{"id":"https://openalex.org/W7225826226","doi":"https://doi.org/10.37349/etat.2026.1002412","title":"Unmet needs beyond precision in gastrointestinal cancers","display_name":"Unmet needs beyond precision in gastrointestinal cancers","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225826226","doi":"https://doi.org/10.37349/etat.2026.1002412"},"language":"en","primary_location":{"id":"doi:10.37349/etat.2026.1002412","doi":"https://doi.org/10.37349/etat.2026.1002412","is_oa":true,"landing_page_url":"https://doi.org/10.37349/etat.2026.1002412","pdf_url":"https://www.explorationpub.com//uploads/Article/A1002412/1002412.pdf","source":{"id":"https://openalex.org/S4210215942","display_name":"Exploration of Targeted Anti-tumor Therapy","issn_l":"2692-3114","issn":["2692-3114"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exploration of Targeted Anti-tumor Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.explorationpub.com//uploads/Article/A1002412/1002412.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071949598","display_name":"Alessandro Ottaiano","orcid":"https://orcid.org/0000-0002-2901-3855","observed_orcids":["https://orcid.org/0000-0002-2901-3855"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Ottaiano","raw_affiliation_strings":["Department of Abdominal Oncology, Istituto Nazionale Tumori di Napoli, IRCCS \u201cG. Pascale\u201d, 80131 Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2901-3855","affiliations":[{"raw_affiliation_string":"Department of Abdominal Oncology, Istituto Nazionale Tumori di Napoli, IRCCS \u201cG. Pascale\u201d, 80131 Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113689741","display_name":"Anna Chiara Carrat\u00f9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Chiara Carrat\u00f9","raw_affiliation_strings":["Department of Abdominal Oncology, Istituto Nazionale Tumori di Napoli, IRCCS \u201cG. Pascale\u201d, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Abdominal Oncology, Istituto Nazionale Tumori di Napoli, IRCCS \u201cG. Pascale\u201d, 80131 Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010570032","display_name":"Francesco Sabbatino","orcid":"https://orcid.org/0000-0001-6431-8278","observed_orcids":["https://orcid.org/0000-0001-6431-8278"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Sabbatino","raw_affiliation_strings":["Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035279182","display_name":"Marco Cascella","orcid":"https://orcid.org/0000-0002-5236-3132","observed_orcids":["https://orcid.org/0000-0002-5236-3132"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Cascella","raw_affiliation_strings":["Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy"],"raw_orcid":"https://orcid.org/0000-0002-5236-3132","affiliations":[{"raw_affiliation_string":"Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052216253","display_name":"Francesco Perri","orcid":"https://orcid.org/0000-0001-8158-7509","observed_orcids":["https://orcid.org/0000-0001-8158-7509"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Perri","raw_affiliation_strings":["Department of Abdominal Oncology, Istituto Nazionale Tumori di Napoli, IRCCS \u201cG. Pascale\u201d, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Abdominal Oncology, Istituto Nazionale Tumori di Napoli, IRCCS \u201cG. Pascale\u201d, 80131 Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041596182","display_name":"Oreste Gualillo","orcid":"https://orcid.org/0000-0002-7154-1328","observed_orcids":["https://orcid.org/0000-0002-7154-1328"]},"institutions":[{"id":"https://openalex.org/I200284239","display_name":"Universidade de Santiago de Compostela","ror":"https://ror.org/030eybx10","country_code":"ES","type":"education","lineage":["https://openalex.org/I200284239"]},{"id":"https://openalex.org/I4210096311","display_name":"Complejo Hospitalario Universitario de Santiago","ror":"https://ror.org/00mpdg388","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096311"]},{"id":"https://openalex.org/I4210148771","display_name":"Instituto de Investigaci\u00f3n Sanitaria de Santiago","ror":"https://ror.org/05n7xcf53","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210148771"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Oreste Gualillo","raw_affiliation_strings":["Laboratory of Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases, IDIS, Complexo Hospitalario Universitario de Santiago de Compostela, University of Santiago de Compostela, 15706 Santiago de Compostela, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases, IDIS, Complexo Hospitalario Universitario de Santiago de Compostela, University of Santiago de Compostela, 15706 Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I200284239","https://openalex.org/I4210096311","https://openalex.org/I4210148771"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050677254","display_name":"Silvia Zappavigna","orcid":"https://orcid.org/0000-0003-4787-3776","observed_orcids":["https://orcid.org/0000-0003-4787-3776"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Zappavigna","raw_affiliation_strings":["Department of Precision Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Precision Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073891277","display_name":"Michele Caraglia","orcid":"https://orcid.org/0000-0003-2408-6091","observed_orcids":["https://orcid.org/0000-0003-2408-6091"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Caraglia","raw_affiliation_strings":["Department of Precision Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Precision Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062904109","display_name":"Massimiliano Berretta","orcid":"https://orcid.org/0000-0002-9837-9148","observed_orcids":["https://orcid.org/0000-0002-9837-9148"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimiliano Berretta","raw_affiliation_strings":["Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074752423","display_name":"Guglielmo Nasti","orcid":"https://orcid.org/0000-0002-3590-382X","observed_orcids":["https://orcid.org/0000-0002-3590-382X"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Guglielmo Nasti","raw_affiliation_strings":["Department of Abdominal Oncology, Istituto Nazionale Tumori di Napoli, IRCCS \u201cG. Pascale\u201d, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Abdominal Oncology, Istituto Nazionale Tumori di Napoli, IRCCS \u201cG. Pascale\u201d, 80131 Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0746999979019165,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.7232999801635742},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.637499988079071},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5683000087738037},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.48899999260902405},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.46219998598098755},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.44920000433921814},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4408000111579895},{"id":"https://openalex.org/C542804219","wikidata":"https://www.wikidata.org/wiki/Q5526839","display_name":"Gastrointestinal cancer","level":4,"score":0.4311000108718872},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.4219000041484833},{"id":"https://openalex.org/C3020497934","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision oncology","level":3,"score":0.4088999927043915},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4025999903678894},{"id":"https://openalex.org/C2781335228","wikidata":"https://www.wikidata.org/wiki/Q19596321","display_name":"Circulating tumor DNA","level":3,"score":0.3991999924182892},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.3709999918937683},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33640000224113464},{"id":"https://openalex.org/C169087156","wikidata":"https://www.wikidata.org/wiki/Q2131593","display_name":"Framing (construction)","level":2,"score":0.3057999908924103},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.303600013256073},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2971999943256378},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2930999994277954},{"id":"https://openalex.org/C2775941552","wikidata":"https://www.wikidata.org/wiki/Q25212305","display_name":"Isolation (microbiology)","level":2,"score":0.28690001368522644},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.2840000092983246},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.28360000252723694},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2777000069618225},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.2702000141143799},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.26910001039505005},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.2676999866962433},{"id":"https://openalex.org/C14224292","wikidata":"https://www.wikidata.org/wiki/Q13600188","display_name":"Conceptual