985034464","https://openalex.org/W1985036499","https://openalex.org/W1986986500","https://openalex.org/W1988091937","https://openalex.org/W1989857595","https://openalex.org/W1994643710","https://openalex.org/W1995992973","https://openalex.org/W2000995214","https://openalex.org/W2001900040","https://openalex.org/W2003949305","https://openalex.org/W2008200902","https://openalex.org/W2012708621","https://openalex.org/W2018123501","https://openalex.org/W2020130975","https://openalex.org/W2020209588","https://openalex.org/W2024726841","https://openalex.org/W2025290408","https://openalex.org/W2025757816","https://openalex.org/W2029667189","https://openalex.org/W2030479202","https://openalex.org/W2030584341","https://openalex.org/W2033061640","https://openalex.org/W2040868638","https://openalex.org/W2042930314","https://openalex.org/W2045683699","https://openalex.org/W2047968138","https://openalex.org/W2064235624","https://openalex.org/W2071239596","https://openalex.org/W2071704671","https://openalex.org/W2073971570","https://openalex.org/W2074117796","https://openalex.org/W2080632083","https://openalex.org/W2081259911","https://openalex.org/W2083335494","https://openalex.org/W2088793989","https://openalex.org/W2090045987","https://openalex.org/W2093683097","https://openalex.org/W2098610321","https://openalex.org/W2098943363","https://openalex.org/W2106140689","https://openalex.org/W2109532360","https://openalex.org/W2113270377","https://openalex.org/W2114449152","https://openalex.org/W2119850183","https://openalex.org/W2130396567","https://openalex.org/W2140230739","https://openalex.org/W2159382632","https://openalex.org/W2167943118","https://openalex.org/W2170711116","https://openalex.org/W2195020354","https://openalex.org/W2289576126","https://openalex.org/W2319469731","https://openalex.org/W2329971962","https://openalex.org/W2404280981","https://openalex.org/W2510475640","https://openalex.org/W2601081289","https://openalex.org/W2762772696","https://openalex.org/W2786807390","https://openalex.org/W2799972603","https://openalex.org/W2806751886","https://openalex.org/W2883662053","https://openalex.org/W2884279666","https://openalex.org/W2909599471","https://openalex.org/W2909858675","https://openalex.org/W2921396197","https://openalex.org/W2949669744","https://openalex.org/W3010600383","https://openalex.org/W3039725808","https://openalex.org/W3112376546","https://openalex.org/W3125622955","https://openalex.org/W3127488895","https://openalex.org/W3158010409","https://openalex.org/W3210935657","https://openalex.org/W4311300633","https://openalex.org/W4313527862","https://openalex.org/W4313857620","https://openalex.org/W4318753638","https://openalex.org/W4318755402","https://openalex.org/W4322501804","https://openalex.org/W4386823162","https://openalex.org/W4387440676","https://openalex.org/W4393164321","https://openalex.org/W4401584941","https://openalex.org/W4409901056","https://openalex.org/W4410498985"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Antifreeze":[1],"glycoproteins":[2],"(AFGPs)":[3],"enable":[4],"polar":[5,39,92,162,178],"organisms":[6],"to":[7,66,85,223],"survive":[8],"at":[9],"subzero":[10],"temperatures":[11],"by":[12],"inhibiting":[13],"ice":[14,72,148],"growth":[15],"through":[16],"selective":[17,166],"association":[18,145],"with":[19,55,131,146,155],"specific":[20,198],"crystallographic":[21],"planes.":[22],"However,":[23],"the":[24,50,68,87,96,120,132,147,188,195],"molecular":[25,63,69,185,212,225,231],"basis":[26],"of":[27,52,71,89,119,175,192,197],"this":[28,124],"interaction":[29],"and":[30,37,40,62,81,91,104,116,139,157,167,179,182,194,210],"its":[31],"remarkable":[32],"selectivity":[33,191],"remain":[34],"incompletely":[35],"understood,":[36],"both":[38],"hydrophobic":[41,180],"binding":[42,110],"models":[43],"have":[44],"been":[45],"proposed.":[46],"Here,":[47],"we":[48],"combine":[49],"synthesis":[51],"AFGP":[53,98],"variants":[54],"high-resolution":[56],"NMR":[57],"spectroscopy,":[58],"antifreeze":[59],"activity":[60],"measurements,":[61],"dynamics":[64],"simulations":[65],"investigate":[67],"determinants":[70],"recognition.":[73],"Minimally":[74],"perturbative":[75,207],"chemical":[76,216],"modifications,":[77],"including":[78],"site-specific":[79],"deuteration":[80],"fluorination,":[82],"were":[83],"used":[84],"probe":[86],"contributions":[88,222],"nonpolar":[90],"interactions":[93,136,163],"while":[94,228],"preserving":[95,229],"characteristic":[97,189],"conformation.":[99],"The":[100],"combined":[101],"structure\u2013activity":[102],"relationships":[103],"computational":[105],"analyses":[106],"support":[107],"an":[108],"integrative":[109],"model":[111,171],"that":[112,134,164],"provides":[113,183],"a":[114,184],"unified":[115],"parsimonious":[117],"interpretation":[118],"experimental":[121,127],"observations.":[122],"Within":[123],"framework,":[125],"our":[126,203],"evidence":[128],"is":[129],"consistent":[130],"view":[133],"dispersive":[135,221],"involving":[137],"peptide":[138],"carbohydrate":[140,151],"methyl":[141],"groups":[142],"favor":[143],"productive":[144],"surface,":[149],"whereas":[150],"hydroxyl":[152],"groups,":[153],"together":[154],"sugar-":[156],"backbone-associated":[158],"water":[159],"molecules,":[160],"contribute":[161],"promote":[165],"persistent":[168],"binding.":[169],"This":[170],"reconciles":[172],"key":[173],"aspects":[174],"previously":[176],"proposed":[177],"descriptions":[181],"rationale":[186],"for":[187,218],"plane":[190],"AFGPs":[193],"conservation":[196],"sequence":[199],"motifs.":[200],"More":[201],"broadly,":[202],"results":[204],"highlight":[205],"minimally":[206],"isotopic":[208],"substitution":[209],"fluorinated":[211],"editing":[213],"as":[214],"useful":[215],"strategies":[217],"probing":[219],"weak":[220],"complex":[224],"recognition":[226],"processes":[227],"native":[230],"architecture.":[232]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