framework","level":2,"score":0.2542000114917755}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.37349/etat.2026.1002412","doi":"https://doi.org/10.37349/etat.2026.1002412","is_oa":true,"landing_page_url":"https://doi.org/10.37349/etat.2026.1002412","pdf_url":"https://www.explorationpub.com//uploads/Article/A1002412/1002412.pdf","source":{"id":"https://openalex.org/S4210215942","display_name":"Exploration of Targeted Anti-tumor Therapy","issn_l":"2692-3114","issn":["2692-3114"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exploration of Targeted Anti-tumor Therapy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.37349/etat.2026.1002412","doi":"https://doi.org/10.37349/etat.2026.1002412","is_oa":true,"landing_page_url":"https://doi.org/10.37349/etat.2026.1002412","pdf_url":"https://www.explorationpub.com//uploads/Article/A1002412/1002412.pdf","source":{"id":"https://openalex.org/S4210215942","display_name":"Exploration of Targeted Anti-tumor Therapy","issn_l":"2692-3114","issn":["2692-3114"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exploration of Targeted Anti-tumor Therapy","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225826226.pdf","grobid_xml":"https://content.openalex.org/works/W7225826226.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W1922694287","https://openalex.org/W1934094702","https://openalex.org/W2049397238","https://openalex.org/W2100439220","https://openalex.org/W2126547130","https://openalex.org/W2154472748","https://openalex.org/W2262414037","https://openalex.org/W2570401594","https://openalex.org/W2605964154","https://openalex.org/W2767281692","https://openalex.org/W2908573150","https://openalex.org/W2911120667","https://openalex.org/W2913268845","https://openalex.org/W2923282967","https://openalex.org/W2944044607","https://openalex.org/W2947826965","https://openalex.org/W2962976163","https://openalex.org/W3001713806","https://openalex.org/W3010944770","https://openalex.org/W3024247862","https://openalex.org/W3025022288","https://openalex.org/W3049104202","https://openalex.org/W3087252472","https://openalex.org/W3110528877","https://openalex.org/W3125924492","https://openalex.org/W3129191749","https://openalex.org/W3147820834","https://openalex.org/W3148827278","https://openalex.org/W3171517418","https://openalex.org/W3195796166","https://openalex.org/W3195935456","https://openalex.org/W3197326254","https://openalex.org/W3199253355","https://openalex.org/W3201651264","https://openalex.org/W3213277274","https://openalex.org/W4200093229","https://openalex.org/W4205666661","https://openalex.org/W4206475003","https://openalex.org/W4206662285","https://openalex.org/W4229334478","https://openalex.org/W4281630496","https://openalex.org/W4281738617","https://openalex.org/W4281790169","https://openalex.org/W4282945607","https://openalex.org/W4283798885","https://openalex.org/W4285491569","https://openalex.org/W4292210528","https://openalex.org/W4293090492","https://openalex.org/W4294012223","https://openalex.org/W4294192096","https://openalex.org/W4298325890","https://openalex.org/W4306150184","https://openalex.org/W4306650268","https://openalex.org/W4308438676","https://openalex.org/W4309048328","https://openalex.org/W4310071462","https://openalex.org/W4311425047","https://openalex.org/W4313231809","https://openalex.org/W4315647566","https://openalex.org/W4365813058","https://openalex.org/W4365998338","https://openalex.org/W4382932420","https://openalex.org/W4382933583","https://openalex.org/W4385429828","https://openalex.org/W4386224107","https://openalex.org/W4386324836","https://openalex.org/W4386895237","https://openalex.org/W4387849849","https://openalex.org/W4390637357","https://openalex.org/W4390907638","https://openalex.org/W4391160703","https://openalex.org/W4392605344","https://openalex.org/W4393236029","https://openalex.org/W4396939189","https://openalex.org/W4398220733","https://openalex.org/W4399070697","https://openalex.org/W4399119041","https://openalex.org/W4399176411","https://openalex.org/W4399785536","https://openalex.org/W4400747878","https://openalex.org/W4403253898","https://openalex.org/W4404165915","https://openalex.org/W4404725547","https://openalex.org/W4406717200","https://openalex.org/W4407235348","https://openalex.org/W4407260447","https://openalex.org/W4408234715","https://openalex.org/W4409350464","https://openalex.org/W4412491140","https://openalex.org/W4413970234","https://openalex.org/W4414104868","https://openalex.org/W4414590999","https://openalex.org/W4415356957","https://openalex.org/W7134963772","https://openalex.org/W7162952636","https://openalex.org/W7163058381"],"related_works":[],"abstract_inverted_index":{"Gastrointestinal":[0],"(GI)":[1],"cancers":[2,117],"account":[3],"for":[4,42,98,217],"a":[5,14,210],"substantial":[6],"proportion":[7],"of":[8,17,73,125,143,177,188,204,212,257,270],"global":[9],"cancer":[10,205,273],"mortality":[11],"and":[12,19,32,37,48,71,80,94,119,128,140,154,185,226,231,260,267],"remain":[13,75],"major":[15,60,108],"focus":[16],"translational":[18],"clinical":[20,61,96,130,220,227],"oncology.":[21],"Over":[22],"the":[23,69,123,149,175,186,254,264],"past":[24],"decade,":[25],"advances":[26],"in":[27,63,160],"molecular":[28,195],"profiling,":[29],"biomarker":[30],"development,":[31],"systemic":[33],"therapies\u2014including":[34],"liquid":[35],"biopsy":[36],"circulating":[38],"tumor":[39,78],"DNA":[40],"(ctDNA)":[41],"minimal":[43],"residual":[44],"disease":[45,81,183,238],"(MRD)":[46],"detection":[47],"longitudinal":[49,223],"monitoring\u2014have":[50],"substantially":[51],"enhanced":[52],"biological":[53,85,266],"resolution.":[54],"Precision":[55],"oncology":[56,259],"has":[57,87],"already":[58],"produced":[59],"successes":[62],"selected":[64],"molecularly":[65],"defined":[66],"subsets,":[67],"although":[68,135],"magnitude":[70],"breadth":[72],"benefit":[74],"heterogeneous":[76],"across":[77],"types":[79],"settings.":[82],"Yet,":[83],"increasing":[84],"precision":[86,258],"not":[88],"always":[89],"translated":[90],"proportionally":[91],"into":[92],"predictable":[93],"actionable":[95,155],"decisions":[97],"individual":[99],"patients.":[100],"In":[101],"this":[102,214],"critical":[103],"narrative":[104],"review,":[105],"we":[106],"examine":[107],"GI":[109,272],"cancers\u2014including":[110],"colorectal,":[111],"gastric,":[112],"esophageal,":[113],"pancreatic,":[114],"biliary":[115],"tract":[116],"(BTCs),":[118],"hepatocellular":[120],"carcinoma":[121],"(HCC)\u2014through":[122],"lens":[124],"conceptual":[126],"limitations":[127,176],"unmet":[129],"needs.":[131],"Across":[132],"these":[133],"malignancies,":[134],"with":[136],"important":[137],"tumor-specific":[138],"exceptions":[139],"different":[141],"levels":[142],"supporting":[144],"evidence,":[145,213],"recurring":[146],"themes":[147],"emerge:":[148],"gap":[150],"between":[151],"precise":[152],"prognostication":[153],"treatments,":[156],"exemplified":[157],"by":[158],"settings":[159],"which":[161],"ctDNA":[162],"identifies":[163],"high-risk":[164],"patients":[165],"without":[166],"providing":[167],"an":[168,201],"effective":[169],"strategy":[170],"to":[171,181,234,263],"modify":[172],"that":[173],"risk;":[174],"static":[178],"models":[179],"applied":[180],"dynamic":[182],"processes;":[184],"persistence":[187],"empirically":[189],"driven":[190],"decision-making":[191],"despite":[192],"increasingly":[193],"detailed":[194],"information.":[196],"By":[197],"framing":[198],"uncertainty":[199],"as":[200,237],"intrinsic":[202],"feature":[203],"biology":[206],"rather":[207,240,251],"than":[208,241,252],"simply":[209],"failure":[211],"review":[215],"argues":[216],"more":[218],"adaptive":[219],"frameworks":[221,248],"integrating":[222],"molecular,":[224],"genetic,":[225],"information,":[228],"allowing":[229],"therapeutic":[230],"surveillance":[232],"strategies":[233],"be":[235,261],"reassessed":[236],"evolves":[239],"relying":[242],"exclusively":[243],"on":[244],"single-time-point":[245],"characterization.":[246],"Such":[247],"should":[249],"complement,":[250],"replace,":[253],"established":[255],"achievements":[256],"tailored":[262],"distinct":[265],"evidentiary":[268],"context":[269],"each":[271],"type.":[274]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
